Cancer & Depression - Sociology
Cancer & Depression Research Article Summaries This assignment is the first step toward completing the literature review in Week 3. · Choose a general topic that you are interested in. Use the  Area of Interest interactive    download to guide your efforts. Narrow the topic so that you are looking for research to answer a particular question. For example: “What is the experience of military families when their soldier is deployed?” or “Is there a link between hours of television viewing and violent behavior in children aged 8-14?” Think of a question that might be answered in a number of different ways. Briefly describe your topic and research question. · Conduct a search through the Ashford University Library and locate a minimum of five (5) research studies from peer-reviewed sources that are related to the topic of your choice. Find at least two studies that use qualitative data and at least two studies that use quantitative data. · Write a 350-word (double-spaced) synopsis/review of each article in your own words. Be sure to read the article fully to accomplish this goal. Do NOT simply rely on the Abstract, as the Abstract is limited in two ways: 1) it omits important information you might find useful; and, 2) it does not describe all aspects of the research that you will need for your literature review in Week 3. Thus, be sure to discuss what you find significant about the study for your topic, not just, what the author thought. · The assignment should include: 1. A brief discussion of your topic and research question. For each article, turn in 2. The citation (properly formatted in APA style), 3. The article’s original abstract. 4. Your one-page synopsis, and 5. Whether the study is a quantitative approach (uses statistical analyses) or a qualitative approach. Howard Sharp, K. M., Fisher, R. S., Clark, O. E., Dunnells, Z. D. O., Murphy, L. K., Prussien, K. V., Vannatta, K., Compas, B. E., & Gerhardt, C. A. (2020). Long-term trajectories of depression symptoms in mothers of children with cancer. Health Psychology, 39(2), 89–98. https://doi-org.proxy-library.ashford.edu/10.1037/hea0000826 Niedzwiedz, C. L., Knifton, L., Robb, K. A., Katikireddi, S. V., & Smith, D. J. (2019). Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority. BMC Cancer, 19(1), 943. https://doi-org.proxy-library.ashford.edu/10.1186/s12885-019-6181-4 Saracino, R. M., Aytürk, E., Cham, H., Rosenfeld, B., Feuerstahler, L. M., & Nelson, C. J. (2020). Are we accurately evaluating depression in patients with cancer? Psychological Assessment, 32(1), 98–107. https://doi-org.proxy-library.ashford.edu/10.1037/pas0000765.supp (Supplemental) Kang, E., Keam, B., Lee, N.-R., Kang, J. H., Kim, Y. J., Shim, H.-J., & Jung, K. H. (2021). Impact of family caregivers’ awareness of the prognosis on their quality of life/depression and those of patients with advanced cancer: a prospective cohort study. Supportive Care in Cancer, 29(1), 397. https://doi-org.proxy-library.ashford.edu/10.1007/s00520-020-05489-8 Annunziata, M. A., Muzzatti, B., Bidoli, E., Flaiban, C., Bomben, F., Piccinin, M., Gipponi, K. M., Mariutti, G., Busato, S., & Mella, S. (2020). Hospital Anxiety and Depression Scale (HADS) accuracy in cancer patients. Supportive Care in Cancer, 28(8), 3921–3926. https://doi-org.proxy-library.ashford.edu/10.1007/s00520-019-05244-8 Long-Term Trajectories of Depression Symptoms in Mothers of Children With Cancer Katianne M. Howard Sharp The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, and The Ohio State University Rachel S. Fisher, Olivia E. Clark, and Zackery D. O. Dunnells The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio Lexa K. Murphy and Kemar V. Prussien Vanderbilt University Kathryn Vannatta The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, and The Ohio State University Bruce E. Compas Vanderbilt University Cynthia A. Gerhardt The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, and The Ohio State University Objective: To identify trajectories of depression symptoms in mothers of children with cancer from diagnosis/relapse through 5 years and examine maternal factors at diagnosis/relapse predicting member- ship in these trajectories. Method: Mothers (n � 327; Mage � 37.6 years, SD � 7.7 years; 85.9\% White) reported depression symptoms near the time of their child’s diagnosis/relapse and then again at 1-, 3-, and 5-years postdiagnosis/relapse. Mothers also reported perceived stress, coping (primary control, secondary control, and disengagement coping), and spirituality near the time of diagnosis. Latent class growth analysis was used to identify latent trajectories of depression symptoms, and a 3-step multinomial logistic regression tested covariate predictors of membership in the trajectories. Results: Three trajectories were identified: “low depression symptoms” (63.3\%), “moderate depression symptoms” (31.5\%), and “high depression symptoms” (5.2\%). Mothers who used more primary and secondary control coping were more likely to be in the low depression symptom trajectory as compared with the moderate (OR � 1.64, p � .024 and OR � 1.38, p � .013, respectively) or high trajectories (OR � 1.99, p � .008 and OR � 1.81, p � .001, respectively). Conclusions: Although mothers of children with cancer generally displayed improved mental health further from diagnosis, mothers with more depression symptoms after diagnosis/ relapse displayed substantial stability in depression symptoms over the 5 years. Mothers of children with cancer may benefit from early screening of mental health and coping strategies, as well as interventions to bolster effective coping for those with elevated depression symptoms. Keywords: coping, mothers’ depressive symptoms, latent class growth analysis, pediatric cancer, trajectories With improved survival rates for pediatric cancer (DeSantis et al., 2014), it is increasingly important to understand the long-term effects of pediatric cancer on families. A child’s diagnosis of cancer affects the entire family, particularly parents. Parental dis- This article was published Online First December 2, 2019. X Katianne M. Howard Sharp, Center for Biobehavioral Health, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, and Department of Pediatrics, The Ohio State University; Rachel S. Fisher, Olivia E. Clark, and Zackery D. O. Dunnells, Center for Biobehavioral Health, The Research Institute at Nationwide Children’s Hospital; Lexa K. Murphy and Kemar V. Prussien, Department of Psychology and Human Development, Vanderbilt University; Kathryn Vannatta, Center for Biobe- havioral Health, The Research Institute at Nationwide Children’s Hospital, and Department of Pediatrics, The Ohio State University; Bruce E. Com- pas, Department of Psychology and Human Development, Vanderbilt University; Cynthia A. Gerhardt, Center for Biobehavioral Health, The Research Institute at Nationwide Children’s Hospital, and Department of Pediatrics, The Ohio State University. Katianne M. Howard Sharp is now at the Department of Psychology, St. Jude Children’s Research Hospital, Memphis, Tennessee. Rachel Fisher is now at the Department of Psychology, Oklahoma State University. Olivia Clark is now at the Department of Psychology, Loyola University Chicago. Zackery Dunnells is now at Anne and Henry Zarrow School of Social Work, The University of Oklahoma. This research was supported by a grant from the National Institutes of Health (R01CA118332). Portions of this work were presented at the Society of Pediatric Psychology Annual Conference, Orlando, Florida (April 2018). We thank the families who generously participated in this work. Correspondence concerning this article should be addressed to Cynthia A. Gerhardt, Center for Biobehavioral Health, The Research Institute at Nation- wide Children’s Hospital, Room FB3135, 700 Children’s Drive, Columbus, OH 43205-2696. E-mail: [email protected] T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. Health Psychology © 2019 American Psychological Association 2020, Vol. 39, No. 2, 89 –98 ISSN: 0278-6133 http://dx.doi.org/10.1037/hea0000826 89 tress after diagnosis has critical implications for parents’ physical health, family/marital adjustment, and child adjustment (Kearney, Salley, & Muriel, 2015). However, relatively little is known about which parents are at risk for long-term adjustment problems and what protective factors may mitigate their distress. By better understanding trajectories of parent adjustment and factors that predict risk for long-term distress, interventions may be introduced earlier to foster resilience. Although many parents of children with cancer are resilient (Kearney et al., 2015; Phipps et al., 2015), a subset experience marked distress or mental health problems (e.g., anxiety, depres- sion), even years after diagnosis (Compas et al., 2015; Creswell, Wisk, Litzelman, Allchin, & Witt, 2014; Kazak et al., 2015; Norberg & Boman, 2008; Wijnberg-Williams, Kamps, Klip, & Hoekstra-Weebers, 2006). Parents of children with cancer also report more emotional distress than healthy comparison parents (Creswell et al., 2014; Maurice-Stam, Oort, Last, & Grootenhuis, 2008; Norberg & Boman, 2008; Pai et al., 2007; Wijnberg- Williams et al., 2006). Specifically, parents of children with cancer may be more likely to experience prolonged clinically elevated depression symptoms than either anxiety or posttraumatic stress symptoms (Katz et al., 2018). In contrast with parents of healthy children, parents of children with cancer display more depression symptoms at multiple time points from diagnosis through 5 years postdiagnosis (Katz et al., 2018; Norberg & Boman, 2008; Vrijmoet-Wiersma et al., 2008; Wijnberg-Williams et al., 2006). Furthermore, mothers tend to report more adjustment difficulties than do fathers across the illness trajectory (Clarke, McCarthy, Downie, Ashley, & Anderson, 2009; Pai et al., 2007; Vrijmoet- Wiersma et al., 2008), perhaps because mothers are often the primary caregiver and typically accompany the child to cancer- related procedures (Kazak et al., 1996). Given elevated risk for depression symptoms in mothers, it is particularly important to elucidate trajectories of mothers’ depression symptoms after their child’s diagnosis of cancer. Bonanno and Diminich (2013) suggest that adults’ long-term adjustment patterns to stressful life events are most appropriately differentiated by comparing latent trajectories of functioning in the years after the stressor. Three trajectories have consistently emerged across studies and types of potentially traumatic events (e.g., natural disaster, breast cancer): (a) minimal-impact resil- ience, characterized by a mild and transient stress response at the time of the stressor followed by stable, low levels of distress; (b) chronically high distress; and (c) recovery, characterized by mod- erate to high distress that decreases to low levels (Bonanno & Diminich, 2013). In cases of pediatric cancer, longitudinal studies of mothers’ adjustment have generally measured mean levels of distress, documenting elevated depression symptoms after diagno- sis that decrease over subsequent months (Katz et al., 2018; Kazak et al., 2015; Kearney et al., 2015). However, variance in trajecto- ries of caregiver depression symptoms suggests the presence of distinct latent trajectories of depression symptoms (Katz et al., 2018). Indeed, distinct latent trajectories of parent distress have emerged in the 6 months after diagnosis (Dolgin et al., 2007; Steele, Dreyer, & Phipps, 2004), including high, moderate, de- creasing, and low distress trajectories. However, it is unknown whether these trajectories remain stable beyond 6 months. Approx- imately one fourth of parents report clinically elevated distress even 5 years after their child’s diagnosis (Kazak et al., 2015; Wijnberg-Williams et al., 2006), suggesting the possibility of a chronically distressed or delayed distress trajectory. Therefore, it is critical to elucidate long-term trajectories of adjustment (e.g., chron- ically high depression symptoms, resilience) and to identify risk and resilience factors that predict membership in these trajectories. Studies examining protective factors in parents of children with cancer have generally focused on external (e.g., high socioeco- nomic status, social support; Bemis et al., 2015) or trait-based factors (e.g., personality; Kearney et al., 2015). However, internal processes, such as perception of stress, coping, and spirituality, have received less attention and may shed light on modifiable protective factors that can be enhanced in interventions to promote resilience. The diagnosis and treatment of pediatric cancer results in marked stress for parents, including stresses of daily/role func- tioning (e.g., job-related changes), cancer communication (e.g., talking to children about cancer), and cancer caregiving (e.g., child’s treatment-related effects; Rodriguez et al., 2012). In con- trast to measuring external stress exposure or context-specific types of stress (e.g., cancer-related stressors, caregiver stress), perceived stress reflects individuals’ subjective stress reactions. In other words, high perceived stress indicates that an individual subjectively experiences their current life circumstances as stress- ful. In the broader depression literature, more perceived stress has been linked with a trajectory of chronically high depression symp- toms, with those in a consistently low depression trajectory report- ing less perceived stress compared to those with fluctuating de- pression (increasing or decreasing; Repetto, Caldwell, & Zimmerman, 2004). Thus, elevated perceived stress following diagnosis might be expected to relate to patterns of chronically elevated depression symp- toms or recovery. Although perceived stress is broadly related to adjustment in mothers of children with cancer (Bemis et al., 2015; Han, 2003), it has not been examined as a predictor of mothers’ adjustment over time; thus, it is unknown whether perceived stress following diagnosis might relate to patterns of minimal-impact resil- ience, recovery, or more chronic distress. Adaptive coping may serve as a resource for parents of children with cancer (Compas et al., 2015; Compas, Jaser, Dunn, & Rodri- guez, 2012; Maurice-Stam et al., 2008). A control-based model of coping has been used to understand parental coping with pediatric chronic illness and posits three voluntary coping factors: primary control, secondary control, and disengagement, (Compas et al., 2015; Connor-Smith, Compas, Wadsworth, Thomsen, & Saltz- man, 2000). Primary control coping includes active, voluntary efforts to alter the situation or a person’s emotional state (e.g., problem-solving, emotional regulation, emotional expression). Secondary control coping refers to efforts to adapt to or fit into present conditions (e.g., positive thinking, cognitive restructuring, acceptance). Disengagement coping refers to voluntarily retreating from addressing or acknowledging stressors (e.g., avoidance, de- nial). Coping responses corresponding to primary or secondary control coping are associated with fewer depression symptoms for mothers and fathers near diagnosis (Compas et al., 2015; Maurice- Stam et al., 2008; Turner-Sack, Menna, Setchell, Maan, & Cataudella, 2016). In contrast, disengagement coping at diagnosis is linked with elevated maternal distress or depression symptoms (Greening & Stoppelbein, 2007; Lindahl Norberg, Pöder, & von Essen, 2011). Mothers with a tendency to cope with cancer-related stressors by disengaging might thus be expected to exhibit a pattern of chronic depression symptoms. Longitudinal research to T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. 90 HOWARD SHARP ET AL. determine the role of coping across the cancer continuum has been recommended (Vrijmoet-Wiersma et al., 2008); however, cancer- specific coping has yet to be examined as a predictor of long-term maternal depression. Lastly, spirituality is hypothesized to serve a protective function against the uncertainty of illness and treatment (Cadell, 2012; Landis, 1996; Weaver & Flannelly, 2004). Separate from religion (Hill et al., 2000), spirituality refers to existential questioning and a search for spiritual meaning (Hatch, Burg, Naberhaus, & Hell- mich, 1998; Hill et al., 2000). Although spirituality has not been previously linked with depression in mothers of children with cancer, it has been associated with depression more generally (Koenig, 2009). Moreover, spirituality is associated with more active coping, meaning-making, and posttraumatic growth in care- givers of chronically ill children (Cadell, 2012; Landis, 1996; Schneider & Mannell, 2006; Weaver & Flannelly, 2004), which may in turn reduce the risk for depression. Thus, spirituality may promote resilience for mothers of children newly diagnosed with cancer, suggesting that mothers who are more spiritual may exhibit patterns of distress more consistent with minimal-impact resilience. This study empirically identified subgroups of mothers with qualitatively different trajectories of depression symptoms over the 5 years after their child’s initial diagnosis/relapse using a large sample and longitudinal prospective design. Based on contempo- rary theory (Bonanno & Diminich, 2013) and prior pediatric can- cer studies using smaller samples and shorter time frames (Steele et al., 2004), it was predicted that three to six trajectories would emerge, including patterns of chronically high, chronically low, and decreasing depression symptoms. As a second aim, mothers’ trajectory membership was examined in relation to their perceived stress, coping (primary control, secondary control, and disengage- ment coping), and spirituality near the time of diagnosis. To the extent that trajectories were characterized by chronic and/or ele- vated depression symptoms, it was hypothesized that trajectory membership would be predicted by more perceived stress, less primary and secondary control coping, less spirituality, and more disengagement coping. In contrast, it was predicted that less per- ceived stress, more primary and secondary control coping, more spirituality, and less disengagement coping would predict trajec- tory membership characterized by chronically low or transient, decreasing symptoms. Method Procedure Mothers were recruited as participants in a larger, longitudinal study examining family adjustment to childhood cancer (Compas et al., 2015). However, the present analyses were secondary and not a priori aims of the larger study. Following institutional review board approval at Nationwide Children’s Hospital and Vanderbilt University, eligible families were identified from cancer registries. Families were eligible if their child was: (a) aged 5–17 years, (b) recently diagnosed with new or relapsed cancer, (c) English- speaking, and (d) without a preexisting developmental delay. El- igible families were approached for recruitment by trained re- search assistants in outpatient oncology clinics and inpatient rooms