Social Anxiety - Psychology
What is social anxiety? Please read the attached instructions carefully Instructions: APA Format Please read carefully!!!!!! Cognitive Behavioral therapy and social anxiety? Who does it affect most? What are some cultural differences? Must demonstrate an excellent understanding of all of the concepts and key points presented in the text(s) and Learning Resources. Paper provides significant detail including multiple relevant examples, evidence from the readings and other sources, and discerning ideas. Must be well organized, uses scholarly tone, follows APA Style, uses original writing and proper paraphrasing, contains very few or no writing and/or spelling errors, and is fully consistent with graduate-level writing style. Must contain multiple, appropriate and exemplary sources expected/required for the Assignment. The first section is the Introduction (1 paragraph). Create an introduction, explains what the paper will be about. -The second section is entitled Topic (Social Anxiety)(2 pgs). *Examine topic and decide on an aspect of the topic *The topic should be narrow enough to be able to research it in the scholarly literature. *Support your description with the information cited from two peer-reviewed articles. - The third section is Literature Review (8 pgs). ALL LITERATURE and REFERENCES are ATTACHED *peer-reviewed journal articles *Brief introduction explaining the topic *Provide an integrated synthesis of your resources related to your topic *Conclude with a summary paragraph - The fourth section is Research Gap and Problem Statement (1pg). *A problem statement is a concise description of the specific focus for a study.  You have reviewed the research literature about your topic/problem and identified a gap in the research that needs further study *Describe the gap and complete a concise problem statement -The fifth section is Positive Social Change (1pg). *Write a statement describing the implications for positive social change that could result from research *Support ideas with information from scholarly resources. -The final section is a Conclusion (2 paragraphs). Use section headings Introduction, Topic, Literature Review, Research Gap and Problem Statement, Positive Social Change, Conclusion and References. References Anderson, K. N., Jeon, A. B., Blenner, J. A., Wiener, R. L., & Hope, D. A. (2015). How people evaluate others with social anxiety disorder: A comparison to depression and general mental illness stigma. American Journal Of Orthopsychiatry, 85(2), 131-138. Boukhechba, M., Chow, P., Fua, K., Teachman, B. A., & Barnes, L. E. (2018). Predicting Social Anxiety From Global Positioning System Traces of College Students: Feasibility Study. JMIR mental health, 5(3), e10101. https://doi.org/10.2196/10101 Cao, J., Yang, J., Zhou, Y., Chu, F., Zhao, X., Wang, W., Wang, Y., & Peng, T. (2016). The effect of Interaction Anxiousness Scale and Brief Social Phobia Scale for screening social anxiety disorder in college students: a study on discriminative validity. Journal of Mental Health, 25(6), 500–505. https://doi-org.ezp.waldenulibrary.org/10.3109/09638237.2015.1124391doi:10.1037/ort0000046 Dryman, M. T., McTeague, L. M., Olino, T. M., & Heimberg, R. G. (2017). Evaluation of an open-access CBT-based Internet program for social anxiety: Patterns of use, retention, and outcomes. Journal of Consulting and Clinical Psychology, 85(10), 988-999. doi:10.1037/ccp0000232 Grumet, R., & Fitzpatrick, M. (2016). A case for integrating values clarification work into cognitive behavioral therapy for social anxiety disorder. Journal Of Psychotherapy Integration, 26(1), 11-21. doi:10.1037/a0039633 Hajure, M., & Abdu, Z. (2020). Social Phobia and Its Impact on Quality of Life Among Regular Undergraduate Students of Mettu University, Mettu, Ethiopia. Adolescent health, medicine and therapeutics, 11, 79–87. https://doi.org/10.2147/AHMT.S254002 Hakami, R. M., Mahfouz, M. S., Adawi, A. M., Mahha, A. J., Athathi, A. J., Daghreeri, H. H., Najmi, H. H., & Areeshi, N. A. (2018). Social anxiety disorder and its impact in undergraduate students at Jazan University, Saudi Arabia. Mental illness, 9(2), 7274. https://doi.org/10.4081/mi.2017.7274 Kampmann, I. L., Emmelkamp, P. M. G., Hartanto, D., Brinkman, W.-P., Zijlstra, B. J. H., & Morina, N. (2016). Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial. Behaviour Research & Therapy, 77, 147–156. https://doi-org.ezp.waldenulibrary.org/10.1016/j.brat.2015.12.016 Kivity, Y., Cohen, L., Weiss, M., Elizur, J., & Huppert, J. D. (2021). The role of expressive suppression and cognitive reappraisal in cognitive behavioral therapy for social anxiety disorder: A study of self-report, subjective, and electrocortical measures. Journal of Affective Disorders, 279, 334–342. https://doi-org.ezp.waldenulibrary.org/10.1016/j.jad.2020.10.021 Mesri, B., Niles, A. N., Pittig, A., LeBeau, R. T., Haik, E., & Craske, M. G. (2017). Public speaking avoidance as a treatment moderator for social anxiety disorder. Journal of behavior therapy and experimental psychiatry, 55, 66–72. https://doi.org/10.1016/j.jbtep.2016.11.010 Pickard, H., Rijsdijk, F., Happé, F., & Mandy, W. (2017). Are Social and Communication Difficulties a Risk Factor for the Development of Social Anxiety?. Journal of the American Academy of Child and Adolescent Psychiatry, 56(4), 344–351.e3. https://doi.org/10.1016/j.jaac.2017.01.007 NIMH » Social Anxiety Disorder: More Than Just Shyness. (2021). Retrieved 27 August 2021, from https://www.nimh.nih.gov/health/publications/social-anxiety-disorder-more-than-just-shyness Rosen, A. (2021). How Social Anxiety Impacts Higher Education and Career Choices - The Center for Treatment of Anxiety and Mood Disorders. Retrieved 27 August 2021, from https://centerforanxietydisorders.com/social-anxiety-impacts-higher-education-career-choices/ Wedding, D., & Corsini, R. J. (Eds.). (2014). Current psychotherapies (10th ed.). Belmont, CA: Brooks/Cole, Cengage Learning See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/296707124 A case for integrating values clarification work into cognitive behavioral therapy for social anxiety disorder Article  in  Journal of Psychotherapy Integration · March 2016 DOI: 10.1037/a0039633 CITATIONS 7 READS 940 2 authors: Robin Grumet McGill University 3 PUBLICATIONS   86 CITATIONS    SEE PROFILE Marilyn Fitzpatrick McGill University 53 PUBLICATIONS   1,010 CITATIONS    SEE PROFILE All content following this page was uploaded by Robin Grumet on 04 March 2016. 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Cognitive behavioral therapy (CBT) has been found to be efficacious in treating SAD, however, barriers to successful treatment still remain. In particular, given the difficulty of engaging clients in anxiety-inducing exposure interventions, it is important to address issues of client motivation in treatment. The current article provides a rationale for incorporating values clarification work from an acceptance and commitment therapy perspective into CBT for SAD. More specifically, it proposes helping clients in CBT for SAD to clarify their values and commit to behaving in ways consistent with their values. The rationale is that values work could enhance treatment motivation and adherence by providing motivation to engage in the difficult work of exposure. Values work also contributes to a sense of meaning and purpose that can enhance positive well-being and quality of life. Finally, values work might be beneficial in maintaining gains following the termination of treatment. Suggestions for application strategies of incorporating values work in to CBT for SAD are provided, in addition to recommendations for research. Keywords: cognitive behavioral therapy, social anxiety disorder, acceptance and com- mitment therapy, values clarification Social anxiety disorder (SAD) is a debilitat- ing psychological disorder characterized by an intense fear of social situations, particularly those in which there is the possibility of scrutiny or negative evaluation from others (American Psychiatric Association, 2013). SAD is the third most common psychiatric disorder, with a life- time prevalence estimated at 13% in the Uni- ted States (Kessler, Petukhova, Sampson, Zaslavsky, & Wittchen, 2012), and is associated with significant functional impairment in social, occupational, and other areas of functioning (American Psychiatric Association, 2013). SAD is also associated with a markedly reduced qual- ity of life (QOL; Hambrick, Turk, Heimberg, Schneier, & Liebowitz, 2003; Kessler, 2003; Stein & Kean, 2000), diminished positive affect (Kashdan, 2007; Kashdan & McKnight, 2013), and fewer positive psychological experiences, such as curiosity (Kashdan, 2007; Weeks & Heimberg, 2012), as well as physical health problems (Sareen, Cox, Clara, & Asmundson, 2005) and suicidal ideation and attempts (Cougle, Keough, Riccardi, & Sachs-Ericsson, 2009). Given the prevalence of SAD and its debilitating impact, it is important to extend the impact of validated treatments to address SAD symptoms and to improve QOL and foster pos- itive functioning among sufferers. CBT for SAD: The Need for Values There is ample evidence that cognitive be- havioral therapy (CBT) is efficacious in treating SAD in both individual (Clark et al., 2003; Lincoln et al., 2003; Stangier, Heidenreich, Peitz, Lauterbach, & Clark, 2003) and group formats (Heimberg & Becker, 2002; Hope, Heimberg, & Bruch, 1995; McEvoy, Nathan, Rapee, & Campbell, 2012; Mörtberg, Clark, & Bejerot, 2011). The fundamental aim of CBT for SAD is to modify the socially relevant dys- functional cognitions that maintain avoidance Robin Grumet and Marilyn Fitzpatrick, Department of Educational and Counselling Psychology, McGill Univer- sity. Correspondence concerning this article should be ad- dressed to Robin Grumet, Department of Educational and Counselling Psychology, McGill University, 3700 McTav- ish Street, Montreal, Quebec, H3A 1Y2. E-mail: robin [email protected] T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. Journal of Psychotherapy Integration © 2016 American Psychological Association 2016, Vol. 26, No. 1, 11–21 1053-0479/16/$12.00 http://dx.doi.org/10.1037/a0039633 11 mailto:[email protected] mailto:[email protected] http://dx.doi.org/10.1037/a0039633 behavior and the symptoms of the disorder (Hope, Burns, Hayes, Herbert, & Warner, 2010). This is achieved through two types of (related) interventions. First, cognitive restruc- turing is used to help clients identify, reexam- ine, and modify distorted cognitions (i.e., thoughts, core