week 4 project pharm - Nursing
asapnursing For this assignment, you are to complete a PowerPoint presentation addressing the specific criteria below, on Otitis Media.  The PowerPoint presentation will be based on Otitis Media. Your presentation must include the following headings. Heading - Title Page Heading - Pathophysiology of Assigned Disease Heading - Definitions of the Two Assigned Drug Classes Heading - Discussion of 4 Medications (2 drugs from each assigned drug class) Heading - Pharmacokinetics, Pharmacodynamics, Safety/Monitoring, & Pregnancy/Lactation of the 4 Medications Discussed Earlier Heading - Contraindications of the 4 Medications Discussed Earlier Heading - Conclusions Heading - References please use apa style The Powerpoint template titled Pharmacological -Management Project for you to use as a guide for this assignment. Pharmacological Management Project Student Name NSG6005 Faculty name Pathophysiology of assigned disease Assigned Disease: Primary Biliary Cholangitis Pathophysiology: Primary biliary cholangitis (PBC, formerly known as primary biliary cirrhosis) is an uncommon cholestatic liver disease characterized by immune-mediated destruction of biliary epithelial cells. PBC is female preponderant and typically presents in the fifth or sixth decade of life. The clinical presentation may include generalized pruritus, dryness of eyes and mouth, fatigue, and upper abdominal discomfort; patients may be asymptomatic. Typical laboratory findings are elevations in serum alkaline phosphatase levels, increased serum immunoglobulin M levels, and the presence of antimitochondrial antibodies or specific subtypes of antinuclear antibodies. A diagnosis of PBC is usually made without histologic examination. When used, liver biopsy typically reveals nonsuppurative granulomatous cholangitis with loss of small bile ducts and lymphocytic portal inflammation. Patients who do not achieve an adequate biochemical response to first-line therapy have a greater risk of disease progression to cirrhosis and may ultimately require liver transplantation. Definition of the two assigned drug Classifications Classification 1: Bile Acid Analog Bile acids aid in the digestion and solubilization of lipophilic nutrients and drugs in the small intestine, they signal endocrine molecules that regulate the glucose, lipid, and energy metabolism through complex and intertwined pathways that are largely mediated by activation of nuclear receptor farnesoid X receptor (FXR) and cell surface G protein-coupled receptor 1, TGR5 (also known as GPBAR1). Classification 2: Immunomodulatory therapy Immunomodulatory drugs modify the response of the immune system by increasing (immunostimulators) or decreasing (immunosuppressives) the production of serum antibodies. Immunostimulators are prescribed to enhance the immune response against infectious diseases, tumours, primary or secondary immunodeficiency, and alterations in antibody transfer, among others. Immunosuppressive drugs are used to reduce the immune response against transplanted organs and to treat autoimmune diseases. Discussion of 4 medications – 2 from each drug classification (you are to choose the drugs – they must belong to the drug class) Classification 1: Bile Acid analog Drug 1: Actigall (ursodiol) 13 – 15 mg/kg/day orally given in 2 – 4 divided doses Give with food Drug 2: Obeticholic acid 5 – 10 mg PO qD Start 5mg PO qd x 3 months, then may increase to 10mg PO qd if needed Classification 1: immunomodulatory therapy Drug 1: prednisone 20 – 30 mg PO qd initially for one month, titrate downward according to IgG concentration Drug 2: Mycophenolate mofetil 500 – 1000 mg PO qd BID Pharmacokinetics, Pharmacodynamics, safety/monitoring & pregnancy/lactation of the 4 Medications you discussed earlier Drug 1: actigall (ursodiol) Metabolism: Liver, GI Tract, CYP450; half-life unknown Excretion: feces primarily; urine Mechanism of Action: decreases cholesterol synthesis, secretion, and absorption; alters bile cholesterol composition Monitoring Parameters: liver function tests q months x 3months, then q6 months Pregnancy: may use during pregnancy; no known risk of fetal harm based on human data Lactation: may use while breastfeeding; no known risk of infant harm based on limited human data Drug 1: obeticholic Metabolism: live; no CYP450; enterohepatically recirculated; active metabolites Excretion: feces 87%; urine <3%; half-life 24 hours Mechanism of Action: agonizes farnesoid X receptor, decreasing intracellular hepatocyte concentrations of bile acids Monitoring Parameters: liver function tests at baseline, then frequently, especially if there is an increase in risk of hepatic decompensation or before dose adjustment; lipid panel Pregnancy: caution advised during pregnancy; inadequate human data available to assess risk Lactation: caution advised while breastfeeding; no human data available to assess risk of infant harm or effects on milk production Drug 1: prednisone Metabolism: liver; CYP450 – 3A4 substrate; prodrug converted to prednisolone Excretion: urine; half-life: 2-4 hours (plasma); 18-36 hours (biological) Mechanism of Action: exact mechanism of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects Monitoring Parameters: electrolytes; BP; weight; 2 hours postprandial glucose; chest x-ray if prolonged treatment; ophthalmic exam if treatment >6weeks Pregnancy: weight risk/benefit during pregnancy, especially in 1st trimester; risk of orofacial cleft based on limited human data; possible risk of teratogenicity based on animal data Lactation: may use while breastfeeding, consider breastfeeding at least 4 hours after high-dose prednisone use; no known risk of infant harm Drug 1: mycophenolate mofetil Metabolism: liver; CYP450-unknown; UGT: 1A9 substrate; info: prodrug converted to mycophenolic acid Excretion: urine 93%, feces 6%, half-life: 17.9 hour (PO route), 16.6h (IV route) Mechanism of Action: inhibits B- and T-lymphocyte proliferation Monitoring Parameters: pregnancy test immediately prior to treatment start, then 8-10 days later, then continue at routine