BIOLOGY

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The standard of care for      ischemic stroke is:    steroids   (cortisone/prednisone), to prevent edema   recombinant tissue   plasminogen activator (tPA), aka alteplase (Activase) within three hours of onset, to dissolve the clot   Hemodilution (replacement   of some whole blood with plasma/saline), to reduce whole blood viscosity and   improve perfusion   Hemicraniectomy   (cutting a hole in the), to relieve pressure 10 points    QUESTION 2 What are neural      progenitor cells? What populations of cells to they give rise to? Are they      only present in early development or do they persist in the adult brain      (in rodents and/or humans)?      10 points    QUESTION 3 What does it mean that a      drug is an agonist of a receptor or pathway? What about an      antagonist? 10 points    QUESTION 4 What is      angiogenesis?  What secreted substances are mainly responsible for      angiogenesis in the brain?       10 points    QUESTION 5 What sort of markers do      the authors rely on to (a) identify and (b) assess differentiation      potential of neural progenitor cells?     10 points    QUESTION 6 Describe the MCAO. What      processes are typically responsible for the actual lesion formed in the      brain following MCAO? 10 points    QUESTION 7 Choose one (1) neurological      or motor function test from figure 1, and describe it. Also, look at those      p-values! 1.776x10^-15, what do you think that even means?    10 points    QUESTION 8 Figure 2: What are      sham, vehicle, and sova? What can you      say about the expression of doublecortin in the fore/midbrain of rats that      experienced an ischemic attack (both those treated with vehicle and those      that received the drug)?    10 points    QUESTION 9 In case its not clear,      Id like to point out that in figure 3B (and others) the p values are      between the bars on the left and right sides of the line. For example,      p=0.128 represents the difference between Sham_RH and Veh_RH.      Questions:      What pair(s) of groups show a statistically significant difference in the      expression of HuC/HuD?      What are HuC/HuD?    10 points    QUESTION 10 Figure 4 A and B show      that the mature neuron marker NeuroD1 is very significantly upregulated      post-injury in sovateltide-treated brains. What is the experiment shown in      4C and 4D?     10 points    QUESTION 11 Figure 5, why do you      think the authors looked at Drp1 and Mfn2? What results are shown? What      could those results mean?    10 points    QUESTION 12 Figures 6 and 7 show      mitochondria (the powerhouse of the cell) responding to model stroke and      sovateltide. Are mitochondria only important because of their critical      role in energy homeostasis? If not (obviously the answer to that last      question is no), what are some consequences of mitochondrial      dysfunction following ischemia/reperfusion? That is, whats the mechanism      by which damage to the mitochondria causes/worsens the lesion in the brain1 Vol.:(0123456789) Scientific RepoRtS | (2020) 10:12737 | https://doi.org/10.1038/s41598-020-69673-w www.nature.com/scientificreports Sovateltide (IRL‑1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke Amaresh K. Ranjan1*, Seema Briyal1 & Anil Gulati1,2* The development of effective drugs for stroke is urgently required as it is the 2nd largest killer in the world and its incidence is likely to increase in the future. We have demonstrated cerebral endothelin B receptors (ETBR) as a potential target to treat acute cerebral ischemic stroke. However, the mechanism of ETBR mediated neural regeneration and repair remains elusive. In this study, a permanent middle cerebral artery occluded (MCAO) rat model was used. Sovateltide (an ETBR agonist) injected intravenously showed better survival and neurological and motor function improvement than control. Higher neuronal progenitor cells (NPCs) differentiation along with better mitochondrial morphology and biogenesis in the brain of sovateltide rats were noted. Exposure of cultured NPCs to hypoxia and sovateltide also showed higher NPC differentiation and maturation. This study shows a novel role of ETBR in NPCs and mitochondrial fate determination in cerebral ischemia, and in improving neurological deficit after stroke. Endothelin B receptors (ETBR) are G-protein coupled receptors and are expressed abundantly in vascular and neural cells and are also known to be involved in the central nervous system (CNS) development, neural cell survival and proliferation1–3. Their role in developing CNS, neuronal proliferation and migration as well as in the expression of angiogenic growth factors have been demonstrated with ontological studies4,5. Their deficiency at the prenatal stage of life resulted in fatal birth defects in the animal models, while their deficiency at the post- natal stage resulted in an increase in apoptosis and decrease in NPC within the dentate gyrus and cerebellum of the brain2,4,6. ETBR play a crucial role not only in the early developmental stages of the CNS, but its stimulation following CNS damage later in life has also been shown to enhance neurogenesis and angiogenesis, thereby promoting CNS repair7–9. We demonstrated that selective stimulation of ETBR by its agonist, IRL-1620 (INN approved by WHO is sovateltide), could significantly improve neurological and motor functions, with concurrent decrease in infarct volume and oxidative stress damage following permanent middle cerebral artery occlusion (MCAO) in rats10,11. We have also shown that administration of sovateltide in newborn rat pups increased vas- cular endothelial growth factor (VEGF) but had no effect on nerve growth factor (NGF) in postnatal developing brains5. Moreover, sovateltide treatment after cerebral ischemia protected neurons by enhancing angiogenesis, as we noted an increase in neuronal nuclei number an
