Group Project - Economics
Summary The Process for completing this portion of the assignment · First, locate articles related to the subject chosen. Selected below and attached · Cite the article using the APA style. Added below · Write a concise summary – in your own words, no copying - of no less than 150 words for each assigned article that complies with the following: o    the authority or background of the author, including why we should trust the source of the material, · summarize the information presented · Possible shortcomings or biases of the work · Remember that these articles have been peer reviewed by others in the field. Article 1- Is recession bad for your mental health? The answer could be complex: evidence from the 2008 crisis in Spain APA Reference: Moncho, J., Pereyra-Zamora, P., Tamayo-Fonseca, N., Giron, M., Gomez-Beneyto, M., & Nolasco, A. (2018). Is recession bad for your mental health? The answer could be complex: evidence from the 2008 crisis in Spain. BMC Medical Research Methodology, 18(1). https://doi.org/10.1186/s12874-018-0538-2 Article 2- Effect of the economic recession on pharmaceutical policy and medicine sales in eight European countries APA Reference: Leopold, C., Mantel-Teeuwisse, A. K., Vogler, S., Valkova, S., de Joncheere, K., Leufkens, H. G. M., Wagner, A. K., Ross-Degnan, D., & Laing, R. (2014). Effect of the economic recession on pharmaceutical policy and medicine sales in eight European countries/Effet de la recession economique sur la politique pharmaceutique et les ventes de medicaments dans huit pays europeens/El efecto de la recesion economica sobre la politica farmaceutica y la venta de medicinas en ocho paises europeos. Bulletin of the World Health Organization, 92(9), 630. https://doi.org/10.2471/BLT.13.129114 Article 3- Psychological Well-Being During the Great Recession: Changes in Mental Health Care Utilization in an Occupational Cohort. APA Reference: Modrek, S., Hamad, R., & Cullen, M. R. (2015). Psychological Well-Being During the Great Recession: Changes in Mental Health Care Utilization in an Occupational Cohort. American Journal of Public Health, 105(2), 304–310. https://doi.org/10.2105/AJPH.2014.302219 Article 4- Government spending, recession, and suicide: evidence from Japan. APA Reference: Matsubayashi, T., Sekijima, K., & Ueda, M. (2020). Government spending, recession, and suicide: evidence from Japan. BMC Public Health, 20(1), 1–8. https://doi.org/10.1186/s12889-020-8264-1 Article 5- Influence of the Economic Crisis in 2008 on the Performance of Companies in Wood-processing Industry APA Reference: Sujova, A. (2015). Influence of the Economic Crisis in 2008 on the Performance of Companies in Wood-processing Industry. Procedia Economics and Finance, 34, 581–586. https://doi.org/10.1016/S2212-5671(15)01671-8 Procedia Economics and Finance 34 ( 2015 ) 581 – 586 Available online at www.sciencedirect.com 2212-5671 © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of the Organizing Committee of BEM2015 doi: 10.1016/S2212-5671(15)01671-8 ScienceDirect Business Economics and Management 2015 Conference, BEM2015 Influence of the Economic Crisis in 2008 on the Performance of Companies in Wood-processing Industry Andrea Sujova*a aMendel University in Brno, Zemědělská 3, Brno 613 00, Czech Republic Abstract The last global economic recession has broken out in 2008. Impacts of the crisis have appeared in 2009 in the European countries. In the current globalized world of closely interdependent economies, the crisis affected almost every part of the world. Export oriented countries noticed a stronger recession in foreign trade due to decreased demand. In the time of economic crisis the enterprises are forced to reduce production volume, costs and number of employees in aim to keep performance or to survive. The paper deals with influence of economic recession on the performance of companies in wood-processing industry of Slovakia and the Czech Republic. The attention is paid to ratio indicators of performance and their indexes in the period 2006 – 2011. The aim of the paper is to summarize performance indicators and to show their changes during economic recession in wood- processing companies with focus on added value, labour productivity and investment effectiveness. © 2016 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the Organizing Committee of BEM2015. Keywords: economic crisis; performance; ratio indicator; wood-processing companies; 1. Introduction Performance is an ability to achieve required outputs or effects in measurable units. However, there are different understandings for evaluation of the performance at a macroeconomic and microeconomic levels. Macroeconomic performance is measured via indicator of value added, which reflects a value of final goods made in the economy. (Sujová, 2005). Corporate performance is defined as an ability to reevaluate consumed sources and to create a surplus. (Drábek, Potkány 2008). Indicators for measuring corporate performance come out from financial analysis which are dealt by several authors of professional publications (Kislingerová and Hnilica 2005, Zalai, 2008; * Corresponding author. Tel.: +420 545-134-075. E-mail address: [email protected] © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of the Organizing Committee of BEM2015 http://crossmark.crossref.org/dialog/?doi=10.1016/S2212-5671(15)01671-8&domain=pdf http://crossmark.crossref.org/dialog/?doi=10.1016/S2212-5671(15)01671-8&domain=pdf 582 Andrea Sujova / Procedia Economics and Finance 34 ( 2015 ) 581 – 586 Hajduchova, 2011; Holler, 2009; Polach et al., 2012) and they can be divided into two groups: traditional and modern. Scientific literature doesn´t contain any universally valid and generally accepted definition of the term: performance of the branch or industry. In the case of sector performance it is going on interconnection of the macro and micro-economic evaluation of the performance on a sectoral approach, thus there is an overlap of macro and micro level view on performance. The paper deals with influence of an economic recession on the performance of companies in wood-processing industry of Slovakia and the Czech Republic. The focus of the paper on WPI has several reasons. Wood processing industry is one of the sectors in which the Czech and Slovak economies can affect European markets by maximum use of their own resources. The need to deal with chosen topic of the paper is mainly due to the fact that the EU puts emphasis on the economic development based on renewable resources. The WPI is an important part of developing economies, a new prospective direction based on biotechnology. Despite these facts, there is insufficient attention paid to analysis of performance development of WPI and its changes, by now no study in the subject has been published. The aim of the paper is to summarize performance indicators and to show their changes during economic recession in wood-processing companies with focus on added value, labour productivity and investment effectiveness. 2. Material and methods The required material for achievement of relevant outputs was obtained from the secondary research based on the analysis of available scientific literature dealing with the issues of performance of enterprises and countries and on the use of a statistics of economic results in the wood processing industry. Analysis of knowledge in scientific literature led us to finding, that performance can be evaluated via a wide scale of indicators, which are different at the macro a micro level. Trend of economic indicators of Czech wood processing industry is analyzed by Kupčák (2003, 2006), Hlaváčková a Šafařík (2013, 2014). Performance of wood processing industry from the view of investment effectiveness and investment rate in the sector is dealt by authors Merková a Drábek (2011, 2012). On the basis of literature dealing with the assessment of performance of national economy and enterprises, a system of indicators suitable for evaluating the performance of the sector was set up: The first group is represented by indicators of profitability of the sector, which are based on comparison of economic result with volume of used sources to its achievement. Positive results of profitability are achieved plus values and their increasing trend. According to type of used source there exist following indicators (Zalai et al. 2008; Hajdúchová, 2011): return on equity (ROE), return on sales (ROS), return on costs (ROC), return on investment (ROI). (1) (2) The second group of indicators is based on creation of value added: value added per one employee and per one enterprise in the sector and the rate of value added creation (RVA) expressing a percentage share of value added on revenues, production and investment: (3) (4) (5) The third group of indicators concern evaluation of labour effectiveness: - Labour productivity (LP) has a several modifications and presents a share of revenues (R), production (Q) and profit (P) to one employee of the sector: (6) 583 Andrea Sujova / Procedia Economics and Finance 34 ( 2015 ) 581 – 586 - Labour productivity rate (LPR) expresses number of employees for one monetary unit of revenues or production: (7) The fourth group of indicators regards investment effectiveness: - The investment rate (IR), which shows what proportion of the generated funds is invested. Investment rate can be calculated as a share of investment (I) on revenues (R): IRR = I/R (8) - Efficiency of investments referred to as the productivity of investments is the efficiency of capital using. A background characteristic is the average product of capital, which in microeconomic theory represents the share of production volume fallen on one invested monetary unit. Effectiveness of investments should be monitored in relation to production, sales and value-added. The efficiency of investment in relation to revenues (EIR) reflects how many revenues (R) fall on one invested monetary unit: EIR = R / I (9) Additional indicators for evaluation of sector performance are: unit perfomance as the share of economic outputs of the sector (value added, production, revenues, profit, investment) on one enterprise and the export performance (EP) as the share of export on the revenues and production of the sector. EP = EX / R (Q) (10) Calculation of individual indicators for measuring the performance was applied in the wood processing industry (WPI) and its individual sections in Slovakia and the Czech Republic. A characteristic feature of the WPI is processing of raw wood and wood products production at various stage of finalisation. WPI within the classification of business activities of the EU (NACE) consists of three sections: - NACE 16: primary mechanical wood processing (timber industry), - NACE 17: primary chemical wood processing (pulp and paper industry), - NACE 31: secondary wood processing (production of furniture). The aim was to determine an influence of economic crisis in 2008 on performance of wood-processing industry. It is possible by identification of changes in performance indicators in the period 2006 - 2011. Changes of values of performance indicators were identified through change indexes as follows: - Average absolute index: (11) - Change index: (12) where: pn = indicator value in period n p0 = indicator value in basic period The application in MS Excel was created for appropriate applications of statistical methods and for calculating performance indicators and their indexes. 3. Results and Discussion The study of knowledge concerning evaluation of performance ate the macro and micro levels les us to conclusion that performance at the sector level is possible to assess on the basis of ability of the sector to create value added, profit and on the basis of efficiency by utilization of production sources. When evaluating sector performance it is needed to consider not only absolute indicators, but also ratio indicators. By considering an influence of economic crisis on sector performance, a calculation of indexes of indicators and analyzing their values is required. 584 Andrea Sujova / Procedia Economics and Finance 34 ( 2015 ) 581 – 586 The results of indicators measuring the performance of wood processing industry in Slovakia and the Czech Republic and their indexes for a period of five years are shown in Table 1. Basic input data was economic results of the industry. The values in the table are in millions euro. Table 1. Performance of Wood Processing Industry (WPI) in Slovakia and the Czech Republic Source: own calcuations In wood processing industry of the Czech Republic the crisis had the most marked influence on the export performance, which has fallen to one third value during 2008 and 2009 and stagnated. Its rise is noticed in 2010. Profitability also decreased when return on equity halved and return on sales dropped by one third. The crisis negatively affected labour productivity, which decreased by 5% and employment rate raised. The reason can be fall of revenues and no adaption of number of employees to lower level. Investment rate decreased during crisis and two following years. Positive trend in time of crisis was noticed by rate of value added and its rise in 2009 and also by Indicator (mil. €)/year 2006 2007 2008 2009 2010 2011 The Czech Republic EP (%) 55,3 56,7 57,2 57,6 61,0 62,9 Absolute index 1,4 0,5 0,4 3,4 1,9 ROE 18,4 21,0 14,6 11,3 12,2 11,8 Absolute index 2,6 -6,4 -3,3 0,9 -0,4 ROS 6,1 6,9 5,2 4,5 4,9 4,6 Absolute index 0,8 -1,7 -0,7 0,4 -0,3 RVAR 25,7 25,4 25,1 25,6 24,8 23,4 Absolute index -0,3 -0,3 0,5 -0,8 -1,4 LPR 73,4 82,8 78,7 79,1 92,4 96,2 Absolute index 9,4 -4,1 0,4 13,3 3,8 LPRR 13,62 12,08 12,71 12,64 10,83 10,39 Absolute index -1,54 0,63 -0,07 -1,81 -0,44 IRR 0,06 0,07 0,08 0,07 0,06 0,05 Absolute index 0,01 0,01 -0,01 -0,01 -0,01 EIR 17,48 15,25 12,49 14,86 16,96 18,74 Absolute index -2,23 -2,76 2,37 2,1 1,78 Slovakia EP (%) 80,00 77,19 69,66 64,57 87,42 68,54 Absolute index -2,81 -7,53 -5,09 22,85 -18,88 ROE 22,0 22,0 23,1 3,0 18,3 9,8 Absolute index 0 1,1 -20,1 15,3 -8,5 ROS 4,9 4,3 4,7 0,8 4,9 1,9 Absolute index -0,6 0,4 -3,9 4,1 -3 RVAR 20,2 18,6 19,2 22,6 25,1 21,4 Absolute index -1,6 0,6 3,4 2,5 -3,7 LPR 97,3 101,7 102,2 92,4 95,8 113,2 Absolute index 4,4 0,5 -9,8 3,4 17,4 LPRR 10,28 9,84 9,79 10,82 10,43 8,84 Absolute index -0,44 -0,05 1,03 -0,39 -1,59 IRR 0,098 0,113 0,091 0,073 0,061 0,053 Absolute index 0,015 -0,022 -0,018 -0,012 -0,008 EIR 10,211 8,828 10,992 13,642 16,289 18,882 Absolute index -1,383 2,164 2,65 2,647 2,593 585 Andrea Sujova / Procedia Economics and Finance 34 ( 2015 ) 581 – 586 efficiency of investment which increased significantly and its increase continued in years after crisis. In Slovak wood processing industry the crisis deepened fall of export performance by 20% except year 2010 as the only year when it increased markedly, by 35%. Profitability was affected by crisis one year later, in 2009, when it dropped by 84% and after recovery in 2010 there was a significant decrease again. Labour productivity declined and productivity rate increased in 2009 when a negative influence of the crisis approved. Investment rate has fallen gradually since 2008 to one half compared to period before crisis. In contrary, a positive trend in time of crisis can be seen by efficiency of investment, which after its fall in time before crisis has risen gradually since 2008. The rate of value added increased only in time of crises. A comparison of impacts if crisis on wood processing companies in Slovakia and the Czech Republic is presented by chain indexes of ratio performance indicators displayed in figures 1 and 2. Fig. 1. Chain indexes of profitability and export performance in Slovak and Czech WPI Fig. 2. Chain indexes of performance indicators in Slovak and Czech WPI A significant negative influence of economic crisis can be seen by profitability and value added rate of Slovak wood processing industry in 2009 which dropped very rapidly. Czech wood processing enterprises registered crisis affect already in 2008 and the impact of crisis is noticeable in years after crisis when the performance in slight holding decrease, however, a marked fall of performance wasn´t noticed. 