visits, creatinine at baseline, CBC qwk x 1 month, then 2x/mo x 2mo, then q month during 1st year of treatment Pregnancy: avoid use during pregnancy; risk of fetal harm; included teratogenicity and spontaneous abortion, based on human data Lactation: weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm though possible drug excretion into milk Contraindications of the 4 medications discussed earlier Actigall (ursodiol) Hypersensitivity to drug, unremitting acute cholecystitis, acute cholangitis, biliary obstruction, gallstone pancreatitis Obeticholic acid Hypersensitivity to drug; complete biliary obstruction, caution if Child-Pugh Class B or C hepatic impairment, caution if prior hepatic decompensation event prednisone Systemic fungal infection, cerebral malaria, avoid abrupt withdrawal, caution in pediatrics, pregnancy, if immunosuppressed, if active infection, if TB infection, if hypertensive, if diabetic Mycophenolate mofetil Hypersensitivity to polysorbate 80, pregnancy, avoid donating blood during treatment and 6 weeks after d/c, avoid semen donation during treatment and 90 days after d/c, caution HBV or HCV infection, caution if CrCl <50 conclusion Summarize what you learned on this slide – what are the important things to know about the disease, the classifications, drugs and risks references Include all the references used following the APA 7th Edition
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Indigenous Australian Entrepreneurs Exami Calculus (people influence of  others) processes that you perceived occurs in this specific Institution Select one of the forms of stratification highlighted (focus on inter the intersectionalities  of these three) to reflect and analyze the potential ways these ( American history Pharmacology Ancient history . Also Numerical analysis Environmental science Electrical Engineering Precalculus Physiology Civil Engineering Electronic Engineering ness Horizons Algebra Geology Physical chemistry nt When considering both O lassrooms Civil Probability ions Identify a specific consumer product that you or your family have used for quite some time. This might be a branded smartphone (if you have used several versions over the years) or the court to consider in its deliberations. Locard’s exchange principle argues that during the commission of a crime Chemical Engineering Ecology aragraphs (meaning 25 sentences or more). Your assignment may be more than 5 paragraphs but not less. INSTRUCTIONS:  To access the FNU Online Library for journals and articles you can go the FNU library link here:  https://www.fnu.edu/library/ In order to n that draws upon the theoretical reading to explain and contextualize the design choices. Be sure to directly quote or paraphrase the reading ce to the vaccine. Your campaign must educate and inform the audience on the benefits but also create for safe and open dialogue. A key metric of your campaign will be the direct increase in numbers.  Key outcomes: The approach that you take must be clear Mechanical Engineering Organic chemistry Geometry nment Topic You will need to pick one topic for your project (5 pts) Literature search You will need to perform a literature search for your topic Geophysics you been involved with a company doing a redesign of business processes Communication on Customer Relations. Discuss how two-way communication on social media channels impacts businesses both positively and negatively. Provide any personal examples from your experience od pressure and hypertension via a community-wide intervention that targets the problem across the lifespan (i.e. includes all ages). Develop a community-wide intervention to reduce elevated blood pressure and hypertension in the State of Alabama that in in body of the report Conclusions References (8 References Minimum) *** Words count = 2000 words. *** In-Text Citations and References using Harvard style. *** In Task section I’ve chose (Economic issues in overseas contracting)" Electromagnetism w or quality improvement; it was just all part of good nursing care.  The goal for quality improvement is to monitor patient outcomes using statistics for comparison to standards of care for different diseases e a 1 to 2 slide Microsoft PowerPoint presentation on the different models of case management.  Include speaker notes... .....Describe three different models of case management. visual representations of information. They can include numbers SSAY ame workbook for all 3 milestones. You do not need to download a new copy for Milestones 2 or 3. When you submit Milestone 3 pages): Provide a description of an existing intervention in Canada making the appropriate buying decisions in an ethical and professional manner. Topic: Purchasing and Technology You read about blockchain ledger technology. Now do some additional research out on the Internet and share your URL with the rest of the class be aware of which features their competitors are opting to include so the product development teams can design similar or enhanced features to attract more of the market. The more unique low (The Top Health Industry Trends to Watch in 2015) to assist you with this discussion.         https://youtu.be/fRym_jyuBc0 Next year the $2.8 trillion U.S. healthcare industry will   finally begin to look and feel more like the rest of the business wo evidence-based primary care curriculum. Throughout your nurse practitioner program Vignette Understanding Gender Fluidity Providing Inclusive Quality Care Affirming Clinical Encounters Conclusion References Nurse Practitioner Knowledge Mechanics and word limit is unit as a guide only. The assessment may be re-attempted on two further occasions (maximum three attempts in total). All assessments must be resubmitted 3 days within receiving your unsatisfactory grade. You must clearly indicate “Re-su Trigonometry Article writing Other 5. June 29 After the components sending to the manufacturing house 1. In 1972 the Furman v. Georgia case resulted in a decision that would put action into motion. Furman was originally sentenced to death because of a murder he committed in Georgia but the court debated whether or not this was a violation of his 8th amend One of the first conflicts that would need to be investigated would be whether the human service professional followed the responsibility to client ethical standard.  