at both children’s hospitals. All parents were invited to participate; however, only one parent was required to participate for a family to be enrolled, with the current analyses only examining the maternal caregivers. Parents provided written informed consent. Mothers completed questionnaires in the hospital or at home after diagnosis/relapse (M � 2.5 months, SD � 2.0 months) and at 1 year (M � 14.0 months postdiagnosis/relapse, SD � 3.1 month), 3 years (M � 41.0 months postdiagnosis/relapse, SD � 3.8 months), and 5 years (M � 63.3 months postdiagnosis/relapse, SD � 5.2 months) after enrollment. Families were compensated for their time. Participants Three hundred and twenty-seven mothers reported on symptoms of depression at one or more study time point(s). Mothers of enrolled families were eligible to participate at all time points (even if they did not participate in baseline data collection) unless their child died. However, mothers’ predeath data were included in the analyses if their child had died during the course of the study to prevent exclusion of the families of children with poor progno- ses. At enrollment, 336 of 380 eligible families consented to participate, and 321 mothers completed questionnaires. At approx- imately 1-year postdiagnosis, 10\% (n � 34) of children had died, and one child became ineligible because of a diagnosis of devel- opmental disability. Of the remaining 301 eligible families, most mothers had complete data at 1-year postdiagnosis (n � 217, 72\%). At the 3-year follow-up, an additional 21 children had died, another child was ineligible because of a diagnosis of develop- mental disability, and 47 families were not approached because they were already beyond 3-years postdiagnosis at the time that 3- and 5-year follow-ups were IRB approved. Of the 232 remaining families who were approached, 46\% (n � 107) of mothers partic- ipated. At the 5-year follow-up, four additional children had died. Of the 275 families approached, 39\% (n � 108) of mothers participated. Attrition was not significantly related to primary variables of interest in this study: depression, spirituality, coping (all p values nonsignificant). Mothers who did not participate at 1-year postdi- agnosis reported more perceived stress following diagnosis, t � 2.00, p � .047, had children with higher treatment intensity, t � 2.31 (204), p � .022, and were more likely to have a child who had relapsed, �2(1) � 7.04, p � .008. However, only treatment inten- sity significantly differentiated attrition when controlling for fam- ilies lost to follow-up due to child death (n � 34, 10\%), t � 2.41 (200), p � .017 (other p values nonsignificant). At 3- and 5-year follow-ups, attrition was more likely for mothers of older children, t � 1.98 (230.42), p � .049 and t � 2.41 (322), p � .016, respectively, and mothers of children who had relapsed, �2(1) � 17.60, p � .001 and �2(1) � 8.91, p � .003, respectively. After controlling for child death, attrition was higher at 3-year follow-up for children who had relapsed, �2(1) � 3.91, p � .048, and at 5-year follow-up for older children, t � 2.10 (259), p � .037. No other demographic (age, marital status, years of education, family income, socioeconomic status [SES], child gender) or clinical variables (Central Nervous System [CNS] directed treatment [yes/ no], diagnosis, length of treatment) significantly differentiated attrition (all p values nonsignificant). Measures Demographic and clinical variables. Mothers reported their age, marital status, race, education, family income, number of T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. 91TRAJECTORIES OF DEPRESSION SYMPTOMS children, SES, and child gender. Children’s medical diagnosis, date of diagnosis, date of final treatment, and treatment informa- tion were collected through medical chart review. Length of treat- ment was calculated by subtracting date of diagnosis from date of final treatment. The Intensity of Treatment Rating Scale 2.0 (ITR-2) provided an overall rating of treatment intensity using diagnosis, stage/risk level, and treatment modality (Werba et al., 2007). Chart reviews were completed at 5-years postenrollment for participants who had reconsented during a 3- or 5-year follow-up, yielding incomplete length of treatment data due to missing date of final treatment for dropouts or deceased patients. Depression symptoms. Mothers completed the BDI-II (Beck, Steer, & Brown, 1996), which contains 21 items ranging from 0 to 3. The total score corresponds to increasing severity of depression symptoms, with clinical ranges of minimal (0 –13), mild (14 –19), moderate (20 –28), and severe (29 – 63; Beck et al., 1996). This is a well-established and standardized measure that demonstrates good construct validity and internal consistency (Steer, Ball, Ran- ieri, & Beck, 1997). Internal consistency in the current study was excellent (� � .93). Perceived stress. The Perceived Stress Scale is a 10-item questionnaire using a Likert scale ranging from 0 (never) to 4 (very often) that measures the extent to which one appraises events during the past month as stressful (Cohen, Kamarck, & Mermel- stein, 1983; Cohen & Williamson, 1988). This measure has strong psychometric properties (Cohen et al., 1983; Cohen & Williamson, 1988) and demonstrated good internal consistency in the present study (� � .85). Coping. The Responses to Stress Questionnaire-Pediatric Cancer version (RSQ-PC) is a 57-item, validated measure of maternal coping responses to pediatric cancer (Compas et al., 2012; Connor-Smith et al., 2000). Mothers rated how they coped with cancer-specific stressors on a Likert scale ranging from 1 (not at all) to 4 (a lot). The current study examined voluntary coping factors of the RSQ-PC (i.e., primary control coping, secondary control coping, and disengagement). Ratio scores representing total individual factor scores divided by the total score for the entire measure were used as recommended (Compas et al., 2015; Connor-Smith et al., 2000). Internal consistency for these factors was acceptable in this sample (� � .74 –.75). Spiritual involvement and beliefs. The Spiritual Involve- ment and Beliefs Scale (SIBS; Hatch et al., 1998) is a 24-item questionnaire assessing engagement in spiritual actions and beliefs without religion-specific language. Mothers rated items on a Likert scale from 1 (strongly agree) to 5 (strongly disagree). The SIBS consists of four subscales with strong psychometric properties, including strong internal consistency and construct validity (Hatch et al., 1998). However, given the high subscale intercorrelations in the current study (r � .5–.89) and low internal consistency for the humility/application subscale (� � .45), all items were summed for an overall spirituality score with excellent internal consistency (� � .91). Statistical Analyses Descriptive statistics and Pearson correlations were calculated in SPSS (Version 25), with subsequent analyses conducted in Mplus (Version 7.3). The average pattern of change in maternal depression symptoms was first characterized using latent growth curve modeling (LGCM). Single-group LGCMs were analyzed for intercept-only, linear, and quadratic models and empirically com- pared. Strong model fit is indicated by a nonsignificant �2 test statistic, comparative fit index (CFI) � .95, root mean square error of approximation (RMSEA) � .05, and standardized root-mean- square residual (SRMR) � .08 (Hu & Bentler, 1999). Homogeneous trajectories were empirically identified using la- tent class growth analysis with maximum likelihood estimation. Unconditional models with an increasing number of class solutions were compared according to interpretability, theory, parsimony, and model fit criteria (i.e., Bayesian information criteria [BIC]; Schwarz, 1978; entropy, average class assignment probabilities, and likelihood ratio tests). Lower BIC suggests better fit, with BIC differences of 0 –2, 2– 6, 6 –10, and �10 considered weak, posi- tive, strong, and very strong evidence for one model over another, respectively (Kass & Raftery, 1995; Raftery, 1995). Entropy and average class assignment probabilities (ranging from 0 –1) reflect classification accuracy and certainty of class assignment, respec- tively, with larger values reflecting higher accuracy and certainty of assignment and �.80 considered strong evidence (Rost, 2006). Lastly, the Lo-Mendell-Rubin test (LMR; Lo, Mendell, & Rubin, 2001) and the bootstrap likelihood ratio difference test (BLRT; McLachlan & Peel, 2000) compare each model with the model containing one fewer class (e.g., four-class solution vs. the three- class solution). Models were estimated using all available data and missing data were estimated using maximum likelihood, which is suitable for small sample sizes and yields similar to less biased estimates compared to multiple imputation (Shin et al., 2017). The three-step approach was used (Asparouhov & Muthén, 2014; Vermunt, 2010) to examine how perceived stress, coping, and spirituality at diagnosis related to mothers’ membership in the identified latent trajectories. This approach conducts a multinomial logistic regression predicting latent class membership while main- taining the probabilistic nature of the latent class variable and accounting for the variance of all predictors. Therefore, rather than assigning participants to their most likely class, participants re- tained partial membership in classes according to their probability of class membership. Given that maternal age, education, income, race, relapse, and child death are associated with maternal depres- sion in this population (Bemis et al., 2015; Wijnberg-Williams et al., 2006), these variables were included as covariates (i.e., 1 � relapse before/during study, 0 � never relapsed; 1 � child de- ceased, 0 � child living) in the model with significant predictors. Treatment intensity was also included as a covariate given that it significantly differentiated attrition at 1-year follow-up. Missing data for these analyses were estimated using multiple imputation given that Mplus Version 7.3 does not permit estimation of miss- ing data using maximum likelihood for the three-step approach. Results Preliminary Analyses Demographic information for patients and mothers is presented in Table 1. Means, standard deviations, and correlations are pre- sented in Table 2. On average, mothers’ BDI-II scores were in the mild range (Beck et al., 1996) at diagnosis (M � 15.00, SD � 10.59) and in the minimal range 1 to 5 years after study enrollment (M � 8.61–12.27, SD � 8.74 –10.95). At diagnosis/relapse, 11\% T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. 92 HOWARD SHARP ET AL. (n � 35) of mothers reported BDI-II scores in the severe range, and 18\% (n � 57) reported scores in the moderate range. At 1-year follow-up, 7\% (n � 16) reported scores in the severe range, and 16\% (n � 35) reported scores in the moderate range. At 3-years postdiagnosis/relapse, 5\% (n � 5) reported scores in the severe range, and 10\% (n � 11) reported scores in the moderate range. At 5-years postdiagnosis/relapse, 6\% (n � 6) reported scores in the severe range, and 3\% (n � 3) reported scores in the moderate range. Depression symptoms were negatively correlated with primary and secondary control coping and positively correlated with dis- engagement coping and perceived stress (see Table 2). Spirituality was significantly correlated with depression symptoms at diagno- sis/relapse and 1 year, but not at 3 or 5 years. Coping variables were associated with perceived stress and spirituality in expected directions, and coping factors were highly intercorrelated. Toler- ance (all �.47) and the variance inflation factor (VIF; all �2.12) suggest minimal multicollinearity despite … Are We Accurately Evaluating Depression in Patients With Cancer? Rebecca M. Saracino Memorial Sloan Kettering Cancer Center, New York, New York, and Fordham University Ezgi Aytürk and Heining Cham Fordham University Barry Rosenfeld Memorial Sloan Kettering Cancer Center, New York, New York, and Fordham University Leah M. Feuerstahler Fordham University Christian J. Nelson Memorial Sloan Kettering Cancer Center, New York, New York Depression remains poorly managed in oncology, in part because of the difficulty of reliably screening and assessing for depression in the context of medical illness. Whether somatic items really skew the ability to identify “true” depression, or represent meaningful indicators of depression, remains to be determined. This study utilized item response theory (IRT) to compare the performance of traditional depression criteria with Endicott’s substitutive criteria (ESC; tearfulness or depressed appearance; social withdrawal; brooding; cannot be cheered up). The Patient Health Questionnaire (PHQ-9), ESC, and Center for Epidemiologic Studies Depression Scale (CES-D) were administered to 558 outpatients with cancer. IRT models were utilized to evaluate global and item fit for traditional PHQ-9 items compared with a modified version replacing the 4 somatic items with ESC. The modified PHQ-9 ESC scale was the best fit using a partial credit model; model fit was improved after collapsing the middle 2 response categories and removing psychomotor agitation/retardation. This improved model showed satisfactory scale precision and internal consistency, and was free from differential item functioning for gender, age, and race. Concurrent and criterion validity were supported. Thus, as many have speculated, utilizing the ESC may result in more accurate identification of depressive symptoms in oncology. Depressed mood, anhedonia, and suicidal ideation retained their expected properties in the modified scale, indicating that the traditional underlying syndrome of depression likely remains the same, but the ESC may provide more specificity when assessing patients with cancer. Public Significance Statement Alternative approaches to assessing depression in patients with cancer may be more accurate than current approaches, which rely heavily on physical symptoms. An improved approach might eliminate physical symptoms and focus more on emotional symptoms. Keywords: depression, diagnostic criteria, oncology, IRT, screening Supplemental materials: http://dx.doi.org/10.1037/pas0000765.supp Accurate assessment of depression in patients with medical illness is critically important, as those with comorbid mood disorders are at significantly greater risk for nonadherence to medical treatments and premature mortality (DiMatteo, Lepper, & Croghan, 2000; Misono, Weiss, Fann, Redman, & Yueh, 2008). Historically, clinicians and researchers have debated whether or not the reliance on somatic This article was published Online First August 8, 2019. X Rebecca M. Saracino, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, and Department of Psychology, Fordham University; Ezgi Aytürk and Heining Cham, Department of Psychology, Fordham University; Barry Rosenfeld, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, and Department of Psychology, Fordham University; X Leah M. Feuerstahler, Department of Psychology, Fordham University; Christian J. Nelson, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center. This research was supported by funding from the National Institutes of Health (T32CA009461 and P30CA008748). Correspondence concerning this article should be addressed to Rebecca M. Saracino, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, 7th Floor, New York, NY 10022. E-mail: [email protected] T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. Psychological Assessment © 2019 American Psychological Association 2020, Vol. 32, No. 1, 98 –107 ISSN: 1040-3590 http://dx.doi.org/10.1037/pas0000765 98 items when rendering a depression diagnosis inappropriately in- flates the prevalence of depressive disorders among the medically ill, especially in oncology settings (Jones et al., 2015; Krebber et al., 2014; Saracino, Rosenfeld, & Nelson, 2018). Somatic items (i.e., sleep disturbance, fatigue, appetite changes, diminished con- centration) may reflect side effects of treatment or the pathology of the underlying illness itself. Despite this concern, the Patient Health Questionnaire-9 item (PHQ-9; Kroenke & Spitzer, 2002), which relies exclusively on Diagnostic and Statistical Manual of Mental Disorders criteria, remains one of the most widely utilized depression screening measures across medical settings (e.g., pri- mary care, oncology, cardiovascular disease; Dyer, Williams, Bombardier, Vannoy, & Fann, 2016; Forkmann, Gauggel, Span- genberg, Brähler, & Glaesmer, 2013; Gothwal, Bagga, & Suma- lini, 2014; Kendel et al., 2010; Pedersen, Mathiasen, Christensen, & Makransky, 2016; Williams et al., 2009). The PHQ-9 consists of nine items, each of which corresponds to one of the nine symptoms required for a diagnosis of a major depressive disorder (MDD) as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM; American Psychi- atric Association, 2013). Respondents are asked to rate how often they have been bothered by each of the nine symptoms over the preceding 2 weeks. Respondents rate each item on a 4-point scale (0 � not at all, 1 � several days, 2 � more than half the days, 3 � nearly every day). Due to its popularity, a handful of studies have used item response theory (IRT) to examine the PHQ-9 in samples of medical patients (Dyer et al., 2016; Forkmann et al., 2013; Gothwal et al., 2014; Kendel et al., 2010; Pedersen et al., 2016; Williams et al., 2009). For example, Kendel et al. (2010) observed that among 1,271 patients undergoing coronary artery bypass graft surgery, most of the somatic items on the PHQ-9 did not meet criteria for a good overall model fit (i.e., according to fit statistics). Instead, they found that six out of seven items on the Hospital Anxiety and Depression Scale Depression subscale (HADS-D; Zigmond & Snaith, 1983), which rely entirely on cognitive and affective symptoms, and the two PHQ-9 items reflecting the DSM gateway symptoms of MDD (i.e., depressed mood and anhedonia) plus fatigue, were the strongest indicators of the underlying con- struct. They also identified differential item functioning (DIF) across genders on two PHQ-9 items; women were more likely than men to endorse depressed mood and fatigue conditional on the latent trait. In theory, DIF is an undesirable property of an item, as it indicates that respondents from different groups (e.g., males and females) with the same level of the latent trait have different probabilities of endorsing an item (Holland & Wainer, 1993). A study of 1,531 patients with heart disease and implantable cardioverter defibrillators identified PHQ-9 items reflecting de- pressed mood, feeling bad about yourself or that you are a failure, and suicidal ideation, as being the best items for discriminating individuals with higher and lower levels of depression (Pedersen et al., 2016). They also found significant DIF for gender for the depressed mood item, such that women were more likely than men to endorse this item at the