0 100 200 300 400 500 600 700 2007 2008 2009 2010 2011 Chain indexes EP, ROE, ROS of WPI SR and CR EP SR ROE SR ROS SR EP CR ROE CR ROS CR 0 50 100 150 2007 2008 2009 2010 2011 Chain indexes LP, EIR, RVA of WPI SR and CR LPR SR EIR SR RVA SR LPR CR EIR CR RVA CR 586 Andrea Sujova / Procedia Economics and Finance 34 ( 2015 ) 581 – 586 4. Conclusion Results of scientific studies of internationally known professionals mention a negative influence of economic crises especially on sales, production, investment and profit of enterprises what was approved by worsened profitability of wood processing enterprises and by their export performance fall. Trend of ratio indicators showed that companies in Slovakia and also in the Czech Republic didn´t reflect to fall of sales in number of employees and their reduction wasn´t in such rate as fall of revenues was in time of crisis. The result was a decrease of labour productivity and in contrary increase of value added rate that can be considered to be a positive effect. Interesting finding is a rise of investment efficiency in relation to revenues that can be caused by deep decrease of investments during the crisis. Implemented crisis actions in wood processing companies had a short term effect because of improvement of performance only for a short time of one year after time of crisis in 2010. References Dobrovič, J. 2010. Development trends in management during the reform of the tax administration of the Slovak republic. Intercathedra, 36: 117- 120 Ďurisova, M., Kucharčíková, A. 2014. The Quantitative expression of Factors which Affect the Cost of Transport Enterprise. In Transport means 2014: proceedings of the 18th International conference, October 23-24, 2014, Kaunas University of Technology Lithuania, p. 190-193. Drábek, J., Potkány, M. 2008. Ekonomika podniku, Zvolen, Technická univerzita vo Zvolene. Hajdúchová, I. 2011. Finančná stabilita podniku. Zvolen, Technická univerzita vo Zvolene. Hajdúchová, I., Hlaváčková, P. 2014. Vplyv globálnej ekonomiky na lesnícko-drevársky sektor v Českej a Slovenskej republike. Acta Facultatis Xylologiae, 56(2): 135-146. Hlaváčková, P., Šafařík, D. 2014. Problémy českých dřevozpracujících podniků a indikátory konkurenceschopnosti. Manažment podnikov, 4(1): 3-8. Holler, A. 2009. New metrics for value based management. Wiesbaden: Springer, 2009. 217 s. Kupčák, V. 2006. Timber industry in the Czech Republic - present situation and prospects. Intercathedra. 22, 61-64. Merkova, M., Drabek, J., Polach, J. 2011. Impact of investment on labour productivity growth in wood processing industry in Slovak Republic. Finance and the performance of firms in science, education and practice. Zlin, p. 324-332. Merková, M., Drábek, J., Jelačić, D. 2012. Determinants of Effects of Foreign Direct Investment in Terms of Slovak Republic and Wood- processing Industry of Slovakia. Drvna Industrija, 63(2):129–142 Polách, J., Drábek, J., Merková, M., Polách, J. jr. 2012. Reálné a finanční investice. Praha, C. H. Beck. Sujová, A. 2005. Makroekonómia, Zvolen, TU Zvolen, pp. 160 Sujová, A., Hlaváčková, P., Marcineková, K. 2015. Measuring the Impact of Foreign Trade on Performance Growth of the Wood Processing Industry. In Wood Research, 60(3): 491-502. Šafařík, D., Badal, T. 2013. The economic efficiency of forest energy wood chip production in regional use – a case study. Acta Univ. Agric. Silvic. Mendelianae Brunensis 61(2): 1391-1398. Zalai, K. et al. 2008. Finančno-ekonomická analýza podniku. Bratislava, Sprint. Czech Statistical Office. [online] Available at: http://www.czso.cz Statistical Office of the Slovak Republic: Database Slovstat. [online] Available at: <http://slovak.statistics.sk> RESEARCH ARTICLE Open Access Is recession bad for your mental health? The answer could be complex: evidence from the 2008 crisis in Spain Joaquín Moncho1, Pamela Pereyra-Zamora1* , Nayara Tamayo-Fonseca1, Manuel Giron1,2, Manuel Gómez-Beneyto2,3 and Andreu Nolasco1 Abstract Background: We explored the impact of 2008 recession on the prevalence of mental health problems in Spain. Methods: Repeated cross-sectional survey design. Datasets from 2006 and 2011 were used, and temporal change was examined. The study was conducted on the economically active population (16–64 years old). The two surveys included 29,478 and 21,007 people, obtaining a 96 and 89.6% response rate, respectively. Multiple logistic regression models were adjusted to identify poor mental health risk factors. A standardisation analysis was performed to estimate the prevalence of people at risk of poor mental health (GHQ+). Results: The prevalence of GHQ+ following the crisis increased in men and decreased in women. Two logistic regression analyses identified GHQ+ risk factors. From 2006 to 2011, unemployment rose and income fell for both men and women, and there was a decline in the prevalence of somatic illness and limitations, factors associated with a higher prevalence of GHQ+. After controlling for age, the change in employment and income among men prompted an increase in the prevalence of GHQ+, while the change in somatic illness and limitations tended to mitigate this effect. After the recession, unemployed men showed a better level of somatic health. The same effects were not detected in women. Conclusions: The economic recession exerted a complex effect on mental health problems in men. The reduction of prevalence in women was not associated with changes in socioeconomic factors related to the economic crisis nor with changes in somatic health. Keywords: Mental health, Population study, Economic recession, Unemployment, Prevalence Background In his seminal work “Le suicide” (1897) [1], Durkheim argued that economic crises could increase psychiatric pathology. There are good grounds for thinking that this may be so, including consistent evidence that those who become unemployed during a recession may have worse mental health than those who do not [2]. Some studies have documented the direct effect of the economic re- cession on the general population’s mental health by comparing outcomes before and after the onset of the crisis [3–6]. However, the independent effect of changes in the distribution of socioeconomic and health risk factors has not been investigated. An economic recession does not exert a homogeneous effect on the population’s health status [7, 8], and the hypothesis of a “protective” effect of the downturn phase of the economic cycle on mental health has not been studied. This hypothesis is plausible because it is known that somatic morbidity is a risk factor for poor mental health [9] and that the population’s health status may improve during a recession, especially during periods of very rapid industrial contraction [10–12]. In 2008, following a period of economic growth based largely on the property market, Spain entered a severe and lasting economic crisis that generated a significant decline in macroeconomic activity (GDP) and a number * Correspondence: [email protected] 1Research Unit for the Analysis of Mortality and Health Statistics, University of Alicante, Campus de San Vicente del Raspeig s/n, Ap. 99, 03080 Alicante, Spain Full list of author information is available at the end of the article © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Moncho et al. BMC Medical Research Methodology (2018) 18:78 https://doi.org/10.1186/s12874-018-0538-2 http://crossmark.crossref.org/dialog/?doi=10.1186/s12874-018-0538-2&domain=pdf http://orcid.org/0000-0001-8993-3349 mailto:[email protected] http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ of other factors with a clear impact on the population, such as an acute rise in unemployment and a deterioration in the standard of living. A substantial and rapid rise in unemployment can have negative effects on mental health, but positive effects on somatic health [10], giving rise to complex explanatory models. The Spanish National Health Surveys (SNHS) conducted in 2006 (pre-crisis) and 2011 (crisis) by the National Statistics Institute (Ministerio de Sanidad Servicios Sociales e Igualdad) consider a repre- sentative sample of the Spanish population. These surveys include Goldberg’s General Health Questionnaire (GHQ) and items relating to demographic, socioeconomic, support and health factors. The aim of this study was to analyse the impact of the economic recession on mental health, including possible pro-cyclical effects, and specifically, to investigate variation in the prevalence of mental health problems (GHQ+ caseness) in the general population in relation to variations in demographic and socioeconomic factors related to the crisis, as well as social support and health. The study was conducted in four phases: 1) estimation of the prevalence of GHQ+ and identification of the risk factors in 2006 and 2011; 2) esti- mation of changes in risk factor frequency and prevalence between the two periods; 3) analysis of the relationship between changes in risk factor frequency and changes in GHQ+ prevalence; 4) exploration of the relationship between unemployment and somatic health. Methods Data source We used data from the Spanish National Health Survey [13] for two periods: 2006 (before the start of the crisis) and 2011 (during the crisis). National health surveys employ a multistage, stratified-random design to identify samples of adults. All residents in each household were screened and one person was selected at random for the interview. Data were collected between June 2006 and June 2007 (2006 survey), and between July 2011 and June 2012 (2011 survey). Face-to-face interviews were carried out at home by fully trained interviewers. We restricted the selected sample to the economically active population (16–64 years old). A total of 29,478 people aged > 15 years old responded to the SNSH health question- naire in 2006, and 21,007 in 2011, obtaining a response rate of about 96 and 89.6%, respectively. Of these, 20,787 and 14,835, respectively, were aged between 16 and 64 years old, and these were the populations considered in the present study. Due to the complex sample design, sample subjects were weighted to determine the number of subjects represented by each individual in the sample [14]. The weightings were included in the databases provided by the National Statistics Institute. Risk of poor mental health and explanatory variables The risk of poor mental health was the outcome variable in 2006 and 2011 and was measured with the 12-item version of the General Health Questionnaire GHQ-12 [15, 16]. This screening measure detects probable psychiatric disor- ders. We used a 2-point scoring method, rating a problem as absent (0) or present (1) according to the method recommended by the developers of the questionnaire. Responses were summed, and subjects obtaining scores of 3 or above (out of 12) were classified as having poor mental health (GHQ+). The same explanatory variables obtained in both 2006 and 2011 were: (a) Sociodemographic: sex (male/female), age (16–34/35–49/50–64), marital status (single/married/separated or divorced/widowed), educational level (higher/other). (b) Socioeconomic variables related to crises: occupation (employed/unemployed/other; such as: [retired, student, houseworker, disabled]) and household income (euros per month, high/average/low). (c) Social support (measured by means of the 11-item Duke Social Support Index) [17]. Higher scores for individual items indicate better social support. Responses were summed, and subjects obtaining scores of ≤32 (out of 55) were classified as having low social support [18]. (d) Health variables: presence of a somatic illness confirmed by a doctor (yes/no), and presence of a limitation due exclusively to a somatic illness (yes/no). In order to determine the presence of somatic illness during the last year confirmed by a doctor, the surveys posed the following questions: “I’m going to read a list of illnesses or health problems; do you have or have you ever had any of them? If yes, was this in the last 12 months? Have you consulted a doctor about it?” The list was as follows: high blood pressure, heart attack, other cardiovascular diseases, varicose veins in the legs, osteoarthritis, arthritis or rheumatism, chronic back pain (cervical), chronic back pain (lumbar), chronic allergy, asthma, chronic bronchitis, diabetes, stomach or duodenal ulcer, urinary incontinence, high cholesterol, cataracts, chronic skin problems, chronic constipation, stroke, migraine or frequent headaches, hemorrhoids, cancer, osteoporosis, thyroid problems, prostate problems, menopausal problems. To analyze the change in prevalence we considered three groups: cardiovascular (high blood pressure, heart attack, other cardiovascular diseases, stroke), osteoarticular (osteoarthritis, arthritis or rheumatism, chronic back pain-cervical, chronic Moncho et al. BMC Medical Research Methodology (2018) 18:78 Page 2 of 10 back pain-lumbar) and other. A fair agreement between questionnaire data and medical records has been well established in the case of common chronic disorders. [19, 20]. In order to determine the presence of a limitation due exclusively to a somatic illness, the surveys posed the following questions: “In the last six months, to what extent have you suffered limitations in activities of daily living?” Response options were: not limited at all/ limited. For this question, only physical limitations were considered. Data analysis Analyses were performed for men and for women. Multiple logistic regression models were fitted to allow calculation of adjusted odds ratios (ORs) and 95% confidence intervals (CIs). A standardisation analysis was performed, considering age and variables that maintained a statistically significant relationship with a GHQ+ in the multivariate logistic regression analyses in the two surveys, and which showed a significant change in frequency between 2006 and 2011 for either sex. The expected prevalences of GHQ+ in 2011 were estimated as if the population had retained the same population structure observed in 2006. The difference between expected and observed prevalences in 2011 could indicate the effect of the crisis in terms of the controlled risk variables. Specifically, to study possible changes in GHQ+ preva- lence in men and women for the years 2006 and 2011 ad- justed for age, employment status, income level, presence of a somatic illness and presence of limitations derived from a somatic illness, the population distribution in 2006 for each of the levels and sublevels of the previous variable categories was projected onto the 2011 population (2 sex categories × 3 age categories × 3 employment status categories × 3 income level categories × 2 somatic illness categories × 2 limitation categories = 216 cells or levels) as follows: P2011ei ¼ P2006iP P2006i X P2011i � � ; i ¼ 1; 2; 3…::; 216 Where: P2011ei = expected population in 2011 in level i. P2006i = observed population in 2006 in level i. P2011i = observed population in 2011 in level i. Once the 2011 population had been estimated in each of the cells, the observed prevalence in 2011 was applied at the same level of disaggregation to obtain the expected GHQ+ cases and the corresponding prevalence, as described below: ne GHQþ 2011 i ¼ P2011ei � prev 2011 i ¼ P2011ei � nGHQþ2011i P2011i ; i ¼ 1; 2; 3; …; 216 prev2011e;i ¼ ne GHQþ2011i P2011ei Where: ne GHQþ2011i = expected GHQ+ frequency in 2011 in level i. prev2011i = observed GHQ+ prevalence in 2011 in level i. nGHQþ2011i = observed GHQ+ frequency in 2011 in level i. Lastly, global prevalence was calculated disaggregated by sex, adding all previous cells, as follows: prev2011e;total ¼ P ne GHQþ2011iP P2011ei In addition, expected prevalences were calculated adjust- ing for sex, age, income level and employment status, and for sex, age, somatic illness and limitations. This standardisation system made it possible to distin- guish between: (1) changes in global prevalence due to variations in population structure between 2006 and 2011 (in terms of the variables considered), and (2) changes in prevalence that could not be explained by changes in the population structure. Furthermore, variation in variables for which a significant change in the population distri- bution was observed between the two periods under consideration could be related to variations in global GHQ+ prevalence. Results Relationship between the risk of poor mental health and sociodemographic, socioeconomic, support and comorbidity variables Table 1 shows the estimations of GHQ+ prevalence together with the adjusted odds ratios using multivariate logistic regression, and the frequencies of the different risk factors in 2006 and 2011. The prevalence of GHQ+ increased in men but decreased in women. For both men and women, being a GHQ+ case presented a statistically significant association (p < 0.05) with a low educational level (2006 survey), being divorced/separated (2006), low social support (2006, 2011), unemployment (2006, 2011), low and average household income (2006, 