Miami Diethyl phthalate & DnBP Defects on Pregnant Woman Articles Discussion - Science
Read both the articles attached here and do it. The assignmentFor each project, you will be given a news story and a scientific journal article that goes with it, posted to Canvas by the instructor. Each of these journal articles will have been published in a reputable online magazine, newspaper, or journal. The news story may or may not be.You will then write a short essay, 2-3 full pages in length, detailing the parts of the scientific method discussed in your article and comparing that information to what was reported in the news story. Each entry will be written in a logical and professional manner using the APA template attached to the post.The entire entry must be written IN YOUR OWN WORDS. Direct quotes of the articles are not allowed. However, when you summarize or paraphrase something from one of the articles you will need to provide an in-text APA reference. The guide to APA referencing is attached to this post.The essay must be written entirely in third person. DO NOT USE FIRST OR SECOND PERSON. This means you cannot use the words “I”, “we”, or “you”.What is turned in to the instructor?For each week that a journal assignment is due, you will submit your journal entry via Canvas by its due date.Entry ContentYou will be graded on the following content that combines information you obtain from both the news story and the scientific article:Introduction (1 paragraph)This section identify which of the two articles was the scientific study and the subject of the scientific study. You will also identify the problem or observation that spurred the research. DO NOT LIST THE RESULTS OF THE STUDY ITSELF HERE. You will identify the hypothesis the scientists were testing. Remember that a hypothesis is a testable educated guess. Thus, it is not appropriate to pose a question here. However, while reading your articles, it can be helpful to ask yourself what explanation scientists tried to use to explain their initial observation. You will then transition into the body of the journal.Body (~1 paragraph each)Here, you will identify the test or experiment that was performed to address the hypothesis. You should be detailed here. It may be helpful to pull from other sources, if you do not fully understand how the experiment was conducted. After detailing how the experiment was done compared to how it reported in the media, you will transition into a discussion of the results.In this section of your entry you will identify the experimental results that the scientists obtained. What did the scientists find after doing their experiment? Again, you can be detailed here. After detailing the results, you will transition into the conclusion sections.The last paragraph of the body should explain the conclusion of the study. You should address whether the hypothesis was supported or rejected, and how the results led to that finding. Also provide a possible new avenue of research the scientists might pursue based on what was discovered in this study.Evaluation (1 paragraph)Here you will signal the end of your entry. In this section you will identify the new study about the scientific study and discuss whether or not the news story was a representative reporting of the scientific study. Did the news change anything or leave out something important from the scientific study? Summarize the important content from your entry, then you will end with a definitive final statement.Constructing your journal entryIn addition to the criteria above, you will be graded on the quality of your writing; please write with proper grammar, punctuation, and style. The essay will be graded using the Dialogues of Learning Written Communication Rubric.All sources (including the original 2 articles) should be properly documented. You must include an APA style reference page. Your TurnItIn score
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4/8/2019
Could Using Air Fresheners During Pregnancy Boost Childhood Asthma Risk? - Scientific American
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HE ALTH
Could Using Air Fresheners During Pregnancy Boost
Childhood Asthma Risk?
The first study to look at prenatal phthalate exposure and later effects on respiration suggest
some worrisome results
By Dina Fine Maron on September 17, 2014
Véalo en español
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Everyday exposure to a ubiquitous compound that makes plastics flexible and
stabilizes air fresheners may result in lasting damage to children’s respiratory
systems. The first study to explore the relationship between phthalates during
pregnancy and future childhood asthma reveals a strong link between the two, but
cannot conclusively say that asthma is a result of the exposure.
Phthalates are known to impede the endocrine system, the regulatory mechanism
that dictates hormonal distribution in the body. The chemicals’ disruptive prowess
have been linked to health problems including birth defects, cancers and diabetes. Yet
until now there has been no data to suggest they were also harming children’s
respiratory systems.
