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Article 1
Article 2
Girvalaki, C., Papadakis, S., Vardavas,
C., Petridou, E., Pipe, A., Lionis, C., …
Theodoros, V. (2017). Smoking
cessation delivery by general
practitioners in Crete,
Greece. European Journal of Public
Health, 28(3), 542–547.
https://doi.org/10.1093/eurpub/ckx
201
Nucifora, J., Howard, Z., Jackman, A.,
Bongers, M., Corcoran, K., Weir, K. A., &
Briffa, K. (2018). Outcomes of a
physiotherapy-led pelvic health
clinic. Australian & New Zealand
Continence Journal, 24(2), 43–50.
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-3802-46af-867ea5028b1a1acf\%40sessionmgr103
Point
Broad Topic
Area/Title
Define Hypotheses
Description
Description
Define
Independent and
Dependent
Variables and
Types of Data for
Variables
Population of
Interest for the
Study
Sample
Sampling Method
How Were Data
Collected?
2
542
European Journal of Public Health
.........................................................................................................
The European Journal of Public Health, Vol. 28, No. 3, 542–547
ß The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.
doi:10.1093/eurpub/ckx201 Advance Access published on 13 November 2017
.........................................................................................................
Smoking cessation delivery by general practitioners in
Crete, Greece
Charis Girvalaki1, Sophia Papadakis1,2,3, Constantine Vardavas1, Eleni Petridou4, Andrew Pipe2,3,
Christos Lionis1, on behalf of the Practice Based Research Network in Primary Care in Crete
1
2
3
4
Department of Medicine, Clinic of Social and Family Medicine, University of Crete, Heraklion, Crete, Greece
Division of Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Division of Cardiology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of
Athens, Athens, Greece
The members of the Practice Based Research Network in Primary Care in Crete are listed in the Acknowledgements.
Correspondence: Charis Girvalaki, Department of Medicine, Clinic of Social and Family Medicine, University of Crete, PO
Box 70013, Heraklion, Crete, Greece, Tel: +30 2810 394596, Fax: +30 2810 394606, e-mail: charis@tobcontrol.eu
Background: Tobacco dependence treatment in clinical settings is of prime public health importance, especially in
Greece, a country experiencing one of the highest rates of tobacco use in Europe. Methods: Our study aimed to
examine the characteristics of tobacco users and document rates of tobacco treatment delivery in general practice
settings in Crete, Greece. A cross-sectional sample of patients (n = 2, 261) was screened for current tobacco use in
25 general practices in Crete, Greece in 2015/16. Current tobacco users completed a survey following their clinic
appointment that collected information on patient characteristics and rates at which the primary care physician
delivered tobacco treatment using the evidence-based 4 A’s (Ask, Advise, Assist, Arrange) model during their
medical appointment and over the previous 12-month period. Multi-level modeling was used to analyze data
and examine predictors of 4 A’s delivery. Results: Tobacco use prevalence was 38\% among all patients screened.
A total of 840 tobacco users completed the study survey [mean age 48.0 (SD 14.5) years, 57.6\% male].
Approximately, half of the tobacco users reported their general practitioner ‘asked’ about their tobacco use
and ‘advised’ them to quit smoking. Receiving ‘assistance’ with quitting (15.7\%) and ‘arranging’ follow-up
support (<3\%) was infrequent. Patient education, presence of smoking-related illness, a positive screen for
anxiety or depression and the type of medical appointment were associated with 4 A’s delivery. Conclusion:
Given the fundamental importance of addressing tobacco treatment, increasing the rates of 4 A’s treatment in
primary care settings in Greece is an important target for improving patient care.
.........................................................................................................
Introduction
obacco use is the leading cause of premature death and disability
1,2
Each year,
more than 700 000 Europeans die from tobacco-related illness.2 The
World Health Organization’s (WHO) European region has one of
the highest proportions of death attributable to tobacco, with an
estimated 16\% of all deaths among adults over 30 years of age due
to tobacco use.1 Despite the decline in the prevalence of tobacco use,
more than 125 million Europeans (26\% of the population) continue
to smoke, representing the highest rate of tobacco use among all the
WHO regions.3 Moreover, tobacco use imposes a huge economic
burden on the European health care systems, with the direct health
care costs alone estimated to be 100 billion Euros.4,5
There is overwhelming evidence attesting to the health and
economic benefits of smoking cessation.6 Quitting smoking
reduces the excess risk of smoking-related coronary heart disease,
for example, by approximately 50\% within 1 year, and to normal
levels within 5 years.7 Smoking cessation is highly cost-effective with
the cost per life-year saved estimated to be between ?1500 and
?3000.8,9 Tobacco use is also a priority among young European
due to the fact that 94\% of smokers start smoking before the age
of 25 years and quitting smoking as early in life substantially reduces
future disease risk.10
General practices have been identified as important settings
for the delivery of smoking cessation treatment.1,4,11,12 The WHO1
and the European Network For Smoking and Tobacco Prevention13
Tand the largest threat to public health in Europe.