same underlying level of depression. Additionally, overall model fit was substantially improved after collapsing the two middle response options (several days and more than half the days) in the 4-point scale, indicating that these two response options were not meaningfully distinguished from one another. Another study of 100 adults with a history of traumatic brain injury demonstrated similar findings, as all PHQ-9 items demonstrated good fit when the two intermediate response cate- gories were collapsed (Dyer et al., 2016). Thus, regardless of the relative performance of individual items across clinical samples, a collapsed, three response option format may be most suitable for the PHQ-9. In oncology settings, alternative approaches to depression as- sessment have been proposed (e.g., Cavanaugh, 1995; Endicott, 1984) in order to increase the specificity of depression screening measures and decrease the potential overinclusivity of the criteria used by the DSM. The most widely recognized of these approaches are the substitutive criteria proposed by Endicott (1984; ESC), who recommended replacing the four somatic symptoms with four alternative symptoms: tearfulness or depressed appearance in face or body posture; social withdrawal or decreased talkativeness; brooding, self-pity, or pessimism; and cannot be cheered up, doesn’t smile, no response to good news or funny situations. Although widely cited, there is a dearth of published research that has systematically evaluated this proposal. Only one prior study has utilized IRT to compare the perfor- mance of traditional DSM criteria with the Endicott substitutive approach, using a structured clinical interview to rate each of the criteria under investigation. Akechi et al. (2009) examined the utility of the DSM–IV criteria for MDD, along with the Endicott’s substitutive criteria and those proposed by Ca- vanaugh (1995), who recommended replacing the four DSM somatic items with two behavioral criteria: “not participating in medical treatment in spite of ability to do so” and “functioning at a lower level than medical condition warrants or failure to progress in recovery despite improved medical condition.” In a sample of 728 cancer patients diagnosed with depression (based on DSM–IV criteria), these authors found that the Endicott and Cavanaugh’s criteria were among the symptoms with the most utility in assessing depression across the spectrum of severity. Endicott’s “tearfulness or depressed appearance” and “brood- ing, self-pity, or pessimism” were particularly good indicators of mild depression, while “not participating in medical care” (Cavanaugh) and “social withdrawal” (Endicott) were good indicators of moderate to severe depression. For patients with severe depression, Endicott’s “cannot be cheered up . . .” symptom was the most salient indicator. Although none of the DSM–IV criteria had a high ability to discriminate between individuals with more or less severe depression in this sample, this finding may have been impacted by their study methodol- ogy, because they included only patients that met DSM criteria for MDD (thereby reducing the variability in the DSM–IV symptoms). Nevertheless, the authors suggested that the sub- stitutive criteria proposed by Endicott and Cavanaugh are prom- ising, given their apparent utility in discriminating depressive symptom severity. In addition to a restricted symptom range due to inclusion criteria, this study also relied on clinician interview, which is a costly and unrealistic approach to depres- sion screening, particularly in busy oncology settings in which clinicians do not have the training nor the time to conduct psychiatric diagnostic interviews. Despite its popularity, no studies to date have utilized IRT to examine the PHQ-9 in patients with cancer, nor have these methods been extended to study the Endicott’s substitutive criteria in a self-report format. Cancer and its treatment have unique disease sequelae and treatment side effects that are not T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. 99DEPRESSION EVALUATION IN CANCER necessarily as salient in other medical conditions such as heart disease or brain injury. While fatigue may be cross-cutting, symptoms such as appetite, concentration, and sleep distur- bances are particularly salient in oncology (Akechi et al., 2003). Given its wide popularity and development for specific use in oncology, the present study focused on the classic symptoms of MDD and Endicott’s criteria only; the alternative symptoms proposed by Cavanaugh were not included in the current study as they were developed for general medical settings, not spe- cifically for use with cancer patients. While depression screen- ing measures can identify general distress, dysphoria, and sub- syndromal depression (in addition to MDD), the goal of the current study was to evaluate the DSM criteria for MDD (via the PHQ-9) and the Endicott’s substitutive criteria as a first step toward further psychometric validation of the substitutive ap- proach. The present study searched for the best-fitting measure- ment structure for the 13 items (nine DSM criteria plus four Endicott’s substitutive criteria items) using several IRT models. Differential item functioning (DIF) of the selected measurement structure was also tested across gender (males vs. females), age (40 – 69 years old vs. 70 or above), and racial groups (non- Hispanic White participants vs. ethnic minority participants), as well as precision and internal consistency of scale scores and concurrent validity of score interpretations. Method Participants and Procedure Participants were recruited from outpatient clinics at Memorial Sloan Kettering Cancer Center (MSK) between January 2016 and May 2016. To be eligible for participation, patients had to be 40 years or older,1 fluent in English, and have a cancer diagnosis. Patients were approached by trained research personnel while awaiting routine clinic appointments; those who were eligible were informed of the study procedures, risks, and benefits, and invited to participate. The study was approved by the MSK and Fordham University Institutional Review Boards. Measures All participants completed a packet of questionnaires in a fixed order, including the Patient Health Questionnaire-9 (PHQ-9) and four items assessing the Endicott criteria. Table 1 presents the PHQ-9 items and Endicott’s substitutive criteria (ESC) items, along with the percentage endorsing each response option. As noted above, respondents were asked to rate how often they have been bothered by the symptoms described by the items over the last 2 weeks on a 4-point scale (0 � not at all, 1 � several days, 2 � more than half the days, 3 � nearly every day). Endicott (1984) proposed four alternative symptoms (tearfulness or de- pressed appearance in face or body posture; social withdrawal or decreased talkativeness; brooding, self-pity, or pessimism; and cannot be cheered up, doesn’t smile, no response to good news or funny situations) as substitutes for four DSM symptoms that are most commonly confounded by medical illness (sleep disturbance, fatigue, appetite changes, diminished concentration). These four items were assessed using the same instructions and response scale as PHQ-9 items. Participants were also administered the Center for Epidemio- logic Studies Depression Scale (CES-D; Radloff, 1977), a self- report measure of 20 depressive symptoms. Past research indicates acceptable psychometric properties and has supported a four-factor structure: depressed affect, positive affect, somatic complaints, and interpersonal problems (Nelson, Cho, Berk, Holland, & Roth, 2010; Saracino, Cham, Rosenfeld, & Nelson, 2018; Vodermaier, Linden, & Siu, 2009). The CES-D was used to examine the concurrent validity of PHQ-9 and ESC item scores; it was not included in IRT analyses as the primary focus was on approximat- ing DSM criteria for MDD, which are more directly assessed by the PHQ-9. Sociodemographic and medical data were also col- lected by participant self-report. Data Analyses Missing data analysis. A total of 663 patients completed the study questionnaires. Missing data rates for the PHQ-9 and ESC items were low (M � 7.2\%, range: 6.5\% to 7.7\%). The differences between the sample with complete data (N � 558) and those with missing observations were small in effect sizes (all Cohen’s d � .29 and W � .15; Cohen, 1988) across sociodemographic and medical data, indicating that listwise deletion was appropriate to handle cases with the missing values. IRT analysis. Following prior studies (e.g., Dyer et al., 2016; Forkmann et al., 2013; Gothwal et al., 2014; Kendel et al., 2010; Lamoureux et al., 2009; Pedersen et al., 2016; Williams et al., 2009), two polytomous Rasch models were used: the partial credit model (PCM; Masters, 1982) and the rating scale model (RSM; Andrich, 1978). Two polytomous non-Rasch models were also analyzed: the generalized partial credit model (GPCM; Muraki, 1992) and graded response model (GRM; Samejima, 1969). Rasch models (PCM and RSM) use observed item response patterns to estimate a person’s ability (in this case, depression severity) and an item’s difficulty (depression level that the item represents) on a continuous latent variable (depression). It models the probability of a given response as a logistic function of the difference between a person’s ability and item difficulty (Andrich, 1978). With di- chotomous data (e.g., yes/no or correct/incorrect), the higher the person’s ability relative to the item difficulty, the more likely a person is to endorse the item. With polytomous data, Rasch models estimate the response category threshold parameters. Category thresholds refer to the point where the probability of choosing either one of two adjacent response options (e.g., “not at all” vs. “several days”) is equal. RSM is the simplest (most constrained) polytomous Rasch model which assumes equal category thresh- olds across all items of a given scale and estimates a difficulty parameter for each item. The PCM is more relaxed than RSM as it estimates separate item thresholds for each item. However, both models assume the same discrimination for all items (i.e., the degree to which an item differentiates people with different depression levels). In these two models, average or sum scores 1 Age 40 was selected as the inclusion criteria cut-off in order to differentiate the sample from what the National Comprehensive Cancer Network (Coccia et al., 2018) operationalized as “adolescent and young adult,” which refers to patients from 15 to 39 years of age. This age group was selected as the primary purpose was to examine depression assessment in adults. T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. 100 SARACINO ET AL. of the items can be used as the overall scale score. The GPCM and GRM differ from the polytomous Rasch models in that they estimate different discrimination parameters for each item (the degree to which an item differentiates people with different depression levels). Because the items can have different dis- criminating power in GPCM and GRM, both models require specialized algorithms to computing the scale scores. Unlike the GPCM, the GRM estimates the probability of choosing a par- ticular response category or above, but assumes that the item category thresholds are always ordered. Three indices of model fit criteria were used to select the best-fitting model(s): (a) C2 goodness-of-fit test statistic (Cai & Monroe, 2014; Maydeu-Olivares & Joe, 2006); (b) Akaike Infor- mation Criterion (AIC; small value indicates better model fit); and (c) Bayesian Information Criterion (BIC; small value indicates better model fit). The unidimensional structure was first tested with PHQ-9 items only (termed PHQ-9-Original) and then a uni- dimensional structure with the four PHQ-9 items (sleep distur- bances, fatigue, appetite changes, trouble concentrating) substi- tuted by the ESC items (termed PHQ-9-Substitutive). Both measurement structures were tested with the PCM, RSM, GPCM, and GRM models. Based on the results of these analyses, the models were modified by collapsing the response options of the items and removing items that negatively impacted model fit (described in more detail below). DIF analysis. After deciding on the optimal measurement structure for the IRT analysis, the simultaneous item bias test (SIBTEST; Shealy & Stout, 1993) was used to examine if there was differential functioning of PHQ-9 and Endicott items across gender (males: n � 288 vs. females: n � 270), age (younger: 40 – 69 years old; n � 380 vs. older: 70 or above; n � 178), and racial groups (non-Hispanic White: n � 455 vs. ethnic minority participants: n � 103). Age 70 was used to bifurcate the sample as patients with cancer who are over 70-years-old have been shown to experience significantly more medical comorbidity that those younger than 70 (Bluethmann, Mariotto, & Rowland, 2016). Both uniform DIF and nonuniform DIF were tested with one crossing point (Chalmers, 2018; Li & Stout, 1996). The SIBTEST estimates a standardized mean difference (�) capturing the group differences in correct response probabilities (� � 0 indicates no DIF) and provides a significance test to determine if � is significantly different from zero. � values between zero and .05 are considered small DIF, between .05 and .1 are considered moderate DIF, and .1 or above are considered large DIF (Shealy & Stout, 1993). To avoid inflated Type I error rate due to multiple testing of � for each item, Holm’s (1979) procedure was used to adjust p values (Kim & Oshima, 2013). Validity analysis. The proportion of participants who ob- tained the lowest possible scale score on the PHQ-9-Original and on the selected substitutive measurement structure was calculated. It was expected that there would be a higher proportion of patients with a scale score of zero in the selected substitutive structure. To examine the convergent and discriminant validity of the selected substitutive structure and compare the relative differences between the selected substitutive structure and PHQ-9-Original, we calcu- lated the correlations between the scale scores of the selected substitutive structure, PHQ-9-Original, and the CES-D total score and factors (depressed affect, positive affect, somatic complaints, and interpersonal problems). It was expected that there would be larger correlations between the selected substitutive structure and the CES-D depressed affect factor and total scores, because the depressed affect factor is most closely aligned with the affective DSM criteria. Finally, participants who reported receiving treat- ment for depression and those who did not were compared on the scale scores of the selected substitutive structure and PHQ-9- Original. It was anticipated that the difference between the two groups would be larger on the selected substitutive structure than the PHQ-9-Original. All IRT and DIF analyses (except for person separation reliabil- ity; described in more detail below) were conducted using the R mirt package (Version 1.29; Chalmers, 2012). Person separation reliability indices were calculated using the R eRm package (Ver- sion 0.16 –1; Mair & Hatzinger, 2007). Table 1 Percentage (\%) of Response Options of PHQ-9 and Endicott’s Substitutive Criteria Items Abbreviated item label Percentage (\%) endorsing response option Not at all (0) Several days (1) More than half the days (2) Nearly every day (3) Patient Health Questionnaire-9 Item (PHQ-9) 1. Anhedonia 64.0 21.5 9.1 5.4 2. Depressed mood 63.8 26.0 6.4 3.8 3. Sleep disturbances 44.8 28.7 14.0 12.5 4. Fatigue 32.4 37.5 15.4 14.7 5. Appetite changes 58.6 22.6 10.2 8.6 6. Feeling bad about yourself 77.8 14.9 4.8 2.5 7. Trouble concentrating 65.1 23.7 6.4 4.8 8. Psychomotor agitation and retardation 80.3 10.9 5.9 2.9 9. Suicidal ideation 92.6 6.3 .9 .2 Endicott’s substitutive criteria 1. Socially withdrawn 75.1 16.5 5.0 3.4 2. Tearfulness 78.1 14.7 5.0 2.2 3. Brooding 71.1 21.0 4.7 3.2 4. Could not be cheered up 82.8 12.2 3.9 1.1 T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. 101DEPRESSION EVALUATION IN CANCER Results Participant Characteristics The sample (N � 558) was approximately evenly split by gender (51.6\% male; n � 288) and ranged in age from 40 to 90 years or older2 (M � 64.7, SD � 10.3; see Table 2). Most participants were White (87.6\%; n � 489; including n � 455 non-Hispanic and n � 34 Hispanic), married or living with a partner (70.6\%; n � 394), and had a college and/or graduate education (70.4\%; n � 393). The most common cancer diagnoses were gynecological (16.8\%; n � 94), lung (15.2\%; n � 85), and prostate (13.1\%; n � 73). Over one third of participants reported Stage IV disease (37.5\%; n � 209). The majority of participants had received active cancer treatment within the preceding 6 months (71.3\%; n � 398). Initial Analysis of Unidimensionality Confirmatory factor analysis (CFA) was conducted to test the unidimensionality of the PHQ-9-Original and PHQ-9-Substitutive. Models were estimated using polychoric correlations and diago- nally weighted least squares estimation via the R lavaan package (Rosseel, 2012). A full report of the results can be found in the online supplementary materials. The comparative fit index (CFI) and Tucker-Lewis index (TLI) suggested good model fit of both the PHQ-9-Original and PHQ-9-Substitutive (all values � .99); however, the PHQ-9-Original had slightly worse RMSEA than PHQ-9-Substitutive (i.e., .066 vs. .028, respectively). Taken to- gether, these model fit indices suggest that both PHQ-9-Original and PHQ-9-Substitutive were sufficiently unidimensional for IRT analysis. IRT Analysis All the IRT models (PCM, RSM, GPCM, GRM) converged properly in the PHQ-9-Original and PHQ-9-Substitutive measure- ment structures. Panels A and B in Table 3 present the global model fit results for the IRT models of the two structures. Com- pared with PHQ-9-Original, the PHQ-9-Substitutive structure had a better model fit in terms of AIC and BIC across all four IRT models. Therefore, the remaining analyses used only the PHQ-9- Substitutive structure. However, the PHQ-9-Subsitutive structure generated a significant C2 test statistic (ps � .001) for all four models, indicating that none of the models fit the data well. Since the more complex GPCM and GRM did not fit better than PCM and RSM, they were not considered further.3 Next, the item fit of the PCM and RSM were compared using the PHQ-9-Substitutive structure using: (a) S-�2 item fit test sta- tistic (Kang & Chen, 2008; Orlando & Thissen, 2000); and (b) item infit (information weighted mean square), where a value of 1.0 indicates perfect fit and values between 0.7 and 1.3 are con- sidered acceptable fit (Wright & Linacre, 1994). Results showed that Item 8 on the PHQ-9 (“moving or speaking so slowly that other people could have noticed or the opposite— being so fidgety or restless that you have been moving a lot more than usual”) was the only item that showed both significant S-�2 test statistics, PCM: S-�2(df � 22) � 39.63, p � .01; RSM: S-�2(df � 23) � 45.37, p � .004, as well as infit values beyond the acceptable range (PCM: 1.45; RSM: 1.57). Following Forkmann et al. (2013) and Kendel et al. (2010), this item was removed from PHQ-9- Substitutive structure and the PCM and RSM models were fit again to this new structure (termed PHQ-8-Substitutive).4 In PHQ-8-Substitutive, the PCM had a significant C2 test sta- tistic, C2(df � 27) � 46.7, p � .01, while RSM did not, C2(df � 2 Due to HIPPA protection participants who were 90 years or older (n � 2) checked a box indicating they were in this age range. 