beliefs; Hope et al., 2010). Cli- ents then complete exposure tasks that put them in situations that they fear and would typically avoid (e.g., assigning a client homework to go to a party and initiate a conversation with a stranger) until they habituate to the feared stim- uli (Hope et al., 2010). In addition to cognitive restructuring, expo- sure is also meant to restructure cognitions and disconfirm false and maladaptive beliefs by pro- viding an experience that is contrary to the distorted cognition (Heimberg, 2002). Exposure also improves SAD symptomatology through a behavioral route. Fear extinction occurs when the individual faces a feared situation with high anxiety; the anxiety is reduced over time until it ultimately abates (Heimberg, 2002). Emotional processing theory posits that extinction occurs through exposure when new incompatible learning takes place and replaces the old faulty association (Foa & Kozak, 1986; Foa & Mc- Nally, 1996). The individual habituates to the feared stimulus, producing a corrective learning experience (Foa & Kozak, 1986; Foa & Mc- Nally, 1996). The newer inhibitory learning model of extinction postulates that a new asso- ciation is developed while the original fear as- sociation remains intact (Craske et al., 2008; Craske, Treanor, Conway, Zbozinek, & Verv- liet, 2014). Both associations remain accessible, indicating that the original fear association can arise in some contexts. Working to enhance the retrieval of inhibitory learning is essential (Craske et al., 2008, 2014). From this perspec- tive, habituation per se is not the central focus, but rather the importance of distress tolerance is highlighted. Exposure interventions have received an abundance of empirical attention, as they are considered powerful and efficacious interven- tions (Dalrymple & Herbert, 2007). Though re- sults have been mixed, there is some evidence to suggest that exposure treatments are at least as effective as full CBT treatments that include both cognitive restructuring and exposure (Feske & Chambless, 1995; Gould, Buckmin- ster, Pollack, Otto, & Massachusetts, 1997; Hope et al., 1995). For instance, there is re- search to support the efficacy of exposure inter- ventions (used independently) in producing cognitive changes similar to the effect produced by cognitive restructuring techniques on their own (Newman, Hofmann, Trabert, Roth, & Taylor, 1994). Despite the well-documented effectiveness of CBT for SAD, it is not always successful. Some clients do not make a full recovery or improve at all; they even occasionally deteriorate (McAleavey, Castonguay, & Goldfried, 2014). Additionally, of those individuals that do re- spond to treatment, many still experience resid- ual symptoms (Dalrymple & Herbert, 2007). Furthermore, a number of clients (10% to 20%) also terminate treatment prematurely (Es- kildsen, Hougaard, & Rosenberg, 2010). Even more concerning, when dropout rates are in- cluded, 40% to 50% of individuals with SAD show little or no improvement following CBT treatment (Eskildsen et al., 2010); clearly, this group needs something else. Exposure interven- tions, in particular, have been associated with an increased risk for dropout (McAleavey et al., 2014). In addition, clients sometimes do not adhere to treatment protocols and neglect to do homework. Furthermore, though some evidence indicates an improvement in QOL following participation in CBT for SAD, findings suggest that treated individuals still do not achieve the same levels of QOL as nonclinical populations (Dalrymple & Herbert, 2007). Thus, barriers to successfully treating this population using CBT still remain. McAleavey and colleagues (2014) investi- gated clinician’s perceptions of barriers to treat- ment in CBT for SAD and found a myriad of issues that interfere with treatment and contrib- ute to less optimal outcomes. For instance, cli- ent motivation was a prominent barrier; 60.5% of clinicians reported that they believed that when client motivation was minimal at the out- set of treatment, CBT would be less successful, and that CBT would be more successful if mo- tivation improved. Relative to client motivation, 57.2% of clinicians were concerned about pre- mature termination and found that motivation decreased as patients attributed gains to medi- cations (26.1%), as improvement occurred (16.3%), or as an understanding of social phobia developed (9.1%). Notably, 55.4% of practitio- ners reported clients not working independently 12 GRUMET AND FITZPATRICK T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. between sessions as a barrier. Relatedly, 27.5% also endorsed fear of exposure and associated emotional reactions as a barrier to successful treatment. Taken together, these findings indi- cate that clinicians saw client motivation and commitment to the therapeutic tasks as impor- tant obstacles to progress. In addition to thera- pists’ perspectives on client motivation, client self-reports have been related to outcomes in the treatment of anxiety disorders (de Haan et al., 1997; Keijsers, Hoogduin, & Schaap, 1994a, 1994b). However, findings in studies using self- report to assess motivation have been mixed. This inconsistency has been attributed to mea- surement issues with self-report (Lombardi, Button, & Westra, 2014). In a recent study using observational coding, Lombardi et al. (2014) found that client motivational language early in therapy was a strong predictor of treat- ment outcome in CBT for generalized anxiety disorder (GAD). Given the perceived importance of motiva- tion to treatment outcome in the context of CBT for SAD, McAleavey et al. (2014) suggest that clinicians might find it helpful to complement their CBT for SAD treatment plan using other techniques to foster client motivation. As an example, they discuss motivational interview- ing (MI) to uncover clients’ intrinsic motivation to change. MI is predicated on the notion that in order to effectively foster readiness and com- mitment to change, the motivation for change should not be imposed from the outside (e.g., the therapist), but rather should be elicited from within the client (Hettema, Steele, & Miller, 2005). Given that personal values are an inher- ently motivational, direct human behavior (Bardi & Schwartz, 2003), and are intrinsic to the individual (Plumb, Stewart, Dahl, & Lund- gren, 2009), integrating values clarification work into CBT for SAD could enhance motiva- tion for SAD treatment. Another strong argument for including values work in CBT treatment of SAD is to foster positive psychological functioning and augment QOL. Research indicates that values-behavior congruence (i.e., acting in a manner consistent with personal values) is associated with several wellness outcomes, including increased life sat- isfaction (Lundgren, Dahl, & Hayes, 2008) and QOL (Michelson, Lee, Orsillo, & Roemer, 2011). Relative to anxiety disorders, Michelson et al. (2011) found that values– behavior con- gruence was associated with increased self- reports of QOL in a population of individuals with GAD. In terms of SAD, following an ex- posure-based treatment for SAD, including val- ues work in a full acceptance and commitment therapy (ACT) model, individuals reported greater functioning and QOL, in addition to greater values-behavior congruence (Dalrymple & Herbert, 2007). These authors noted that “the focus on experiential acceptance in the context of behavior change consistent with personal values may hold the potential to result in greater functional improvement and quality of life” (Dalrymple & Herbert, 2007, p. 546). As the research suggests, individuals suffer- ing from SAD not only experience negative affect but also lack elements of positive well- being (Kashdan, 2007; Kashdan & McKnight, 2013; Weeks & Heimberg, 2012). Interventions fostering positive psychological functioning are important to SAD sufferers. Integrating values interventions in CBT treatment plans for SAD may facilitate this endeavor. Recently, similar integration approaches have been suggested. For instance, Macarthur (2013) proposes an as- similative integration approach to treating SAD, particularly with regard to addressing the core beliefs characteristic of this disorder. In a sim- ilar vein, Cameron, Reed, and Gaudiano (2014) proposed a rationale for incorporating values- based exercises into dialectical behavior ther- apy to treat borderline personality disorder. Similar to the current rationale, they reason that values integration could help to promote moti- vation to engage in treatment and adhere to treatment protocol (Cameron et al., 2014). The current article discusses the integration of values clarification work from an ACT framework into CBT treatment for SAD. Many of the suggestions in this article have applica- tion to CBT in general; however, there are sev- eral compelling reasons for focusing on SAD. The threats associated with many anxiety dis- orders and phobias tend to be circumscribed to specific stimuli (e.g., fear of elevators), whereas in SAD, the nature of the threat is social and pervasive. SAD can interfere with vocational success and the quality of romantic relation- ships and life satisfaction; individuals with a diagnosis of SAD are less likely to be married or in a romantic relationship (Teo, Lerrigo, & Rogers, 2013), and are more likely to experi- ence social issues and impairments in education 13VALUES CLARIFICATION WORK T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. (Van Ameringen, Mancini, & Farvolden, 2003) and employment (Bruch, Fallon, & Heimberg, 2003; Stein & Kean, 2000). Because of the pervasiveness and importance of values in all life domains, values work in SAD has particular salience. Research indicates that although all anxiety disorders are associated with negative affect, SAD is unique in its association with low levels of positive affect (Kashdan et al., 2013) and high levels of experiential avoidance (Kashdan et al., 2013). In avoiding negative internal ex- periences, individuals with SAD often avoid social interactions. Kashdan et al. (2013) re- cently suggested that when working with indi- viduals with SAD, clinicians should incorporate more strategies targeting experiential avoidance and enhancing positive experience. The current article argues that values in the context of CBT treatment for SAD can support this strategy. Prior to elaborating the rationale for incorpo- rating ACT values work in to CBT for SAD, a brief description of ACT as well as the defini- tion of values from this framework are pro- vided. Next, the rationale