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Could Using Air Fresheners During Pregnancy Boost Childhood Asthma Risk? - Scientific American
This new study of 300 inner-city women and their children found that women who
were exposed to elevated levels of two common phthalates—butylbenzl phthalate and
di-n-butyl phthalate—during pregnancy were more likely to have children who
developed asthma. The researchers discovered this by scouring metabolites in the
women’s urine and then tracking their children via questionnaires and physicians’
diagnoses.
Children of women who were exposed to higher levels of phthalate during pregnancy
(in some cases a dozen times higher) were some 70 percent likelier to develop asthma
by age 11 compared with the offspring of mom’s with lower exposure. But with both
exposure groups the levels were still not that high—the concentration of the
phthalates among all the women were generally comparable with those of a
representative sample of the U.S. population taken over roughly the same time
period. If the asthma findings are replicated by other studies, this new link could have
serious implications for the general population.
In this study all the mothers were from low-income areas and the women selfidentified as African-American or Dominican. Typically people who live in
impoverished urban neighborhoods are more prone to have higher asthma rates due
to a variety of factors including elevated exposure to harmful pollutants like diesel
exhaust. That makes the new findings even more striking because it would typically
be harder to pick up increased rates of asthma compared with an already high
number of background cases. The women and their children were enrolled in a
longitudinal study run by the Columbia Center for Children’s Environmental Health.
This research, published in the journal Environmental Health Perspectives,
controlled for many factors that could account for the findings like maternal asthma
and smoking status. The phthalate levels we see here are typical in the U.S.
population and not “whoopingly high,” which makes this an important finding, says
Linda Birnbaum, director of the National Institute of Environmental Health Sciences.
“The population distribution here isn’t that different than [earlier work looking at
such exposures in the general population].” The study is also of interest because it
indicates that not all phthalate exposures have the same effects, she says. The work
looked at four types of phthalate but only two of them were associated with elevated
asthma risk.
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Could Using Air Fresheners During Pregnancy Boost Childhood Asthma Risk? - Scientific American
Limiting exposure to worrisome phthalates is doable, says lead author Robin Whyatt,
a professor in the Department of Environmental Health Sciences at Columbia
University. She tells people worried about these exposures to never microwave
plastic, avoid plastics with “3” or “7” on the bottom (because they can be made with
phthalates and bisphenol A) and to store food in glass jars instead of plastic. Also,
avoid scented products whenever possible, such as room fresheners and scented
detergents.
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Dina Fine Maron, formerly an associate editor at Scientific American, is now a
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Journal of Exposure Science and Environmental Epidemiology (2010) 20, 625–633
r 2010 Nature America, Inc. All rights reserved 1559-0631/10
www.nature.com/jes
Urinary and air phthalate concentrations and self-reported use of personal
care products among minority pregnant women in New York city
ALLAN C. JUSTa, JENNIFER J. ADIBIb, ANDREW G. RUNDLEa, ANTONIA M. CALAFATc, DAVID E. CAMANNd,
RUSS HAUSERe,f, MANORI J. SILVAc and ROBIN M. WHYATTa
a
Columbia Center for Children’s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA
c
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
d
Southwest Research Institute, San Antonio, Texas, USA
e
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
f
Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
b
Diethyl phthalate (DEP) and di-n-butyl phthalate (DnBP) are used extensively in personal care products, including fragrances (DEP) and nail polish
(DnBP). Between May 2003 and July 2006, we gathered questionnaire data on the use of seven product categories (deodorant, perfume, hair spray, hair
gel, nail polish/polish remover, liquid soap/body wash, and lotion/mist) over 48 h during the third trimester of pregnancy from 186 inner-city women. A
48-h personal air sample was collected and analyzed for DEP and DnBP; a maternal spot urine sample was collected and analyzed for their monoester
metabolites, monoethyl phthalate (MEP) and mono-n-butyl phthalate (MnBP), respectively. In all, 97\% of air samples and 84\% of urine samples were
collected within ±2 days of the questionnaire. During the 48 h, 41\% of women reported perfume use and 10\% reported nail polish/polish remover use.