3 GPCM and GRM results for all steps are available upon request. 4 Analysis of the PCM threshold parameter estimates and item response curves of this item in PHQ-9-Substitutive supported this decision (avail- able upon request). Table 2 Demographic Characteristics Demographic Frequency \% Gender Male 288 48.4 Female 270 51.6 Race White 489 87.6 African American 29 5.2 Asian or Pacific Islander 21 3.8 Other 19 3.4 Ethnicity Hispanic 48 8.6 Not Hispanic 510 91.4 Marital status Single (never married) 40 7.2 Married/living with partner 394 70.6 Divorced/separated 75 13.4 Widowed 49 8.8 Education Did not … ORIGINAL ARTICLE Hospital Anxiety and Depression Scale (HADS) accuracy in cancer patients Maria Antonietta Annunziata1 & Barbara Muzzatti1 & Ettore Bidoli2 & Cristiana Flaiban1 & Francesca Bomben1 & Marika Piccinin1 & Katiuscia Maria Gipponi1 & Giulia Mariutti1 & Sara Busato1 & Sara Mella1 Received: 5 April 2019 /Accepted: 11 December 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract Purpose The Hospital Anxiety and Depression Scale (HADS) is a self-report questionnaire designed to screen anxious and depressive states in patients in non-psychiatric settings. In spite of its large use, no agreement exists in literature on HADS accuracy in case finding. The present research addresses the issue of HADS accuracy in cancer patients, comparing its two subscales (HADS-A and HADS-D) against tools not in use in psychiatry, which are able to detect prolonged negative emotional states. Methods 2121 consecutive adult cancer inpatients were administered the HADS together with the State Anxiety subscale of State-Trait Anxiety Inventory and the Center for Epidemiologic Studies Scale on Depression. Receiver operating characteristic (ROC) curves were computed to identify a cut-off for anxious and depressive states in cancer patients. All indicators were computed together with their corresponding 95\% confidence interval (95\% CI). Results Data of 1628 and 1035 participants were used to assess the accuracy in case finding of HADS-A and HADS-D, respectively. According to the ROC analysis, the optimal cut-off was > 9 units for the HADS-A and > 7 units for the HADS- D. The area under the ROC curve was 0.90 for HADS-A (95\% CI 0.88–0.91) and 0.84 for HADS-D (95\% CI 0.81–0.86). Conclusions This study suggested that risk scores of anxious and depressive states above specific HADS cut-offs are useful in identifying anxious and depressive states in cancer patients, and they may thus be applicable in clinical practice. Keywords Accuracy . Cancer . Hospital Anxiety and Depression Scale . Oncology . Psychometrics . Receiver operating characteristic curve Introduction The Hospital Anxiety and Depression Scale (HADS) [1–3] is a well-known emotional distress self-report questionnaire, and it is one of the most frequently used in oncology [4–6] as well as in other physical health settings (e.g., cardiology, brain injury, general medicine). Originally, it was designed to screen emotional suffering of patients in non-psychiatric settings by detecting the two most frequent distress components: anxiety and depression. Since it is specific to patients with organic diseases, HADS excludes somatic symptoms of emotional distress (e.g., headache, weight loss, insomnia) that could be caused by the illness itself (including its treatments) rather than being emotional distress expressions [1, 2, 4, 5]. Furthermore, to improve sensitivity to medical conditions, severely psychopathological symptoms are not covered by HADS [1, 2, 4]. Thus, HADS is a measure of prolonged state rather than trait [4], and it is not recommended in detecting psychopathological disorders. In spite of this, no agreement exists in literature on HADS accuracy in case finding [7–9] also because of the large range of cut-off rankings used by different authors [6, 7, 9]. In 2011, Vodermaier and Millman [10] conducted a meta-analysis to identify optimal, empirically derived HADS thresholds for clinical decision-making. Analyzing data from 28 different studies comparing HADS (entirely and/or in its subscales) against a semi-structured or structured clinical interview as a Maria Antonietta Annunziata and Barbara Muzzatti should be considered joint first author. * Maria Antonietta Annunziata [email protected] 1 Unit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081 Aviano, PN, Italy 2 Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy https://doi.org/10.1007/s00520-019-05244-8 / Published online: 19 December 2019 Supportive Care in Cancer (2020) 28:3921–3926 reference standard, they provided the most accurate (i.e., those with best sensitivity and specificity) HADS cut-offs for any mental disorder and depressive disorder alone. The present research also addresses the issue of HADS accuracy, though with an approach that differs from those applied to previously published studies [7–10]. In fact, since HADS is considered inadequate as screening tool for diagnos- tic purposes in psychopathology, we compared it against other (validated but lengthy and time-consuming administration) screening tools able to detect prolonged negative emotional states rather than against psychiatric assessment tools. Moreover, since a previously published study [11], conducted in a similar setting and on a large sample like the present one, suggested to use HADS as a measure of anxious and depres- sive states rather than as a global measure of emotional dis- tress, we tested the accuracy of the two HADS subscales against two different gold standard tools (one able to detect anxious states, the other able to detect depressive states). Methods Participants Study participants were consecutive adult cancer inpatients, admitted to the same cancer institute for cancer treatments. The eligibility criteria were the following: age ≥ 18 years old; good understanding of the Italian language; absence of mental disorders; absence of physical or sensory disabilities that would interfere with completing the questionnaires; and signed informed consent form. Materials and procedure The HADS together with the State Anxiety (Anxiety-S) sub- scale of the State-Trait Anxiety Inventory, Form Y (STAI-Y) [12], and the Center for Epidemiologic Studies Scale on Depression (CES-D) [13] were used in this study. HADS consists of two subscales: HADS-A, designed to detect anxious states, and HADS-D, designed to detect depressive states. Each subscale consists of seven items with a 4-point ordinal response format. Scores ranges from 0 to 21 in each subscale, with higher scores indicating higher levels of anxious or depressive state. Participants answer each item thinking of how they felt and/or behaved during the past week. The STAI-Y is a questionnaire widely used to assess anxiety in its trait and state components. Spielberger val- idated the Italian version [14–16]. STAI-Y consists of 40 items (20 for trait anxiety and 20 for state anxiety), which participants rate on a 4-point scale. Scores range from 20 to 80 for each scale (i.e., trait anxiety and state anxiety), with higher scores indicating higher levels of state and trait anxiety. In this study, only state subscale (STAI-S) was administered and participants were requested to an- swer each item thinking of how they felt and/or behaved during the past week. Since it registers anxious states rather than general anxiety disorder (or other psychopath- ological disturbances), STAI-S was chosen as gold stan- dard for HADS-A.STAI-S scores over 1.5 standard devi- ation of the normative sample (depending on gender and age) in the Italian manual [14], which were used to dis- tinguish participants with anxious state from participants without anxious state. Since a hospital stay may induce, per sè, an anxiety state, we decided to raise the cut-off from one standard deviation to 1.5, over the normative score; concurrently, we fixed it a 1.5 standard deviation rather than at 2 standard deviations over the normative score to reduce false negatives. The CES-D is a measure of depressive symptomatology that consists of 20 items, which participants rate on a 4-point scale, thinking of how they felt and/or behaved during the past week. The results are graded on a 0–60-point scale and are proportional to depressive state intensity. Italian validation data were provided by Pierfederici et al. [17] and Fava [18] for both the general population and general hospital inpatients. Since it was developed to screen for depression in the general population (therefore, primarily focused on depression affec- tive components, such as depressed mood and feelings of helplessness), and since it has adequate psychometric proper- ties and has been widely used as screening tool in oncology [6, 19], CES-D was chosen as gold standard for HADS-D. According to a previous research on depression in general hospital inpatients [17], cut-off of 28+ was used to distinguish participants in a depressive state from participants who were not. Potential participants were selected by consulting clinical files. The three above-mentioned tools, together with the in- formed consent form to participate in the study, were illustrat- ed to each eligible participant by a psychologist. The forms were autonomously filled out by participants in one occasion and subsequently they were collected by the psychologist who also debriefed the participants. Participants’ socio- demographic and clinical data were collected by the psychol- ogist consulting clinical files. All participants gave their informed consent for inclusion before they participated in the study. The study was conducted in accordance with the Declaration of Helsinki, and the pro- tocol was approved by the Ethics Committee of the Centro di Riferimento Oncologico di Aviano (CRO) IRCCS (CRO- 2011-27). Sample size For HADS-A, we estimated the minimum sample size by assuming the following parameters: a type I error of 5\%; a 3922 Support Care Cancer (2020) 28:3921–3926 power of 90\%; a hypothesized AUC of 0.8 for HADS-A; a null hypothesis AUC of 0.7 for STAI-Y; and a ratio of positive/negative patients of 1. The number of participants required was 290 (145 cases and 145 controls). For HADS- D, we estimated the minimum sample size by assuming the following parameters: a type I error of 5\%; a power of 90\%; a hypothesized AUC of 0.8 for HADS-D; a null hypothesis AUC of 0.7 for CES-D; and a ratio of positive/negative pa- tients of 1. The number of participants required was 290 (145 cases and 145 controls) [20]. A quota sampling method was used to gather the necessary number of cases. All consecutive inpatients filled in the STAI- Y and CES-D questionnaires in order to be classified as cases or non-cases. Due to the sampling method used and the rela- tively low number of detected cases by means of the two gold standard tests, an elevated number of controls were detected until the required number of cases was obtained. Thus, the final sample consisted of a number of non-cases higher than expected. According to this final sample size and to the ratio of positive/negative patients observed, we recomputed the power of the analysis a posteriori. The power was 99\%, with a type I error of 1\%, for HADS-A, and 98\%, with a type I error of 1\%, for HADS-D. Consequently, the power of the analysis was higher than initially declared by the sample size computation. Statistical analyses The ability of HADS-A and HADS-D to discriminate cancer patients with or without respectively anxious or depressive state was made by means of receiver operator characteristic (ROC) curves [21]. The following indicators were calculated: area under the curve (AUC), sensitivity and specificity, with their corresponding 95\% confidence interval (95\% CI). The Youden index was also calculated and, in conjunction with the ROC curve, allowed to select the optimal cut-off for each test [20]. In particular, the optimal cut-off of HADS-A and the optimal cut-off of HADS-D, located in the most superior top-left point on the ROC curve, were derived in each curve from the point with the maximum Youden index that repre- sented the maximized sensitivity and specificity [20]. All tests were two-tailed and a p value < 0.05 was considered statisti- cally significant. The statistical analyses were performed using the SAS language program (Version 9.4, SAS Institute Inc., Cary, NC). Results To reach the necessary sample size, we recruited 2121 inpa- tients, of whom 1628 (76.8\%) provided complete subscale HADS-A and STAI-S (necessary to verify the accuracy of HADS_A) and 1035 (48.8\%) provided complete both HADS-D and CES-D (necessary to verify the accuracy of HADS-D). Table 1 summarizes the main socio-demographic and clinical characteristics of the final sample. HADS-A accuracy in case finding The performance of HADS-A scores was evaluated according to ROC curves. The optimal cut-off value of the HADS-Awas > 9 units (Fig. 1). The AUC was 0.90 (95\% CI 0.88–0.91), p value<0.001, with a sensitivity of 83.2\% (95\% CI 76.6–88.5) and a specificity of 80.5\% (95\% CI 78.4–82.5). When considering a cut-off value > 9 units of the HADS-A subscale, 423 participants (26\% for the whole sample) result- ed to be in the anxious state (see Table 2). HADS-D accuracy in case finding The performance of HADS-D was evaluated according to ROC curves. The optimal cut-off value of the HADS-D was > 7 units (Fig. 2). The AUC was 0.84 (95\% CI 0.81–0.86), p value < 0.001, with a sensitivity of 72.9\% (95\% CI 64.9–80.0) and a specificity of 79.0\% (95\% CI 76.2–81.6). When considering a cut-off value > 7 units of the HADS-D subscale, 292 participants (28.2\% of the whole sample) result- ed to be in the depressive state (see Table 2). Discussion HADS seems to be the tool of choice for detecting negative emotional states in cancer patients, thanks to its features (i.e., specific of medical settings; good psychometric properties; brief; rapid administration; and good compliance) [1–6]. Although it is necessary to identify the optimal thresholds to differentiate cases from non-cases (accuracy) for the HADS reliable and valid use in both clinical practice and research, no agreement exists in literature on this issue. The present work contributes to define HADS accuracy in case finding. However, it addresses this issue in an original manner, i.e., by comparing it against other already validated screening tools able to detect prolonged negative emotional states rather than against psychiatric assessment tools useful in psychopathological diagnosis. According to the present results, the optimal cut-off values were > 9 units for the HADS-A and > 7 units for the HADS-D. These thresholds are different from the cut- off provided for HADS in previous literature [6–10]. These dissimilarities find an explanation in the different psycho- logical constructs (emotional states vs. psychopathological disorders) assessed by the tools used as reference standard. For both established thresholds, sensibility and specificity were adequate. Indeed, given that HADS is an emotional state screening tool rather than a diagnostic one, a higher 3923Support Care Cancer (2020) 28:3921–3926 number of false positives (i.e., lower specificity) is accept- able and finds its balance in a well-recognized feasibility. In other words, with respect to the two employed gold standard tools (STAI-S e CES-D), the HADS subscales, anxiety, and depression, induce additional false positives, but they are quicker in terms of administration and scoring, more appropriate to capture patients emotional states in medical settings, as a consequence they can be usefully employed to detect anxious and depressive states in oncol- ogy settings. The employment of gold standard tools developed to detect emotional states, rather than gold standard psychiatric diagnostic tools, as well as the rigorous data analysis proce- dure and the adequate statistical power represent the major strengths of this study. Furthermore, our findings are easily reproducible as they were obtained in a non-selected consec- utive population of cancer inpatients. Mental disorders (i.e., documented presence and/or history of a psychiatric syn- drome) were an exclusion criterion for the present study to avoid their possible confusing role on detecting prolonged negative emotional states associated with cancer and its treatments. A potential study limitation may consist of the non- negligible percentage of the enrolled sample that had provided Table 1 Socio-demographic and clinical characteristics of sub- samples used to test HADS-A accuracy (N = 1628), and HADS- D accuracy (N = 1035) HADS-A accuracy test (N = 1628) HADS-D accuracy test (N = 1035) N \% N \% Gender Male 460 28.3 294 28.4 Female 1168 71.7 741 71.6 Education Compulsory 642 39.4 418 40.4 Secondary 756 46.4 476 46.0 Post-secondary 230 14.1 141 13.6 Occupational status Employed 919 56.4 584 56.4 Unemployed/homemaker/student 599 36.8 383 37.0 Missing datum 110 6.8 68 6.6 Marital status Partnered 1234 75.8 788 76.1 Non-partnered 393 24.1 247 23.9 Missing datum 1 0.1 0 – Cancer diagnosis Oro-pharyngeal 47 2.9 32 3.1 Digestive apparatus 246 15.1 126 12.2 Respiratory system and intrathoracic organs 65 4.1 55 5.3 Breast 520 31.9 329 31.8 Genito-urinary 391 24.0 265 25.6 Hematologic 204 12.5 134 12.9 Others 155 9.5 94 9.1 Anxious state (STAI-Y) Non-case 1462 89.8 – – Case 166 10.2 – – Depressive state (CES-D) Non-case – – 891 86.1 Case – – 144 13.9 Mdn Range Mdn Range Age (years) 53 18–83 53 21–83 3924 Support Care Cancer (2020) 28:3921–3926 invalid data and were consequently dropped from the study. Unfortunately, reasons for providing incomplete or unfilled questionnaires were not recorded; consequently, no specula- tions on this point may be done. Finally, the obtained results should be considered in the light of the ongoing debate on the HADS dimensional struc- ture [5, 6, 22–25], of the related item formulation, and of the translation aspects [9, 26–28]. Concerning the dimensional aspect of the HADS, a previous study [11], conducted on a large sample with similar characteristics to the present one, has shown that the bi-factorial structure is more appropriate than the mono-factorial one [29]. The satisfactory balance between sensitivity and specificity of both HADS-A and HADS-D subscales, emerging in the present study, supports their appropriateness in terms of content validity—therefore, an adequate formulation of each single item—at least for the Italian