for incorporating ACT values work in to CBT for SAD is dis- cussed. Finally, suggestions for implementing this work, as well as directions for future re- search, are offered. ACT Values Work: Fitting into CBT for SAD ACT is a third-wave behavioral therapy, which aims to teach individuals to accept and embrace difficult psychological experience in order to live a life in service of their personal values (Hayes, Luoma, Bond, Masuda, & Lillis, 2006). ACT is composed of six components (acceptance, mindfulness, cognitive defusion, self-as context, values clarification, and com- mitted action). A full description of ACT is beyond the scope of this article (see Hayes et al., 2006, for a comprehensive presentation). Instead, we will focus on values and committed action as the components that have most to complement existing exposure-based methods of SAD treatment. These components were cho- sen because they give meaning to, and are the reason for the other ACT treatment processes, which “help clear the path for a more vital, values-consistent life. Values dignify these other processes and make them meaningful” (Hayes, Levin, Plumb-Vilardaga, Villatte, & Pi- storello, 2013, p. 186). A focus on values in CBT can infuse meaning and motivation into the CBT treatment process. In addition, values and committed action work involves setting short-, medium-, and long-term behavioral change goals that support valued living (Hayes et al., 2013) and is highly congruent with tradi- tional CBT protocols (Hayes et al., 2013). In ACT, values are defined as “chosen qual- ities of purposive action that can never be ob- tained as an object but can be instantiated mo- ment by moment” (Hayes et al., 2006, p. 9). Unlike goals, values can never be achieved but can be continually expressed in moment-to- moment behavior. A commonly used metaphor in ACT is that values are more like a direction on a compass, as opposed to a destination or goal (Yadavaia & Hayes, 2009). For example, if the value is “living generously,” it is possible to achieve a goal of raising $2,000 for a local charity or of giving an hour of your time weekly to visit your elderly grandmother; however, the quality of generosity can never actually be achieved. Values also cross contexts; one can be generous in a variety of times and situations. I can be generous with time; generous with mon- ey; generous in my compassion for friends, family, or coworkers; or even generous with myself, by making time for self-care. Helping clients with SAD understand the way that val- ues cross contexts can help them to apply new learning from CBT more broadly. This is par- ticularly important in SAD, given its pervasive impairments to daily living. According to the ACT conceptualization, val- ues are freely chosen; they are not needed to please others or to avoid negative consequences (Ciarrochi, Fisher, & Lane, 2011; Plumb et al., 2009; Wilson, Sandoz, Kitchens, & Roberts, 2010). As such, they should be intrinsically motivating, inherently rewarding, and satisfy- ing. For example, one should value generosity for its own sake and not because one gets rec- ognition or praise from others. Although valued living is rewarding, it is not always easy and can be painful (Hayes et al., 2013). Accordingly if the difficulties of exposure in SAD treatment can be related to goals that are values consis- tent, motivation even in the face of psycholog- ical barriers may increase. This is particularly relevant with SAD, in which anxiety, fear, and negative emotions pre- 14 GRUMET AND FITZPATRICK T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. vent individuals from engaging in activities that create a sense of worth. For example, it is well- documented that anxiety about social perfor- mance often promotes avoidant behavior in in- dividuals with SAD (Dalrymple & Herbert, 2007). Research has shown that helping indi- viduals to focus on what is deeply important to them (i.e., what they value) can help them to persist in valued directions even in the face of hardship. For instance, values interventions have been found to increase persistence in pain- tolerance tasks (Páez-Blarrina et al., 2008). There is also evidence to indicate that including values work in therapy can enhance treatment adherence (Forman, Butryn, Hoffman, & Her- bert, 2009; Woods, Wetterneck, & Flessner, 2006). Helping individuals to clarify their per- sonal values and commit to values-congruent action is a promising way of increasing motiva- tion for exposure. To do such work, clients need to be helped to connect their personal value to the treatment process and understand its relevance to the chal- lenges of exposure (e.g., negative internal ex- perience). Individuals with SAD can then be helped to use their values as a guide to decision making and behavior, replacing the use of neg- ative internal experience as a guide and facili- tating the use of approach, rather than avoid- ance-based, behaviors (Kashdan & McKnight, 2013). For example, if an individual values liv- ing vitally but is reluctant to engage in some difficult aspects of treatment, it might be worth- while to connect the hard work in treatment to the experience of vitality in the long term. Us- ing the values example of living generously, the act of attending a friend’s birthday dinner can be understood as generosity to a friend and might improve client motivation to tolerate the difficulty of the event. Different values can serve the same goal. For example, a socially anxious person who values authentic connec- tion but is afraid of social rejection might be motivated to attend the birthday dinner to create an opportunity for strengthening her connection with the friend. A SAD sufferer who has clari- fied the value of promoting harmony in the world might see the dinner as an opportunity to interact harmoniously. The value may serve as the basis for increasing motivation in the con- text of the difficult exposure task. As described above, challenge of exposure tasks in the treat- ment of SAD can be mitigated if clients can clarify personal values and translate them to committed action in service of a value. The process of values clarification and fostering val- ues-congruent behavior is elaborated in greater detail below. In addition to supporting motivation for ex- posure, the addition of values work in CBT for SAD may also serve to foster positive function- ing (e.g., enhancing meaning in life) and well- being. Efficacy of CBT for SAD is often gauged in terms of symptom reduction. Although this is an important goal, well-being is more than the absence of psychological distress (Duckworth, Steen, & Seligman, 2005). Subjective well- being (SWB), or “happiness,” a widely used measure of well-being, is comprised of two components: life satisfaction, and the relative presence of positive affect and absence of neg- ative affect (Diener, 2000). Furthermore, from a positive psychology perspective, experiencing positive emotions, having a sense of meaning in life, and engaging in rewarding activities all contribute to SWB (Duckworth et al., 2005). However, research indicates that individuals with SAD have impaired positive functioning (Kashdan, 2007; Weeks & Heimberg, 2012), including less positive emotions, less meaning in life, as well as lower self-esteem when com- pared with their nonclinical counterparts (Kash- dan & McKnight, 2013). Effort toward living with a greater purpose in life has been associ- ated with greater positive emotions, increased self-esteem, and greater meaning in life in indi- viduals with SAD (Kashdan & McKnight, 2013). Though values and purpose are not syn- onymous, the constructs are closely related: “Purpose can be viewed as a subcategory of values, reflecting the most important or central. As a self-organizing system, purpose provides a framework for people to create goals and then specific behaviors that, if pursued, reflect com- mitted action” (Kashdan & McKnight, 2013, p. 1150). However, individuals with SAD report greater obstacles and failures and less intrinsic motivation in working toward their purpose (Kashdan & McKnight, 2013). Methods to ef- fectively address values are potentially useful in this work. Using values to foster purpose and meaning in life throughout the therapeutic pro- cess in CBT for SAD may result in enhanced well-being for clients. Given the pervasive nature of values (across both time and contexts), values work in the 15VALUES CLARIFICATION WORK T hi s do cu m en t is co py ri gh te d by th e A m er ic an P sy ch ol og ic al A ss oc ia ti on or on e of it s al li ed pu bl is he rs . T hi s ar ti cl e is in te nd ed so le ly fo r th e pe rs on al us e of th e in di vi du al us er an d is no t to be di ss em in at ed br oa dl y. context of CBT for SAD might also be a useful tool for maintaining gains and even continuing to achieve new gains following termination of treatment. For instance, a client might be helped and supported by a therapist to drop several safety behaviors (e.g., sitting at a far distance from others in a social situation) over the course of treatment. With a clear sense of values as well as an understanding of how this behavior interferes with values-congruent goals (e.g., meeting new people for a client who values novel experience and authentic connection), the likelihood of maintaining these treatment gains and reducing safety behaviors might be en- hanced. Furthermore, with a commitment to working toward a values-congruent lifestyle, the client might also drop other … [page 42] [Mental Illness 2017; 9:7274] Social anxiety disorder and its impact in undergraduate stu- dents at Jazan University, Saudi Arabia Ramzi M. Hakami,1 Mohamed S. Mahfouz,2 Abdulrahman M. Adawi,1 Adeebah J. Mahha,1 Alaa J. Athathi,1 Hadi H. Daghreeri,1 Hatim H. Najmi,1 Nuha A. Areeshi1 1Faculty of Medicine, Jazan University, Jazan; 2Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia Abstract Although social anxiety disorder (SAD) is a common mental disorder, it is often under diagnosed and under treated. The aim of this study is to assess the preva- lence, severity, disability, and quality of life towards SAD among students of Jazan University, Saudi Arabia. A cross-sectional study was conducted among a stratified sample of 500 undergraduate students to identify the prevalence of SAD, its corre- lates, related disability, and its impact on the quality life. All participants completed the Social Phobia Inventory, Leibowitz Social Anxiety Scale, Sheehan Disability Scale, and the WHO Quality of Life – BREF ques- tionnaire. Of 476 students, 