2011), having a somatic illness (2006, 2011) and the presence of a limita- tion arising from a somatic illness (2006, 2011). For the latter 4 risk factors (income, unemployment, somatic illness, limitation derived from somatic illness), differences in the distribution of frequencies were ob- served between 2006 and 2011 (Table 1). Frequencies Moncho et al. BMC Medical Research Methodology (2018) 18:78 Page 3 of 10 Table 1 Prevalence of risk of mental health problems (GHQ+), odds ratios (OR) and 95% confidence intervals (95% CI) for the association between GHQ+ and other explanatory variables, and distribution of population, by sex and year of survey Men Prevalence of Total Mental Health Problems 2006 (n = 7681), 14.5% (13.8, 15.2) 2011 (n = 5479), 16.9% (16.0, 17.7) OR (95% CI) Distribution of population (%) (95%CI) 2006 2011 2006 2011 Age p < 0.001 p < 0.001 16–34 1 1 41.6 (40.6, 42.5) 36.6 (35.5, 37.7) 35–49 0.93 (0.79, 1.10) 1.42c (1.17,1.73) 34.9 (34.0, 35.8) 36.6 (35.5, 37.7) 50–64 0.62c (0.51,0.76) 0.82 (0.65, 1.03) 23.5 (22.7, 24.3) 26.8 (25.8, 27.8) Educational level p = 0.011 p = 0.154 Higher/university 1 1 28.0 (27.2, 28.9) 24.5 (23.5, 25.5) Others 1.21a (1.04, 1.41) 1.16 (0.95,1.41) 72.0 (71.1, 72.8) 75.5 (74.5, 76.5) Marital status p < 0.001 p = 0.540 Single 1 1 43.0 (42.0, 43.9) 41.0 (39.9, 42.1) Married 1.05 (0.89, 1.23) 1.10 (0.91, 1.32) 52.7 (51.7, 53.8) 54.3 (53.2, 55.5) Divorced/separated 2.07c (1.54, 2.78) 1.10 (0.76, 1.59) 3.6 (3.3, 4.0) 4.1 (3.6, 4.5) Widowed 0.78 (0.36, 1.69) 1.66 (0.75, 3.68) 0.7 (0.5, 0.9) 0.6 (0.5, 0.8) Social support p < 0.001 p = 0.004 High 1 1 97.1 (96.8, 97.4) 97.4 (97.1, 97.8) Low 5.05c(3.90, 6.55) 1.71b (1.19, 2.46) 2.9 (2.6, 3.2) 2.6 (2.2, 2.9) Employment status p < 0.001 p < 0.001 Employed 1 1 74.9 (74.1, 75.7) 61.3 (60.2, 62.4) Unemployed 2.49c(2.35, 3.06) 2.52c (2.09,3.05) 7.6 (7.1, 8.1) 20.7 (19.8, 21.6) Other activity 1.56c (1.34, 1.86) 1.85c (1.50,2.28) 17.5 (16.8, 18.2) 18.0 (17.2, 18.9) Household income p = 0.007 p < 0.001 High 1 1 36.6 (35.6, 37.5) 38.7 (37.6, 39.8) Average 0.97 (0.84, 1.12) 1.33b (1.10, 1.61) 50.1 (49.2, 51.1) 35.6 (34.5, 36.7) Low 1.28a (1.06, 1.56) 1.91c(1.55,2.36) 13.3 (12.7, 14.0) 25.7 (24.7, 26.6) Somatic morbidity p < 0.001 p < 0.001 No 1 1 43.8 (42.8, 44.7) 47.9 (46.8, 49.1) Yes 2.17c(1.88, 2.49) 1.79c (1.52,2.10) 56.2 (55.3, 57.2) 52.1 (50.9, 53.2) Limitation derived from somatic morbidity p < 0.001 p < 0.001 No 1 1 86.9 (86.3, 87.6) 89.5 (88.8, 90.2) Yes 2.50c (2.15, 2.91) 3.18c (2.61,3.88) 13.1 (12.4, 13.7) 10.5 (9.8, 11.2) Women Prevalence of Total Mental Health Problems 2006 (n = 11,035), 24.4% (23.6, 25.2) 2011 (n = 5522), 22.6% (21.7, 23.6) OR (95% CI) Distribution of population (%) (95%CI) 2006 2011 2006 2011 Age p = 0.201 p = 0.069 16–34 1 1 40.1 (39.2, 41.0) 35.6 (34.5, 36.7) 35–49 1.03 (0.90, 1.18) 1.24a (1.03, 1.49) 34.8 (33.9, 35.7) 36.8 (35.8, 37.9) 50–64 0.91 (0.78, 1.07) 1.17 (0.95, 1.44) 25.1 (24.2, 25.9) 27.5 (26.5, 28.5) Educational level p < 0.001 p = 0.568 Higher/university 1 1 26.9 (26.0, 27.7) 27.2 (26.1, 28.2) Others 1.36c (1.20, 1.55) 1.05 (0.89, 1.25) 73.1 (72.3, 74.0) 72.8 (71.8, 73.9) Moncho et al. BMC Medical Research Methodology (2018) 18:78 Page 4 of 10 of unemployed people and people living in low-income households increased, and frequencies of those living in average-income households and those with a somatic illness and a limitation deriving from a somatic illness decreased. Effect of changes in the frequency of socioeconomic and somatic health variables on the change in GHQ+ prevalence The variables included in the standardisation analysis were employment status, household income, presence of a somatic illness and presence of a limitation. A slight increase was observed in 2011 in the percentage of people who were divorced/separated; however, the marital status variable was not included in the analysis due to the small number of subjects. Table 2 shows the GHQ+ prevalences observed for the different levels of explana- tory variables. Once adjusted for age, a higher GHQ+ prevalence was observed among both men and women in 2006 and 2011 in the higher risk levels (unemployment, low income level, somatic illness, presence of limitation). Since the percentage distribution of risk factors varied differently between the 2 periods (the percentage of unemployed people and low-income households in- creased while the percentage of people with somatic ill- ness and limitation derived from somatic illness decreased), its impact on the expected prevalence of GHQ+ in 2011 also had different effects. In 2011, the standardised (expected) GHQ+ prevalence in men by age and socioeconomic risk variables related to the crisis (em- ployment status and income) was 14.8%, lower than the prevalence actually observed in 2011 (16.9%) (Table 2, Model 1). This indicates that the rise in unemployment and low-income households in both periods may explain the increase in observed GHQ+ prevalence. However, the standardised prevalence by age and variables re- lated to somatic illness was 17.8%, higher than the observed prevalence (Table 2, Model 2). This indi- cates that the decrease in the frequency of having a somatic illness and limitations between the two pe- riods may explain a decrease in observed GHQ+ prevalence. Model 3 (Table 2) corresponds to the prevalence of GHQ+ in 2011 standardised for all the above variables (age, employment status, income, somatic illness, limitation), which was 15.6%, lower than the ob- served prevalence in 2011 (16.9%). For women, the models adjusted for age and these two groups of risk factors did Table 1 Prevalence of risk of mental health problems (GHQ+), odds ratios (OR) and 95% confidence intervals (95% CI) for the association between GHQ+ and other explanatory variables, and distribution of population, by sex and year of survey (Continued) Marital status p < 0.001 p = 0.015 Single 1 1 32.6 (31.7, 33.5) 34.9 (33.8, 36.0) Married 0.92 (0.81, 1.05) 0.85 (0.71, 1.01) 59.3 (58.3, 60.2) 55.6 (54.4, 56.7) Divorced/separated 1.30a (1.03, 1.64) 1.13 (0.86, 1.48) 5.5 (5.0, 5.9) 6.7 (6.2, 7.3) Widowed 1.45a(1.07, 1.98) 1.25 (0.86, 1.82) 2.7 (2.4, 3.0) 2.8 (2.4, 3.2) Social support p < 0.001 p < 0.001 High 1 1 97.0 (96.7, 97.3) 96.6 (96.2, 97.0) Low 4.31c(3.34, 5.56) 3.41 (2.51, 4.63) 3.0 (2.7, 3.3) 3.4 (3.0, 3.8) Employment status p < 0.001 p = 0.001 Employed 1 1 52.3 (51.3, 53.3) 51.2 (50.0, 52.3) Unemployed 1.38c (1.17, 1.63) 1.44c(1.19,1.74) 10.1 (9.6, 10.7) 16.1 (15.3, 17.0) Other activity 1.05 (0.94, 1.18) 1.12 (0.95, 1.32) 37.6 (36.6, 38.5) 32.7 (31.6, 33.7) Household income p < 0.001 p < 0.001 High 1 1 32.2 (31.3, 33.1) 35.1 (34.0, 36.2) Average 1.24b (1.09, 1.40) 1.30b(1.10, 1.55) 52.1 (51.1, 53.0) 35.4 (34.4, 36.5) Low 1.83c (1.56, 2.15) 1.61c(1.33,1.94) 15.7 (15.0, 16.4) 29.5 (28.4, 30.5) Somatic morbidity p < 0.001 p < 0.001 No 1 1 31.9 (31.0, 32.8) 37.8 (36.7, 38.9) Yes 2.06c (1.81, 2.33) 2.18c (1.85,2.56) 68.1 (67.2, 69.0) 62.2 (61.1, 63.3) Limitation derived from somatic morbidity p < 0.001 p < 0.001 No 1 1 84.7 (84.0, 85.4) 85.8 (85.0, 86.6) Yes 2.07c (1.82, 2.35) 2.53c (2.14,3.00) 15.3 (14.6, 16.0) 14.2 (13.4, 15.0) ap < 0.05, bp < 0.01, cp < 0.001 Moncho et al. BMC Medical Research Methodology (2018) 18:78 Page 5 of 10 Table 2 Percentage of population (Pop %) and prevalences observed in 2006 and 2011 (Po) and expected in 2011 (Pe) according to different standardisation models by sex 2006 2011 2011 Pop % Po Pop % Po Model 1 a Pe Model 2 a Pe Model 3 a Pe Men MHP (95% CI) 14.5 (13.8;15.2) 16.9 (16.0, 17.7) 14.8 (14.0, 15.6) 17.8 (16.9, 8.7) 15.6 (14.8, 16.4) Age 16–34 41.6 13.6 36.6 14.2 11.9 14.9 12.2 35–49 34.9 15.0 36.6 19.4 16.4 20.8 17.7 50–64 23.5 15.3 26.8 17.0 17.7 18.6 18.7 Household Income low 11.9 23.1 18.9 28.5 24.6 26.7 average 44.7 13.6 26.3 17.1 15.6 16.1 high 32.5 12.2 28.6 11.6 10.9 11.2 no information 10.9 15.7 26.2 14.1 12.5 14.6 Occupation Employed 74.9 12.1 61.3 12.0 12.3 12.9 Unemployed 7.6 28.1 20.7 28.4 25.9 28.0 Others 17.5 18.6 18.0 20.2 20.6 21.9 Somatic Illness yes 56.1 19.0 52.1 21.6 22.5 19.4 no 43.9 8.7 47.9 11.7 11.8 10.8 Limitation yes 13.1 29.7 10.5 41.2 37.9 37.8 no 86.9 12.2 89.5 13.5 14.8 12.3 Women MHP (95% CI) 24.4 (23.6, 25.2) 22.6 (21.7, 23.6) 22.3 (21.3, 23.2) 23.4 (22.4, 24.3) 23.3 (22.4, 24.3) Age 16–34 40.1 21.4 35.6 17.5 17.9 18.9 19.3 35–49 34.8 24.8 36.8 24.0 22.9 24.7 23.8 50–64 25.0 28.6 27.5 27.5 28.4 28.7 29.2 Household Income low 13.6 36.4 21.1 30.9 30.8 31.9 average 45.4 24.8 25.4 23.6 23.3 24.8 high 28.0 18.6 25.2 17.7 17.6 17.9 no information 13.0 22.7 28.3 19.9 19.7 20.9 Occupation Employed 52.3 22.1 51.2 18.8 19.0 20.1 Unemployed 10.1 30.1 16.1 30.5 27.4 29.8 Others 37.5 26.1 32.7 24.8 25.3 26.1 Somatic Illness yes 68.1 29.0 62.2 28.6 28.2 28.4 no 31.9 14.5 37.8 12.9 13.0 12.3 Limitation yes 15.3 40.1 14.2 48.5 42.8 43.9 no 84.7 21.5 85.8 17.3 19.9 19.6 (a) Model 1 = standardised prevalence by age, household income and occupation Model 2 = standardised prevalence by age, somatic illness and limitation Model 3 = standardised prevalence by age, household income, occupation, somatic illness and limitation Moncho et al. BMC Medical Research Methodology (2018) 18:78 Page 6 of 10 not show any major differences between expected and observed prevalence. Employment status and somatic illness Table 3 shows a statistically significant reduction of som- atic diseases in unemployed men and employed women. Using the presence of somatic illness as the response variable, the multivariate logistic regression models built for the periods 2006 and 2011 showed no statistically significant association between employment status and somatic health before the economic crisis in both sexes. However, during the crisis, unemployed men were sig- nificantly less likely to report poor health compared with employed people. There was a positive and statistically significant relationship between been a member of any of the three groups of somatic illness and being classified as GHQ+ case, in both 2006 and 2011. The prevalence of osteoarticular illnesses diminished in both sexes, the reduction being higher in the unemployed group. The prevalence of cardiovascular and other diseases dimin- ished significantly in employed women. Discussion This study has revealed that the 2008 economic recession has exerted a complex effect on the prevalence of men at risk of poor mental health. Compared with the pre-crisis period, the period of recession was characterised by an increase in unemployment and financial difficulties and by a decrease in health problems, factors all of them related with a higher prevalence of GHQ+ before and after the crisis. The increase in socioeconomic factors related to the crisis had a significant impact on the increased prevalence of GHQ+ cases. In contrast, the decrease in somatic illness and somatic illness derived limitations during the recession tended to mitigate this prevalence. Overall, these opposite effects tended to neutralise the crisis effect on the prevalence of GHQ+ cases in both men and women, indicating that the absolute increase in the observed prevalence of GHQ+ cases in men and its reduction in women must be due to factors other than those studied here. Second, although the prevalence of somatic illnesses decreased in all employment status categories after the onset of the crisis, this reduction was more marked among the unemployed men. The effect of the economic recession on the risk of poor mental health in economically active men, exerted through a rise in unemployment and a drop in household income, is consistent with the model that assumes that the negative impact on health of a contracting economy is the result of undesirable consequences associated with Table 3 Prevalences of somatic illness and adjusted OR (95% IC) for the association between ocupational activity and somatic illness in economically active population Employed Unemployed 2006 2011 diference 2006 2011 diference Men Cardiovascular 14.6 (13.8, 15.3) 15.8 (14.7, 16.8) 1.2 14.1 (11.7, 16.5) 15.8 (13.9, 17.6) 1.7 Osteoarticular 23.1 (22.2, 24.0) 19.2 (18.0, 20.3) −3,9b 27.9 (24.8, 31.0) 17.4 (15.8, 18.3) −10,5b Other 42.1 (41.0, 43.2) 41.0 (39.6, 42.4) −1,1 42.1 (38.7, 45.5) 37.4 (35.0, 39.8) −4,7 Total 55.2 (54.1, 56.3) 52.9 (51.5, 54.4) −2.3 57.8 (54.3, 61.2) 48.6 (46.1, 51.1) −9.2b Adjusted Odds ratio a 1 1 0.97 (0.81, 1.16) 0.85 (0.72, 0.99) Women Cardiovascular 12.3 (11.4, 13.2) 10.2 (9.3, 11.2) −2,1b 12.8 (10.8, 14.9) 14.4 (12.4, 16.4) 1,6 Osteoarticular 34.4 (33.1, 35.6) 29.1 (27.6, 30.5) −5,3b 38.4 (35.5, 41.4) 30.1 (27.5, 32.6) −8,3b Other 55,7 (54.3, 57.0) 51,0 (49.4, 52.5) −4,7b 56.5 (53.5, 59.5) 52.3 (49.5, 55.2) −4,2 Total 66.0 (64.7, 67.2) 60.5 (58.9, 62.0) −5.5b 67.6 (64.8, 70.4) 62.6 (59.8, 65.3) −5.0 Adjusted Odds ratio a 1 1 1.03 (0.87, 1.20) 1.09 (0.91, 1.29) aMultivariate Logistic regression analysis controlling for age, social support, educational level, marital status, GHQ caseness, and household income bStatistically significant change between 2006 and 2011 Moncho et al. BMC Medical Research Methodology (2018) 18:78 Page 7 of 10 job loss (anticipated or actual job loss, income reduc- tion, difficulty in paying bills) [21–23]. Our results do not agree with those obtained in studies conducted in England [3, 4], where no relationship was found between a change in employment status and an increase in poor mental health in men. This discrepancy may be due to differences between the increase in unemployment in England and Spain (much lower in the former), the periods studied, and definitions of poor mental health and analysis methods. This study provides evidence of the “protective” effect of economic recession on the risk of poor mental health among economically active men through a reduction in somatic health problems. This decrease in health prob- lems during an economic recession has been reported in other studies conducting comparing outcomes before and after the crisis [11, 12]. This study has shown that unemployment exerts a direct effect increasing the prevalence of GHQ+ in men. How- ever, this effect may have been mitigated by a decrease in somatic illness among the newly unemployed. The differ- ence between the adjusted OR in 2006 and 2011 may be explained by the intake of previously healthy people among the newly unemployed, a phenomenon to be expected in periods of very rapid industrial contraction [10]; by a reduction in negative, unexpected health consequences of economic processes such as an increase in work, promo- tion at work and income level as anomic processes [22], or by a reduction in somatic problems due to the avoidance of jobs that endanger health (for example, due to a reduc- tion in employment and workplace accidents in construc- tion) [24, 25]. According to the Spanish Labor Ministry, total workplace accidents in Spain decreased between 2006 and 2011 by 68.5% in the construction sector and 34.4% in the other sectors, a decrease that may be related to the housing recession and the decline in global economic activity. This is consistent with the observed decrease … Psychological Well-Being During the Great Recession: Changes in Mental Health Care Utilization in an Occupational Cohort Sepideh Modrek, PhD, Rita Hamad, MD, and Mark R. Cullen, MD A vast literature documents a robust relation- ship between unemployment and a variety of mental health disorders.1,2 Although studies show that mental health deteriorates because of job loss,3,4 which increases during recessions, less evidence exists on the impacts of recession on the mental health of remaining workers. However, the impacts of recessions on mental health may extend beyond the direct effect of unemployment.5,6 Increased job insecurity,6---9 feelings of powerlessness,10 increased workload, and changes in job scope—as well as anger or sympathy for laid-off coworkers—may affect mental health. It is difficult to study the mental health of workers during recessions because measuring changes in mental health requires sensitive measures and panel data. We previously ex- amined changes in new diagnoses of depres- sion for an employed population during the recent recession and found no significant as- sociation, but this may be attributable to the high specificity of our measure, which might not have been sensitive enough to capture subtle changes in how workers feel.11 Although self-reported symptoms or depression scales are thought to be sensitive to small changes in mental health, surveys with these measures tend to be cross-sectional and therefore cannot account for workers’ previous mental health.1 If remaining workers are selected