context. Future studies mirroring the methodology herein reported, in linguistic-cultural contexts other than the Italian one and in clinical settings different from the oncologic one, will offer useful information for a further in-depth inves- tigation of this aspect. In conclusion, this study suggests that risk scores of anx- ious and depressive states above specific cut-offs derived from HADS may be useful in identifying anxious and depressive states in cancer patients during clinical practice. In oncology, emotional distress (in its main components of anxiety and depression) is expected during the entire disease trajectory. It is a source of suffering on its own, but it may also interfere with treatment adherence, as well as with both health and well-being. Its reliable and valid detection and monitoring represent the first step toward a tailored comprehensive (bio- psycho-social) care of cancer patients. Table 2 Comparison of HADS-A vs. STAI-Y (gold standard) and HADS-D vs. CES-D (gold standard) State Anxious Depressive STAI-Y (gold standard) HADS-A CES-D (gold standard) HADS-D ≤ 9 (non-cases) > 9 (cases) ≤ 7 (non-cases) > 7 (cases) non-cases 1177 285 Non-cases 704 187 Cases 28 138 Cases 39 105 Sensitivity = 83.1 (95\% confidence interval 76.6–88.5) Specificity = 80.5 (95\% confidence interval 78.4–82.5) Sensitivity = 72.9 (95\% confidence interval 64.9–80.0) Specificity = 79.0 (95\% confidence interval 76.2–81.6) Fig. 2 Receiver operative characteristic (ROC) curve, corresponding area under curve (AUC), sensitivity, and specificity of depressive state risk score for distinguishing cases from non-cases (Aviano, Italy) Fig. 1 Receiver operative characteristic (ROC) curve, corresponding area under curve (AUC), sensitivity, and specificity of anxious state risk score for distinguishing cases from non-cases (Aviano, Italy) 3925Support Care Cancer (2020) 28:3921–3926 Acknowledgments The authors wish to thank Ms. Luigina Mei for her editorial assistance. Compliance with ethical standards All participants gave their informed consent for inclusion before they participated in the study. The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of the Centro di Riferimento Oncologico di Aviano (CRO) IRCCS (CRO-2011-27). Conflict of interest The authors declare that they have no conflict of interest. References 1. Zigmond AS, Snaith RP (1983) The hospital anxiety and depres- sion scale. Acta Psychiatr Scand 67:361–370 2. Snaith RP, Zigmond AS (1994) The Hospital Anxiety and Depression Scale manual. Nelson, Windsor, NFER 3. Snaith RP (2003) The Hospital Anxiety and Depression Scale. Health Qual Life Outcomes 1:29 4. Herrmann C (1997) International experiences with the Hospital Anxiety and Depression Scale. A review of validation data and clinical results. J Psychosom Res 42:17–41 5. Bjelland I, Dahl AA, Neckelmann D (2002) The validity of the Hospital Anxiety and Depression Scale: an updated literature re- view. J Psychosom Res 52:69–77 6. Vodermaier A, Linden W, Siu C (2009) Screening for emotional distress in cancer patients: a systematic review of assessment instru- ments. J Natl Cancer Inst 101(21):1464–1488 7. Mitchell AJ, Meader N, Symonds P (2010) Diagnostic validity of the hospital anxiety and depression scale (HADS) in cancer and palliative settings: a metaanalysis. J Affective Disord 126:335–348 8. Brennan C, Worrall-Davies A, McMillan D, Gilbody S, House A (2010) The hospital anxiety and depression scale: a diagnostic meta-analysis of case-finding ability. J Psychosom Res 69:371–378 9. Carey M, Noble N, Sanson-Fisher R, Mackenzie L (2012) Identifying psychological morbidity among people with cancer using the Hospital Anxiety and Depression Scale: time to revisit first principles? Psycho-Oncol. 21:229–238 10. Vodermaier A, Millman RD (2011) Accuracy of the Hospital Anxiety and Depression Scale as a screening tool in cancer patients: a systematic review and meta-analysis. Support Care Cancer 19: 1899–1908 11. Annunziata MA, Muzzatti B, Altoè G (2011) Defining Hospital Anxiety and Depression Scale (HADS) structure by confirmatory factor analysis: a contribution to validation for oncological settings. Ann Oncol 22:2330–2333 12. Spielberger CD (1983) State-trait anxiety inventory (form Y). Mind Garden, Palo Alto (CA) 13. Radloff L (1977) The CES-D Scale: a self-report depression scale for research in the general population. Appl Psych Meas 1:385–401 14. Spielberger CD (1989) S.T.A.I. (State-Trait-Anxiety Inventory). Inventario per l’ansia di stato e di tratto. Forma Y. Organizzazioni Speciali, Firenze 15. Pedrabissi L, Santinello M (1989) Verifica della validità dello STAI forma Y di Spielberger. BPA. 191:11–14 16. Macor A, Pedrabissi L, Santinello M. (190). Ansia di stato e di tratto: ulteriore contributo alla verifica della validità psicometrica e teorica dello S.T.A.I. forma Y di Spielberger. Psicologia e Società. 15: 67–74 17. Pierfederici A, Fava GA, Munari F et al (1982) Validazione italiana del CES-D per la misurazione della depressione. In: Canestrari R (ed) Nuovi metodi in psicoterapia. Organizzazioni Speciali, Firenze, pp 95–103 18. Fava GA (1983) Assessing depressive symptoms across cultures: Italian validation of the CES-D self-rating scale. J Clin Psychol 39: 249–251 19. Hann D, Winter K, Jacobsen P (1999) Measurement of depressive symptoms in cancer patients: evaluation of the Center for Epidemiological Studies Depression Scale (CES-D). J Psychosom Res 46:437–443 20. Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 143:29–36 21. Metz CE (1978) Basic principles of ROC analysis. Semin Nucl Med 8:283–298 22. Rodgers J, Martin C, Morse R et al (2005) An investigation into the psychometric properties of the Hospital Anxiety and Depression Scale in patients with breast cancer. Health Qual Life Outcomes 3:41 23. Cosco TD, Doyle F, Ward M, McGee H (2012) Latent structure of the Hospital Anxiety And Depression Scale: a 10-year systematic review. J Psychosom Res 72:180–184 24. Norton S, Cosco T, Doyle F, Done J, Sacker A (2013) The Hospital Anxiety and Depression Scale: a meta confirmatory factor analysis. J Psychosom Res 74:74–81 25. Straat JH, van der Ark LA, Sijtsma K (2013) Methodological arti- facts in dimensionality assessment of the Hospital Anxiety and Depression Scale (HADS). J Psychosom Res 74:116–121 26. Maters GA, Sanderman R, Kim AY, Coyne JC (2013) Problems in cross-cultural use of the Hospital Anxiety and Depression Scale: “no butterflies in the desert”. PLoS One 8:e70975 27. Cameron IM, Scott NW, Adler M, Reid IC (2014) A comparison of three methods of assessing differential item functioning (DIF) in the Hospital Anxiety Depression Scale: ordinal logistic regression, Rasch analysis and the Mantel chi square procedure. Qual Life Res 23:2883–2888 28. Verdam MG, Oort FJ, Sprangers MA (2017) Item bias detection in the Hospital Anxiety and Depression Scale using structural equa- tion modeling: comparison with other item bias detection methods. Qual Life Res 26:1439–1450 29. Saboonchi S, Wennman-Larsen A, Alexanderson K, Petersson ML (2013) Examination of the construct validity of the Swedish version of Hospital Anxiety and Depression Scale in breast cancer patients. Qual Life Res 22:2849–2856 Publisher’s note Springer Nature remains neutral with regard to jurisdic- tional claims in published maps and institutional affiliations. 3926 Support Care Cancer (2020) 28:3921–3926 Supportive Care in Cancer is a copyright of Springer, 2020. All Rights Reserved. DEBATE Open Access Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority Claire L. Niedzwiedz1* , Lee Knifton2,3, Kathryn A. Robb1, Srinivasa Vittal Katikireddi4 and Daniel J. Smith1 Abstract Background: A cancer diagnosis can have a substantial impact on mental health and wellbeing. Depression and anxiety may hinder cancer treatment and recovery, as well as quality of life and survival. We argue that more research is needed to prevent and treat co-morbid depression and anxiety among people with cancer and that it requires greater clinical priority. For background and to support our argument, we synthesise existing systematic reviews relating to cancer and common mental disorders, focusing on depression and anxiety. We searched several electronic databases for relevant reviews on cancer, depression and anxiety from 2012 to 2019. Several areas are covered: factors that may contribute to the development of common mental disorders among people with cancer; the prevalence of depression and anxiety; and potential care and treatment options. We also make several recommendations for future research. Numerous individual, psychological, social and contextual factors potentially contribute to the development of depression and anxiety among people with cancer, as well as characteristics related to the cancer and treatment received. Compared to the general population, the prevalence of depression and anxiety is often found to be higher among people with cancer, but estimates vary due to several factors, such as the treatment setting, type of cancer and time since diagnosis. Overall, there are a lack of high- quality studies into the mental health of people with cancer following treatment and among long-term survivors, particularly for the less prevalent cancer types and younger people. Studies that focus on prevention are minimal and research covering low- and middle-income populations is limited. Conclusion: Research is urgently needed into the possible impacts of long-term and late effects of cancer treatment on mental health and how these may be prevented, as increasing numbers of people live with and beyond cancer. Keywords: Mental health, Psychiatry, Cancer, Multimorbidity, Depression, Anxiety, Oncology, Survivorship Background A cancer diagnosis can have a wide-ranging impact on mental health and the prevalence of depression and anx- iety among people with cancer is high [1, 2]. Among those with no previous psychiatric history, a diagnosis of cancer is associated with heightened risk of common mental disorders, which may adversely affect cancer treatment and recovery, as well as quality of life and sur- vival [3]. People who have previously used psychiatric services may be particularly vulnerable and at greater risk of mortality following a cancer diagnosis [4]. How- ever, the mental health needs of people with cancer, with or without a prior psychiatric history, are often given lit- tle attention during and after cancer treatment, which is primarily focused on monitoring physical health symp- toms and side effects. Advances in the earlier detection of cancer and improved cancer treatments means that people are now living longer with cancer, presenting a significant global challenge. The total number of people who are alive within 5 years of a cancer diagnosis was estimated to be 43.8 million in 2018 for 36 cancers across 185 countries [5], and in the United States alone, the number of cancer survivors is projected to rise © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. * Correspondence: [email protected] 1Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, UK Full list of author information is available at the end of the article Niedzwiedz et al. BMC Cancer (2019) 19:943 https://doi.org/10.1186/s12885-019-6181-4 exponentially from 15.5 million in 2016 to 26.1 million in 2040 [6]. The main objective of this article is to argue that more research is needed into the prevention, care and treat- ment of co-morbid depression and anxiety among people with cancer and highlight it as a growing clinical and policy priority. For background and to support our argument, we provide a current evidence review of sys- tematic reviews relating to common mental disorders amongst people living with and beyond cancer. We cover the factors that may increase the risk of experien- cing co-morbid depression and anxiety, epidemiology, and potential care and treatment options. We searched three key electronic databases: Medline, PsycINFO and CINAHL (Cumulative Index to Nursing and Allied Health Literature) for relevant reviews (favour- ing those using systematic methods) using the following search terms: (neoplasm OR carcinoma OR tumo*r OR cancer) AND (depression OR anxiety) AND review. Only English language articles were considered and searches were limited to the years 2012 to 2017 and updated during February 2019. These years were considered adequate to capture the main themes relating to cancer and common mental disorders in the current literature. The references of highly relevant articles were scrutinised for additional papers and a Google search for important grey literature was also conducted. A minority of significant research ar- ticles known to the authors were also consulted. Main text Factors influencing the development of depression and anxiety among people with cancer A variety of factors are likely to interact to influence the development of depression and anxiety among people with cancer (summarised in Fig. 1), but these are not well understood [1], and require further research. Individual Fig. 1 Factors that may contribute to depression and anxiety among people living with and beyond cancer Niedzwiedz et al. BMC Cancer (2019) 19:943 Page 2 of 8 risk factors that may increase the risk of depression, simi- lar to the general population, include demographic factors, such as age and gender, and social and economic factors such as unemployment, fewer educational qualifications and a lack of social support [7]. The development of de- pression and anxiety among people with cancer is also likely to depend on factors at the structural level, includ- ing healthcare costs and access, as well as access to welfare support, such as disability benefits, as cancer can have a significant financial impact [8, 9]. Several psychological factors are also important. A key factor is the presence of pre-existing mental health problems and their severity. Research has demonstrated that individuals who have previously accessed mental health services before a cancer diagnosis experience excess mortality due to certain cancers, which may reflect late diagnosis, inadequate treatment and a higher rate of adverse health behaviours [4, 10]. Personality factors, such as neuroticism, and exist- ing coping skills may also contribute [11]. The risk of suicide among people with cancer is higher than the gen- eral population for certain diagnoses that tend to have poorer prognoses, such as mesothelioma and lung cancer, especially in the first 6 months after diagnosis [12, 13]. Individuals who have previously engaged in suicidal be- haviour are likely to be particularly vulnerable. The individual psychological response to a cancer diagnosis is also likely to be an important component. The experience of being diagnosed, particularly if the diagnosis has been delayed, can be a significant source of distress and can impact on illness acceptance [14]. Feelings of hopelessness, loss of control and uncertainty around survival and death can also have a detrimental impact, particularly in patients with a poor prognosis. Anxiety around a cancer diagnosis can also lead to sleep disturbance, which may increase the risk of depression [15]. The stigma surrounding both mental illness and certain types of cancer, such as lung cancer, can lead to feelings of guilt and shame, which could contribute to the onset of depression. For example, the link between smoking and lung cancer can lead to some patients blaming themselves for their illness and experiencing stigma if they have engaged in smoking [14]. A variety of factors related to the cancer and its treatment are likely to impact on the development of depression and anxiety, including the type of cancer, stage and prognosis. Cancer treatments including immunotherapy and chemo- therapy may induce depression through particular biological mechanisms, such as inflammatory pathways, and some medications used to treat chemotherapy-induced nausea can reduce dopaminergic transmission, which is implicated in the development of depressive symptoms [16]. The use of steroids in cancer treatment can induce depression [17], and androgen deprivation therapy in the treatment of prostate cancer is also associated with increased risk [18]. The physical symptoms of specific cancers can also contribute to depression (e.g. incontinence and sexual dysfunction associ- ated with prostate cancer) [19]. Iatrogenic distress is also commonly reported amongst patients, which could increase the risk of experiencing later problems with depression and anxiety, including post-traumatic stress disorder [20]. This is often related to a combination of poor communication, a lack of consideration of psychological concerns and dis- jointed care [14, 20]. Prevalence of depression and anxiety among people with cancer The prevalence of common mental disorders among people with cancer varies widely in the published litera- ture. The mean prevalence of depression using diagnos- tic interviews is around 13\% and using all assessment methods it varies from approximately 4 to 49\% [2, 21]. This wide variation is due to several factors including the treatment setting, type of cancer included and method used to screen for symptoms (e.g. interview by trained psychiatrist or self-report instrument). The esti- mated prevalence of depression was found to be 3\% in patients with lung cancer, compared to 31\% in patients with cancer of the digestive tract, when diagnostic inter- views were used [21]. A meta-analyses of 15 studies meeting a number of quality criteria, including the use of diagnostic interviews, found that the estimated preva- lence of depression varied across treatment settings (5 to 16\% in outpatients, 4 to 14\% in inpatients, 4 to 11\% in mixed outpatient and inpatient samples, and 7 to 49\% in palliative care) [2]. There is no universal standardised tool which is recommended for depression screening in patients with cancer and the method used is likely to differ depend- ing on the treatment setting. A meta-analysis of screening and case finding tools for depression in cancer settings iden- tified 63 studies that used 19 different screening tools for depression [22]. Common screening methods for depression include semi-structured diagnostic interviews, the Hospital Anxiety and Depression Scale - depression subscale (HADS- D) and Center for Epidemiologic Studies Depression Scale (CESD), which are designed to measure the severity of depressive symptoms. An important aspect that needs to be considered is the timing of increased psychiatric risk. Studies demonstrate that depression tends to be highest during the acute phase and decreases following treatment, but again this likely differs depending on the type of cancer and prog- nosis [21]. Using diagnostic interviews, the prevalence of depression during treatment was found to be 14\%, 9\% in the first year after diagnosis and 8\% a year or more after treatment in a meta-analysis of 211 studies [21]. Of the 238 cohorts included, around 30\% included only breast cancer patients and there is a need for research includ- ing rarer