25.8% were screened positive for SAD. About 47.2% of the students had mild symptoms, 42.3% had moderate to marked symptoms, and 10.5% had severe to very severe symptoms of SAD. Students who resulted positive for SAD reported significant disabilities in work, social, and family areas, and this has adversely affected their quality of life as compared to those who screened negative for SAD. Students reported several clinical manifestations that affected their function- ing and social life. Acting, performing or giving a talk in front of an audience was the most commonly feared situation. Blushing in front of people was the most commonly avoided situation. Since the present study showed a marked prevalence of SAD among students, increased disability, and impaired quality of life, rigorous efforts are needed for early recognition and treatment of SAD. Introduction While most of us experience some level of social unease when we feel scrutinized by others, such as while speaking in public or presenting at meetings, social anxiety disorder (SAD) is defined as an excessive and persistent fear of acting in a way that will be embarrassing and humiliating. This fear is almost invariably provoked by the feared situations, which are avoided or endured with severe distress, and interferes significantly with personal, occupational, and social functioning.1 Social anxiety disorder commonly appears in the teenage years,2 and usually affects 3 to 5% of youths.3 It is an extraor- dinarily persistent condition if left untreated and it may lead to a variety of comorbidi- ties, such as other anxiety disorders, affec- tive disorders, nicotine dependence, and substance-use disorder,4-6 predicting poorer treatment outcomes.7 Most of patients with SAD have been reported to have at least moderate impairment at some point in their lives. Education, employment, family, romantic relationships, friendships, social networks, quality of life, and other areas of life have been reported to be liable to impairment in patients with SAD.8-12 Unfortunately, although it is the third most common mental disorder in adults world- wide,13 SAD is often under diagnosed and undertreated.14 Furthermore, it has received little attention by both clinicians and researchers.8 In general, there is a lack of data on the prevalence of SAD and the reported rates vary widely between studies, with much of the variability possibly being due to differ- ent instruments used to determine diagno- sis.10 However, SAD is obviously one of the most common of all anxiety disorders.10 For instance, Kesseler and colleagues (2005) interviewed 9282 English-speaking partici- pants aged 18 years and older and found that SAD was the most common anxiety disorder, with a lifetime prevalence of up to 12%15 and a 12-month prevalence of 6.8%.16 Studies looking at country-specific pop- ulations of university students have pro- duced quite variable results when it comes to the prevalence of SAD. Many studies have indicated that social anxiety is a preva- lent disorder among university stu- dents.11,12,17-20 For example, studies from Sweden and India have reported the preva- lence of SAD among university students to be 16.1% and 19.5%, respectively.11,12 In the Kingdome of Saudi Arabia, less is known about SAD in general and among undergraduate students. However, high prevalence rates have been reported among Saudis, especially adolescents and young adults.21-25 Elhadad and colleagues (2017) have carried out a study on 380 medical stu- dents and found that as high as 59.5% of them were screened positive for SAD. In the same study, SAD was associated with decreased academic achievement, weak clinical exam performance, and avoidance of oral presentation.22 The present study aims to investigate SAD prevalence, severity, related disabili- ties, and its impact in students from five faculties at Jazan University, Saudi Arabia. We expect that this study would be helpful in bridging the gap in the local research of SAD, and will be useful to the future studies attempting to reduce the high prevalence of this disorder and to prevent its long-term consequences. Materials and Methods Study place, design and participants Jazan University is situated in Jazan region, southwest of the kingdom of Saudi Arabia. It is the leading higher educational institution in Jazan province. This is an Mental Illness 2017; volume 9:7274 Correspondence: Ramzi Mohammed Hakami, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia. E-mail: [email protected] Key words: Mental disorder; social phobia; social anxiety disorder; Saudi Arabia; Social Phobia Inventory. Acknowledgements: the authors thank Dr. Rashad Alsanosy (Substance Abuse Research Center (SARC), Jazan University and the Department of Family and Community Medicine) for his assistance with the research project. Contributions: the authors contributed equally. Conflict of interest: the authors declare no potential conflict of interest. Received for publication: 20 June 2017. Revision received: 7 August 2017. Accepted for publication: 8 August 2017. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). ©Copyright R.M.Hakami et al., 2017 Licensee PAGEPress, Italy Mental Illness 2017; 9:7274 doi:10.4081/mi.2017.7274 [Mental Illness 2017; 9:7274] [page 43] observational cross-sectional survey target- ing Jazan University students who are over 18 years and registered for the academic year 2016/2017. The target colleges were Applied Medical Sciences, Pharmacy, Sciences, Computer sciences and Business administration. Sample size and sample design A sample of 400 participants was esti- mated for the purpose of this study. The sample size was calculated using the formu- la for a cross-sectional study, n=[(z2 * p * q)]/d2. Sample size was calculated using the following parameters: p=prevalence of Knowledge 50%, Z=95% confidence inter- val, d=error ≤5%, and a 25% non-response rate. Probability proportional to size sam- pling (PPS) was used to adjust the number of students in each faculty. Data collection The structured questionnaire was writ- ten in Arabic and distributed by six medical students to the study population. After explaining the purpose of the study and obtaining verbal consents, data collectors waited somewhere near for the completion of the questionnaire to give the respondents the opportunity to ask clarifying questions regarding the interpretation of terms or items in the questionnaire. All respondents were asked to fill out the survey separately to make sure that they do not duplicate each other’s answers. The data collection process took place in the period from November 2016 to January 2017. Instruments The questionnaire consisted of demo- graphic information such as age, sex, facul- ty type, family size, birth order, perceived family income, marital status, and housing type. Rating instruments included the Social Phobia Inventory (SPIN) to detect social anxiety disorder, the Leibowitz Social Anxiety Scale (LSAS) to evaluate social anxiety disorder severity, the Sheehan Disability Scale (SDS) to assess disability due to social anxiety disorder, and the WHO Quality of Life – BREF questionnaire to assess the quality of life. All study tools were translated to simple Arabic by the study authors. The questionnaire took about 15 to 20 minutes to complete. Social Phobia Inventory The SPIN is a short, self-rating scale developed by Dr. K.M. Connor to capture the social phobia symptoms.26 It consists of 17 items and each item is rated from 0 (not at all) to 4 (extremely). The scale ranges from 0-68. A score ≥19 suggests social anx- iety disorder. It has good test-retest reliabil- ity, internal consistency, convergent and divergent validity and can be used for screening of and detecting treatment response to social anxiety disorder. Regarding diagnosis of social anxiety disor- der, it has a sensitivity of 73-85% and a specificity of 69-84%. Although Shah and Kataria12 used a cut-off point of 19 on this scale in a similar study, Dogaheh27 reported that the cut-off point of 29 resulted in bal- anced sensitivity (0.96) and 1-specificity (0.87), and it was more appropriate for this study (a cut-off point of 19 resulted in an oddly very high prevalence). Liebowitz Social Anxiety Scale The LSAS is self-rating scale developed by Dr. Michael Liebowitz to rate fear/anxi- ety and avoidance regarding 24 commonly feared performance or social situations.28 It consists of 13 performance-related items and 11 social-related items which are rated from 0 (none/never) to 3 (severe/usually). It has a good internal consistency and evalu- ates the severity of fear and avoidance in common social situations. A score of <55 suggests mild social anxiety disorder, 55-64 suggests moderate social anxiety disorder, 65-79 suggests marked social anxiety disor- der, 80-94 suggests severe social anxiety disorder, and >95 suggests very severe social anxiety disorder. Sheehan Disability Scale The SDS is a simple and commonly used scale developed by David V. Sheehan29 to evaluate functional impair- ments/disabilities in the domains of work, social life/leisure and family life/home responsibility due to an anxiety disorder. Each domain is rated on an 11-point, where 0=no impairment, 10=most severe, 1- 3=mild, 4-6=moderate, and 7-9=marked. WHO Quality of Life – Bref The WHOQOL-BREF is an abbreviated version of the WHOQOL-100 developed by the WHOQOL Group30 to assess the quality of life in multiple dimensions, and it is applicable cross-culturally. It consists of 26 items based on a four-domain structure: Physical health (7 items), Psychological health (6 items), Social relationships (3 items) and Environment (8 items), along with a self-rating of general quality of life Article Table 1. Socio-demographic characteristics of participants. Characteristics Male, n (%) Female, n (%) Total, n (%) N=243 N=233 N=476 Age in years* 19 – 21 78 (32.1) 161 (70.9) 239 (50.8) 22 – 24 152 (62.6) 64 (28.2) 216 (45.9) 25 – 27 13 (5.3) 2 (0.9) 15 (3.2) College Applied Medical Sciences 44 (18.1) 41 (17.6) 85 (17.9) Pharmacy 14 (5.8) 5 (2.1) 19 (4.0) Business Administration 70 (28.8) 86 (36.9) 156 (32.7) Computer Sciences 59 (24.3) 39 (16.7) 98 (20.6) Sciences 56 (23) 62 (26.6) 118 (24.8) Marital status* Single 232 (95.9) 192 (83.8) 424 (90.0) Married 8 (3.3) 31 (13.5) 39 (8.3) Divorced 2 (0.8) 6 (2.6) 8 (1.7) Family size* <6 42 (17.3) 33 (14.4) 75 (15.9) 06-10 135 (55.6) 162 (70.7) 297 (62.9) >10 66 (27.2) 34 (14.8) 100 (21.2) Birth order* First or only child 46 (18.9) 47 (20.5) 93 (19.2) In the middle 159 (65.4) 144 (62.9) 303 (64.1) Last baby 38 (15.6) 38 (16.6) 76 (16.1) Perceived family income (SR/month)* Very good 49 (20.3) 38 (17.4) 87 (19.0) Good 117 (48.5) 98 (45.0) 215 (46.8) Bad 75 (31.1) 82 (37.6) 157 (34.2) Housing type* Owning housing 191 (78.9) 207 (90.0) 398 (84.3) Rent housing 51 (21.1) 23 (10.0) 74 (15.7) *Because of missing responses, the total percentages do not add up to 100%. (1 item) and general satisfaction with health (1 item). It is self-administered and each item is scaled from 1-5 in a positive direc- tion, which means that higher scores indi- cate a higher quality of life. Each domain score (mean score of items within that domain) is converted to a scale of 0-100 and indicates an individual’s perception of qual- ity of life in that domain. In the absence of clear cut-off point for such study, a cut-off point of 88.22 (70% of the total scores) was used as suggested by Al-Fayez and Ohaeri31 and Xia et al.32 Statistical analysis The data was analysed using SPSS ver- sion 20. Descriptive (frequency and per- centage) and inferential statistics (chi- square test) were used to interpret the data. An independent samples t-test was used to analyse the difference between the two groups (students with/without social anxi- ety disorder). Pearson correlation coeffi- cient was used for correlation analysis. Ethical consideration All participants were informed of their rights to participate and that their informa- tion would be kept anonymous and only used for the purpose of this study. Ethical approval was obtained from the University Ethical Committee. Results Of 500 questionnaires, students com- pleted 476 questionnaires giving a response rate of 95.2%. Table 1 details the sociode- mographic distribution of the study popula- tion. The results show that 243 (51.1%) of respondents were males and 233 (48.9%) were females. The respondents’ age ranged from 19 to 27 years. The mean, median, and mode of students’ age were 21.49, 21, and 22 years, respectively (SD=1.57), which indicates a fairly even distribution of partic- ipants’ ages. The sample consisted of differ- ent faculties with the highest number from Business administration (156, 32.7%) and the lowest number from Pharmacy (19, 4.0%). Most of the respondents (90%) were single (N=424), 8.3% were married (N=39), and 1.7% were divorced (N=8). Those who lived in families consisted of 6-10 members comprised the majority of the study popula- tion (62.9%). Regarding birth order, a high frequency of respondents (303, 64.1%) reported that they were in the middle of their families. Most of the study population perceived their family income as very good (19.0%) and good (46.8%), and lived in their own household (84.3%). Using a cut-off score of 29, participants were screened positive for social anxiety disorder if they scored 29 or higher on the SPIN scale. Table 2 shows that 123 (25.8%) students were screened positive for SAD, 71 of them (51.1%) were males and 52 were females (42.3%). There was a statistically significant difference in the prevalence of SAD regarding the birth order. Being a first- born child (or the only child) was associated with least prevalence of SAD (15.6%) and being a middle born child was associated with higher prevalence of SAD (61.5%) (X2=6.407, P<0.05). However, with respect to gender, faculty type, family size, per- ceived family income, and housing type, there was no statistically significant differ- ence in the prevalence of SAD (all P values >0.05). In addition, as the range of age groups was narrow, (i.e. most of students were young adults, who are the target popu- lation of this study) and as most of the stu- dents were single, these two parameters (age and marital status) were not signifi- cantly associated (P=0.777 and P=0.511, respectively) with the prevalence of SAD. The Cronbach’s alpha for SPIN scale obtained in this study sample was 0.85. Using the LSAS scale to detect the severity of SAD, 47.2% (N=58) had mild symptoms, 42.3%, (N=52) had moderate to marked symptoms, and 10.5% (N=13) had severe to very severe symptoms. As shown in Table 3, the descending ranking of com- monly feared/avoided situations (LSAS scale) was obtained. The most commonly feared situations reported by students were acting, performing or giving a talk in front of an audience (75.0%, N=357), followed by taking a test (74.0%, N=352). The most commonly avoided situations reported by students were blushing in front of people (79.4%, N=377), followed by having to give speeches (76.7%, N=365). The majority of students (76.5%, N=364) reported that being embarrassed or looking stupid is among their worst fears. The Cronbach’s alpha for LSAS scale obtained in this sam- ple was (0.87) and (0.85) for the fear/anxi- ety and avoidance domains, respectively. An independent samples t-test was employed to compare between students with SAD and students without SAD in their scores on the SDS and QOL scales. As Table 4 shows, the difference between the two groups was statistically significant. Students who screened positive for SAD reported significantly more disabilities in the work (t(474)=6.596, P<0.01), social life (t(473)=6.941, P<0.01), and home areas Article Table 2. Comparing social phobia with demographic variables of the participants. Demographic variables SPIN score <29 SPIN score ≥29 X2 P value n (%) n (%) Study population 353 (74.2) 123 (25.8) Gender 2.956 0.090 Male 172 (48.7) 71 (57.7) Female 181 (51.3) 52 (42.3) Age* 0.504 0.777 19 – 21 179 (51.1) 60 (50.0) 22 – 24 161 (46.0) 55 (45.8) 25 – 27 10 (2.9) 5 (4.2) Faculty type 0.225 0.705 Health faculties 79 (22.4) 25 (20.3) Others 274 (77.6) 98 (79.7) Family size* 0.611 0.737 <6 53 (15.1) 22 (18.0) 06-10 223 (63.7) 74 (60.7) >10 74 (21.1) 26 (21.3) Birth order 6.407 0.041 First or only child 74 (21.1) 19 (15.6) In the middle 228 (65.1) 75 (61.5) Last baby 48 (13.9) 28 (23.0) Perceived family income (SR/month)* 0.480 0.787 Very good 31 (9.2) 10 (8.3) Good 104 (30.8) 34 (28.1) Bad 203 (60.1) 77 (63.6) Housing type* 1.985 0.192 Owning housing 300 (85.7) 98 (80.3) Rent housing 50 (14.3) 24 (19.7) SPIN, Social Phobia Inventory. *Because of missing responses, total percentages do not add up to 100%. [page 44] [Mental Illness 2017; 9:7274] [Mental Illness 2017; 9:7274] [page 45] (t(474)=4.375, P<0.01). As well, students who screened positive for SAD reported significantly worse quality of life, that is, they scored lower than students who screened negative for SAD on the physical health domain (t(473)=4.220, P<0.01), psy- chological health domain (t(459)=3.970, P<0.01), social relationship domain (t(472)=1.999, P<0.05), and environment domain (t(474)=2.297, P<0.05). The Cronbach’s alpha for SDS scale obtained in this sample was (0.74), and for QOL scale, the Cronbach’s alpha for the respective domains were 0.64 (physical health), 0.64 (psychological health), 0.55 (social rela- tionships), and 0.72 (environment). As shown in Table 5, both SPIN and LSAS scores were positively correlated with SDS scores. Thus, SAD and its severi- ty were significantly associated with report- ed disabilities in the areas of work, social life, and home life. In contrast, both SPIN and LSAS scores were negatively correlat- ed with QOL score. This means that SAD and its severity were significantly associat- ed with deterioration in all domains of qual- ity of life. In general, these results suggest that students who screened positive for SAD suffered more than students who screened negative from deteriorated func- tioning and quality of life. Discussion The main purpose of the present study was to investigate SAD prevalence, severi- ty, related disabilities, and its impact in undergraduate students at Jazan University. SAD symptoms may overlap with other dis- eases making it challenging to recognize and separate SAD from shyness or poor social skills. Many studies of SAD from dif- ferent countries and cultures reported wide- ly varied estimates of the prevalence rang- ing from 1.9% and 20.4% among the gener- al population and depending on the diag- nostic threshold.33 In the present study, SAD was as high as 25.8% among the study population, much higher than many other studies among undergraduate stu- dents.11,12,17,18,34 However, as SPIN, the screening scale used in this study, has a specificity of 0.84-0.94 and the analysis using LSAS shows that 47.2% of those with SAD have a mild degree of SAD, it can be inferred that the prevalence might be lower than identified. However, the prevalence looks quite high even after this considera- tion. Within the Saudi context, a few studies have investigated SAD among university students and most of them have been con- ducted on medical students, making it diffi- cult to compare our findings with a similar study. However, consistently with the pres- ent study, social anxiety have been revealed to be a highly prevalent disorder in Saudi Article Table 3. Rank ordering of most commonly feared/avoided situations. Rank Situation N (%) Feared situations 1 Acting, performing or giving a talk in front of an audience 357 (75.0) 2 Taking a test 352 (74.0) 3 Speaking up at a meeting 326 (68.5) 4 Talking to people in authority 299 (62.8) 5 Meeting strangers 289 (60.7) 6 Working while being observed 289 … Contents lists available at ScienceDirect Clinical Psychology Review journal homepage: www.elsevier.com/locate/clinpsychrev Review Gender differences in social anxiety disorder: A review Maya Ashera, Anu Asnaanib, Idan M. Aderkaa,⁎ a Department of Psychology, University of Haifa, Israel b Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA A R T I C L E I N F O Keywords: Social anxiety disorder Gender differences Review Prevalence Impairment A B S T R A C T Gender differences in social anxiety disorder (SAD) have not received much empirical attention despite the large body of research on the disorder, and in contrast to significant literature about gender differences in other disorders such as depression or posttraumatic stress disorder. To address this gap, we comprehensively reviewed the literature regarding gender differences in eight domains of SAD: prevalence, clinical presentation, functioning and impairment, comorbidity, course, treatment seeking, physiological arousal, and the oxytocin system. Findings from the present review indicate that women are more likely to have SAD and report greater clinical severity. Notwithstanding, men with the disorder may seek treatment to a greater extent. According to the present review, the course of SAD seems to be similar for men and women, and findings regarding gender differences in functional impairment and comorbidity are inconclusive. We highlight areas requiring future research and discuss the findings in the context of a number of theoretical perspectives. We believe that further research and integration of scientific findings with existing theories is essential in order to increase our understanding and awareness of gender differences in SAD, thus facilitating gender-sensitive and specifically- tailored interventions for both men and women with the disorder. 