on mental health, then cross-sectional estimates may un- derestimate the true effect of recessions on the mental health of remaining workers, similar to the well-known healthy worker bias.12 To estimate changes in mental health, panel data are necessary to take into account workers’ previous mental health. As an alternative to self-reported depression scales, we exploited detailed claims data for a panel of continuously employed, continu- ously insured workers during 2007 to 2010 to examine changes in use of mental health services and medications during the recent recession. We explored the yearly number of mental health inpatient and outpatient visits before and during the recession, as well as the yearly supply of prescriptions filled for opiates, antidepressants, sleep aids, and anxiolytics. We examined these 4 drug classes because pre- vious research suggests that job stress is related to the onset of generalized anxiety disorder and depression13 and that sleep disorders and drug abuse are often precursors to depression.14 In addition, we examined opiates because stress is known to relate to a wide variety of psycho- somatic illnesses, including chronic pain.15,16 We focused on discontinuous changes in the trend for these 4 medication classes because evidence shows an increasing trend in their use across developed countries.17 We found de- scriptive evidence of selection into our panel on both physical and mental health, making the remaining continuously employed and insured cohort healthier. We used piecewise regres- sion, a method used to compare trends in an outcome variable before and after a defined discontinuity, to examine changes in trends after 2009. We accounted for individual-level unobservable time-invariant characteristics (e.g., gender, race, underlying health) with fixed-effects regressions. We also accounted for area-level changes in the unemployment rate. We explored the extent to which heightened job insecurity, caused by local plant layoffs, may have led to an increase in mental health services and treatments. We also examined the medium-term patterns in the mental health outcomes for the subset of workers who remained employed and insured through 2012, to investigate whether any of the ob- served changes in mental health---related utili- zation were long lasting or dissipated with the improvement in the economy in 2011 to 2012. METHODS We selected workers for our sample from linked administrative personnel and claims data sets from a multisite US manufacturing firm. These data are described elsewhere.8,11,18 We focused on 2 cohorts: a panel of 11625 employees who were continuously employed at the 25 largest plants, in 15 states, from Objectives. We examined the mental health effects of the Great Recession of 2008 to 2009 on workers who remained continuously employed and insured. Methods. We examined utilization trends for mental health services and medica- tions during 2007 to 2012 among a panel of workers in the 25 largest plants, located in 15 states, of a US manufacturing firm. We used piecewise regression to compare trends from 2007 to 2010 in service and medication use before and after 2009, the year of mass layoffs at the firm and the peak of the recession. Our models accounted for changes in county-level unemployment rates and individual- level fixed effects. Results. Mental health inpatient and outpatient visits and the yearly supply of mental health–related medications increased among all workers after 2009. The magnitude of the increase in medication usage was higher for workers at plants with more layoffs. Conclusions. The negative effects of the recession on mental health extend to employed individuals, a group considered at lower risk of psychological distress. (Am J Public Health. 2015;105:304–310. doi:10.2105/AJPH.2014.302219) RESEARCH AND PRACTICE 304 | Research and Practice | Peer Reviewed | Modrek et al. American Journal of Public Health | February 2015, Vol 105, No. 2 January 2007 to December 2010, in which we examined short-term changes in outcomes, and a panel of 10 242 employees who were contin- uously employed at the same 25 plants from January 2007 to December 2012, in which we examined medium-term changes. All employees in the sample had insurance coverage through- out the study period, ensuring access to mental health services. The firm provided health in- surance benefits with identical provider net- works to employees and families through a local preferred provider organization, subject to choice in family coverage and deductible rates. Limited changes in preferred provider coverage, copays, and deductibles occurred during the study period. We used claims data to quantify utilization of mental health services and medications. These data provided detailed claims records for each inpatient and outpatient medical en- counter and for each prescription filled and included International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9- CM)19 codes and Current Procedural Terminol- ogy (CPT) codes.20 We used ICD-9-CM codes to identify relevant diagnoses and CPT codes to categorize face-to-face physician visits. Measures We used the following ICD-9-CM codes to identify encounters with any mental health component: 296 (bipolar disorder), 300 (anxiety disorder), 304 (opiate dependence), 305 (alcohol abuse), 309 (mood disorder), and 311 (major depression). For each worker, we totaled the number of encounters an individual had in each year in 2 domains: outpatient physician visits (including emergency room visits) and inpatient hospitalizations. For outpatient visits, we only considered encounters that had a face-to-face visit with a doctor, as indicated by the CPT code. We used the pharmacy claims data to calculate use of mental health---related medi- cations, according to the number of days’ supply that an individual filled in a year for 4 categories of medications: opiates, antidepres- sants, sleep aids, and anxiolytics (Appendix A, Table A, available as a supplement to the online version of this article at http://www. ajph.org, lists the drugs in each class). We included opiates because they may be used for self-medication, especially among individuals with a history of substance abuse.21 We also included sleep aids because insomnia often precedes the onset of depression, and they are often prescribed for insomnia related to de- pression.22 We assumed that an increase in supply was directly related to an increase in the use of these medications, so we refer generally to medication use here. Although many of these medications are prescribed for multiple diagnoses, our analysis examined deviations from the mean use for each person across the years. Therefore, if individuals consistently used these drugs for other purposes, that would not affect our results. The analysis only cap- tured marked changes in use of these drugs. The period of our study was marked by a rapid change in the national unemployment rate. We accounted for changes in regional labor market conditions by including the yearly county-level unemployment rate from the Bu- reau of Labor Statistics23 as a control variable in all of our models. We used unemployment rates for the county in which each plant was located. We used the personnel data set to identify plants experiencing high layoff rates. If a plant had a mass termination event in which 40 or more employees were laid off on a single day, we considered it a high-layoff plant. We as- sumed that surviving employees at these 7 plants experienced greater job insecurity than did those at the 18 other plants. We used mass termination events to categorize job instability in previous studies.8,11 Data Analysis We described selection on health and mental health in particular to establish that continuously employed workers were healthier than their counterparts who dropped out of the sample. We categorized workers’ baseline health status in 2007 with a health risk score, computed with a third-party algorithm (DxCG software, Verisk Health Inc, Waltham, MA), which uses an in- dividual’s historical CPT and ICD-9-CM codes and utilization of health care services to de- termine a risk stratification score. This score has been used to adjust for underlying health, particularly in health services research.24---26 A score of1indicates that the individual’s health expenditures are likely to fall at the mean in the following year. Each unit increase predicts a 100% increase in expenditures above the mean. We also compared mental health---related inpatient and outpatient visits and use of the 4 classes of mental health---related medications for workers who remained employed and those who left in 2008 to 2010. Our primary analysis involved the cohort of continuously employed and insured workers. We used piecewise regression, which parti- tioned the data into 2 intervals, allowing us to estimate a separate trend line for each interval. The boundaries between the segments are known as breakpoints. We modeled the breakpoint in 2009, the peak of major layoffs at the company and the nadir of the gross national product nationally, comparing trends in 2007 to 2008 with those in 2009 to 2010. We used this breakpoint in previous studies of the cohort,8,11 and it coincided with a company press release in January 2009 announcing plans for a reduction in the workforce of 13%, citing “extraordinary times requiring extraor- dinary actions.”27 Although layoffs at the company ended in March 2010, hiring and pay freezes continued at least through 2013. We therefore investigated the medium-term impacts by extending the postrecession seg- ment from 2009 to 2012. We also included county-level unemployment rates to account for changes in the regional labor market. Because our data included multiple obser- vations for each individual—that is, 1 observa- tion per person per year—we controlled for time-invariant characteristics by including a fixed-effects parameter at the individual level. The inclusion of individual-level fixed effects in the model allowed us to use only within-individual variation to identify discontinuous changes in utilization of mental health services and med- ications after 2009. The inclusion of the fixed effect precluded controlling for age directly, but all specifications accounted for aging by in- cluding a second- and third-degree polynomial for age. Robust standard errors clustered at the individual level. We assessed heterogeneity in employees’ responses to the recession through the use of an interaction term between the time trend variable and whether an individual’s plant experienced a mass termination event. RESULTS Table 1 presents the sample characteristics for 3 groups: (1) 11 625 workers who were active on January 1, 2007, and continuously RESEARCH AND PRACTICE February 2015, Vol 105, No. 2 | American Journal of Public Health Modrek et al. | Peer Reviewed | Research and Practice | 305 employed and insured from 2007 to 2010; (2) 10 242 workers who were active on January 1, 2007, and continuously employed and insured from 2007 to 2012; and (3) 2946 workers who were active on January 1, 2007, and whose contract of employment was termi- nated between 2008 and 2010. The second group was a subset of the first group. The workers in groups 1 and 2 were predomi- nantly White men, aged 45 years on average; 56% worked at high-layoff plants. These workers’ average risk score was 1, suggesting that their overall health care utilization in 2007 fell at the mean of a working aged population. By contrast, the workers who left in 2008 to 2010 (group 3) were on average 3 years older, were more likely to be female, and had higher risk scores in 2007 (all, P < .001). Table A2 (available as an online supplement) shows baseline differences in mental health utili- zation between those who left the firm and those who remained, confirming that the workers who left had higher mental health inpatient and outpatient utilization in 2007. They also used more antidepressants, anxiolytics, and opiates. Results presented here focus only on the contin- uously employed and insured workforce. Changes in Utilization of Mental Health Services After 2009 Table 2 presents results on inpatient visits with a mental health---related diagnosis for the 2007 to 2010 and 2007 to 2012 cohorts. We found a marginally significant increase in inpatient utilization in 2009 to 2010 from 2007 to 2008 (b = 0.00189; P = .078). The magnitude of the postrecession trend line was about 4 times as great as that of the prere- cession trend line in the short term. In the medium term, the prerecession and postre- cession trends were almost identical, suggest- ing that the increase in inpatient visits was abrupt and short lived. Table 2 also shows models that included an interaction term for working at a high-layoff plant. We found no difference in the trend among those with higher job insecurity. We documented that changes in county-level un- employment rate were related to decreases in mental health inpatient visits. Table 3 presents results for the number of outpatient visits with a mental health---related diagnosis. The results suggested a statistically significant increase in the trends in outpatient utilization in 2009 to 2010 over 2007 to 2008. The increase in the trend remained elevated and significant, but the magnitude was substantially reduced in a comparison of the yearly increases of 2009 to 2012 and 2007 to 2008. These results were driven by a decreasing prerecession trend and a discon- tinuous and increasing postrecession trend. We observed no difference between em- ployees at high-layoff plants and those at other plants. We also documented that changes in county-level unemployment rates were related to increases in mental health outpa- tient visits. When we allowed for differences by plant-level layoffs, the magnitude between increases in unemployment rates and in- creases in mental health outpatient visits was similar across both the 2007 to 2010 and the 2007 to 2012 periods. Changes in Utilization of Mental Health Medications After 2009 Table 4 presents changes in the supply of opiates, antidepressants, sleep aids, and anxio- lytics. We examined the number of days’ supply of each drug category separately, and we exam- ined differential patterns among workers who worked in high-layoff plants. Workers used more opiates, antidepressants, sleep aids, and anxio- lytics in 2009 to 2010 than in 2007 to 2008. The increases in use of opiates and anxiolytics were only marginally significant. Opiate use increased 8.8% a year (a figure derived from the mean initial use of 8.8 pills), or almost 5 times the prerecession trend. We found a 13% increase in antidepressant use (derived from the mean initial use of 27.1 pills). The increasing trend in the use of antidepressants in the post- recession period was particularly notable because of the decreasing trend in antidepressant use before the recession. Workers increased their use of sleep aids by 23% per year (derived from the mean initial use of 4.4 pills). The difference in the trend for sleep aids was driven by a small increasing trend in the use of sleep aids in the post- recession period and a large decreasing trend before the recession. The 11% increase in use of anxiolytics (derived from the mean initial use of 7.2 pills) was almost 5 times the prerecession trend. Use of antidepressants was also statistically significantly higher in high- layoff plants than in other plants. We found no difference in trends for opiates, sleep aids, or anxiolytics at high-layoff plants. Results also suggested that changes in county-level unemployment rates were robustly related to increased use of opiates, and sleep aids. In the medium term, our results suggested that the increase in the trend for antidepres- sants and sleep aids remained significant among the 2007 to 2012 cohort, but the magnitude of the increase was smaller. The increase in use of antidepressants in high-layoff plants remained significant, though the TABLE 1—Characteristics of Workers in Continuously Employed Cohorts and Those Employed in 2007 but Terminated Before 2010: 2007–2012 Characteristic 2007–2010 Cohort,a No. or % or Mean 6SD 2007–2012 Cohort,a No. or % or Mean 6SD Workers Laid Off in 2008–2010, No. or % or Mean 6SD Sample size 11 625 10 242 2946 Female 20.1 19.3 25 Age in 2007, y 45.6 69.0 45.2 68.7 48.7 612.2 Race White 82 82 80.9 Black 8.7 8.6 9.4 Hispanic 6.3 6.3 6.5 Other 3 3.1 3.2 2007 Risk score 1.0 61.0 0.98 60.96 1.42 61.95 Employed at high-layoff plant b 55.9 56.4 52.6 aInclusion criteria were continuous employment and continuous insurance coverage during