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Your assignment may be more than 5 paragraphs but not less. INSTRUCTIONS:  To access the FNU Online Library for journals and articles you can go the FNU library link here:  https://www.fnu.edu/library/ In order to n that draws upon the theoretical reading to explain and contextualize the design choices. Be sure to directly quote or paraphrase the reading ce to the vaccine. Your campaign must educate and inform the audience on the benefits but also create for safe and open dialogue. A key metric of your campaign will be the direct increase in numbers.  Key outcomes: The approach that you take must be clear Mechanical Engineering Organic chemistry Geometry nment Topic You will need to pick one topic for your project (5 pts) Literature search You will need to perform a literature search for your topic Geophysics you been involved with a company doing a redesign of business processes Communication on Customer Relations. Discuss how two-way communication on social media channels impacts businesses both positively and negatively. Provide any personal examples from your experience od pressure and hypertension via a community-wide intervention that targets the problem across the lifespan (i.e. includes all ages). Develop a community-wide intervention to reduce elevated blood pressure and hypertension in the State of Alabama that in in body of the report Conclusions References (8 References Minimum) *** Words count = 2000 words. *** In-Text Citations and References using Harvard style. *** In Task section I’ve chose (Economic issues in overseas contracting)" Electromagnetism w or quality improvement; it was just all part of good nursing care.  The goal for quality improvement is to monitor patient outcomes using statistics for comparison to standards of care for different diseases e a 1 to 2 slide Microsoft PowerPoint presentation on the different models of case management.  Include speaker notes... .....Describe three different models of case management. visual representations of information. They can include numbers SSAY ame workbook for all 3 milestones. You do not need to download a new copy for Milestones 2 or 3. When you submit Milestone 3 pages): Provide a description of an existing intervention in Canada making the appropriate buying decisions in an ethical and professional manner. Topic: Purchasing and Technology You read about blockchain ledger technology. Now do some additional research out on the Internet and share your URL with the rest of the class be aware of which features their competitors are opting to include so the product development teams can design similar or enhanced features to attract more of the market. The more unique low (The Top Health Industry Trends to Watch in 2015) to assist you with this discussion.         https://youtu.be/fRym_jyuBc0 Next year the $2.8 trillion U.S. healthcare industry will   finally begin to look and feel more like the rest of the business wo evidence-based primary care curriculum. Throughout your nurse practitioner program Vignette Understanding Gender Fluidity Providing Inclusive Quality Care Affirming Clinical Encounters Conclusion References Nurse Practitioner Knowledge Mechanics and word limit is unit as a guide only. The assessment may be re-attempted on two further occasions (maximum three attempts in total). All assessments must be resubmitted 3 days within receiving your unsatisfactory grade. You must clearly indicate “Re-su Trigonometry Article writing Other 5. June 29 After the components sending to the manufacturing house 1. In 1972 the Furman v. Georgia case resulted in a decision that would put action into motion. Furman was originally sentenced to death because of a murder he committed in Georgia but the court debated whether or not this was a violation of his 8th amend One of the first conflicts that would need to be investigated would be whether the human service professional followed the responsibility to client ethical standard.  While developing a relationship with client it is important to clarify that if danger or Ethical behavior is a critical topic in the workplace because the impact of it can make or break a business No matter which type of health care organization With a direct sale During the pandemic Computers are being used to monitor the spread of outbreaks in different areas of the world and with this record 3. Furman v. Georgia is a U.S Supreme Court case that resolves around the Eighth Amendments ban on cruel and unsual punishment in death penalty cases. The Furman v. Georgia case was based on Furman being convicted of murder in Georgia. Furman was caught i One major ethical conflict that may arise in my investigation is the Responsibility to Client in both Standard 3 and Standard 4 of the Ethical Standards for Human Service Professionals (2015).  