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by Adam Ellsworth, Adam Ellsworth
on 25 May 2018
have called for tobacco dependence to be a clinical priority of all
health professionals.1,13 The 5A’s of smoking cessation are an internationally recognized evidence-based schema to guide interventions
with tobacco users in all clinical settings including primary care.13,14
The 5 As include: ‘ask’ patients about smoking status; provide brief
quit smoking ‘advice’; ‘assess’ readiness to quit smoking; ‘assist’
patients with making a quit attempt using behavioral techniques
and pharmacotherapies; and, ‘arrange’ follow-up support
throughout the quitting process. Internationally, and in Europe, a
practice gap in rates of 5 As delivery in clinical settings has been
documented.15–17
Greece has one of the highest rates of tobacco use among
members of the European Union, estimated at 38\% of the adult
population.3 Little is known about the characteristics of tobacco
users and current rates of tobacco treatment delivery in primary
care settings in Greece. As a consequence, this study sought to
examine the characteristics of tobacco users visiting general practitioners (GPs) in Crete, Greece and to document the rates of tobacco
treatment delivery. We also examined patient-, GP- and clinic-level
predictors of tobacco treatment delivery.
Methods
Design and setting
Here, we report the cross sectional baseline data collected as part of
the Global Bridges TiTAN Crete project. The purpose of the TiTAN
Smoking cessation delivery by general practitioners in Crete
Crete project (http://titan.uoc.gr/index_en.html) is to create a
network of GPs trained in evidence-based smoking cessation
treatments. Data collection took place in Crete, Greece between
May 2015 and June 2016. GPs were surveyed and a cross-sectional
sample of their patients was screened for current tobacco use. All
current tobacco users were asked to complete a survey following
their clinic appointment. The survey documented the characteristics
of tobacco users and assessed rates at which their GPs delivered
tobacco treatment during the patient’s same day medical appointment (index visit) and during the previous 12-month period. The
study received ethics approval from the University Hospital of
Heraklion Ethics Board (ref# 18078).
Procedures
During recruitment, all GPs located in the regions of Heraklion and
Rethymnon in Crete, Greece were invited to participate in the study
by email. To be eligible for the study GPs need to be: currently
working in Primary Health Care practice in the geographic recruitment area. Twenty-five of twenty-six eligible GPs agreed to participate (response rate 96.2\%). A follow-up telephone call was made by
a member of the project team to confirm interest in participation.
Informed consent was obtained from all participating GPs. GPs
completed a questionnaire to document demographic characteristics
including: age, gender, number of years practicing medicine,
previous cessation training and personal smoking status. A
standardized description of clinic characteristics was assembled; it
included details of practice size, geography, payment methods and
use of an electronic medical record.
Within all participating GP’s offices, consecutive patients
(n = 2261) were screened for eligibility using a brief written survey
administered in the waiting room of the practice upon arrival for
their appointment. Eligibility criteria included: being 18-years of age
or older; a current tobacco user (1 cigarette per day on most days
of the week); attending clinic for a non-urgent medical visit; and,
ability to understand Greek. Eligible patients who agreed to participate in the study provided informed consent (n = 840, response rate
97.7\%) and were asked to complete a brief survey following their
medical appointment.
The patient survey collected demographic variables (age, sex,
ethnicity, years of formal education, occupation, income and
postal code), a brief medical history and smoking related variables.
The presence of any smoking-related illness was documented
including heart disease, stroke, chronic obstructive pulmonary
disease and cancer. A validated Greek version of the four-item
Patient Health Questionnaire (PHQ), a tool used by health care
professionals for diagnosing mental health disorders was administered.18,19 The two-item Heaviness of Smoking Index (HSI) was used
to assess the degree of nicotine dependence.20,21 The HSI score
ranges from 0 to 6 with higher HSI scores reflecting greater
nicotine dependence. Smoking history was assessed by documenting
the number of years a participant had been smoking. The number of
previous quit attempts (lasting 24-h or longer) in the past year was
also documented.