study period. bPlant that laid off ‡ 40 employees in 1 day. RESEARCH AND PRACTICE 306 | Research and Practice | Peer Reviewed | Modrek et al. American Journal of Public Health | February 2015, Vol 105, No. 2 magnitude was diminished. We found no difference in trend for sleep aids, anxiolytics, or opiates at high-layoff plants in the longer period. However, in the models that accounted for differences by plant-level job insecurity, changes in county-level unemployment rates were robustly related to increased use of opiates and sleep aids. DISCUSSION We examined changes in utilization of mental health services and medications in a cohort of continuously employed and insured workers employed at a firm that experienced significant downsizing events during the 2008 to 2009 Great Recession. We documented that remaining workers had better overall health and significantly less utilization of mental health services and medications in the years before the recession. Despite their lower use of mental health services and medications at baseline, workers who remained employed increased their utili- zation of inpatient and outpatient mental health TABLE 2—Mental Health Inpatient Utilization Among Continuously Employed and Insured Workers: 2007–2012 Yearly Mental Health Inpatient Visits Variable 2007–2010 Cohort, b (95% CI) 2007–2012 Cohort, b (95% CI) 2007–2010 Cohort, With Interactions at High-Layoff Plants, a b (95% CI) 2007–2012 Cohort, With Interactions at High-Layoff Plants, a b (95% CI) Time trend before 2009 0.00056 (–0.00034, 0.00146) 0.00035 (–0.00047, 0.00117) 0.00087 (–0.00034, 0.00208) 0.00051 (–0.00065, 0.00167) Time trend after 2009 0.00245* (0.00058, 0.00433) 0.00036 (–0.00010, 0.00083) 0.00126 (–0.00100, 0.00351) 0.00004 (–0.00061, 0.00069) Interaction terms: job security Before 2009 x high layoff –0.00046 (–0.00170, 0.00078) –0.00037 (–0.00153, 0.00079) After 2009 x high layoff 0.00215 (–0.00144, 0.00575) 0.00058 (–0.00026, 0.00143) High layoff 0.00027 (–0.00157, 0.00210) –0.00032 (–0.00193, 0.00129) Unemployment rate –0.00029* (–0.00054, –0.00005) –0.00011 (–0.00031, 0.00010) –0.00031* (–0.00057, –0.00006) –0.00009 (–0.00028, 0.00011) Constant 0.00423 (–0.00190, 0.01037) 0.00082 (–0.00249, 0.00413) 0.00447 (–0.00181, 0.01074) 0.00087 (–0.00267, 0.00442) Model comparisons Difference in trend, before vs after recession 0.00189 0.00028 Note. CI = confidence interval. Analyses were conducted with piecewise regression with a discontinuity in 2009, with fixed effects at the individual level. Models controlled for age squared and age cubed. The 2007–2010 cohort had 46 500 observations for 11 625 individuals; the 2007–2012 cohort had 61 452 observations for 10 242 individuals. aA high-layoff plant laid off ‡ 40 employees in 1 day (n = 7). Reference group = all other plants (n = 18). *P < .05. TABLE 3—Mental Health Outpatient Utilization Among Continuously Employed and Insured Workers: 2007–2012 Yearly Mental Health Outpatient Visits Variable 2007–2010 Cohort, b (95% CI) 2007–2012 Cohort, b (95% CI) 2007–2010 Cohort, With Interactions at High-Layoff Plants, a b (95% CI) 2007–2012 Cohort, With Interactions at High-Layoff Plants, a b (95% CI) Time trend before 2009 –0.0107*** (–0.0171, –0.0043) –0.0051 (–0.0112, 0.0010) –0.0102** (–0.0172, –0.0032) –0.0093* (–0.0168, –0.0017) Time trend after 2009 0.0085* (0.0006, 0.0163) 0.0060*** (0.0029, 0.0092) 0.0066 (–0.00353, 0.0166) 0.0091 (–0.0017, 0.0199) Interaction terms: job security Before 2009 x high layoff 0.0006 (–0.0067, 0.0079) 0.0010 (–0.0067, 0.0087) After 2009 x high layoff 0.0037 (–0.0120, 0.0193) –0.0000 (–0.0167, 0.0167) High layoff 0.0173** (0.0065, 0.0281) 0.0169** (0.0056, 0.0283) Unemployment rate 0.0050*** (0.0025, 0.0076) 0.0029* (0.0005, 0.0053) 0.0046*** (0.0021, 0.0072) 0.0042** (0.0015, 0.0069) Constant 0.0331 (–0.0059, 0.0722) 0.0631** (0.0222, 0.1041) 0.0298 (–0.0089, 0.0685) 0.0395 (–0.0029, 0.0819) Model comparisons Difference in trend, before vs after recession 0.0192*** 0.0112** Note. CI = confidence interval. Analyses were conducted with piecewise regression with a discontinuity in 2009, with fixed effects at the individual level. Models controlled for age squared and age cubed. The 2007–2010 cohort had 46 500 observations for 11 625 individuals; the 2007–2012 cohort had 61 452 observations for 10 242 individuals. aA high-layoff plant laid off ‡ 40 employees in 1 day (n = 7). Reference group = all other plants (n = 18). *P < .05; **P < .01; ***P < .001. RESEARCH AND PRACTICE February 2015, Vol 105, No. 2 | American Journal of Public Health Modrek et al. | Peer Reviewed | Research and Practice | 307 TA B LE 4 — M e n ta l H e a lt h M e d ic a ti o n S u p p ly fo r W o rk e rs in 2 0 0 7 – 2 0 1 0 a n d 2 0 0 7 – 2 0 1 2 C o n ti n u o u sl y E m p lo ye d C o h o rt s Ye ar ly M ed ic at io n Co un t Ye ar ly M ed ic at io n Co un t, H ig h- La yo ff Pl an ts a Va ria bl e O pi at es , b (9 5% CI ) An tid ep re ss an ts , b (9 5% CI ) Sl ee p Ai ds , b (9 5% CI ) An xi ol yt ic s, b (9 5% CI ) O pi at es , b (9 5% CI ) An tid ep re ss an ts , b (9 5% CI ) Sl ee p Ai ds , b (9 5% CI ) An xi ol yt ic s, B (9 5% CI ) 20 07 –2 01 0 C oh or t Ti m e tr en d be fo re 20 09 0. 20 8 (– 0. 43 5, 0. 85 2) –0 .2 89 (– 1. 54 5, 0. 96 6) –0 .7 49 ** (– 1. 25 2, –0 .2 46 ) 0. 19 3 (– 0. 37 1, 0. 75 6) 0. 12 0 (– 0. 59 6, 0. 83 7) –0 .0 86 8 (– 1. 42 6, 1. 25 2) –0 .6 56 * (– 1. 18 0, –0 .1 32 ) 0. 17 8 (– 0. 39 7, 0. 75 2) Ti m e tr en d af te r 20 09 0. 98 5* ** (0 .4 39 , 1. 53 1) 3. 25 0* ** (2 .2 54 , 4. 24 6) 0. 24 8 (– 0. 14 8, 0. 64 4) 0. 96 3* ** (0 .4 40 , 1. 48 6) 0. 65 4 (– 0. 08 3, 1. 39 0) 1. 41 8* (0 .0 60 , 2. 77 7) –0 .1 42 (– 0. 69 2, 0. 40 9) 0. 72 3 (– 0. 03 9, 1. 48 5) In te ra ct io n te rm s: jo b se cu rit y Be fo re 20 09 x hi gh la yo ff 0. 24 1 (– 0. 40 7, 0. 88 9) –0 .3 35 (– 1. 55 3, 0. 88 4) –0 .1 36 (– 0. 66 9, 0. 39 7) 0. 04 05 (– 0. 51 3, 0. 59 3) Af te r 20 09 x hi gh la yo ff 0. 60 6 (– 0. 42 6, 1. 63 8) 3. 28 3* ** (1 .3 04 , 5. 26 1) 0. 70 2 (– 0. 06 8, 1. 47 1) 0. 43 1 (– 0. 60 4, 1. 46 6) H ig h la yo ff 1. 07 8 (– 0. 82 2, 2. 97 8) 1. 97 6 (– 1. 37 2, 5. 32 3) 1. 10 0 (– 0. 02 3, 2. 22 4) 0. 06 5 (– 1. 58 9, 1. 71 9) U ne m pl oy m en t ra te 0. 69 6* ** (0 .4 10 , 0. 98 3) 0. 47 4 (– 0. 02 5, 0. 97 3) 0. 29 2* * (0 .1 04 , 0. 48 1) 0. 12 9 (– 0. 10 5, 0. 36 2) 0. 67 5* ** (0 .3 91 , 0. 96 0) 0. 46 8 (– 0. 03 6, 0. 97 3) 0. 28 5* * (0 .0 94 , 0. 47 6) 0. 12 5 (– 0. 11 6, 0. 36 6) Co ns ta nt –5 .0 60 * (– 9. 62 8, –0 .4 91 ) –5 .7 79 (– 14 .7 29 , 3. 17 0) –5 .1 65 ** (– 8. 48 0, –1 .8 50 ) –4 .5 28 * (– 8. 53 6, –0 .5 19 ) –5 .3 65 * (– 9. 94 7, –0 .7 83 ) –6 .4 86 (– 15 .5 54 , 2. 58 1) –5 .5 24 ** * (– 8. 88 1, –2 .1 68 ) –4 .5 27 * (– 8. 48 5, –0 .5 68 ) M od el co m pa ri so ns D iff er en ce in tr en d, be fo re vs af te r re ce ss io n 0. 77 7b 3. 54 0* ** 0. 99 7* * 0. 77 0c 20 07 –2 01 2 C oh or t Ti m e tr en d be fo re 20 09 0. 92 7* * (0 .3 53 , 1. 50 1) 0. 23 9 (- 0. 98 7, 1. 46 6) –0 .4 12 (- 0. 88 1, 0. 05 6) 0. 35 7 (- 0. 17 7, 0. 89 2) 0. 55 4 (- 0. 09 2, 1. 20 1) –0 .2 40 (- 1. 59 4, 1. 11 3) –0 .3 74 (- 0. 87 8, 0. 13 0) 0. 15 4 (- 0. 43 1, 0. 73 8) Ti m e tr en d af te r 20 09 0. 99 9* ** (0 .6 97 , 1. 30 2) 2. 58 3* ** (1 .9 92 , 3. 17 5) 0. 27 3* * (0 .0 69 , 0. 47 6) 0. 49 5* ** (0 .2 08 , 0. 78 2) 0. 78 4* ** (0 .3 89 , 1. 17 9) 1. 52 8* ** (0 .7 37 , 2. 31 9) 0. 11 4 (- 0. 13 5, 0. 36 4) 0. 40 4* (0 .0 15 , 0. 79 2) In te ra ct io n te rm s: jo b se cu rit y Be fo re 20 09 x hi gh la yo ff 0. 47 6 (- 0. 18 4, 1. 13 5) –0 .0 76 (- 1. 40 0, 1. 24 8) –0 .1 85 (- 0. 74 1, 0. 37 0) 0. 28 4 (- 0. 30 9, 0. 87 6) Af te r 20 09 x hi gh la yo ff 0. 42 1 (- 0. 11 2, 0. 95 3) 2. 05 2* ** (0 .9 93 , 3. 11 0) 0. 30 5 (- 0. 05 9, 0. 67 0) 0. 17 9 (- 0. 33 9, 0. 69 6) H ig h la yo ff 1. 26 8 (- 0. 53 6, 3. 07 3) 2. 33 0 (- 1. 16 5, 5. 82 5) 1. 07 2 (- 0. 04 8, 2. 19 3) 0. 79 2 (- 0. 92 3, 2. 50 6) U ne m pl oy m en t ra te 0. 29 1* (0 .0 62 , 0. 51 9) 0. 21 4 (- 0. 24 5, 0. 67 4) 0. 15 5 (- 0. 00 6, 0. 31 5) 0. 00 3 (- 0. 19 8, 0. 20 3) 0. 33 6* * (0 .1 07 , 0. 56 4) 0. 43 7 (- 0. 02 8, 0. 90 2) 0. 18 3* (0 .0 21 , 0. 34 6) 0. 02 2 (- 0. 18 7, 0. 23 0) Co ns ta nt –1 .9 68 (- 6. 62 6, 2. 68 9) –5 .5 4 (- 15 .0 28 , 3. 94 9) –3 .9 76 * (- 7. 51 5, –0 .4 36 ) –4 .0 02 * (- 7. 99 3, –0 .0 11 ) –3 .0 40 (- 7. 85 0, 1. 77 0) –8 .6 77 (- 18 .3 53 , 0. 99 9) –4 .7 06 * (- 8. 37 5, –1 .0 38 ) –4 .5 86 * (- 8. 60 4, –0 .5 67 ) M od el co m pa ri so ns D iff er en ce in tr en d, be fo re vs af te r re ce ss io n 0. 07 2 2. 34 4* * 0. 68 5* 0. 13 8 N ot e. CI = co nfi de nc e in te rv al .A na ly se s w er e co nd uc te d w ith pi ec ew is e re gr es si on w ith a di sc on tin ui ty in 20 09 ,w ith fix ed ef fe ct s at th e in di vi du al le ve l. M od el s co nt ro lle d fo r ag e sq ua re d an d ag e cu be d. Th e 20 07 –2 01 0 co ho rt ha d 46 50 0 ob se rv at io ns fo r 11 62 5 in di vi du al s; th e 20 07 –2 01 2 co ho rt ha d 61 45 2 ob se rv at io ns fo r 10 24 2 in di vi du al s. a A hi gh -la yo ff pl an t la id of f ‡ 40 em pl oy ee s in 1 da y (n = 7) . Re fe re nc e gr ou p = al l ot he r pl an ts (n = 18 ). b Ap pr oa ch in g si gn ifi ca nc e at P = .0 57 . c A pp ro ac hi ng si gn ifi ca nc e at P = .0 52 . *P < .0 5; ** P < .0 1; ** *P < .0 01 . 308 | Research and Practice | Peer Reviewed | Modrek et al. American Journal of Public Health | February 2015, Vol 105, No. 2 services immediately after the downturn. Con- sistent with this evidence, we also found an increase in the use of mental health---related medications, specifically opiates, antidepres- sants, sleep aids, and anxiolytics, for all workers. When we looked at a longer period, including data for those who remained working in 2011 to 2012, we observed no difference in the rate of utilization of mental health---related inpatient visits. Use of antidepressants and sleep aids was still higher among all workers, and workers at high-layoff plants still used more antidepressants, though the magnitudes were diminished. We confirmed that beyond the local plant … Bull World Health Organ 2014;92:630–640D | doi: http://dx.doi.org/10.2471/BLT.13.129114 Research 630 Effect of the economic recession on pharmaceutical policy and medicine sales in eight European countries Christine Leopold,a Aukje K Mantel-Teeuwisse,b Sabine Vogler,a Silvia Valkova,c Kees de Joncheere,d Hubert GM Leufkens,b Anita K Wagner,e Dennis Ross-Degnane & Richard Laingd Introduction European public authorities struggle to maintain a high level of access to health care while restraining increases in expenditure associated with an ageing population and higher demand.1–4 The recent global economic recession has put additional pres- sure on public budgets.5,6 In 2008, Europe was affected by the financial crisis. As the recession in Europe continued, the effect was felt especially in southern European countries and Ireland in 2010 and 2011. Soon the problem of financial debt for individual European countries developed into a crisis in the Eurozone, which then became a high priority for the European Central Bank and the European Parliament. All countries were urged to imple- ment cost-saving measures that affected public financing for health care.7 Recession, which is defined as two successive quarters of negative growth in gross domestic product (GDP), can have a detrimental effect on the health of the population because economic downturns are strongly associated with a decline in health-care utilization and a deterioration in health outcomes.8 For example, suicides and homicides increased among working-age men and women when unemployment rose rapidly during past recessions in Europe.9 In the current recession, the number of uninsured non-elderly Americans increased by 5.6 million between 2007 and 200910 and over a quarter of Americans reported reduced routine use of medi- cal care.11 Over the same period, insurance policy deductibles and copayments for visits to physicians and for prescription medicines increased, leading to a greater cost burden for patients.12–14 Similar effects were seen in Greece. Studying the health effects of the economic crisis in the country it was found that patients had less access to care and preventive services and, consequently, faced higher risks of infection with sexu- ally transmitted diseases.15 The World Health Organization examined the influence of the recession on expenditure on, and the sales and prices of, medicines between 2007 and 2009 in 84 countries. It found that the economic recession had mixed effects and that the largest declines in medicine sales occurred in high-income countries and in Europe, particularly in the Baltic states.16 It has been shown that countries that were seriously af- fected by the crisis, such as the Baltic countries, Greece, Por- tugal and Spain, abruptly implemented several pharmaceutical policy measures between 2010 and 2011. This included price cuts, changes in reimbursement rates and the imposition of value-added tax on medicines.17 In other European countries, such as Italy, in which cost-containment measures were already in place when the crisis began, the implementation of planned policy changes was accelerated.18 Because different countries were affected differently by the recession and attempted to overcome budgetary constraints in different ways, we decided to analyse systematically how European pharmaceutical policies were affected by the reces- Objective To identify pharmaceutical policy changes during the economic recession in eight European countries and to determine whether policy measures resulted in lower sales of, and less expenditure on, pharmaceuticals. Methods Information on pharmaceutical policy changes between 2008 and 2011 in eight European countries was obtained from publications and pharmaceutical policy databases. Data on the volume and value of the quarterly sales of products between 2006 and 2011 in the 10 highest-selling therapeutic classes in each country were obtained from a pharmaceutical market research database. We compared these indicators in economically stable countries; Austria, Estonia and Finland, to those in economically less stable countries, Greece, Ireland, Portugal, Slovakia and Spain. Findings Economically stable countries implemented two to seven policy changes each, whereas less stable countries implemented 10 to 22 each. Of the 88 policy changes identified, 33 occurred in 2010 and 40 in 2011. They involved changing out-of-pocket payments for patients in 16 cases, price mark-up schemes in 13 and price cuts in 11. Sales volumes increased moderately in all countries except Greece and Portugal, which experienced slight declines after 2009. Sales values decreased in both groups of countries, but fell more in less stable countries. Conclusion Less economically stable countries implemented more pharmaceutical policy changes during the recession than economically stable countries. Unexpectedly, pharmaceutical sales volumes increased in almost all countries, whereas sales values declined, especially in less stable countries. a World Health Organization (WHO) Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, Gesundheit Österreich GmbH, Stubenring 6, 1010, Vienna, Austria. b WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands. c IMS Institute for Healthcare Informatics, Philadelphia, United States of America (USA). d Department of Essential Medicines and Pharmaceutical Policies, World Health Organization, Geneva, Switzerland. e Department of Population Medicine, Harvard Medical School, Boston, USA. Correspondence to Christine Leopold (email: [email protected]). (Submitted: 19 August 2013 – Revised version received: 11 February 2014 – Accepted: 20 March 2014 – Published online: 16 June 2014 ) Research Bull World Health Organ 2014;92:630–640D| doi: http://dx.doi.org/10.2471/BLT.13.129114 631 Research Economic recession and pharmaceutical policies sion by comparing changes in pharma- ceutical pricing and reimbursement policies between economically stable and economically less stable countries. In addition, we investigated changes in the sale of pharmaceuticals in major therapeutic classes before and after the recession in these two types of countries. We expected that some of the cost-con- tainment policies, such as those affecting out-of-pocket payments, would shift the financial burden of medicines onto patients and hypothesized that pharma- ceutical sales would decline during this period, especially in less economically stable countries. Methods Data sources For this longitudinal study, we used data from two sources to derive information