1. Introduction Social anxiety disorder (SAD) is a common and debilitating psychiatric disorder with an estimated lifetime prevalence rate of 12.1% (Kessler et al., 2005). It is characterized by a marked and persistent fear of one or more social situations (e.g., talking to a stranger or peer, going to a party) or performance activities (e.g., giving a speech) in which the person is exposed to unfamiliar people, or where they may face possible scrutiny by others (American Psychiatric Association, 2013). Individuals with SAD fear they will act in a way (or show anxiety symptoms) that will be embarrassing and may lead to a negative evaluation by others (Alden & Taylor, 2010). As a result, they tend to avoid social situations, or endure them with significant distress. The difficulties in interpersonal interactions described above result in significant impairment in almost all facets of daily life, including relationships, work, and studies (e.g., Aderka et al., 2012; Alden & Taylor, 2004). Compared to individuals without SAD, those with the disorder are more likely to drop out of school prematurely (Stein & Kean, 2000), to have lower educational attainment (Katzelnick & Greist, 2001; Wittchen, Stein, & Kessler, 1999), to hold jobs below their level of qualification (Katzelnick & Greist, 2001), to have lower income and to be unemployed (Lecrubier et al., 2000), and even when employed, tend to miss 8 times more work days (Wittchen, Fuetsch, Sonntag, Müller, & Liebowitz, 2000). Individuals with SAD report poor quality of life (Alonso et al., 2004), are more likely to attempt suicide (Wunderlich, Bronisch, & Wittchen, 1998), and are more likely to have alcohol and nicotine dependence (Wittchen et al., 1999). Thus, SAD results in significant negative health, economic and functional consequences. Considering the large body of research on SAD, and despite accumulating data about gender differences in other disorders (e.g., agoraphobia: Bekker, 1996; specific phobias: Fredrikson, Annas, Fischer, & Wik, 1996; obsessive-compulsive disorder: Bogetto, Venturello, Albert, Maina, & Ravizza, 1999; panic disorder: Barzega, Maina, Venturello, & Bogetto, 2001; generalized anxiety disorder: Vesga-López et al., 2008; posttraumatic stress disorder: Tolin & Foa, 2006; depression: Parker & Brotchie, 2010) there is a paucity of research directly examining gender differences in SAD. This is particu- larly surprising because several older epidemiological studies have found that SAD is more frequent in women compared to men (e.g., Kessler et al., 1994). Although the gender literature for SAD is limited, it can offer meaningful information for both researchers and clinicians (Schneier & Goldmark, 2015). The goal of the present review is to systematically review the literature, identify studies reporting on gender differences in SAD, structure and integrate the findings, present the findings clearly, and interpret the findings within the context of http://dx.doi.org/10.1016/j.cpr.2017.05.004 Received 25 December 2016; Received in revised form 24 May 2017; Accepted 29 May 2017 ⁎ Corresponding author at: Department of Psychology, Mount Carmel, Haifa 31905, Israel. E-mail address: [email protected] (I.M. Aderka). Clinical Psychology Review 56 (2017) 1–12 Available online 30 May 2017 0272-7358/ © 2017 Elsevier Ltd. All rights reserved. MARK http://www.sciencedirect.com/science/journal/02727358 http://www.elsevier.com/locate/clinpsychrev http://dx.doi.org/10.1016/j.cpr.2017.05.004 http://dx.doi.org/10.1016/j.cpr.2017.05.004 mailto:[email protected] http://dx.doi.org/10.1016/j.cpr.2017.05.004 http://crossmark.crossref.org/dialog/?doi=10.1016/j.cpr.2017.05.004&domain=pdf extant theories of both SAD and gender differences. Specifically, this paper will review gender differences in eight domains of SAD: prevalence, clinical presentation, functioning and impairment, comor- bidity, course, treatment seeking, physiological arousal, and the oxytocin system. Finally, an additional goal of this paper is to map different areas requiring further research. Understanding gender differences in SAD can have implications for clinical assessment and diagnosis, as well as for treatment delivery. For instance, information regarding gender differences in types of feared situations can guide and inform clinical assessment, as well as choice of exposure exercises for men and women. We believe that this review can contribute to a more refined and gender-sensitive understanding of the disorder and can ultimately facilitate clinical work specifically tailored to men and women. 2. Literature search The literature search for the present review was conducted in a number of stages. First, we searched the PubMed, PsycINFO, and the Cochrane Library databases using a number of keywords to identify relevant studies. Key words included: social anxiety, gender, differ- ences, men, women, male, female, boys, girls. In the second stage, we reviewed the reference lists of relevant papers to identify additional sources that may have been missed in our database search. In addition to peer reviewed publications, we reviewed book chapters on gender differences in SAD (and their reference lists) to reduce the risk of biases in the peer review process. In the fourth and final stage, we sent an e- mail to researchers in the field of social anxiety disorder, requesting additional unpublished data on gender differences in order to reduce the risk of publication bias. 3. Gender differences in prevalence According to the DSM-5, prevalence of SAD is higher in women and this difference is more pronounced among adolescents (American Psychiatric Association, 2013). This statement is based on a number of epidemiological studies which have demonstrated that women are more likely than men to meet diagnostic criteria for SAD. For example, the Epidemiologic Catchment Area study (ECA; Schneier, Johnson, Hornig, Liebowitz, & Weissman, 1992) is an older epidemiologic study which examined approximately 13,000 young adults aged 18–29 which found that compared to men, women are 1.5 times more likely to meet diagnostic criteria for SAD; lifetime prevalence rates reported in that study were 3.1% in women, compared to 2.0% in men. Data from the National Comorbidity Survey (NCS), with a sample of over 8000 individuals aged 15–54, also indicated a higher lifetime prevalence rate of 15.5% for women, compared to 11.1% for men (Kessler et al., 1994). Recently, a study based on data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) with a sample of 43,093 adults found similar results, indicating that significantly more women suffer from SAD, with a lifetime prevalence of 4.2% for men, compared to 5.7% for women (Xu et al., 2012). In sum, despite differences in overall lifetime prevalence rates between epidemiological studies, a number of epidemiological studies have shown that women are consistently found to have higher rates of SAD compared to men. It is important to note that whereas the studies mentioned above demonstrated significant gender differences in SAD prevalence, a study by McLean, Asnaani, Litz, and Hofmann (2011) reported divergent findings. These authors examined data from the Collaborative Psychia- try Epidemiology Studies (CPES), which is an integration of three national surveys of mental health conducted among an overall of 20,013 adult (aged 18 and older) residents of the United States (U.S.). The pattern of gender differences found was in contrast to those reported in previous studies; in fact, SAD was the only anxiety disorder that did not evidence significant gender differences in current or lifetime rates. However, it is important to note that these null findings were found using a Bonferroni correction accounting for 20 compar- isons (i.e., critical level for significance = 0.0025) and controlling for SES, education level, age, and race. Both Bonferroni correction and the practice of including multiple covariates in regression analyses have been criticized for significantly reducing statistical power (e.g., Perneger, 1998; Tabachnick & Fidell, 2013) suggesting that interpreta- tion of these null findings should be done with caution. Moreover, descriptive statistics were in the direction indicating greater prevalence among women compared to men (lifetime prevalence for wo- men = 10.3%, lifetime prevalence for men = 8.7%). Studies conducted outside the United States have demonstrated similar gender differences in SAD prevalence as found in the majority of epidemiological findings within the U.S. For example, results from a European study with a sample of 18,980 individuals (aged 15 or older) from the United Kingdom, Germany, Italy, Spain, and Portugal indi- cated that prevalence rates were found to be higher in women compared to men, with an odds ratio of 1.6 (Ohayon & Schatzberg, 2010). Similar findings were reported in a prospective longitudinal study, which followed 591 young adults in Switzerland from the age of 18 to the age of 35 (Merikangas, Avenevoli, Acharyya, Zhang, & Angst, 2002). In this study, women exhibited higher lifetime prevalence rates of SAD, as well as higher sub-clinical levels of social anxiety compared to men. A community study conducted in France (Lépine & Lellouch, 1995), with a sample of 1787 participants aged 18 and above also found higher lifetime prevalence rates of SAD in women compared to men (5.4% and 2.1% respectively). Results from the Canadian Community Health Survey Cycle 1.2. (MacKenzie & Fowler, 2013) with a sample of 36,984 Canadians aged 15 or older indicated that women were 1.5 times more likely to meet diagnostic criteria for SAD. Another study conducted in Russia has also demonstrated a higher lifetime prevalence of SAD in women compared to men (Pakriev, Vasar, Aluoja, & Shlik, 2000). Studies conducted in East Asia have revealed similar patterns of gender differences in SAD prevalence. A study conducted in Korea (Cho et al., 2007), with a sample of 6275 adults aged 18–64, demonstrated higher descriptive 12-month and lifetime prevalence rates in women compared to men (no inferential tests were reported). However, it is