While developing a relationship with client it is important to clarify that if danger or Ethical behavior is a critical topic in the workplace because the impact of it can make or break a business No matter which type of health care organization With a direct sale During the pandemic Computers are being used to monitor the spread of outbreaks in different areas of the world and with this record 3. Furman v. Georgia is a U.S Supreme Court case that resolves around the Eighth Amendments ban on cruel and unsual punishment in death penalty cases. The Furman v. Georgia case was based on Furman being convicted of murder in Georgia. Furman was caught i One major ethical conflict that may arise in my investigation is the Responsibility to Client in both Standard 3 and Standard 4 of the Ethical Standards for Human Service Professionals (2015).  Making sure we do not disclose information without consent ev 4. Identify two examples of real world problems that you have observed in your personal Summary & Evaluation: Reference & 188. Academic Search Ultimate Ethics We can mention at least one example of how the violation of ethical standards can be prevented. Many organizations promote ethical self-regulation by creating moral codes to help direct their business activities *DDB is used for the first three years For example The inbound logistics for William Instrument refer to purchase components from various electronic firms. During the purchase process William need to consider the quality and price of the components. In this case 4. A U.S. Supreme Court case known as Furman v. Georgia (1972) is a landmark case that involved Eighth Amendment’s ban of unusual and cruel punishment in death penalty cases (Furman v. Georgia (1972) With covid coming into place In my opinion with Not necessarily all home buyers are the same! When you choose to work with we buy ugly houses Baltimore & nationwide USA The ability to view ourselves from an unbiased perspective allows us to critically assess our personal strengths and weaknesses. This is an important step in the process of finding the right resources for our personal learning style. Ego and pride can be · By Day 1 of this week While you must form your answers to the questions below from our assigned reading material CliftonLarsonAllen LLP (2013) 5 The family dynamic is awkward at first since the most outgoing and straight forward person in the family in Linda Urien The most important benefit of my statistical analysis would be the accuracy with which I interpret the data. The greatest obstacle From a similar but larger point of view 4 In order to get the entire family to come back for another session I would suggest coming in on a day the restaurant is not open When seeking to identify a patient’s health condition After viewing the you tube videos on prayer Your paper must be at least two pages in length (not counting the title and reference pages) The word assimilate is negative to me. I believe everyone should learn about a country that they are going to live in. It doesnt mean that they have to believe that everything in America is better than where they came from. It means that they care enough Data collection Single Subject Chris is a social worker in a geriatric case management program located in a midsize Northeastern town. She has an MSW and is part of a team of case managers that likes to continuously improve on its practice. The team is currently using an I would start off with Linda on repeating her options for the child and going over what she is feeling with each option.  I would want to find out what she is afraid of.  I would avoid asking her any “why” questions because I want her to be in the here an Summarize the advantages and disadvantages of using an Internet site as means of collecting data for psychological research (Comp 2.1) 25.0\% Summarization of the advantages and disadvantages of using an Internet site as means of collecting data for psych Identify the type of research used in a chosen study Compose a 1 Optics effect relationship becomes more difficult—as the researcher cannot enact total control of another person even in an experimental environment. Social workers serve clients in highly complex real-world environments. Clients often implement recommended inte I think knowing more about you will allow you to be able to choose the right resources Be 4 pages in length soft MB-920 dumps review and documentation and high-quality listing pdf MB-920 braindumps also recommended and approved by Microsoft experts. The practical test g One thing you will need to do in college is learn how to find and use references. References support your ideas. College-level work must be supported by research. You are expected to do that for this paper. You will research Elaborate on any potential confounds or ethical concerns while participating in the psychological study 20.0\% Elaboration on any potential confounds or ethical concerns while participating in the psychological study is missing. Elaboration on any potenti 3 The first thing I would do in the family’s first session is develop a genogram of the family to get an idea of all the individuals who play a major role in Linda’s life. After establishing where each member is in relation to the family A Health in All Policies approach Note: The requirements outlined below correspond to the grading criteria in the scoring guide. At a minimum Chen Read Connecting Communities and Complexity: A Case Study in Creating the Conditions for Transformational Change Read Reflections on Cultural Humility Read A Basic Guide to ABCD Community Organizing Use the bolded black section and sub-section titles below to organize your paper. For each section Losinski forwarded the article on a priority basis to Mary Scott Losinksi wanted details on use of the ED at CGH. He asked the administrative resident