on pharmaceutical policies: (i) the Phar- maceutical Pricing and Reimbursement Information Network (Austrian Health Institute, Vienna, Austria), which col- lects information from experts in na- tional pharmaceutical pricing and from authorities responsible for reimburse- ment – the latter provide regular phar- maceutical policy updates; and (ii) the PharmaQuery database (IMS Health, Philadelphia, United States of America), which contains data on pharmaceuti- cal policies. In addition, we included information on policy changes reported in the published literature. We grouped policy changes into 6-month implemen- tation periods from January 2008 until December 2011 and we categorized policy as relating to one of three main areas: (i) pricing; (ii) reimbursement; and (iii) generic drugs. Table 1 defines the policy measures in these three areas. Quarterly pharmaceutical sales data for the period January 2006 to December 2011 were obtained from the IMS MIDAS (Multinational Inte- grated Data Analysis System) Quantum pharmaceutical market research service (IMS Health, Philadelphia, USA). Data were expressed in standard units for the volume of sales and in constant United States dollars (US$) for the value of sales. A standard unit, as defined by IMS Health, is the smallest dose of a product – it may be one tablet or capsule for oral preparations, one teaspoon (i.e. 5 mL) for a syrup or one ampoule or vial for an injectable product. The value of sales was derived from the price deemed most accurate for the relevant country and was expressed in constant US$, which were calculated by converting the local currency into United States dollars at a constant exchange rate. In most coun- tries, the price used was the ex-factory price; in Estonia, Finland, Greece and Ireland, ex-factory prices were derived from wholesale prices. Average stan- dard conversion factors, which were determined with the co-operation of the pharmaceutical industry for each country, were applied to estimate prices at various points along the distribution chain. The price calculations did not take into account any discounts between manufacturers, wholesalers and payers and were not adjusted for inflation. Our study considered only prescrip- tion medicines, whether on or off patent, that were available in the retail market for the 10 highest-selling therapeutic classes. We identified the 10 highest- selling classes by ranking therapeutic classes according to their sales volume in each country. Together the combined sales volume of products in these 10 classes accounted for at least 50% of the total sales volume of all medicines in each of the eight countries from 2008 to 2011 (Table 2). Data were aggregated by therapeutic class for each country. We had no data on individual drugs. Country groups We considered eight European countries in which the majority of the population was covered by a social security system or national health service: Austria, Esto- nia, Finland, Greece, Ireland, Portugal, Slovakia and Spain. We selected these countries because they represented a va- riety of geographical regions and levels of economic wealth and stability and had been affected by the recession to differ- ent degrees. We classified them as either economically less stable or economi- cally stable using categories defined by the Organisation for Economic Co- operation and Development (OECD) for the level of fiscal consolidation in 2012. Fiscal consolidation was judged according to whether the country had adopted either concrete policies aimed at stabilizing general government gross debt or a long-term target for the debt- to-GDP ratio of 60%. There were four categories of country: (i) those that had adopted a programme proposed by the International Monetary Fund, the Euro- pean Union and the European Commis- sion (e.g. Greece, Ireland and Portugal); (ii) those that were under clear market pressure (e.g. Belgium, Hungary, Italy, Slovakia and Spain); (iii) those that had a substantial deficit or debt but which were under less market pressure (e.g. Austria, Denmark, Finland, France and Germany); and (iv) those that had no or only a marginal need for consolida- tion (e.g. Norway, Sweden and Switzer- land).21 In this study, we regarded eco- nomically less stable countries as those belonging to the first two categories (i.e. Greece, Ireland, Portugal, Slovakia and Spain) and economically stable coun- tries as those belonging to the third and fourth categories (i.e. Austria, Estonia and Finland). Data analysis First, we described and analysed the number of policy measures implement- ed per year, per country group and per policy category. Next, we determined the volume and value of the sales of drugs in each therapeutic class between 2006 and 2011 in each country and, then, we cal- culated the combined volume and value of the sales of drugs for all 10 therapeutic classes for each country. Since our find- ings for individual therapeutic classes and for all therapeutic classes combined were similar, we present only the results for all therapeutic classes combined. For this analysis, we divided the volume and value of sales by the size of the country’s population to control for population growth; annual population figures were obtained from the OECD.22 We derived the annual and average growth rates over the study period using both the volume and value of pharma- ceutical sales per capita: AGR y y = −         × − S S 1 1 100 (1) AAGR AGR = ∑ n (2) where AGR is the annual growth rate, Sy is the per capital sales in a year, Sy–1 is the per capital sales in the previous year, AAGR is the average annual growth rate and n is the number of years. To compare changes in the volume and value of sales, we calculated the dif- Bull World Health Organ 2014;92:630–640D| doi: http://dx.doi.org/10.2471/BLT.13.129114632 Research Economic recession and pharmaceutical policies Table 1. National policy measures influencing pharmaceutical sales19 Policy measure Definition Pricing Price cut A cost-containment measure whereby the set price of a medicine is reduced by the authorities. External price referencing External price referencing is the practice whereby the price of a medicine in one or several other countries is used to derive a benchmark or reference price for the purpose of setting or negotiating the medicine’s price in a given country. Policy changes in external price referencing include the introduction or abolition of this pricing policy and altering the methodology (e.g. changing the basket of reference countries or the way of calculating the benchmark price). Distribution remuneration (i.e. mark-ups, margins and fees for service) Distribution remuneration is the payment of a health-care provider, whether an individual or an organization, for the services provided. In the distribution of pharmaceuticals, wholesalers and pharmacies are remunerated using mark-ups or regressive margin schemes or, for pharmacies alone, by paying a “fee for service”. With mark-ups, a defined linear or percentage amount is added to the cost of a good to ensure a profit at the wholesale or retail level or both. With regressive margin schemes, the margin is expressed as a percentage of the selling price. Policy changes in distribution remuneration include adjusting the mark-ups or margins used for wholesalers or pharmacies or changing the type of distribution remuneration for a defined actor. Changes may also be made to the types of medicines (e.g. reimbursable medicines or prescription-only medicines) to which distribution remuneration applies. VAT on medicine VAT is a sales tax on products that is collected in stages. It is a wide-ranging tax that is usually designed to cover most or all goods and services, including medicines. Policy changes in VAT include the introduction or abolition of VAT on medicines and altering the VAT rate on medicines. Extraordinary price review Price reviews involve reviewing the process by which the set price of a medicine was established. Reviews may or may not be performed in combination with reimbursement reviews. Reviews can be performed systematically (e.g. once a year) for all reimbursed medicines or for a group of medicines (e.g. for a specific indication) or at any time. Reimbursement Reference price system With a reference price system, which is also referred to as internal or therapeutic reference pricing, the third party payer determines a reference price for the reimbursement of medicines with a particular active ingredient or in a given therapeutic class. If the price of the medicine exceeds the reference price, the health-care consumer must pay the difference between the fixed reimbursed amount (i.e. the reference price) and the actual pharmacy retail price in addition to any copayments (e.g. prescription costs and percentage copayment rates). Policy changes in the reference price system include the introduction or abolition of a reference price system and changing the methodology by which clusters of medicines are established for determining a reference price (e.g. by grouping identical or similar medicines). Out-of-pocket payments Out-of-pocket payments are payments made by health-care consumers that are not reimbursed by a third-party payer. They include cost-sharing, fixed or percentage copayments and informal payments to health-care providers. Delisting Delisting is the exclusion of a medicine from a reimbursement list (e.g. a positive list), which often results in exclusion from reimbursement. Generic drugs INN prescribing With INN prescribing, prescribers (e.g. physicians) are required to prescribe medicines using the INN for the pharmaceutical (i.e. the name of the active ingredient) instead of a brand name. Policy changes in INN prescribing include its introduction or abolition, changing the way INN prescribing is organized (e.g. by imposing or eliminating financial incentives) and changing from indicative to obligatory INN prescribing. Generic substitution Generic substitution is the practice of substituting a medicine, whether marketed under a trade name or generic name (i.e. a branded or unbranded drug), by a less expensive medicine (e.g. a branded or unbranded generic drug), which often contains the same active ingredients. Generic substitution may be encouraged (i.e. indicative generic substitution) or required (i.e. mandatory generic substitution). Policy changes in generic substitution include its introduction or abolition, changing the way generic substitution is organized (i.e. imposing or eliminating financial incentives) and moving from indicative to obligatory generic substitution. Public campaigns Policies, regulations, measures and initiatives promoting the use of generic drugs or licensed, off- patent medicines are typically undertaken by government authorities. Policy on generic drugs may be targeted at prescribers, pharmacists, patients or consumers, or other stakeholders. INN: international nonproprietary name; VAT: value-added tax. Bull World Health Organ 2014;92:630–640D| doi: http://dx.doi.org/10.2471/BLT.13.129114 633 Research Economic recession and pharmaceutical policies ference between the annual growth rate in the value of pharmaceutical sales and the annual growth rate in the volume of sales for each country. Results Changes in policy Table 3, Table 4 and Table 5 (avail- able at: http://www.who.int/bulletin/ volumes/92/9/13-129114) summarize the 88 policy changes we identified in pricing, reimbursement and generic drugs, respectively. Economically stable countries implemented 7 or fewer policy changes each between 2008 and 2011; the lowest number was 2 in Finland (Table 6). Less economically stable countries implemented between 10 and 22 changes each; the highest number was 22 in Portugal. The greatest number of policy adjustments occurred in 2010 (33) and 2011 (40) and the most fre- quently used policy measures involved changes in out-of-pocket payments by patients (16), changes in regula- tions controlling the mark-up of prices (13) and price reductions (11). Some countries implemented several pricing measures. For example, Spain enacted four price cuts between 2008 and 2011. Most changes concerned reimbursable medicines and built on existing poli- cies; only a few changes involved newly implemented policies, such as the in- troduction of internal reference pricing in Finland.17 Changes in sales The small increase in the volume of pharmaceutical sales in all countries between 2006 and 2011 is shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Table 7: the average annual per capita growth in sales volume ranged from 0.8% in Greece and 1.0% in Portugal to 3.7% in Ireland, 4.0% in Slovakia and 4.6% in Estonia. However, annual growth rates were much more variable: from 2006 to 2007 the growth rate was over 3.7% for all countries, with Estonia having the highest rate at 12.2%. Between 2007 and 2009, growth remained fairly stable in Austria and Finland but there was a sharp decline in Estonia: the annual growth rate was −0.5% from 2007 to Table 2. Ten highest-sellinga therapeutic drug classes in eight European countries,b 2008–2011 Third-level code of the ATC classification20 Therapeutic class A10C, A10H, A10J, A10K, A10L, A10M, A10N, A10S and A10X Antidiabetes products A02B Antiulcer products B01C Platelet aggregation inhibitors C10A, C10C and C11A Lipid regulators C09A and C09B ACE inhibitors, either as single agents or in combination with other antihypertensives M01A and M02A Antirheumatics N02A Non-narcotic analgesics N06A Antidepressants R01A6, R01B and R06A Antiallergy drugs: systemic and nasal preparations and topical products R03A, R03B, R03C, R03D, R03E, R03F, R03G, R03H, R03I, R03J and R03X Respiratory agents ACE: angiotensin-converting enzyme; ATC: Anatomical Therapeutic Chemical. a Together the products in these classes accounted for at least 50% of sales by volume in each country under investigation. b Austria, Estonia, Finland, Greece, Ireland, Portugal, Slovakia and Spain. Table 6. Policy measures influencing pharmaceutical sales in eight European countries, 2008–2011 Policy measure No. of measures implemented between 2008 and 2011a Total Economically stable countriesb Economically less stable countriesb Austria Estonia Finland Greece Ireland Portugal Slovakia Spain Pricing Price cuts 0 0 0 2 2 3 0 4 11 External price referencing 0 0 0 3 0 2 2 1 8 Distribution remuneration 0 1 0 3 3 3 0 3 13 VAT on medicines 1 1 0 1 1 1 0 1 6 Extraordinary price review 0 0 0 2 2 1 1 1 7 Reimbursement Internal reference pricing 0 1 1 1 0 2 2 1 8 Out-of-pocket payments 4 1 0 0 1 5 3 2 16 Delisting 0 0 1 2 0 1 0 1 5 Generics INN prescribing 0 1 0 0 0 1 1 1 4 Generic substitution 0 0 0 0 0 0 0 0 0 Public campaigns and other generic policies 1 2 0 0 1 3 1 2 10 Total 6 7 2 14 10 22 10 17 88 INN: international nonproprietary name; VAT: value-added tax. a The number of measures implemented in each year was: 4 in 2008; 11 in 2009; 33 in 2010; and 40 in 2011. b The three economically stable countries implemented 15 measures during 2008–2011 compared with 73 in the five economically less stable countries. Bull World Health Organ 2014;92:630–640D| doi: http://dx.doi.org/10.2471/BLT.13.129114634 Research Economic recession and pharmaceutical policies 2008 and −9.0% from 2008 to 2009. The growth rate declined in all economically less stable countries but more gradually. After the steep year-on-year decline in Estonia in 2009, the volume of sales grew 17.1% from 2009 to 2010. In contrast, the volume continued to decline in economically less stable countries: for example, from 2009 to 2010, there was a decline of −4.1% in Greece and −0.5% in Portugal. From 2010 to 2011, two of the less economically stable countries experienced a high growth in sales vol- ume (5.5% in Spain and 7.8% in Ireland), while the growth rate was between 1.0% and 3.1% in most other less economi- cally stable countries. The exception was Portugal, which experienced a decline of −3.7%. The average annu a l p er c apit a growth in the value of sales between 2006 and 2011 varied between −2.1% in Portugal and 6.0% in Estonia. Af- ter 2009, all countries except Austria experienced a decrease in the value of sales in at least one year. The larg- est annual declines were observed in Greece (−13.5% from 2009 to 2010) and Portugal (−11.1% from 2010 to 2011). Moreover, the value of sales declined from 2010 to 2011 in all economically less stable countries. Fig. 5 depicts the difference be- tween the annual growth rate in the value of pharmaceutical sales and the annual growth rate in the volume of sales in each country between 2006 and 2011. In