important to note that prevalence in this sample was distinctly lower than that observed in Western samples (e.g., 0.4% lifetime prevalence for women vs. 0.1% for men). This may be due to differences between individualistic and collectivistic cultures both in general (Oyserman & Lee, 2008) and in SAD specifically (Chang, 1997; Hofmann, Asnaani, & Hinton, 2010; Schreier et al., 2010). In addition, differences in stigma of mental disorders between countries and cultures can also contribute to the observed differences in prevalence (e.g., Griffiths et al., 2006; Ryder et al., 2008). Importantly, these explanations are by no means exhaustive, and many other potential explanations can contribute to these findings. In an older large epidemiologic study conducted in Taiwan (The Taiwan Psychiatric Epidemiological Project; TPEP) gender differences in SAD prevalence were found (Hwu, Yeh, & Chang, 1989). This study was based on three samples of 5005, 3004 and 2995 participants aged 18 and above, selected from metropolitan Taipei, 2 small towns and 6 rural villages in Taiwan, respectively. It was found that women in metropolitan Taipei had a higher lifetime prevalence of SAD compared to men in the same area (9.5% and 2.4% respectively). Interestingly, this difference in prevalence was found only in the metropolitan area but not in small towns and rural villages. In addition, it is important to note that the study was conducted over 25 years ago and was based on DSM-III criteria. Additional studies in East Asian countries are needed to draw firm conclusions regarding gender differences in SAD. Finally, it is important to note that a review of 43 epidemiological studies from all around the world (Furmark, 2002), and a review of 21 epidemio- logical studies conducted in European countries (Fehm, Pelissolo, Furmark, & Wittchen, 2005) both concluded that women are more likely to have SAD compared to men. M. Asher et al. Clinical Psychology Review 56 (2017) 1–12 2 Studies on adolescents have also revealed similar gender differences in prevalence of SAD. For example, data from the Early Developmental Stages of Psychopathology Study (EDSP), with a sample of 3021 German adolescents aged 14–25 years indicated a higher lifetime prevalence rate of SAD in girls and women compared to boys and men (9.5% and 4.9% respectively; Wittchen et al., 1999). In addition, according to data from the National Comorbidity Survey Replicatio- n–Adolescent Supplement (NCS-A), SAD was more prevalent in girls compared to boys, with lifetime prevalence rates of 11.2% and 7% respectively (Merikangas et al., 2010). Another study (Essau, Conradt, & Petermann, 1999) with a sample of 1035 German adoles- cents aged 12–17 years indicated that girls were twice as likely to meet lifetime diagnostic criteria for SAD compared to boys (2.1% and 1% respectively). Although the higher rates of SAD found in girls compared to boys are consistent with previous findings, it is worth noting that the overall lifetime prevalence of SAD in this study was distinctly lower than those observed in other samples of adolescents. Finally, results from studies conducted in non-clinical samples of adolescents (e.g., La Greca & Lopez, 1998; Ranta et al., 2007) indicated that girls reported higher levels of social anxiety compared to boys. In sum, the literature consistently points to a higher prevalence rate of SAD in women compared to men, and this difference may be greater among adolescents (see Table 1 for a summary of findings on prevalence). Findings on gender differences in prevalence rates have been replicated in studies conducted around the world (U.S., Europe, East Asia), and using different designs (e.g., epidemiological studies, prospective longitudinal studies) indicating that the difference is robust. 4. Gender differences in clinical presentation In this section we will review findings regarding gender differences in (1) clinical severity, (2) types of social situations feared, and (3) subjective distress. 4.1. Clinical severity Turk et al. (1998) found that women who sought treatment for SAD reported greater clinical severity compared to men on a number of symptoms measures (the Social Interaction Anxiety Scale, Social Phobia Scale, the Fear Questionnaire – Social Phobia subscale and the Liebowitz Social Anxiety Scale – Performance Fear subscale). Moreover, in that study women reported greater fear and avoidance compared to men when constructing an individualized hierarchy of social anxiety- provoking situations. Finally, women reported greater anxiety com- pared to men both in anticipation of and during a brief exposure. Another study based on data from the Australian National Survey of Mental Health and Well-being (NSMHWB; Crome, Baillie, & Taylor, 2012), with a sample of 1755 adults reporting at least one social fear, demonstrated that women tended to report higher levels of social fear, compared to men. Similarly, a number of studies have demonstrated that women with SAD endorse a greater number of social fears compared to men with SAD (Turk et al., 1998; Xu et al., 2012). For example, data from the National Comorbidity Survey Replication (NCS-R), demonstrated that SAD involving 1–4 social fears is more common among men, whereas SAD involving a larger number of fears is more common in women (Ruscio et al., 2008). Finally, women with SAD were more likely to endorse a desire to die and a desire to commit suicide compared to men with SAD. This finding was above and beyond the contribution of comorbid depression indicating that the difference cannot be attributed women's greater likelihood to receive a diagnosis of major depressive disorder (Lépine & Lellouch, 1995). In sum, women with SAD report more severe symptoms, a greater number of social fears, as well as a greater desire to die and commit suicide, compared to men. Importantly, all the findings described in this section are based on self-report methodology. Thus it remains unclear if women actually experience social anxiety more than men or simply report more social anxiety compared to men. Although a comprehensive and definitive answer to this question is beyond the scope of the present review, we discuss gender differences in physiological arousal (in Section 9) as well Table 1 Gender differences in social anxiety disorder (SAD) prevalence among males and females with SAD. Study Sample type Location Type of diagnosis Prevalence Significance Males Females Schneier, Johnson, Hornig, Liebowitz and Weissman, 1992 > 13,000 young adults (18–29) USA Lifetime SAD 2% 3.1% Yes Kessler et al., 1994 > 8000 adults (15–54) USA Lifetime SAD 11.1% 15.5% Yes Xu et al., 2012 43,093 adults USA Lifetime SAD 4.2% 5.7% Yes McLean, Asnaani, Litz and Hofmann, 2011 20,013 adults (18+) USA Lifetime SAD 8.7% 10.3% No Ohayon & Schatzberg, 2010 18, 980 individuals (15+) U.K., Germany, Italy, Spain, and Portugal Current SAD 3.4% 5.4% Yes Merikangas, Avenevoli, Acharyya, Zhang and Angst, 2002 Longitudinal study (following 591 young adults from the age of 18 to 35) Switzerland Cumulative 12-months prevalence across the years of the study 3.7% 7.3% Yes Lépine & Lellouch, 1995 1787 adults (18+) France Lifetime SAD 2.1% 5.4% Yes MacKenzie & Fowler, 2013 36,984 individuals (15+) Canada Lifetime SAD 3.3 5% Yes Pakriev, Vasar, Aluoja and Shlik, 2000 855 adults (18–65) Russia Lifetime SAD 37.5% 51.8% Yes Cho et al., 2007 6275 adults (18–64) Korea Lifetime SAD 0.1 0.4 No inferential tests were reported Hwu, Yeh and Chang, 1989 5005, 3004 and 2995 adults (18+) Taiwan (Taipei, 2 small towns and 6 rural villages) Lifetime SAD 2.4% (Taipei) 9.5% (Taipei) Yes-only in Taipei Wittchen et al., 1999 3021 adolescents (14–25) Germany Lifetime SAD 4.9% 9.5% Yes Merikangas et al., 2010 10,123 adolescents (13–18) USA Lifetime SAD 7% 11.2% Yes Essau, Conradt and Petermann, 1999 1035 adolescents (12–17) Germany Lifetime SAD 1% 2.1% Yes M. Asher et al. Clinical Psychology Review 56 (2017) 1–12 3 as studies of reporting biases in anxiety (in Section 12) which converge to suggest that women may experience more anxiety above and beyond the possible effect of biased reporting. This topic is discussed in more detail in the Discussion section. 4.2. Types of feared situations Differences have been found in the types of anxiety-provoking situations feared by men and women with SAD. Specifically, women with SAD reported significantly greater fear compared to men with SAD when interacting with authority figures, giving a talk in front of an audience, working while being observed, entering a room when others are already seated, being the center of attention, expressing disagree- ment or disapproval, giving a report to a group, and having a party. Men reported more fear compared to women when urinating in a public restroom and returning goods to a store (Turk et al., 1998). It is important to note that men and women with SAD were found to experience similar fears in two domains: informal social interactions (e.g., participating in small groups, going to a party) and being observed (e.g., telephoning in public, eating in public). Interestingly, in contrast to the null findings regarding gender differences in being observed (Turk et al., 1998), a large community study in Germany found that women with SAD were more likely to report fear of eating and drinking in public compared to men with SAD (Wittchen et al., 1999). An additional gender difference was reported by Flynn, Markway, and Pollard (1992) who asked individuals with SAD to rate their fear that other people would describe them using 26 negative adjectives (e.g., weak, crazy). Compared to men with SAD, significantly more women with SAD feared other people would describe them as crazy, making no sense, being a bad parent, and being too fat or too tall. Recent data from the epidemiologic sample of alcohol and related conditions (NESARC) demonstrated that compared to men with SAD, women with SAD were more likely to fear professional situations such as being interviewed, speaking to an authority figure, and speaking up in a meeting (Xu et al., 2012). They were also more likely to fear taking an important exam and eating and drinking in front of others. Men with SAD, however, were more likely to fear dating. Taken together, the data suggest that women fear a wider range of social situations compared to men; however, it is important to note that the studies documenting such differences are about two decades old and no recent examinations have been made of such gender differences. Given the significant changes observed in gender roles across the world in the past decade (e.g., changes in employment, education patterns, and assumed family roles for women and men; Cotter, England, & Hermsen, 2008; England et al., 2004; Cotter, Hermsen, & Vanneman, 2011; Bolzendahl & Myers, 2004), it is possible that the types of social situations that are feared by women versus men with social anxiety have also changed. Future studies in the current cultural context of gender roles are needed in order to draw firm conclusions regarding differences in the types of social situations feared by men and women. 