Advanced Toxicology - Environmental science
Metals are basic elements that do not degrade any further, so they are able to persist in the environment. Metals may not always stay in the same form because they are able to react to form different compounds. Research a metal that was discussed in the textbook reading such as mercury, arsenic, or cadmium. Create a PowerPoint presentation at least seven slides in length, discussing the following:
background information on the metal,
the cornerstone xenobiotic pharmacokinetic properties and effects of the metal,
the bioaccumulative effects of the metal in the environment and how it affects humans and the environment, and
concentration of metal that is considered toxic and symptoms of toxicity by this metal.
Your PowerPoint should be a cumulation of what you have learned throughout the course. For instance, if the metal has particular effects on a certain body system or organ, be sure to give information about these effects. The assignment should meet the following requirements:
The length should be a minimum of seven slides, not including your title and reference slides.
Use speaker notes to explain the key points that are provided in the slides.
Include least two visual aids and/or graphics.
A minimum of two credible sources should be used for this assignment, and the references should be properly cited in a reference list at the end of the PowerPoint.MOS 5425, Advanced Toxicology 1
Course Learning Outcomes for Unit VII
Upon completion of this unit, students should be able to:
2. Summarize the principles of toxicology.
2.1 Discuss the cornerstone xenobiotic pharmacokinetic properties (absorption, distribution,
metabolism, and excretion) and common effects of metals.
5. Examine toxic substances that pose a risk to human population and the environment.
5.1 Explain the bioaccumulation of metals as it affects ecology and humans.
Course/Unit
Learning Outcomes
Learning Activity
2
Unit Lesson
Chapter 19
2.1
Unit Lesson
Chapter 16
PowerPoint Presentation
5
Unit Lesson
Chapter 19
5.1
Unit Lesson
Chapter 16
PowerPoint Presentation
Reading Assignment
Chapter 16: Properties and Effects of Metals, pp. 283-304
Chapter 19: Nanotoxicology, pp. 359-370
Unit Lesson
Unit VII is the first of a two-part discussion on toxic substances and risk assessment. The assigned textbook
reading covers topics such as toxicity of metals and nanotoxicity. You will find noteworthy discussion on
additional topics such as food additives, contaminants, and over-the-counter preparations. Although the latter
is not assigned reading, you may find more on some of these topics in the textbook as well as in the CSU
Online Library.
Toxicity of Metals
As you know, many factors can determine the toxicity of a toxicant. These factors include the type of
exposure and duration of exposure as well as various characteristic properties of the toxicant as it undergoes
biotransformation. Metals are naturally occurring elements that do not degrade in the environment. The
inability of metals to be broken down means that they persist in the environment as elements, and they are
also able to react with other molecules to form numerous compounds. Metal speciation is the main factor in
determining the toxicity potential of a metal. Human activity can alter the degree of exposure to metals by
impacting the movement and transformation of metals (Roberts, James, & Williams, 2015). The general
properties of exposure, how the metal enters the body, and how it is processed through the body can greatly
affect toxicity.
UNIT VII STUDY GUIDE
Nanotoxicity and Toxicology of
Metals and Food Additives
MOS 5425, Advanced Toxicology 2
UNIT x STUDY GUIDE
Title
The textbook discusses various common toxic mechanisms of metals that include direct effects, indirect
effects, substitution, and metal imbalance (Roberts et al., 2015). Direct effects cause damage to the cells by
interrupting their structure or function. Indirect effects interrupt biological functions by binding to molecules
and inhibiting certain events from taking place. Substitution is when the metal is similar to other biological
molecules and binds or accumulates in place of an essential element, interrupting the activity of the essential
element. Metal imbalance is due to an overexposure of some met
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