general, between 2006 and 2008, the annual value of pharmaceutical sales increased more than the annual volume of sales in both economically stable and less stable countries, which indicates that the average price per unit increased. From 2009 onwards, during the period when most policy changes were imple- mented, the growth in the annual value of sales was less than the growth in the annual volume, which indicates a de- crease in average price per unit. Discussion Although countries adjust their phar- maceutical policy frameworks continu- ously, a surge of policy changes seems to have taken place during the economic recession, particularly in 2010 and 2011. Unexpectedly, both economically stable and economically less stable countries Fig. 1. Volume of pharmaceutical sales, quarterly, in three economically stable European countries, 2006–2011 Vo lu m e of sa le s (s ta nd ar d un its p er ca pi ta )a 90 80 70 60 50 40 30 20 10 0 Year Austria EstoniaFinland 2006 2007 2008 2009 2010 2011 a The volume of pharmaceutical sales is for the 10 highest-selling therapeutic classes in each country. Fig. 2. Volume of pharmaceutical sales, quarterly, in five economically less stable European countries, 2006–2011 Vo lu m e of sa le s (s ta nd ar d un its p er ca pi ta )a 120 100 80 60 40 20 0 Year Greece SlovakiaPortugalIrelandSpain 2006 2007 2008 2009 2010 2011 a The volume of pharmaceutical sales is for the 10 highest-selling therapeutic classes in each country. Fig. 3. Value of pharmaceutical sales, quarterly, in three economically stable European countries, 2006–2011 Va lu e of sa le s (c on st an t U S$ p er ca pi ta )a 30 25 20 15 10 5 0 Year Austria EstoniaFinland 2006 2007 2008 2009 2010 2011 US$: United States dollars. a The value of pharmaceutical sales is for the 10 highest-selling therapeutic classes in each country. Bull World Health Organ 2014;92:630–640D| doi: http://dx.doi.org/10.2471/BLT.13.129114 635 Research Economic recession and pharmaceutical policies experienced a slight increase in the consumption of pharmaceuticals in the 10 highest-selling therapeutic classes, as measured in standard units per capita. As expected, the annual growth in the per capita value of medicine sales decreased in economically less stable countries in 2010 and 2011. Our study shows that economi- cally stable countries implemented fewer policy measures between 2008 and 2011 than economically less stable countries. The most f re quent ly i mplemente d policy changes targeted out-of-pocket payments for patients. Previous studies have shown that increases in copay- ments, such as prescription fees, tend to lead to lower medicine utilization, especially in times of economic reces- sion and increased unemployment.23–30 Policy measures such as the medicine price cuts (also applied in the form of discounts) that were implemented in Greece, Portugal and Spain could have had a negative effect on the availability of medicines if they caused pharmaceutical companies to withdraw their products from national reimbursement lists.31 Contrary to our expectations, however, we did not observe a major decline in the consumption of pharmaceuticals during the recession in the therapeutic categories studied as most countries continued to experience a moderate positive annual growth in sales volume. However, in line with media reports of drug shortages in Greece and Portugal, our data showed that the sales volumes of important medicines for chronic diseases, such as angiotensin-converting enzyme inhibitors and antidepressants, dropped drastically in these two coun- tries in 2010.31 Hence, although the over- all growth in sales volume was positive, the rate of growth appears to have fallen to below the prerecession level, which ranged from 5% to 12%. In contrast, the rate of growth in the value of pharmaceutical sales de- clined, especially in economically less stable countries. This decrease may have been due partly to inflation: the average inflation rate in 2010 and 2011 gener- ally ranged between 2.0% and 3.4%, although it was as low as −1.6% in 2010 in Greece and as high as 5.1% in 2011 in Estonia.32 Our analysis did not take inflation into account. The decrease may also have occurred because the Fig. 4. Value of pharmaceutical sales, quarterly, in five economically less stable European countries, 2006–2011 Va lu e of sa le s (c on st an t U S$ p er ca pi ta )a 50 45 40 35 30 25 20 15 10 5 0 Year 2006 2007 2008 2009 2010 2011 Greece SlovakiaPortugalIreland Spain US$: United States dollars. a The value of pharmaceutical sales is for the 10 highest-selling therapeutic classes in each country. Table 7. Per capita growth in pharmaceutical sales for the 10 highest-selling therapeutic classes in eight European countries, by volume and value, 2006–2011 Country Per capita annual sales growth (%) 2006– 2007 2007– 2008 2008– 2009 2009– 2010 2010– 2011 Average for 2006–2011 Volume of salesa Economically stable countries Austria 4.6 4.0 2.7 1.5 1.1 2.8 Estonia 12.2 −0.5 −9.0 17.1 3.1 4.6 Finland 3.7 3.8 2.3 3.4 1.0 2.8 Economically less stable countries Greece 5.6 0.3 0.7 −4.1 1.5 0.8 Ireland 4.1 1.4 4.3 0.8 7.8 3.7 Portugal 6.1 1.8 1.1 −0.5 −3.7 1.0 Slovakia 6.1 7.1 1.7 4.1 1.0 4.0 Spain 6.4 0.2 1.5 0.7 5.5 2.9 Value of salesb Economically stable countries Austria 7.3 6.3 2.2 0.4 1.5 3.5 Estonia 20.5 5.2 0.3 7.0 −3.2 6.0 Finland 3.1 6.3 −2.2 −2.6 0.7 1.1 Economically less stable countries Greece 13.3 7.0 6.8 −13.5 −2.4 2.2 Ireland 7.6 7.2 3.6 −1.9 … RESEARCH ARTICLE Open Access Government spending, recession, and suicide: evidence from Japan Tetsuya Matsubayashi1* , Kozue Sekijima2 and Michiko Ueda3 Abstract Backgrounds: Austerity has been shown to have an adverse influence on people’s mental health and suicide rates. Most existing studies have focused on the governments’ reactions to a single event, for example, the Great Recession of 2008. Methods: This study focused on significant changes in fiscal policy between 2001 and 2014 in Japan. The size of expenditures by national and local governments decreased dramatically between 2001 and 2006 under the neoliberal reform and then increased after the global economic crisis and the Great East Japan Earthquake. Using the data from 47 prefectures between 2001 and 2014, we tested whether more spending by the local governments was associated with a lower suicide rate in their jurisdiction. We also investigated whether this relationship was particularly salient during a more severe recession. Results: Our analysis revealed that an increase of 1% in the per capita local government expenditures was associated with a decrease of 0.2% in the suicide rates among males and females aged between 40 and 64 and that this correlation was strengthened as the unemployment rate increased, particularly among males. Conclusions: Government’s reaction to economic crises can either exacerbate or mitigate the negative impact of the economic recession on people’s mental health and suicide rates. Keywords: Suicide, Government spending, Recession, Austerity, Japan Background The relationship between an economic downturn and people’s health has been extensively studied in a variety of disciplines. This topic has drawn increasing attention from scholars after the global economic crisis in 2008 [1–3]. Evidence on whether economic downturn im- proves or worsens people’s health is mixed, depending on the measures of health, demographic groups, levels of economic development, and the degree of downturns [1–4]. The results of previous studies are more consist- ent when we focus on mental health and suicidal risks as a measure of health: mental health worsens, and suicidal risks increase during the recession [5]. The adverse influence of the economic downturn on mental health and suicidal risks could be exacerbated or mitigated by government actions. This possibility be- came particularly evident in the aftermath of the 2008 Great Recession when many nations adopted fiscal auster- ity as a political reaction to the massive economic crisis [6–8]. Austerity in the period of the economic downturn can worsen people’s mental health in two major ways: by increasing economic insecurity among vulnerable individ- uals and by reducing healthcare services [9, 10]. Indeed, suicide rates increased after the Great Recession in coun- tries where the austerity measures had been taken, includ- ing Greece, Ireland, Portugal, and Spain [11–17]. At the same time, the government can mitigate the effect of adverse economic shock by taking proper actions. For example, the amount of New Deal relief spending allocated to the US cities after the Great De- pression between 1929 and 1940 was negatively corre- lated with the suicide rates of the area [18]. Similarly, the negative effect of the recessions on suicide rates was shown to be weakened in countries with relatively larger social welfare spending [19–21], though others reported no such relationship [22]. © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. * Correspondence: [email protected] 1Osaka School of International Public Policy, Osaka University, 1-31 Machikaneyama, Toyonaka, Osaka 560-0043, Japan Full list of author information is available at the end of the article Matsubayashi et al. BMC Public Health (2020) 20:243 https://doi.org/10.1186/s12889-020-8264-1 http://crossmark.crossref.org/dialog/?doi=10.1186/s12889-020-8264-1&domain=pdf http://orcid.org/0000-0001-7922-9630 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ mailto:[email protected] This study offers additional evidence on the role of the government’s actions to prevent suicide in the period of recession using longitudinal data from Japan. The study period is from 2001 to 2014, during which Japan experi- enced both the reduction and expansion of government expenditures under different administrations and polit- ical climates. More precisely, government expenditures significantly decreased under the neoliberal reform be- tween 2001 and 2006 and then increased after the global economic crisis in 2008 and the Great East Japan Earth- quake in 2011. In response to a severe recession that Japan experienced after the Asian financial crisis in the late 1990s, Junichiro Koizumi, who became the prime minister of Japan in 2001, adopted several major neo- liberal reforms that downplayed the economic role of the government. Koizumi’s administration downsized the amount of government expenditures by up to 10% between 2001 and 2006, as compared to 2000. Such aus- terity measures, however, did not continue after Koizumi stepped down in 2006. The several administrations after Koizumi increased the amount of government expendi- tures mainly to stimulate economic activities after the Great Recession in 2008. In particular, Abe’s second ad- ministration (2012-) initiated various aggressive economic measures to recover from the long recession, including in- terventions that increased government spending on public infrastructure. In addition, the amount of public spending also expanded after the Great East Japan Earthquake in 2011 to mitigate its impact and to accelerate recovery from the disaster. Thus, Japan has experienced both austerity and expansion as government policies over the last two decades. These pol- icy changes at the national level also fundamentally affected the financial situation of subnational governments that relied heavily on fiscal transfers from the national government as a source of revenue. Prefectures and municipalities in Japan are administrative units that have independent sources of revenues, but about 30% of their total expenditures rely on a transfer from the national government. Thus, the amount of spending by local government crucially depends on the economic policies of the national government. In particular, when Koizumi’s administration lowered the number of transfers from the central government to subnational governments as part of his neoliberal reform, the volume of spending by subnational government declined, as shown in Fig. 1. The solid line in Fig. 1 depicts the change in the total amount of expenditure by the national government between 2001 and 2014 using the amount in 2000 as a baseline [23]. The dashed line in Fig. 1 depicts the total amount of spending by local governments [24]. The figure indicates that local gov- ernment expenditures were highly correlated with national government expenditures and that local government expenditures decreased until 2007 and then increased. Notably, Fig. 1 also shows that the overall crude sui- cide rate shown as a solid gray line declined rapidly just after the amount of national and local govern- ment spending increased. This study used these changes in the amount of local government spending associated with the policy changes at the national level in Japan to understand how the level of government expenditures affects sui- cide rates. Using data from 47 prefectures between 2001 and 2014, we tested two hypotheses: (1) Higher spending by the local governments was correlated with the lower suicide rates in their jurisdictions, and (2) the negative relationship between local government spend- ing and the suicide rates was particularly strong during a more severe recession. Fig. 1 The change in the expenditures of the national and local governments and the suicide rate per 100,000 in Japan between 2001 and 2014, as the year of 2000 as a baseline (=100). Note: Data on the amount of expenditures were adjusted for inflation Matsubayashi et al. BMC Public Health (2020) 20:243 Page 2 of 8 Our study improves upon previous studies on the role of government expenditures on suicide by focusing on different time horizons and types and levels of policy- making [25]. First, the evidence presented here does not concern only the government reaction to a single event, such as the studies focusing on the Great Recession of 2008. We examined the impact of various government actions over a period of 14 years. Second, this is the first study on the association between government spending and suicide in a non-European country, whereas the existing literature focused primarily on European coun- tries and the United States. Third, our study is not a cross-country analysis, which often faces a challenge to isolate the effect of government spending from other national-level policy changes. Because our study used subnational variations over time, we were able to use unit-specific and year-specific fixed effects and thus con- trol for unit-specific time-invariant and country-specific characteristics. Methods We created panel data for 47 prefectures between 2001 and 2014. The number of observations was 658. We lim- ited our data coverage until 2014 because of data availabil- ity. Using the panel data, we tested the first hypothesis that the larger amount of spending by subnational govern- ments was correlated with the lower suicide rates in their jurisdictions by estimating the following model: ½S� jt ¼ α½E� jt þ β½U� jt þ λw jt þ μ jT þ φt þ ρ j þ ε jt ð1Þ where the outcome variable [S]jt is a natural log of the suicide rate per 100,000 individuals in the year t in pre- fecture j. Suicide includes all deaths classified as X60- X84 under ICD-10. Considering the possibility that the effects of government expenditures varied by age and sex, we generated the suicide rates for six subpopulation groups: (1) males aged 20–39, (2) males aged 40–64, (3) males aged 65 and over, (4) females aged 20–39, (5) fe- males aged 40–64, and (6) females aged 65 and over. The suicide data were calculated by using data from the Vital Statistics [26]. Our primary explanatory variable is [E]jt, which de- notes the per capita government expenditures in prefec- ture j in the year t. We used the sum of expenditures of the prefectural government in j and all municipal governments in j from the Annual Report of Local Pub- lic Finance [24]. Japan is divided into 47 prefectures, and the number of municipalities in each prefecture ranges from 15 to 179. Both prefectural and municipal governments can use their expenditures on social wel- fare, public health, employment-related issues, public works, education, and disaster relief. We used the total amount of spending, rather than spending specifically for social welfare and public health because other types of local government spending can affect people’s well- being. For example, spending on infrastructure would produce job opportunities for the unemployed and may improve their economic and mental well-being. We transformed the per capita amount, adjusted for infla- tion, into a natural log for estimation. [U]jt in eq. (1) refers to the percentage of