types of cancer. Niedzwiedz et al. BMC Cancer (2019) 19:943 Page 3 of 8 As well as the type of cancer, the type of mental health outcome considered is also important and fewer studies have examined anxiety. A systematic review and meta- analysis study focusing on patients with ovarian cancer found that anxiety tended to be higher following treatment (27\%) and during treatment (26\%), and was lowest pre- treatment (19\%) [23]. The heightened anxiety observed post-treatment may be due to reduced clinical consultations and support following treatment, potential transfer to a pal- liative setting, and fear of recurrence. Fear of recurrence is one of the most commonly reported issues and an import- ant area of unmet need for cancer survivors [24]. A lack of outward physical symptoms in ovarian cancer also means that self-monitoring is difficult [23]. In the same study of ovarian cancer patients, depression was highest before treat- ment (25\%) and during treatment (23\%), and reduced fol- lowing treatment (13\%). This is in the context of a lifetime prevalence for clinical depression and anxiety of around 10 and 8\%, respectively, amongst women in the UK [23, 25]. A similar systematic review of depression and anxiety among patients with prostate cancer found that anxiety tended to be highest pre-treatment (27\%) and lowered during treatment (15\%) and post-treatment (18\%) [26]. Rates of depression were relatively similar following treatment (18\%), during treatment (15\%) and pre- treatment (17\%), with the 95\% confidence intervals for these estimates largely overlapping. For reference, the prevalence of clinical depression and anxiety in men aged over 65 years is less than 9 and 6\%, respectively [26]. A systematic review on the prevalence of psycho- logical distress among testicular cancer survivors dem- onstrated that around one in five experienced clinically significant anxiety, compared to one in eight among general population controls, with fear of recurrence again being one of the key issues reported [27]. How- ever, depression was no more prevalent amongst those surviving testicular cancer compared to the general population. In Scotland, the prevalence of depression was found to be highest in patients with lung cancer (13\%), followed by gynaecological cancer (11\%), breast cancer (9\%), colorectal cancer (7\%), and genitourinary cancer (6\%) [28]. The authors found depression to be more likely among younger and more socially disadvan- taged individuals. In addition, 73\% of the patients with depression were not receiving treatment for their men- tal health. Further research is needed to ascertain the factors which contribute to the uptake and efficacy of treatment for depression. This study also only consid- ered people with cancer who had attended specialist cancer clinics within a defined time period, which likely excluded people who were diagnosed many years ago. The longer-term psychological impact of cancer has received comparatively little research. The few studies in this area have mainly focused on women with breast cancer and demonstrate that depressive symptoms can persist for over 5 years after diagnosis, though the preva- lence of anxiety was not elevated compared to the general population [29]. A systematic review of the prevalence of depression and anxiety among long-term cancer survivors, including all types, found that anxiety was more prevalent among cancer survivors, compared to healthy controls [30]. Few studies have focused specif- ically on younger cancer survivors and more research is needed in this area. A representative study of young adult cancer survivors aged 15 to 39 years in the United States demonstrated that moderate (23\% vs 17\%) and se- vere (8\% vs 3\%) mental distress were significantly higher in those living with cancer for at least 5 years after diag- nosis, compared to controls [31]. 75 and 52\% of people with cancer with moderate and severe distress, respect- ively, had not talked to a mental health professional, with the cost of treatment a potential barrier. Limita- tions of this study included the focus on self-reported mental distress and not clinical depression or anxiety, as well as the relatively small sample size. Many studies in this area have a poor response rate, lack representativeness, are based on a small sample of patients (often with the most common types of cancer), which often exclude those with cognitive impairment and patients who are too physically or mentally unwell to take part [32]. Future studies would benefit from using administrative health data [33], for example, link- ing together cancer registries, inpatient and outpatient records and prescribing data. There are also a lack of studies covering populations from low- and middle- income countries [34]. The estimated prevalence of co- morbid common mental disorders is likely to vary de- pending on the country studied, due to factors such as the health and welfare system. These factors may influ- ence mental health inequalities among people with can- cer, which has received little research focus. In a Scottish study, depression was found to be higher in the least advantaged groups (19\%), compared to the most advantaged (10\%) [35]. Cancer and comorbid anxiety was also unequally distributed; in the least advantaged groups around 12\% had both conditions, compared to 7\% among the most advantaged [35]. Further research is needed in this area to quantify, monitor and prevent in- equalities among people with cancer. It should also be highlighted that the psychological im- pact of cancer may not always be negative and many people will not experience problems with depression and anxiety. Experiencing temporary distress related to a can- cer diagnosis may lead to positive psychological changes in the long-term whereby individuals feel a greater appre- ciation of life and are able to re-evaluate their priorities [36]. The factors that protect against the development of common mental disorders and contribute to positive Niedzwiedz et al. BMC Cancer (2019) 19:943 Page 4 of 8 mental health among people living with and beyond can- cer merits further research. Treatment and management of depression and anxiety among people with cancer To effectively manage and treat depression and anxiety among people with cancer, symptoms must first be identi- fied. However, several social and clinical barriers have been reported. A key issue is the lack of physician time for assessing symptoms. There can also be a normalisation of distress and attribution of the somatic symptoms of depression and anxiety to the cancer. Patients may not disclose psychiatric symptoms because of the stigma sur- rounding mental health conditions [37]. Screening for de- pression and anxiety among patients with cancer is also only of value if it leads to effective treatment and support that is able to improve patient outcomes. Patients may be more reluctant to discuss their mental health needs if they perceive a lack of effective treatment options. The existing evidence for treating anxiety and depression among patients with cancer is limited and of varying quality [38]. Studies with small sample sizes are common; this miti- gates against the detection of meaningful changes in patient outcomes and these studies often suffer from a high rate of attrition, which likely reflects the high symptom burden and reduced survival in this patient population [39]. Sys- tematic reviews demonstrate there is a preponderance of studies from the United States, which include a high num- ber of studies focusing on female patients with breast cancer [40]. However, these studies demonstrate that psy- chotherapy, psychoeducation and relaxation training may have small to medium short-term effects on relieving emo- tional distress and reducing symptoms of anxiety and depression, as well as improving health-related quality of life. The evidence for pharmacological treatment of depres- sion with antidepressants is mixed - there are very few studies in this area and those that exist are of low quality [41]. There is also concern around potential side effects of antidepressants and drug interactions that may affect the efficacy of cancer treatments [42]. A systematic review and meta-analysis focusing on cognitive behavioural therapy (CBT) found that it may be effective in reducing depression and anxiety and im- proving quality of life in patients with cancer in the short-term, but potential long-term effects were only sustained for quality of life [43]. However, in this meta- analysis the included participants were primarily women with breast cancer and there are a lack of studies cover- ing other cancer types. It is likely that collaborative care interventions which involve partnership between psych- iatry, clinical psychology and primary care, overseen by a care manager are likely to be most effective in the man- agement and treatment of depression amongst people with cancer [44]. Treatment should be based on patient preference and also take into account potential adverse side effects [44]. In a UK-based study it was found that only a third of patients with cancer and related psycho- logical or emotional distress were willing to be referred for support [45]. Qualitative studies also demonstrate that patients often do not want to discuss their feelings with nurses during cancer treatment [46]. However, pa- tients valued having the option to talk about their emo- tions, but they preferred to choose with whom and when. There is therefore a need for further research into some of the barriers to obtaining mental health support among those affected by cancer and experiencing dis- tress to prevent future problems. The self-management of psychological distress among people with cancer may be beneficial and could help pre- vent distress becoming clinical depression or anxiety. Self- management can be defined as: “The individual’s ability to manage the symptoms, treatment, physical and psychosocial consequences and lifestyle changes inherent in living with a chronic condition. Efficacious self-management encompasses the ability to monitor one’s condition and to affect the cogni- tive, behavioural and emotional responses necessary to maintain a satisfactory quality of life. Thus, a dynamic and continuous process of self-regulation is established.” [47]. Studies on self-management, cancer and psychological dis- tress have focused on the treatment phase, with fewer investigating interventions following treatment or at the end of life [48]. There is evidence to suggest that self- management of psychological distress in cancer can help to empower patients and families to care for themselves in a way which is preferable for them. Self-management inter- ventions that have shown promise include education, moni- toring, teaching and counselling to help patients manage the short- and long-term physical and psychosocial effects of cancer [48]. However, a recent systematic review exam- ining the impact of self-management interventions on outcomes including quality of life, self-efficacy and symp- tom management (such as psychological distress) amongst cancer survivors demonstrated a lack of evidence to sup- port any specific intervention and found that the six included interventions lacked sustainability, bringing into question their long-term effectiveness and value for money [49]. Again, the included studies were dominated by women with breast cancer, with only two covering other cancers. Effective treatment and management strategies may also differ according to the demographic group affected. In a report by CLIC (Cancer and Leukaemia in Child- hood) Sargent which surveyed 146 young people with cancer, keeping in touch with friends and family, talking to others with similar experiences and access to the internet in hospital were reported to help maintain men- tal health during cancer treatment [50]. Of the young people who mentioned they would find it helpful to talk Niedzwiedz et al. BMC Cancer (2019) 19:943 Page 5 of 8 to other people with similar experiences, 60\% said they would prefer to do this online. Young people also reported that the available services were not tailored to deal with those aged under 18 or the emotional impact of cancer. In addition, those who accessed services men- tioned that there is a lack of suitable long-term emo- tional support. Just over 40\% of the young people who took part did not access support for their mental health needs. It is clear that a more personalised approach to support- ing the psychological health of people with cancer is needed [51]. Some people may not want or require sup- port or treatment, others will be able to self-manage, and some may have more complex needs that require more intensive follow-up and support. At diagnosis, the psycho- logical health of patients should be considered alongside their physical health and sources of support offered. Needs and symptoms may also change over time. Evaluation of more recent personalised approaches to follow-up care that have been adopted in several areas including England and Northern Ireland [51] are needed to understand the role they may have in preventing longer term depression and anxiety amongst cancer survivors. A key barrier affecting research progress in this area is funding [52]. In the UK, money spent on research into the biology of cancer was more than five times than that spent on ‘Cancer Control, Survivorship and Outcomes’ during 2017/18 [53]. Research into the mental health and wellbeing of people living with and beyond cancer is likely to only be a small part of this. Research is ur- gently needed in this area as more people survive cancer and for some cancers, such as multiple myeloma and colorectal cancer, risk is increasing in younger cohorts [54]. The long-term (those that begin during treatment and continue afterwards) and late effects of cancer treat- ment (those that begin after treatment is completed), such as secondary cancers, infertility, chronic pain and insomnia, are likely to affect the mental wellbeing of cancer survivors, potentially contributing to depression and anxiety [6]. The National Cancer Research Institute (NCRI) in the UK have also recently highlighted re- search into the short-term and long-term psychological impacts of cancer and its treatment as a key priority, fol- lowing surveys of over 3500 patients, carers, and health and social care professionals [55]. Conclusion The mental health of people living with and beyond cancer in its various types and stages is an important and growing research and clinical priority. Compared to the general population, the prevalence of anxiety and depression is often higher among people with cancer, but estimates vary due to a number of factors, such as the type and stage of cancer. Patients often do not obtain psychological support or treatment. This is likely due to several factors, including lack of awareness and identification of psychiatric symptoms, an absence of support available or offered, lack of evidence around effective treatments, stigma, and patient preference. In particular, we highlight the lack of high-quality research into the mental health of long-term cancer survivors, the po- tential impact of long-term and late effects of cancer treat- ment, and the few studies focused on prevention. Further research that includes the less common types of cancer is required, as well as the inclusion of younger people and populations from low- and middle-income countries. Given the increasing numbers of people living with and beyond cancer, this research is of timely importance. Abbreviations CBT: Cognitive behavioural therapy; CESD: Center for Epidemiologic Studies Depression Scale; CINAHL: Cumulative Index to Nursing and Allied Health Literature; CLIC: Cancer and Leukaemia in Childhood; HADS-D: Hospital Anxiety and Depression Scale - depression subscale; NCRI: National Cancer Research Institute Acknowledgements This article is built on a literature review conducted by CLN and LK for a project on ‘Supporting the mental and emotional health of people with cancer’ funded by the Big Lottery Fund when CLN was an employee of the Mental Health Foundation in Scotland during 2017. Authors’ contributions CLN and LK conceived the article. CLN conducted the searches and drafted the manuscript. CLN, LK, SVK, KAR and DJS interpreted the findings. All authors critically revised the manuscript, read and approved the final version. Funding CLN is currently supported by the Medical Research Council (grant number MR/R024774/1). SVK is funded by a NHS Research Scotland (NRS) Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_12017/13 & MC_UU_12017/15) and Scottish Government Chief Scientist Office (SPHSU13 & SPHSU15). The funders had no role in the study design; collection, analysis and interpretation of data; the writing of the article; and in the decision to submit it for publication. Availability of data and materials All data generated or analysed during this study are included in this published article. Ethics approval and consent to participate Not applicable Consent for publication Not applicable Competing interests The authors declare that they have no competing interests except for the funding acknowledged. Author details 1Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, UK. 2University of Strathclyde, Centre for Health Policy, Glasgow, Scotland, UK. 3Mental … ORIGINAL ARTICLE Impact of family caregivers’ awareness of the prognosis on their quality of life/depression and those of patients with advanced cancer: a prospective cohort study EunKyo Kang1,2 & Bhumsuk Keam3 & Na-Ri Lee4 & Jung Hun Kang5 & Yu Jung Kim6 & Hyun-Jeong Shim7 & Kyung Hae Jung8 & Su-Jin Koh9 & Hyewon Ryu10 & Jihye Lee11 & Jiyeon Choo11 & Shin Hye Yoo3 & Young Ho Yun1,11 Received: 12 December 2019 /Accepted: 20 April 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020 Abstract Purpose A caregiver’s prognostic awareness can affect clinical decisions for the patient. The purpose of this study was to examine the impact of family caregivers’ prognostic awareness on the quality of life (QOL) and emotional state of both patients with advanced cancer and their caregivers. Methods This prospective cohort study was conducted from December of 2016 to January of 2018. A total of 159 patients with advanced cancer and an equal number of caregivers participated. The investigation tools used include the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C15-Palliative, the McGill Quality of Life Questionnaire, and the Patient Health Questionnaire-9, and evaluation was performed at baseline, 3 months, and 6 months. Covariance analysis with a general linear modeling was used to compare changes in quality of life scores according to the caregivers’ awareness of the prognosis. Results Mean patient overall QOL score increased in the group of caregivers who were aware of prognosis and decreased in the caregivers who were not aware of the prognosis (p = 0.018). The changes over time in the patients’ QOL scores associated with symptoms improved