Consistent with previous research, performance in the delivery of
each of the 4 A’s (ask, advise, assist, arrange) was assessed using an
exit survey.22 The survey instructed participants to respond either
‘yes’, ‘no’ or ‘don’t know’ when asked whether their GP asked them
about their smoking status (ask); advised them to quit smoking
(advise); provided assistance with quitting (assist); or arranged
follow-up support (arrange). For ‘assist,’ we further examined the
type of assistance provided including whether or not the GP:
prescribed pharmacotherapy, provided self-help materials; or set a
quit date. Participants were asked to respond regarding their receipt
of those interventions during that day’s clinic appointment (i.e. the
index appointment) as well as at any time in the previous 12months. We chose not to measure rates at which providers
assessed readiness to quit smoking in the present study. A research
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by Adam Ellsworth, Adam Ellsworth
on 25 May 2018
543
assistant coordinated all screening and data collection activities in
clinic waiting rooms. For patients unable to read/write the research
assistant completed the survey by interview.
The Consolidated Standards of Reporting Trials flow diagram for
the study is presented as Supplementary figure S1.
Statistical analysis
Descriptive statistics assessed GP characteristics, patient characteristics and rates of delivery of the 4 A’s. Given the clustered nature of
data collection, each participating patient was linked to their GP.
Multi-level modeling was used to account for provider-level
clustering.23 An intra-class correlation coefficient (ICC) was
calculated to describe the variation among GPs in rates of 4 A’s
delivery and significance was assessed. The ICC ranges from 0 to 1
with higher scores indicating larger variation among providers in
rates of 4 A’s delivery.23
In order to understand the patient-level, GP-level, and clinic-level
factors associated with each outcome, separate multi-level logistic
regression analyzes were completed. A block approach was used to
examine the factors from each of the three levels that were associated
with each outcome in a separate logistic regression model. Variables
from each level that were significantly associated with each outcome
at P < 0.1 were included in a final model; only variables that were
significantly associated with each outcome at P < 0.05 were retained
in the final model. Results were reported as adjusted odds ratios
(AOR) and 95\% confidence intervals (CI). SAS 9.4 was used to
conduct multi-level modeling.
Results
The majority of GPs were under the age of 50-years (95.8\%) and
practicing in rural settings. Twenty-five percent of GPs reported
current personal tobacco use while less than thirty-five percent of
them reported they had the necessary skills to support their patients
with quitting. Supplementary table S1 presents data on characteristics of providers.
The prevalence of tobacco use among the patients was estimated
at 38\%, their mean age was 48.0 (SD 14.5) years, and 57.6\% were
male (table 1). The majority of tobacco users had smoked for more
than 20-years (67.4\%) and reported high rates of daily tobacco consumption (mean 21.1 SD 11.9). Overall, 65.4\% of participants
reported smoking within the first 30-min of waking while 58\% of
them were thinking of quitting in the next 6-months. Less than 40\%
of those surveyed reported making a quit attempt in the previous
year. The majority of respondents reported low self-efficacy with
quitting while 71.0\% of tobacco users rated their GP’s advice to
quit as important or very important.
Rates of 4 A’s delivery
At the index visit 50.3\% of patient reported receiving advice to quit
smoking from their GP however, only 11.1\% of patients reported
receiving assistance with smoking cessation. A similar pattern was
documented for the previous 12-months. Discussing and prescribing
quit smoking medications and the provision of self-help material
occurred infrequently at both the index visit and during the
previous 12-months (table 2). ICCs indicate substantial interprovider variability for ‘ask’, ‘advice’ and ‘assist’ (table 3). ICCs
for the specific forms of assistance (i.e. self-materials, prescribe
pharmacotherapy) and arrange were non-significant. Figure 1
provides a visual depiction of rates of 4 A’s delivery by GP.
Predictors of 4 A’s delivery
The final model of the multi-level analysis examining predictors of
4 A’s delivery is presented as table 3. Male GPs were significantly
more likely to ‘advise’ patients about the health hazards of smoking
and the value of cessation (AOR 2.88; 95\% CI 1.06, 7.86; P < 0.05).