unemployed people in prefecture j in year t. Building on recent re- search on the same topic [21, 22, 27, 28], we used the unemployment rate as a measure of recession. We used the unemployment rate for the total population, though this data is limited in that it is not age-specific. The data were obtained from Statistics Japan [29]. Further, wjt refers to the socioeconomic characteristics of each prefecture in each year, all of which were likely to affect both the suicide rate and the government’s ex- penditures. Specifically, included in wjt are income per capita, fiscal strength index, population size, and per- centages of the dependent population aged under 14 and 65 and over, in each prefecture and year. Income per capita, obtained from the System of National Accounts, was defined as the total amount of income in prefecture j in the year t divided by the population size [30]. The fi- nancial strength index measures the fiscal conditions of each prefecture each year. The index exceeds 1 if the amount of revenue coming from the prefecture’s finan- cial sources exceeds the amount of fiscal demand and falls below 1 otherwise. This index is used to determine the amount of money transferred from the national to the local government. Because there were considerable year-to-year fluctuations, the values were averaged over the past 3 years. The data were obtained from the An- nual Report of Local Public Finance [24]. The population size and the percentages of the dependent population were obtained from the Annual Resident Registers [31]. We used natural logs of the total population and income per capita in our regression analysis. Finally, φt in eq. (1) represents the year fixed effects, while ρi represents the prefecture fixed effects unique to each prefecture. The year fixed effects allowed us to con- trol for the effects of annual socioeconomic and political changes at the national level, such as the effects of macroeconomic policies and business cycle that might affect the entire country. It also controls for the effects of natural disasters such as the Great East Japan Earth- quake in 2011. The prefecture fixed effects allowed us to control for the effects of time-invariant characteristics of the prefectures, such as the effects of culture related to suicide, and climate and geographic conditions. The in- clusion of the prefecture fixed effects in eq. (1) means that the model used variations in the level of Matsubayashi et al. BMC Public Health (2020) 20:243 Page 3 of 8 government expenditures over time within each local government. We also added the prefecture-specific lin- ear time trends, μjT, to the model to control for the ef- fects of linear trends in the suicide rates unique to each prefecture. To test the second hypothesis that the negative rela- tionship between local government spending and the suicide rates was particularly robust during a more se- vere recession, we included the interaction term between [E]jt and [U]jt in the model as: ½S� jt ¼ α½E� jt þ β½U� jt þ γ½E� jt�½U� jt þ λw jt þ μ jT þ φt þ ρ j þ ε jt ð2Þ Because the marginal effect of local government ex- penditures was hypothesized to change as the unemploy- ment rate increased, we calculated and plotted the marginal effect of [E]jt and its confidence interval at the different values of the unemployment rate. Results The summary statistics of all variables used in our esti- mation are presented in Table 1. The suicide rates were higher among males than females. Males aged 40–64 showed the highest rate among all subgroups. Table 2 reports the estimation results. Columns (1) to (3) report the results using the male suicide rates by three age groups, while columns (4) to (6) report the results using the female suicide rates. The prefecture-specific and year-specific fixed effects and the prefecture-specific linear time trend were always included in the models, but the Table 1 Summary Statistics Mean SD Min Max Log of suicide rate: male 20–39 3.419 0.205 2.674 4.056 Log of suicide rate: male 40–64 3.926 0.257 3.287 4.684 Log of suicide rate: male 65- 3.811 0.214 3.132 4.453 Log of suicide rate: female 20–39 2.399 0.287 1.105 3.070 Log of suicide rate: female 40–64 2.638 0.213 1.733 3.183 Log of suicide rate: female 65- 3.000 0.296 1.749 3.926 Log of government expenditures per capita 13.658 0.212 13.102 14.393 Unemployment rate 4.257 1.029 2.100 8.400 Log of income per capita 14.848 0.153 14.506 15.541 Fiscal strength index 0.457 0.196 0.197 1.406 Log of population size 14.495 0.742 13.283 16.396 Percent under 14 13.848 1.111 10.786 19.879 Percent over 65 22.745 3.357 13.150 31.141 N of observations 658 Note: Data covered the period from 2001 to 2014 in 47 prefectures of Japan Table 2 Estimated influences of government expenditures on suicide rates by sex and age (1) Male 20–39 (2) Male 40–64 (3) Male 65- (4) Female 20–39 (5) Female 40–64 (6) Female 65- Log of government expenditures per capita −0.017 − 0.246 0.069 0.188 −0.207 − 0.043 (−0.183, 0.150) (− 0.428, − 0.063) (− 0.080, 0.219) (− 0.292, 0.669) (− 0.383, − 0.032) (− 0.322, 0.237) Unemployment rate 0.014 0.023 0.062 −0.057 − 0.007 − 0.008 (− 0.039, 0.067) (− 0.017, 0.063) (0.020, 0.105) (− 0.110, − 0.004) (− 0.078, 0.064) (− 0.080, 0.064) Log of income per capita −0.266 − 0.173 −0.109 − 0.183 − 0.236 0.604 (−0.988, 0.457) (− 0.673, 0.327) (− 0.630, 0.413) (− 1.245, 0.879) (− 1.143, 0.671) (− 0.068, 1.276) Fiscal strength index − 0.026 0.038 0.107 − 0.518 − 0.055 − 0.397 (− 0.323, 0.271) (− 0.298, 0.375) (− 0.146, 0.359) (−1.245, 0.208) (− 0.494, 0.383) (− 1.078, 0.283) Log of population size 1.396 3.446 1.881 10.457 0.976 2.042 (−3.959, 6.750) (−0.267, 7.160) (−2.597, 6.360) (−0.311, 21.225) (−5.407, 7.359) (−2.602, 6.686) Percent under 14 0.149 −0.045 −0.095 0.170 −0.005 − 0.233 (−0.061, 0.360) (− 0.185, 0.095) (− 0.289, 0.100) (−0.160, 0.500) (− 0.244, 0.233) (− 0.436, − 0.029) Percent over 65 0.154 0.044 0.017 0.049 −0.023 0.046 (−0.012, 0.319) (−0.085, 0.174) (− 0.106, 0.139) (− 0.176, 0.275) (−0.215, 0.170) (− 0.096, 0.189) Prefecture fixed effect Yes Yes Yes Yes Yes Yes Year fixed effect Yes Yes Yes Yes Yes Yes Prefecture-specific liner trend Yes Yes Yes Yes Yes Yes N of observations 658 658 658 658 658 658 R squared 0.342 0.825 0.405 0.262 0.269 0.448 Note: Table entries are regression coefficients with 95% confidence intervals in parentheses. Standard errors are clustered by prefectures. The dependent variable is a log of the suicide rate per 100,000 by sex and age. Data covered the period from 2001 to 2014 in 47 prefectures of Japan Matsubayashi et al. BMC Public Health (2020) 20:243 Page 4 of 8 estimates are not reported in the table. In order to address the potential heterogeneity and autocorrelation in the error terms within each prefecture, standard errors were clustered by prefectures. Table 2 shows that the log of government expenditures per capita was negatively correlated with the log of suicide rates by males and females aged 40–64. More specifically, as the per capita expenditures decreased by 1%, the suicide rate among males aged 40–64 increased by 0.25% (95% CI: − 0.43, − 0.06) and the suicide rate among females aged 40–64 increased by 0.21% (95% CI: − 0.38, − 0.03). We found that the estimates were small or the confidence intervals were large in the other columns, suggesting that the local government’s expenditures had little relationship with the suicide rates by other sex and age subgroups. Because the local government spending was shown to have a strong relationship only with the suicide rates of middle-aged males and females in Table 2, we focused on these two subgroups and estimated eq. (2). Using the estimated results reported in Table 3, we plotted the marginal effect of local government expenditures in a solid line and its confidence interval in a dashed line at the different values of the unemployment rate in Fig. 2. The vertical solid line in Fig. 2 denotes the average amount of government expenditures. The top panel shows that the negative relationship between local gov- ernment expenditures and the log of suicide rate by males aged 40–64 was particularly relevant when the un- employment rate was modestly to extremely high. The confidence intervals overlap the horizontal line of zero when the unemployment was relatively low, suggesting that local government spending had a negligible relation- ship with the middle-aged male suicide rates when eco- nomic conditions are good. The bottom panel also indicates that the marginal effect of local government expenditures on the suicide rate of middle-aged females became larger as the unemployment rate was higher, but the change in the marginal effect over the scale of the unemployment rate was small. Discussions This study investigated the relationship between govern- ment expenditures and suicide rates by using the varia- tions in the amount of local government spending associated with the national-level economic policy change. Our estimation models controlled for the effects of other relevant factors, such as the unemployment rate and per-capita income, as well as the prefecture- and year-specific factors and time trends. We found that the suicide rates of middle-aged males and females tended to increase when prefectural governments decreased their spending level. This negative association was stron- ger among males when the unemployment rate in- creased. These findings suggest that local suicide rates could be reduced when local governments increase their spending. The magnitude of the effect is not trivial. Dur- ing our study period, the average male suicide rate for the middle-aged was 31.19, and a one-percent increase in government spending would translate to a reduction of the suicide rate per 100,000 by 0.078 cases, which translates to 0.36 cases of suicide in each prefecture and 17 suicides across the whole of Japan per year. However, we also found that the amount of spending by subnational governments had little relationship with the suicide rates of the younger generation and those of the elderly population. The null-finding for the elderly group is not surprising, as they are less likely to be working and, hence, less likely to benefit from any increased economic activities associated with an expansion in government spending. However, they are also more likely to be benefi- ciaries of welfare-related spending, and thus the finding is somewhat counterintuitive at the same time. As for the younger generation, it is possible that their suicide rates are determined by an entirely different set of factors. Ac- cording to the data compiled by the National Police Agency, among those whose motives and reasons behind Table 3 Estimated relationships between government expenditures and suicide rates conditional on the unemployment rate (1) Male 40–64 (2) Female 40–64 Log of government expenditures per capita 0.173 − 0.026 (− 0.343, 0.688) (− 0.458, 0.406) Expenditures × unemployment − 0.090 − 0.039 (− 0.182, 0.002) (− 0.126, 0.047) Unemployment rate 1.256 0.528 (−0.003, 2.515) (−0.648, 1.703) Log of income per capita −0.153 − 0.228 (−0.600, 0.295) (−1.129, 0.674) Fiscal strength index −0.014 −0.078 (−0.301, 0.272) (−0.511, 0.354) Log of population size 3.823 1.140 (0.190, 7.457) (−5.393, 7.672) Percent under 14 −0.036 − 0.002 (− 0.178, 0.105) (− 0.243, 0.240) Percent over 65 0.029 −0.029 (−0.100, 0.158) (−0.222, 0.163) Prefecture fixed effect Yes Yes Year fixed effect Yes Yes Prefecture-specific liner trend Yes Yes N of observations 658 658 R squared 0.827 0.269 Note: Table entries are regression coefficients with 95% confidence intervals in parentheses. Standard errors are clustered by prefectures. The dependent variable is a log of the suicide rate per 100,000 by men and women aged 40 to 64. Data covered the period from 2001 to 2014 in 47 prefectures of Japan Matsubayashi et al. BMC Public Health (2020) 20:243 Page 5 of 8 their suicide are known, 3 and 14% of suicide deaths by those aged less than 20 and aged 20–29 are related to eco- nomic hardship, respectively, whereas 19 and 22% of deaths by those aged 30–39 and 40–49 are attributable to economic conditions, respectively [32]. Among the elderly population (ages 70 and higher), a majority of their sui- cides is due to health-related reasons, and only 6% of their suicides are due to economic factors. We conducted robustness checks to ensure that our re- sults are not sensitive to the specific model and data that were chosen. The above results were based on the total amount of government spending of both prefectural and municipal governments combined. We evaluated the same models with the total amount of government expenditures only by prefecture governments. The main results did not change. In order to check if the expenditures in the previous year matter for the well-being of the population, we also took a one-year lag of local government’s expendi- tures and added the lagged value as an additional regres- sor. We found that the amount of government spending in the previous year does not affect the suicide rate; the es- timated results suggest that only the government expendi- tures in the current year affect the suicide rate for that year. Both results are available upon request. The present study contributes to the existing literature by providing further evidence on the importance of gov- ernment actions on suicide rates. Depending on how the government reacts to economic shocks, it can either ex- acerbate or mitigate the negative impact of the economic recession on the population. The findings of this study are mostly consistent with those of other studies that showed that austerity measures during an economic Fig. 2 The marginal effect of government spending conditional on the unemployment rate in 47 prefectures of Japan. Note: These graphs are based on the estimation results in Table 3 Matsubayashi et al. BMC Public Health (2020) 20:243 Page 6 of 8 crisis could have a detrimental effect on people’s mental health and health in general. The major strength of this study lies in the fact that we examined the effect of different government reactions to multiple economic crises over an extended period within a single country. Most previous studies have examined the impact on people’s health of government reactions to a single major financial crisis, such as the 2008 Great Reces- sion, by using a cross-national comparison. Our analysis of the sub-national data in Japan allowed us to isolate the effect of government spending from other major national- level policy changes, which thus provided more robust evi- dence for the relationship between austerity and suicide. Moreover, to our knowledge, this is the first study on the association between government spending and suicide in a non-European country. This study has several limitations. First, our study can- not provide answers as to why increased government spending can decrease the number of suicides as our study was ecological in nature. Second, our analysis did not explicitly consider the potential effect of various suicide prevention measures on suicide rates. The Japanese government introduced its first national suicide preven- tion program in the mid-2000s, and the suicide rates have decreased since around 2012. The prefecture fixed effects and the prefecture linear trends that we included in the model should capture most of the effects of suicide pre- vention measures. However, in order to check this possi- bility more explicitly, we also added the per capita amount of transfers from the national government earmarked for suicide prevention activities to model (1) to control for the effect of local suicide prevention activities. We found that our main results did not change by this modification and also that the amount spent on suicide prevention ac- tivities does not seem to affect suicide rates in a meaning- ful way. The results of this supplementary analysis are reported in Table 4. Conclusion In conclusion, our findings suggest that government actions can significantly affect the health of the general public, even if the actions are not directly related to spending for public health and social security. Decreasing the level of overall government spending can be detrimental to people’s health. Table 4 Estimated influences of total government expenditures and expenditures for suicide prevention programs on suicide rates by sex and age between 2001 and 2014 in 47 prefectures of Japan (1) Male 20–39 (2) Male 40–64 (3) Male 65- (4) Female 20–39 (5) Female 40–64 (6) Female 65- Log of government expenditures per …
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