with caregiver awareness (pain, p = 0.017; dyspnea, p = 0.048; appetite loss, p = 0.045). The percentage of depressed patients was smaller after 3 months in the group with caregivers aware of the prognosis (baseline to 3 months p = 0.028). Caregivers who did not understand their patients’ prognosis exhibited better existential well-being (p = 0.036), and the incidence of depression was lower in this group at 3 months (p = 0.024). Conclusion Caregivers’ prognostic awareness may improve the quality of life and mood in patients with advanced cancer; however, this awareness may harm the quality of life and mood of the caregivers. These results may aid in developing in- depth interventions regarding prognosis for both patients and their caregivers. Keywords Advanced cancer patients . Caregiver’s awareness . Depression . Prognostic awareness . Quality of life * Young Ho Yun [email protected]; [email protected] 1 Department of Family Medicine, Seoul National University Hospital, Seoul, South Korea 2 Institute for Public Health and Medical Service, Seoul National University Hospital, Seoul, South Korea 3 Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea 4 Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea 5 Department of Internal Medicine, Gyeongsang University Hospital, Jinju, South Korea 6 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea 7 Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea 8 Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea 9 Department of Hematology and Oncology, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, South Korea 10 Internal Medicine, Chungnam National University College of Medicine, Chungnam, South Korea 11 Department of Medical Informatics, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, South Korea https://doi.org/10.1007/s00520-020-05489-8 / Published online: 6 May 2020 Supportive Care in Cancer (2021) 29:397–407 Introduction As the life expectancy of patients with advanced cancer in- creases [1, 2], the role of caregivers who provide comprehen- sive support is becoming more important. Family caregivers deal with the complications of long-term management of can- cer treatment [3], which can impact the quality of life of the patients as well as those who care for them. Supporting cancer patients is associated with considerable physical, mental, and financial burdens for the caregiver [4, 5]. The role of caregivers in treatment decisions and the long- term care of the patient are becoming increasingly important [6]. Studies indicate that caregivers of cancer patients with poor prognosis desire more prognostic information and feel that dis- closure of information about incurable cancer is very important [7, 8]. Caregivers aware of a patient’s incurable illness might want to prevent the patient from learning about their prognosis [9]. In addition, the patient’s caregiver may participate in the discussions between the patient and their physician, or assist the patient with accepting a poor prognosis [10, 11]. Patients and caregivers may differ in their treatment preferences and deci- sions about end-of-life care, which may be influenced by the awareness that the cancer is incurable [12, 13]. Furthermore, according to previous studies, the caregiver’s perception of an incurable disease may affect the intimacy between patient and caregiver, leading to distress [14]. Because of these findings, disclosure of the prognosis to caregivers remains controversial. Studies have found that patients with advanced cancer who are aware of their prognosis are more likely to experience decreased quality of life and increased depression [15–18], which are both associated with poor survival [17]. On the other hand, research suggests that disclosing prognosis to pa- tients reduced their stress and promoted psychological and emotional well-being [19–21]. Few studies are investigating the impact of caregivers’ awareness of prognosis on their quality of life, however, or how this awareness affects patient quality of life [18]. Considering the important role of the family in managing cancer long-term, it is important to investigate the effect of the caregivers’ awareness of prognosis on the quality of life and emotional state of patients. Additionally, a family member’s cancer diagnosis may lead to depression and impaired quality of life for caregivers [22, 23]. It is also important to understand the impact of caregivers’ prognostic awareness on their qual- ity of life and emotional state. The purpose of this study was to investigate the effect of caregivers’ prognostic awareness on their quality of life/ emotional state and the QOL of the patients. Considering the impact of prognostic awareness on the quality of life and emo- tional state of caregivers and patients [10, 24, 25], the results of this study may help identify the effects of caregivers’ lack of prognostic awareness on both the caregivers and patients with incurable cancer. Material and methods Study design This prospective Korean nationwide cohort study was con- ducted across three periods between December 17, 2016, and August 17, 2018. Patients and their caregivers who were (1) diagnosed with advanced cancer and (2) aged ≥ 19 years were eligible for inclusion in this study. Physicians evaluated the patients’ understanding of the purpose of the study and enrolled only those with insight into their disease. The physi- cian enrolled patients only if they had advanced cancer and if their life expectancy was determined to be less than 1 year. All patients and caregivers understood the purpose and methods of the study and provided informed consent to participate, and the institutional review boards of all 21 participating hospitals approved the protocol. This trial is registered with ClinicalTrials.gov (NCT03222258). Data collection The patients’ primary cancer site, Eastern Cooperative Oncology Group (ECOG) performance status, and therapeutic status were collected through a medical record review. The therapeutic status was classified as follows: (1) receiving stan- dard chemotherapy, (2) at an intermittent stage of standard che- motherapy, (3) receiving additional chemotherapy following standard chemotherapy, and (4) at the stage of any chemother- apy yet expected to survive more than 6 months but for less than 1 year. Demographic data and information regarding awareness of prognosis, quality of life, and emotional status were obtained through patient interviews. For data uniformity, research nurses conducted face-to-face patient interviews. The questionnaires required approximately 20 min to complete. The patients and their caregivers were followed up at 3 months and 6 months through direct meetings with the research assistants in the inpatient facility or outpatient clinic. If the patient or care- giver was lost to follow-up (Fig. 1), we checked with the phy- sician regarding the patient’s survival. In Korea, patients’ sur- vival or death data are managed by both the National Health Insurance Service and the National Statistical Office, so physi- cians can verify patient survival. If the patient was alive but not contacted, they were classified as “unable to contact.” Measurements The demographic information included age, sex, educational status, marital status, religion, and place of residence. The patients’ and caregivers’ awareness of the prognosis was assessed through self-administered questionnaires at baseline. The patients and their caregivers were asked the following question: “Do you think your illness (or the patient’s illness) will be cured?” They responded by selecting one of the 398 Support Care Cancer (2021) 29:397–407 following options: (1) my (or the patient’s) cancer will be cured, (2) my (or the patient’s) cancer might be cured if the treatments are effective, (3) my (or the patient’s) cancer cannot be cured, but treatment inhibits cancer progression and ex- tends survival, (4) my (or the patient’s) cancer cannot be cured, and cancer treatment is no longer effective, or (5) I do not know [26]. Awareness of the prognosis was defined as “present” for response options 3 and 4 and “absent” for re- sponse options 1, 2, and 5. Quality of life was measured using two indices: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C15-Palliative (EORTC QLQ-C15-PAL) [27] and the McGill Quality of Life (MQOL) questionnaire [28]. We assessed patients with both the EORTC QLQ-C15-PAL and MQOL questionnaires and assessed the caregivers with the MQOL questionnaire only. The EORTC QLQ-C15-PAL is a questionnaire that in- cludes only 15 of the 30 items in the EORTC QLQ-C30 ques- tionnaire for palliative care. The EORTC QLQ-C15-PAL as- sesses physical and emotional functioning, overall quality of life, and seven symptoms related to quality of life (i.e., fatigue, nausea/vomiting, dyspnea, pain, insomnia, appetite loss, and constipation). High scores related to functioning and overall quality of life indicate a better quality of life. High symptom scores indicate increased severity of symptoms. The MQOL is a multidimensional questionnaire that as- sesses quality of life. In this study, we measured the quality of life associated with two aspects of existential well-being and social support. High scores in the MQOL questionnaire represent a higher quality of life. Cronbach’s alpha coefficients of the EORTC QLQ-C15-PAL for multi-item scales ranged from 0.67 (pain) to 0.85 (emotional functioning) [29]. In this study, the Cronbach’s alpha coefficients of the EORTC QLQ- C15-PAL for multi-item scales ranged from 0.84 to 0.87. The Korean version of the MQOL questionnaire presented a moderate-to-high internal consistency (Cronbach’s alpha, 0.62–0.90) and a good concurrent validity [30]. The Cronbach’s alpha coefficients of the MQOL questionnaire ranged from 0.73 to 0.84 (patients) and 0.67 to 0.80 (caregivers) in this study. The emotional state of patients and caregivers was assessed through the Patient Health Questionnaire-9 (PHQ-9) [31]. Consistent with the Diagnostic and Statistical Manual of Mental Disorders (5th Edition), the PHQ-9 is a self- reporting questionnaire for the diagnosis of depression [32]. Participants with a PHQ-9 score of ≥ 10 were diagnosed with depression. The Korean version of the PHQ-9 questionnaire showed a high internal consistency (Cronbach’s alpha was 0.852) [33]. In this study, the prevalence of depression was presented as the percentage of depressed participants. The Cronbach’s alpha coefficients of the PHQ-9 questionnaire were 0.90 (patients) and 0.91 (caregivers). Statistical analyses The items in the MQOL questionnaire were scored using a scale from 0 to 10. According to the EORTC scoring manual, the items in the EORTC questionnaire were scored using a Fig. 1 The flow of participants through each stage of the study 399Support Care Cancer (2021) 29:397–407 linear scale from 0 to 100 [27]. The primary outcome of this study was a change in patients’ quality of life according to the caregivers’ prognostic awareness. Covariance analysis with general linear modeling was used to compare changes in qual- ity of life scores between the groups. To analyze how caregiv- er awareness affects a patient’s quality of life and depression, a multivariate general linear model (GLM) was fit using an unstructured covariance matrix for the outcome variables (i.e., quality of life × time points) with role (i.e., patient/care- giver) as the within-subjects factor and type of tumor, baseline score, and patients’ ECOG performance as the covariates. The baseline score and ECOG performance status were adjusted. Changes from baseline to 3 months and changes over time were measured (as the difference in time effect [awareness × time] considering the correlation of repeated observa- tions for each participant). In the EORTC questionnaire, one item was missing from the questionnaire of two pa- tients at baseline, and the missing items were handled as recommended in the scoring manual. A multiple imputed data set was produced—excluding patients who expired— via a multiple imputation method. This study used regres- sion methods and propensity scores for imputation. Imputed values were used for covariance analysis. We used the STATA version 14.2 (STATA, College Station, TX) software for all statistical analyses. We considered a two-sided P value < 0.05 as significant. Results Study participants The demographic characteristics of the participants are shown in Table 1. Of the 159 caregivers who responded, 101 (63.5\%) were aware of the patients’ prognosis and 58 (36.5\%) were unaware. The majority of the caregivers were female, whereas the majority of the patients were male. The mean age of the patients was higher than that of the caregivers; however, the age difference between the aware and unaware groups was not statistically significant. Both the patients and the caregivers had an average level of education (below a high school graduate). More caregivers than patients were employed. Notably, there was no signif- icant difference between the two groups in educational sta- tus, occupation, religion, or marital status. According to the awareness of patient caregivers, there was no signifi- cant difference in monthly income and area of residence. Lung cancer was the most common primary cancer report- ed in both groups. In terms of ECOG performance status, ECOG 1 was the most commonly reported grade (48.3\%) in the aware group. However, in the unaware group, ECOG 3 was the most commonly observed grade (49.5\%). The difference between the groups in ECOG status was signif- icant (p = 0.004). Changes in the quality of life of patients over time (EORTC QLQ-C15-PAL) There was no statistically significant difference in the change of quality of life scores related to physical and emotional functioning between the aware and unaware caregiver groups (Fig. 2). However, the mean overall quality of life score for patients increased from 50.5 to 58.3 in the group with care- givers who were aware of the prognosis, whereas it decreased from 55.4 to 53.7 in the group of caregivers with no aware- ness. There was a significant difference between the groups over time (p = 0.018). There were significant differences be- tween the groups in changes over time in the quality of life scores related to symptoms. Regarding pain, the mean score decreased from 32.6 to 24.5 in the aware group, whereas it increased from 26.9 to 32.9 in the unaware group (from base- line to 3 months p = 0.035, changes over time p = 0.017). For dyspnea, the score decreased from 25.8 to 15.4 in the aware- ness group and the unaware group showed limited change (from 28.1 to 28.0) (changes over time p = 0.048). The mean score related to appetite loss decreased in the aware group from 45.7 to 36.8, whereas the mean score reported in the unaware group increased from 34.8 to 39.6 (from baseline to 3 months p = 0.033, over time p = 0.045). Changes in the quality of life of patients and caregivers over time (MQOL) Between baseline and 6 months, the patients’ existential well- being mean score significantly increased in the group with no awareness, whereas it significantly decreased in the group with awareness (changes over time p = 0.031; Fig. 3a). The changes in the mean MQOL existential well-being scores were inversely correlated with a caregiver’s prognostic aware- ness compared with the EORTC QLQ-C15-PAL score. We performed further analyses in four groups, including patient awareness (Appendix, Fig. 5). The results revealed that QOL significantly decreased when both the caregiver and patient were aware of the prognosis, compared with their QOL when both the caregiver and patient remained unaware of the prog- nosis (over time p = 0.048). The difference in the social sup- port scores between the two groups was not significant. Caregivers who were unaware of the patients’ prognosis had better quality of life scores over time, in terms of existential well-being, as compared with caregivers who were aware of the illness (over time p = 0.036; Fig. 3c). Regarding social support, the scores of both groups decreased over time, but there was no significant difference between the groups. 400 Support Care Cancer (2021) 29:397–407 Changes in the proportion of depressed patients and caregivers The proportion of depressed patients in the aware patient group decreased from 42.9 to 24.1\% after 3 months, and the mean score was 37.4\% after 6 months. The proportion of depressed patients in the unaware patient group decreased from 33.4 to 28.5\% (at 3 months) and 31.7\% (at 6 months). The difference between the two groups was significant from baseline to 3 months (p = 0.028; Fig. 4a). In the aware care- giver group, the proportion of depressed caregivers increased from 19.6 (baseline) to 56.6\% (3 months) and 70.1\% (6 months). In the unaware caregiver group, the proportion of depressed caregivers increased from 32.7 (baseline) to 45.5\% (3 months) and 61.9\% (6 months). The changes over time demonstrated significant differences between the two caregiver groups (from baseline to 3 months p = 0.003, over time p = 0.024; Fig. 4b). Discussion The results of this study indicate that caregivers’ prognostic awareness is associated with improvements in patient quality of life, and when caregivers are not aware of the prognosis, there is an associated decrease or lack of significant change in pa- tients’ quality of life. However, the quality of life of caregivers tended to decrease with increased awareness of their patients’ incurable disease. In the aware caregiver group, the patients’ depression improved, but the caregivers’ depression worsened. Previous research has shown that caregivers’ positive atti- tudes about disclosure of disease prognosis were inversely Table 1 Sociodemographic characteristics of the participantsa Caregivers Patients Characteristic Without prognostic awareness (N = 58) With prognostic awareness (N = 101) Without prognostic awareness (N = 58) With prognostic awareness (N = 101) N (\%) Sex Male 12 (20.7) 35 (34.6) 42 (72.4) 61 (60.4) Female 46 (79.3) 66 (65.4) 16 (27.6) 40 (39.6) Age (years) Mean (SD) 54.4 (12.5) 51.3 (14.2) 59.9 (11.0) 63.7 (9.9) Educational status ≤ High school 44 (75.9) 60 (60.0) 46 (79.3) 81 (80.2) College or higher 14 (24.1) 40 (40.0) 12 (20.7) 20 (19.8) Job status Employed 35 (60.3) 73 (73.0) 10 (17.2) 8 (7.9) Unemployed 23 (39.7) 27 (27.0) 48 (82.8) 93 (92.1) Religion Yes 17 (29.3) 39 (39.0) 39 (67.2) 58 (57.4) No 41 (70.7) 61 (61.0) 19 (32.8) 43 (42.6) Marital status Not married 8 (13.8) 15 (15.0) 8 (13.8) 17 (16.8) Married 50 (86.2) 85 (85.0) 50 (86.2) 84 (83.2) Monthly income (USD) < 2000 30 (53.6) 45 (45.5) 32 (58.2) 64 (64.6) 2000–3999 20 (35.7) 25 (25.2) 16 (29.1) 17 (17.2) ≥ 4000 6 (10.7) 29 (29.3) 7 (12.7) 18 (18.2) Residence Rural/suburban 40 (69.0) 70 (70.0) 14 (24.1) 25 (24.8) Urban 18 (31.0) 30 (30.0) 44 (75.9) 76 (75.2) Primary cancer site Breast 13 (22.4) 8 (8.0) Colon 3 (5.2) 13 (13.0) Stomach 7 (12.1) 21 (21.0) Pancreato-biliary 8 (13.8) 17 (17.0) Blood 2 (3.5) 8 (8.0) Lung 25 (43.1) 33 (33.0) ECOG status 0 8 (13.8) 2 (2.0) 1 28 (48.3) 37 (36.6) 2 4 (6.9) 7 (6.9) 3 18 (31.0) 50 (49.5) 4 0 (0.0) 5 (5.0) a In some factors, there may be a missing value due to nonresponse of respondents 401Support Care Cancer (2021) 29:397–407 a Physical Functioning b Emotional Functioning c Overall quality of life d Fatigue e Nausea/Vomiting f Pain g Dyspnea h Insomnia i Appetite loss j Constipation 402 Support Care Cancer (2021) 29:397–407 associated with low quality of life scores in their patients [34]. However, that cross-sectional study did not examine the care- givers’ actual awareness of the prognosis. In this study, the quality of life scores improved in patients whose caregivers were aware of their prognosis. Moreover, the prevalence of depression tended to decrease in the short term in patients whose caregivers were aware of the prognosis. Although previous studies examined the effect of patient awareness on the quality of life and depression of patients and caregivers [35, 36], no studies have yet investigated the effect of caregivers’ prognostic awareness on quality of life and depression among patients and caregivers. Previous studies have shown that the caregiver’s perception of prognosis was associated with patient symptoms and quality of life [37], hospital readmission [38], and survival [39–41]. In addition, caregiver depression or poor health status affected the self- reported quality of patient care [42]. Although the mean MQOL score of patients was inversely correlated with the awareness of caregivers and the EORTC QLQ-C15-PAL score was not, in the analysis that included patient perception, patient awareness may have influenced quality of life (Appendix, Fig. 5). Based on these results, physicians should disclose information about the illness and actively communi- cate with the families of those patients with advanced cancer. Caregivers may be more vulnerable to depression or anxi- ety than patients [43]. The negative impact of the burden as- sociated with caregiving on caregivers’ physical and psycho- logical health and quality of life has been well recognized [44, 45]. Many caregivers want sufficient information on their pa- tient’s illness; however, the effects of this knowledge have not been adequately investigated [43, 46, 47]. In this study, in- creased caregiver prognostic awareness was associated with decreased emotional state and quality of life scores for the caregivers. These findings highlight the need to investigate the negative effects of prognostic awareness of incurable a Existential Well-being (Patients) b Social support (Patients) c Existential Well-being (Family caregivers) d Social support (Family caregivers) Fig. 3 Least square means of quality of life (McGill Quality of Life Questionnaire; the McGill Quality of Life Questionnaire (MQOL) uses existential well-being, and social support) according to family caregiver’s awareness, at all three time points. a, b Patient’s quality of life. c, d Family caregiver’s quality of life (adjusting for the baseline score and ECOG status). All of the response categories are based on numerical scales from 0 to 10, with verbal anchors at the beginning and end of the scales �Fig. 2 Least square means of quality of life (EORTC QLQ-C15-PAL; the items of the EORTC questionnaire were scored using a scale from 0 to 100) according to family caregiver’s awareness of the prognosis at base- line, 3 months, and 6 months (adjusting for the baseline score and ECOG status). a Physical functioning. b Emotional functioning. c Overall quality of life. d Fatigue. e Nausea/vomiting. f Pain.g Dyspnea. h Insomnia. i Appetite loss. j Constipation 403Support Care Cancer (2021) 29:397–407 illness on the caregiver’s emotional state and quality of life. Tailored interventions should be developed based on this ev- idence. Caregivers’ awareness may have a positive impact on patients’ quality of life and emotional state. Therefore, disclo- sure of the prognosis to caregivers through appropriate inter- ventions is important for both caregivers and patients. The methodological advantages of this study are its pro- spective design and nationwide cohort. However, this study exclusively recruited patients from hospitals in Korea. Therefore, our findings may not be generalizable to diverse populations in different geographical areas. Using validated questionnaires, we were able to avoid information bias. However, selection bias in the individuals who participated in the study is possible. However, since there are similar sociodemographic and clinical characteristics among those who participated in the study and those who did not, a strong selection bias seems unlikely. Another potential limitation of this study is its relatively short follow-up period (6 months). Further studies are warranted to assess the long-term effects associated with caregivers’ awareness. High follow-up loss rates could also be a limitation of this study. We performed multiple imputations during data analysis (17 participant’s da- ta at 3-month follow-up analysis and 34 participant’s data at 6- month follow-up analysis). As this study was conducted on advanced cancer patients, the follow-up loss rate was high. Although we made many efforts to follow-up with patients and caregivers, many subjects experienced various end-of- life difficulties, resulting in follow-up losses that may bias the results. In conclusion, the results of this prospective cohort study involving patients with advanced cancer and their caretakers indicate that caregivers’ prognostic awareness was linked to improved patient quality of life. At the same time, the quality of life of the caregivers aware of the prognosis decreased. In addition, caregivers’ prognostic awareness was associated with improved rates of depression in the patients, but it was also associated with a deterioration in the caregivers’ emotion- al state. These results may help predict the impact of prognos- tic disclosure and develop effective interventions regarding incurable illnesses for both patients and their caregivers. Author contributions All authors contributed to the study conception and design. Material preparation and data acquisition were performed by Bhumsuk Keam, Na-Ri Lee, Jung Hun Kang, Yu Jung Kim, Hyun- Jeong Shim, Kyung Hae Jung, Su-Jin Koh, Hyewon Ryu, Jihye Lee, Jiyeon Choo, Shin Hye Yoo, and Young Ho Yun. Statistical analysis was performed by EunKyo Kang and Young Ho Yun. Interpretation of data and analysis were done by EunKyo Kang, Young Ho Yun, Jihye Lee, and Jiyeon Choo. The first draft of the manuscript was written by EunKyo Kang and Young Ho Yun. All authors critically revised the manuscript. All authors read and approved the final version for publication. Funding information This work was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HC15C1391). The funders had no role in the design and conduct of the study; collection, manage- ment, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Compliance with ethical standards Conflict of interest The authors declare that they have no conflict of interest. Ethical approval All procedures executed in this study were performed in accordance with the ethical standards of the institutional and/or nation- al research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The written informed consent forms and the study were approved by the institutional review board at each hospital (IRB No. 1602-142-745). Informed consent was obtained from all participants in this study. a Depression (Patients) b Depression (Family caregivers) Fig. 4 Proportions of depressed patients (the …
CATEGORIES
Economics Nursing Applied Sciences Psychology Science Management Computer Science Human Resource Management Accounting Information Systems English Anatomy Operations Management Sociology Literature Education Business & Finance Marketing Engineering Statistics Biology Political Science Reading History Financial markets Philosophy Mathematics Law Criminal Architecture and Design Government Social Science World history Chemistry Humanities Business Finance Writing Programming Telecommunications Engineering Geography Physics Spanish ach e. Embedded Entrepreneurship f. Three Social Entrepreneurship Models g. Social-Founder Identity h. Micros-enterprise Development Outcomes Subset 2. Indigenous Entrepreneurship Approaches (Outside of Canada) a. Indigenous Australian Entrepreneurs Exami Calculus (people influence of  others) processes that you perceived occurs in this specific Institution Select one of the forms of stratification highlighted (focus on inter the intersectionalities  of these three) to reflect and analyze the potential ways these ( American history Pharmacology Ancient history . Also Numerical analysis Environmental science Electrical Engineering Precalculus Physiology Civil Engineering Electronic Engineering ness Horizons Algebra Geology Physical chemistry nt When considering both O lassrooms Civil Probability ions Identify a specific consumer product that you or your family have used for quite some time. This might be a branded smartphone (if you have used several versions over the years) or the court to consider in its deliberations. Locard’s exchange principle argues that during the commission of a crime Chemical Engineering Ecology aragraphs (meaning 25 sentences or more). Your assignment may be more than 5 paragraphs but not less. INSTRUCTIONS:  To access the FNU Online Library for journals and articles you can go the FNU library link here:  https://www.fnu.edu/library/ In order to n that draws upon the theoretical reading to explain and contextualize the design choices. Be sure to directly quote or paraphrase the reading ce to the vaccine. Your campaign must educate and inform the audience on the benefits but also create for safe and open dialogue. A key metric of your campaign will be the direct increase in numbers.  Key outcomes: The approach that you take must be clear Mechanical Engineering Organic chemistry Geometry nment Topic You will need to pick one topic for your project (5 pts) Literature search You will need to perform a literature search for your topic Geophysics you been involved with a company doing a redesign of business processes Communication on Customer Relations. Discuss how two-way communication on social media channels impacts businesses both positively and negatively. Provide any personal examples from your experience od pressure and hypertension via a community-wide intervention that targets the problem across the lifespan (i.e. includes all ages). Develop a community-wide intervention to reduce elevated blood pressure and hypertension in the State of Alabama that in in body of the report Conclusions References (8 References Minimum) *** Words count = 2000 words. *** In-Text Citations and References using Harvard style. *** In Task section I’ve chose (Economic issues in overseas contracting)" Electromagnetism w or quality improvement; it was just all part of good nursing care.  The goal for quality improvement is to monitor patient outcomes using statistics for comparison to standards of care for different diseases e a 1 to 2 slide Microsoft PowerPoint presentation on the different models of case management.  Include speaker notes... .....Describe three different models of case management. visual representations of information. They can include numbers SSAY ame workbook for all 3 milestones. You do not need to download a new copy for Milestones 2 or 3. When you submit Milestone 3 pages): Provide a description of an existing intervention in Canada making the appropriate buying decisions in an ethical and professional manner. Topic: Purchasing and Technology You read about blockchain ledger technology. Now do some additional research out on the Internet and share your URL with the rest of the class be aware of which features their competitors are opting to include so the product development teams can design similar or enhanced features to attract more of the market. The more unique low (The Top Health Industry Trends to Watch in 2015) to assist you with this discussion.         https://youtu.be/fRym_jyuBc0 Next year the $2.8 trillion U.S. healthcare industry will   finally begin to look and feel more like the rest of the business wo evidence-based primary care curriculum. Throughout your nurse practitioner program Vignette Understanding Gender Fluidity Providing Inclusive Quality Care Affirming Clinical Encounters Conclusion References Nurse Practitioner Knowledge Mechanics and word limit is unit as a guide only. The assessment may be re-attempted on two further occasions (maximum three attempts in total). All assessments must be resubmitted 3 days within receiving your unsatisfactory grade. You must clearly indicate “Re-su Trigonometry Article writing Other 5. June 29 After the components sending to the manufacturing house 1. In 1972 the Furman v. Georgia case resulted in a decision that would put action into motion. Furman was originally sentenced to death because of a murder he committed in Georgia but the court debated whether or not this was a violation of his 8th amend One of the first conflicts that would need to be investigated would be whether the human service professional followed the responsibility to client ethical standard.  While developing a relationship with client it is important to clarify that if danger or Ethical behavior is a critical topic in the workplace because the impact of it can make or break a business No matter which type of health care organization With a direct sale During the pandemic Computers are being used to monitor the spread of outbreaks in different areas of the world and with this record 3. Furman v. Georgia is a U.S Supreme Court case that resolves around the Eighth Amendments ban on cruel and unsual punishment in death penalty cases. The Furman v. Georgia case was based on Furman being convicted of murder in Georgia. Furman was caught i One major ethical conflict that may arise in my investigation is the Responsibility to Client in both Standard 3 and Standard 4 of the Ethical Standards for Human Service Professionals (2015).  Making sure we do not disclose information without consent ev 4. Identify two examples of real world problems that you have observed in your personal Summary & Evaluation: Reference & 188. Academic Search Ultimate Ethics We can mention at least one example of how the violation of ethical standards can be prevented. Many organizations promote ethical self-regulation by creating moral codes to help direct their business activities *DDB is used for the first three years For example The inbound logistics for William Instrument refer to purchase components from various electronic firms. During the purchase process William need to consider the quality and price of the components. In this case 4. A U.S. Supreme Court case known as Furman v. Georgia (1972) is a landmark case that involved Eighth Amendment’s ban of unusual and cruel punishment in death penalty cases (Furman v. Georgia (1972) With covid coming into place In my opinion with Not necessarily all home buyers are the same! When you choose to work with we buy ugly houses Baltimore & nationwide USA The ability to view ourselves from an unbiased perspective allows us to critically assess our personal strengths and weaknesses. This is an important step in the process of finding the right resources for our personal learning style. Ego and pride can be · By Day 1 of this week While you must form your answers to the questions below from our assigned reading material CliftonLarsonAllen LLP (2013) 5 The family dynamic is awkward at first since the most outgoing and straight forward person in the family in Linda Urien The most important benefit of my statistical analysis would be the accuracy with which I interpret the data. The greatest obstacle From a similar but larger point of view 4 In order to get the entire family to come back for another session I would suggest coming in on a day the restaurant is not open When seeking to identify a patient’s health condition After viewing the you tube videos on prayer Your paper must be at least two pages in length (not counting the title and reference pages) The word assimilate is negative to me. I believe everyone should learn about a country that they are going to live in. It doesnt mean that they have to believe that everything in America is better than where they came from. It means that they care enough Data collection Single Subject Chris is a social worker in a geriatric case management program located in a midsize Northeastern town. She has an MSW and is part of a team of case managers that likes to continuously improve on its practice. The team is currently using an I would start off with Linda on repeating her options for the child and going over what she is feeling with each option.  I would want to find out what she is afraid of.  I would avoid asking her any “why” questions because I want her to be in the here an Summarize the advantages and disadvantages of using an Internet site as means of collecting data for psychological research (Comp 2.1) 25.0\% Summarization of the advantages and disadvantages of using an Internet site as means of collecting data for psych Identify the type of research used in a chosen study Compose a 1 Optics effect relationship becomes more difficult—as the researcher cannot enact total control of another person even in an experimental environment. Social workers serve clients in highly complex real-world environments. Clients often implement recommended inte I think knowing more about you will allow you to be able to choose the right resources Be 4 pages in length soft MB-920 dumps review and documentation and high-quality listing pdf MB-920 braindumps also recommended and approved by Microsoft experts. The practical test g One thing you will need to do in college is learn how to find and use references. References support your ideas. College-level work must be supported by research. You are expected to do that for this paper. You will research Elaborate on any potential confounds or ethical concerns while participating in the psychological study 20.0\% Elaboration on any potential confounds or ethical concerns while participating in the psychological study is missing. Elaboration on any potenti 3 The first thing I would do in the family’s first session is develop a genogram of the family to get an idea of all the individuals who play a major role in Linda’s life. After establishing where each member is in relation to the family A Health in All Policies approach Note: The requirements outlined below correspond to the grading criteria in the scoring guide. At a minimum Chen Read Connecting Communities and Complexity: A Case Study in Creating the Conditions for Transformational Change Read Reflections on Cultural Humility Read A Basic Guide to ABCD Community Organizing Use the bolded black section and sub-section titles below to organize your paper. For each section Losinski forwarded the article on a priority basis to Mary Scott Losinksi wanted details on use of the ED at CGH. He asked the administrative resident