544
European Journal of Public Health
Table 1 Socio-demographic and tobacco-related characteristics of
primary care patients sampled (n = 840) in Crete, Greece
Table 2 Rates of 4 A’s tobacco treatment among GPs at index visit
and previous 12-months, in Crete, Greece
Parameter
Response
Value
Parameter
\% Index
\% Previous
ICC
visitn = 752 12-monthsn = 805
Age
Sex
Number of cigarettes (daily)
Education (years)
Mean years (SD)
\% Male
Mean years (SD)
0–6
7–9
10–12
12+
Greek
Yes
Score of 3
Score of 3
<5
6–15
16–25
26–40
>40
After 60 mins
31–60 mins
6–30 mins
Within 5 mins
High
Moderate
Low
0–2
3–9
10–19
20+
Next 30 days
Next 6-months
Not ready to quit
Low (7/10)
High (>7/10)
0
1–2
3+
Yes
None
Some
Most
All
Low (7/10)
High (>7/10)
Very important
Important
Somewhat important
Not at all important
48.0 (14.5)
57.6\%
21.1 (11.9)
21.7\%
20.1\%
30.1\%
27.9\%
97.9\%
18.8\%
6.9\%
15.5\%
4.8\%
32.3\%
39.4\%
19.9\%
3.7\%
20.4\%
14.3\%
35.6\%
29.8\%
20.6\%
56.1\%
23.3\%
1.2\%
7.9\%
23.6\%
67.4\%
24.2\%
34.2\%
41.6\%
85.5\%
14.5\%
61.4\%
32.5\%
6.1\%
58.1\%
4.2\%
38.9\%
52.6\%
4.3\%
37.5\%
62.5\%
21.4\%
49.6\%
18.6\%
10.4\%
Ask
Advise
Quit smoking
Health hazards
Assist
General assistance
Set quit date
Provide self-help material
Discuss medications
Prescribe medication
Arrange
55.7
63.2
0.494 0.006
50.3
32.1
58.3
46.4
0.422 0.006
0.292 0.007
11.1
4.4
2.7
5.3
0.9
2.8
15.7
3.5
5.7
7.8
1.5
2.5
0.459
0.687
0.431
0.884
0.883
0.688
Nationality
Smoking-related illnessa
Depressionb
Anxietyc
Cigarettes/day
Time to first cigarette
HSI
Years of smoking
Readiness to quitd
Self-efficacy with quittinge
Number of quit attempts in past year
Presence of Other smokers in the home
Family/friends who smoke
Perceived importance of quittingf
Importance of doctor’s advice to quit
a: Self- Reported heart disease, stroke, heart failure/cancer/chronic
obstructive pulmonary disease (COPD)? (1 = yes, 0 = no).
b: PHQ-4 for depression.
c: PHQ-4 for anxiety.
d: Which of the following best describes your feelings about
smoking right now? (Responses: 1 = ready to quit in next
30 days, 0= ready to quit in next 6-months or not ready to quit).
e: On a scale of 1–10 how confident are you that you would be able
to quit smoking at this time? (1 = not at all confident,
10 = extremely confident).
f: On a scale of 1–10 how important is it to you to quit smoking at
this time? (Response: 1 = not at all important, 10 = extremely
important.
No other GP level variables were found to be significant in
predicting 4 A’s delivery. ‘Asking’ about tobacco use occurred
more frequently among patient with smoking related illness (AOR
2.07; 95\% CI 1.27, 3.37; P < 0.01). ‘Advice’ regarding the health hazards of smoking was more likely to be delivered to patients with
grade school education, a smoking-related illness (AOR 2.05; 95\%
CI 1.29, 3.27; P < 0.01), a positive screen for anxiety/depression
(AOR 1.83; 95\% CI 1.04, 3.23; P < 0.05) and who were seen in
clinic for a medical examination or prescription. ‘Assistance’ with
quitting was more frequently delivered to patients with a positive
Downloaded from https://academic.oup.com/eurpub/article-abstract/28/3/542/4621433
by Adam Ellsworth, Adam Ellsworth
on 25 May 2018
P-value
ICC
0.024
0.195
0.172
0.354
0.499
0.296
ICC: intra-class correlation coefficient, describes variation in tobacco
treatment among providers sampled and is measured on a scale
from 0 to 1, with a value close to 0 indicating the clusters were
all similar.
Intra-Provider ICC = provider variance/total variance.
P values: reports on significance level of the GP-level variation
observed.
screen for anxiety or depression (AOR 4.67; 95\% CI 2.23, 9.75;
P < 00.1). Additionally a significant (P < 0.01) trend across age
groups was seen in ra ...
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Losinski forwarded the article on a priority basis to Mary Scott
Losinksi wanted details on use of the ED at CGH. He asked the administrative resident