In adjusted analyses, no association was seen between nail product use and air DnBP or urine MnBP concentrations. Women reporting perfume use had
2.3 times higher (95\% CI 1.6, 3.3) urinary MEP concentrations. Personal air DEP increased by 7\% for each 25\% increase in a composite indicator of the
six other product categories (Po0.05), but was not associated with perfume use. Air DEP was correlated with urine MEP concentrations only among
non-perfume users (r ¼ 0.51, Po0.001). Results suggest that perfume use is a significant source of DEP exposure.
Journal of Exposure Science and Environmental Epidemiology (2010) 20, 625–633; doi:10.1038/jes.2010.13; published online 31 March 2010
Keywords: DEP, DnBP, human biomonitoring, personal care products.
Introduction
Phthalates are diesters of phthalic acid that are commonly
used in a wide variety of consumer products. Human
exposures come from their use in toys, household materials,
medical devices, in the processing and packaging of foods,
and personal care products (Schettler, 2006). Some phthalates are under increasing scrutiny in epidemiological studies
examining potential associations with adverse reproductive
and developmental outcomes including changes in gestational
age, urogenital tract development, sperm quality, and asthma
among other end points (Swan, 2008). However, relatively
few studies have examined the relation between sources,
exposure pathways, and internal dosimeters.
1. Address all correspondence to: Allan C. Just, Department of
Environmental Health Sciences, Joseph L. Mailman School of Public
Health, Columbia University, 60 Haven Ave., B-109, New York, NY
10032, USA. Tel.: (646) 459 9609. Fax: (646) 459 9610.
E-mail: acj2109@columbia.edu
Received 6 October 2009; accepted 8 February 2010; published online 31
March 2010
Two phthalates, diethyl phthalate (DEP) and di-n-butyl
phthalate (DnBP), are added as a solvent for fragrances or to
prevent products from becoming brittle, and have been found
at higher concentrations than other phthalates in testing of
personal care products in the United States, South Korea,
and China (Houlihan et al., 2002; Koo and Lee, 2004;
Hubinger and Havery, 2006; Shen et al., 2007). Among
personal care products, DEP and DnBP have been found at
the highest concentrations in fragrance products, including
perfume (DEP), and in nail polishes (DnBP). Figure 1 shows
an adaptation of results from the analysis of DEP in 48
personal care products in the United States (Hubinger and
Havery, 2006). The five fragrance products tested had
concentrations of DEP ranging from 5486 to
38,663 p.p.m., and the next highest DEP concentration of
any other product tested was in a deodorant with
2933 p.p.m. (Hubinger and Havery, 2006). In these data,
fragrances have consistently higher concentrations of DEP
compared with all other products tested, supporting the
separate analysis of perfume from other personal care
product categories as potential sources of DEP. According
to a review of patent records, nail polishes might contain
Phthalates and personal care product use
Just et al.
Perfume (n=5)
Body wash (n=3)
Deodorant (n=9)
Body or skin lotion (n=4)
Hair spray (n=8)
Hair gel or mousse (n=10)
Nail polish (n=6)
< LOD
100
101
102
103
Concentration of DEP (ppm)
104
Figure 1. Diethyl phthalate in personal care products, adapted from Table 2 of Hubinger and Havery (2006). A total of 48 products purchased in
the Washington, DC area were tested. Non-detectable values are displayed as less than the limit of detection of 10 p.p.m. Hand cream (n ¼ 2) and
shampoo (n ¼ 1) are not shown. No direct product testing took place in this study.
50,000 p.p.m (5\%) DnBP (Houlihan et al., 2002), a finding
that was supported by a study that tested six nail enamel
products and found concentrations that ranged from below
the limit of detection to 59,815 p.p.m., or roughly 6\%
(Hubinger and Havery, 2006). Thus, nail polishes should be
analyzed separately from other categories of personal care
products as potential sources of exposure to DnBP because
nail polishes seem to be more likely to contain DnBP and at
higher concentrations than other product categories. Under
current regulations in which ingredients used in fragrances
are exempted from disclosure, phthalates are not generally
listed as ingredients on consumer products in the United
States (Steinemann, 2009).