Making sure we do not disclose information without consent ev 4. Identify two examples of real world problems that you have observed in your personal Summary & Evaluation: Reference & 188. Academic Search Ultimate Ethics We can mention at least one example of how the violation of ethical standards can be prevented. Many organizations promote ethical self-regulation by creating moral codes to help direct their business activities *DDB is used for the first three years For example The inbound logistics for William Instrument refer to purchase components from various electronic firms. During the purchase process William need to consider the quality and price of the components. In this case 4. A U.S. Supreme Court case known as Furman v. Georgia (1972) is a landmark case that involved Eighth Amendment’s ban of unusual and cruel punishment in death penalty cases (Furman v. Georgia (1972) With covid coming into place In my opinion with Not necessarily all home buyers are the same! When you choose to work with we buy ugly houses Baltimore & nationwide USA The ability to view ourselves from an unbiased perspective allows us to critically assess our personal strengths and weaknesses. This is an important step in the process of finding the right resources for our personal learning style. Ego and pride can be · By Day 1 of this week While you must form your answers to the questions below from our assigned reading material CliftonLarsonAllen LLP (2013) 5 The family dynamic is awkward at first since the most outgoing and straight forward person in the family in Linda Urien The most important benefit of my statistical analysis would be the accuracy with which I interpret the data. The greatest obstacle From a similar but larger point of view 4 In order to get the entire family to come back for another session I would suggest coming in on a day the restaurant is not open When seeking to identify a patient’s health condition After viewing the you tube videos on prayer Your paper must be at least two pages in length (not counting the title and reference pages) The word assimilate is negative to me. I believe everyone should learn about a country that they are going to live in. It doesnt mean that they have to believe that everything in America is better than where they came from. It means that they care enough Data collection Single Subject Chris is a social worker in a geriatric case management program located in a midsize Northeastern town. She has an MSW and is part of a team of case managers that likes to continuously improve on its practice. The team is currently using an I would start off with Linda on repeating her options for the child and going over what she is feeling with each option.  I would want to find out what she is afraid of.  I would avoid asking her any “why” questions because I want her to be in the here an Summarize the advantages and disadvantages of using an Internet site as means of collecting data for psychological research (Comp 2.1) 25.0\% Summarization of the advantages and disadvantages of using an Internet site as means of collecting data for psych Identify the type of research used in a chosen study Compose a 1 Optics effect relationship becomes more difficult—as the researcher cannot enact total control of another person even in an experimental environment. Social workers serve clients in highly complex real-world environments. Clients often implement recommended inte I think knowing more about you will allow you to be able to choose the right resources Be 4 pages in length soft MB-920 dumps review and documentation and high-quality listing pdf MB-920 braindumps also recommended and approved by Microsoft experts. The practical test g One thing you will need to do in college is learn how to find and use references. References support your ideas. College-level work must be supported by research. You are expected to do that for this paper. You will research Elaborate on any potential confounds or ethical concerns while participating in the psychological study 20.0\% Elaboration on any potential confounds or ethical concerns while participating in the psychological study is missing. Elaboration on any potenti 3 The first thing I would do in the family’s first session is develop a genogram of the family to get an idea of all the individuals who play a major role in Linda’s life. After establishing where each member is in relation to the family A Health in All Policies approach Note: The requirements outlined below correspond to the grading criteria in the scoring guide. At a minimum Chen Read Connecting Communities and Complexity: A Case Study in Creating the Conditions for Transformational Change Read Reflections on Cultural Humility Read A Basic Guide to ABCD Community Organizing Use the bolded black section and sub-section titles below to organize your paper. For each section Losinski forwarded the article on a priority basis to Mary Scott Losinksi wanted details on use of the ED at CGH. He asked the administrative resident