Phthalates can enter the body through ingestion, dermal
absorption, parenteral intake from medical devices, and
inhalation. They undergo rapid hydrolysis to monoesters;
short-alkyl chain phthalates such as DEP and DnBP are
principally excreted in the urine as hydrolytic monoesters or
as their corresponding glucuronidated conjugates (Silva et al.,
2003). In 16 human volunteers who ingested a labeled dose
of DnBP, 69\% was excreted as mono-n-butyl phthalate
(MnBP) in urine with undetectable levels of urinary MnBP
after the first 24 h (Anderson et al., 2001). Half-lives of DEP
were equally short in animal studies (Api, 2001). Both DEP
and DnBP are also taken up dermally with an estimated 6\%
and 2\%, respectively, excreted as their urinary metabolites
monoethyl phthalate (MEP) and MnBP by human volunteers after dermal application (Janjua et al., 2008). The
majority of dermally absorbed DEP was excreted within 8 h
and MnBP excretion lagged slightly compared with MEP but
was largely excreted within 24 h. Urinary MEP concentrations from a representative sample of the US population
(National Health and Nutrition Examination Survey
(NHANES) 1999–2000) were highest at a midday collection,
which was hypothesized to be related to the application of
personal care products in the morning (Silva et al., 2004).
626
Some evidence already exists for an association between
frequency of personal care product use and urinary
concentrations of phthalates. Men reporting the use of
cologne or aftershave over 48 h had higher urinary MEP
concentrations than other men (Duty et al., 2005). Another
study reported an association between the use of baby care
products and concentrations of MEP and two other
phthalate metabolites but not MnBP in infant urine samples
(Sathyanarayana et al., 2008). An increase in the number of
personal care products used in the previous 48 h was
associated with higher urinary MEP in 19 pregnant women
in Israel (Berman et al., 2009). Working as a manicurist in a
nail-only salon was associated with urinary concentrations of
MnBP in two occupational studies among nail-only salon
workers. Post-shift urinary MnBP concentrations were 49\%
higher than pre-shift in 37 manicurists from Massachusetts in
2004–05 (Kwapniewski et al., 2008). In 26 manicurists in
Maryland studied between 2003 and 2005, those using gloves
had 50\% lower post-shift MnBP concentration compared
with non-users (Hines et al., 2009). Collectively, these five
studies indicate the potential importance of dermal absorption for exposures to DEP and DnBP and the suitability of
urinary metabolites to assess these exposures.
We have reported previously that DEP and DnBP and
their metabolites were found in 100\% of personal air and
urine samples collected from inner-city women during
pregnancy (Adibi et al., 2008). The purpose of this study
was to determine whether personal care product use was
associated with measures of phthalate exposure in air and
urine samples among the same urban cohort of pregnant
women. To carry out this, we evaluated the relationship
between self-reported prenatal personal care product use and
concentrations of DEP and DnBP in personal air samples
and MEP and MnBP in urine samples. The particular focus
was on perfume and nail product use and exposures to DEP
and DnBP, respectively.
Journal of Exposure Science and Environmental Epidemiology (2010) 20(7)
Phthalates and personal care product use
Methods
Study Subjects
Participants (n ¼ 186) were selected from the Mothers and
Newborns cohort study of the Columbia Center for Children’s
Environmental Health (CCCEH) based in Northern
Manhattan and the South Bronx, New York (Perera et al.,
2003; Whyatt et al., 2003). Selection was based on the
availability of a product-use questionnaire and phthalates
measured within a week in either a personal air and/or urine
sample collected during the third trimester of pregnancy. Overall,
97\% of air samples and 84\% of urine samples were collected
within 2 days of the product-use questionnaire. In most cases
there was no difference when the analysis was limited to the
subsets within 2 days and results are given for the whole cohort
unless otherwise specified. The enrollment criteria for the
CCCEH cohort have been described elsewhere (Perera et al.,
2003; Whyatt et al., 2003). The study was restricted to women
18–35 years old who self-identified as either African American or
Dominican and had resided in Northern Manhattan or the
South Bronx for at least 1 year before pregnancy. Women were
excluded at enrollment if they reported that they smoked
cigarettes or used other tobacco products during pregnancy, used
illicit drugs, had diabetes, hypertension or known HIV, or had
their first prenatal visit after the 20th week of gestation. Study
procedures, including questionnaires, personal air monitoring,
and collection of biological samples, were explained to each
subject at enrollment and a signed consent, approved by the IRB
of Columbia University and the Centers for Disease Control and
Prevention (CDC), was obtained.
Product-Use Questionnaire
A brief questionnaire that was administered in the third
trimester (mean gestational age 35 weeks) asked participants to
recall their use of various types of personal care products over
the previous 48 h and throughout the individual trimesters of
pregnancy. They were asked about use (yes or no), the number
of total uses over 48 h, and the frequency of use during each
trimester (41 per day, 1 per day, 2–3 per week, 1 per week,
o1 per week-1 per month, and o1 per month). From the
questionnaire, we selected seven product categories for this
analysis: deodorant, lotion or mist (spray application),
perfume, liquid soap or body wash, hair gel, hair spray, and
nail polish or polish remover. As the questionnaire asked
about nail polish or polish remover together, we refer to this
category as nail products. The product categories selected were
those that are likely to contain DEP or DnBP and which were
used by Z10\% of participants. Information on the frequency
of use of product categories in the 48-h period and third
trimester was missing for 6 and 20 participants, respectively.
Sample Collection and Analysis
Participants carried backpacks for 48 h containing pumps
drawing personal air samples at 4 l/min from near the
Journal of Exposure Science and Environmental Epidemiology (2010) 20(7)
Just et al.
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The word assimilate is negative to me. I believe everyone should learn about a country that they are going to live in. It doesnt mean that they have to believe that everything in America is better than where they came from. It means that they care enough
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Single Subject Chris is a social worker in a geriatric case management program located in a midsize Northeastern town. She has an MSW and is part of a team of case managers that likes to continuously improve on its practice. The team is currently using an
I would start off with Linda on repeating her options for the child and going over what she is feeling with each option. I would want to find out what she is afraid of. I would avoid asking her any “why” questions because I want her to be in the here an
Summarize the advantages and disadvantages of using an Internet site as means of collecting data for psychological research (Comp 2.1) 25.0\% Summarization of the advantages and disadvantages of using an Internet site as means of collecting data for psych
Identify the type of research used in a chosen study
Compose a 1
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effect relationship becomes more difficult—as the researcher cannot enact total control of another person even in an experimental environment. Social workers serve clients in highly complex real-world environments. Clients often implement recommended inte
I think knowing more about you will allow you to be able to choose the right resources
Be 4 pages in length
soft MB-920 dumps review and documentation and high-quality listing pdf MB-920 braindumps also recommended and approved by Microsoft experts. The practical test
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One thing you will need to do in college is learn how to find and use references. References support your ideas. College-level work must be supported by research. You are expected to do that for this paper. You will research
Elaborate on any potential confounds or ethical concerns while participating in the psychological study 20.0\% Elaboration on any potential confounds or ethical concerns while participating in the psychological study is missing. Elaboration on any potenti
3 The first thing I would do in the family’s first session is develop a genogram of the family to get an idea of all the individuals who play a major role in Linda’s life. After establishing where each member is in relation to the family
A Health in All Policies approach
Note: The requirements outlined below correspond to the grading criteria in the scoring guide. At a minimum
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Read Connecting Communities and Complexity: A Case Study in Creating the Conditions for Transformational Change
Read Reflections on Cultural Humility
Read A Basic Guide to ABCD Community Organizing
Use the bolded black section and sub-section titles below to organize your paper. For each section
Losinski forwarded the article on a priority basis to Mary Scott
Losinksi wanted details on use of the ED at CGH. He asked the administrative resident