4.3. Subjective distress Whereas previous data suggest that women have been found to report more fear compared to men in a number of social situations and to have a greater number of social fears compared to men, there are some findings suggesting that men may experience more distress as a result of their social anxiety compared to women. For instance, in a longitudinal community study, men with sub-clinical SAD symptoms were found to report greater subjective distress compared to women with sub-clinical SAD symptoms, suggesting that men experienced substantial distress even at a low level of symptomatology (Merikangas et al., 2002). Along these lines, despite the higher prevalence rate of SAD among women in the community (see Section 3 above), it has been observed that men with SAD are as likely or even more likely to seek treatment compared to women with the disorder (Weinstock, 1999), suggesting that distress or impairment for men may be greater. Patterns of treatment seeking among men and women with SAD will be discussed in Section 8. 5. Gender differences in functioning and impairment Men and women with SAD may have different patterns of impair- ment at work, and in their social life. Regarding employment, studies have shown that compared to men with SAD, fewer women with the disorder are employed (MacKenzie & Fowler, 2013) and among those employed, men are more likely to be employed on a full time basis compared to women (Turk et al., 1998). Considering these findings it is not surprising that women with SAD report having lower personal income compared to men with the disorder (MacKenzie & Fowler, 2013). These gender differences in employment may be related to the types of fears endorsed by men and women (see Section 4 above). Specifi- cally, women have been shown to have greater fear of interacting with authority figures, giving a talk in front of an audience, working while being observed, entering a room when others are already seated, and giving a report to a group – all of which are common situations in work settings (Turk et al., 1998). This has led some researchers to suggest that men may have more exposure to work settings and may thus develop greater comfort on the job compared to women (Turk et al., 1998). Alternatively, women may be less inclined to work or to work full time because of their work-related fears compared to men (Turk et al., 1998). As we noted previously, however, employment patterns and exposure to work settings for women have significantly changed over the past decades (e.g., Cotter et al., 2008). Thus, it is important to conduct current examinations on this topic before firm conclusions can be drawn. In contrast to the findings described above, some studies have found that men have greater work impairment compared to women. For instance, an epidemiological study found greater occupational impair- ment in men with SAD compared to women with the disorder (Lampel, Slade, Issakidis, & Andrews, 2003). However, other studies have found no gender differences in work impairment. For instance, Merikangas et al. (2002) found that along the course of their 15-year longitudinal study, occupational impairment was similar for men and for women. Thus, findings on gender differences in work impairment remain inconclusive at this point. Some studies have found that functioning and impairment in social life may differ between men and women with SAD. Merikangas et al. (2002) found that men had greater social impairment compared to women in their longitudinal study. Along these lines, gender differences in relationship status and living arrangements among individuals with SAD have been reported (MacKenzie & Fowler, 2013). Specifically, it was found that men with SAD were more likely to report being single and living alone compared to women with SAD, whereas women with SAD were more likely to report being widowed, being separated, or divorced. In contrast to findings suggesting that men may have greater impairment in social life, other studies have found the opposite pattern in which socially anxious women may be more socially impaired compared to socially anxious men. For instance, in a community survey, Cuming and Rapee (2010) reported that social anxiety was associated with diminished levels of disclosure and openness in romantic relations and close friendships among women but not among men. A similar pattern of results was also previously found in adolescents. For example, an older study with a sample of 250 high school students ranging from 10th to 12th grade (La Greca & Lopez, 1998) demonstrated that social anxiety (SA) was more strongly linked to girls' social impairment compared to boys, such that girls with higher M. Asher et al. Clinical Psychology Review 56 (2017) 1–12 4 levels of SA reported fewer friendships and less intimacy, companion- ship, and support in their close relationships. Other studies have found no differences between men and women with SAD in their satisfaction of their relationships with their spouse, children, or friends (Yonkers, Dyck, & Keller, 2001). Similarly, Sparrevohn and Rapee (2009) examined individuals with SAD and found no gender differences in quality of romantic relationships, self- disclosure, emotional expression, and intimacy in romantic relation- ships. In a study based on data from the National Comorbidity Survey (NCS; Rodebaugh, Fernandez, & Levinson, 2012), it was found that SAD had a negative effect on friendship quality in both men and women. Whereas in men this negative effect was exacerbated when comorbid with generalized anxiety disorder, in women it was exacerbated when comorbid with MDD. In sum, research on gender differences in functioning and impair- ment has yielded equivocal findings. Currently, opposing findings preclude us from making reliable inferences on gender differences in functioning and impairment and future research is needed to shed light on this issue. 6. Gender differences in comorbidity Data from the national epidemiologic sample on alcohol and related conditions (NESARC) has indicated that whereas men with SAD are more likely to suffer from a comorbid externalizing disorder, women with SAD are more likely to suffer from comorbid … S O C I A L A N X I E T Y D I S O R D E R : More Than Just Shyness Are you extremely afraid of being judged by others? Are you very self-conscious in everyday social situations? Do you avoid meeting new people? If you have been feeling this way for at least six months and these feelings make it hard for you to do everyday tasks— such as talking to people at work or school—you may have a social anxiety disorder. Social anxiety disorder (also called social phobia) is a mental health condition. It is an intense, persistent fear of being watched and judged by others. This fear can affect work, school, and your other day-to-day activities. It can even make it hard to make and keep friends. But social anxiety disorder doesn’t have to stop you from reaching your potential. Treatment can help you overcome your symptoms. What is it like having social anxiety disorder? In school, I was always afraid of being called on, even when I knew the answers. I didn’t want people to think I was stupid or boring. My heart would pound and I would feel dizzy and sick. When I got a job, I hated to meet with my boss or talk in a meeting. I couldn’t attend my best friend’s wedding reception because I was afraid of having to meet new people. I tried to calm myself by drinking several glasses of wine before an event and then I started drinking every day to try to face what I had to do. I finally talked to my doctor because I was tired of feeling this way and I was worried that I would lose my job. I now take medicine and meet with a counselor to talk about ways to cope with my fears. I refuse to use alcohol to escape my fears and I’m on my way to feeling better. What is social anxiety disorder? Social anxiety disorder is a common type of anxiety disorder. A person with social anxiety disorder feels symptoms of anxiety or fear in certain or all social situations, such as meeting new people, dating, being on a job interview, answering a question in class, or having to talk to a cashier in a store. Doing everyday things in front of people—such as eating or drinking in front of others or using a public restroom—also causes anxiety or fear. The person is afraid that he or she will be humiliated, judged, and rejected. The fear that people with social anxiety disorder have in social situations is so strong that they feel it is beyond their ability to control. As a result, it gets in the way of going to work, attending school, or doing everyday things. People with social anxiety disorder may worry about these and other things for weeks before they happen. Sometimes, they end up staying away from places or events where they think they might have to do something that will embarrass them. Some people with the disorder do not have anxiety in social situations but have performance anxiety instead. They feel physical symptoms of anxiety in situations such as giving a speech, playing a sports game, or dancing or playing a musical instrument on stage. Social anxiety disorder usually starts during youth in people who are extremely shy. Social anxiety disorder is not uncommon; research suggests that about 7 percent of Americans are affected. Without treatment, social anxiety disorder can last for many years or a lifetime and prevent a person from reaching his or her full potential. What are the signs and symptoms of social anxiety disorder? When having to perform in front of or be around others, people with social anxiety disorder tend to: Ê Blush, sweat, tremble, feel a rapid heart rate, or feel their “mind going blank” Ê Feel nauseous or sick to their stomach Ê Show a rigid body posture, make little eye contact, or speak with an overly soft voice Ê Find it scary and difficult to be with other people, especially those they don’t already know, and have a hard time talking to them even though they wish they could Ê Be very self-conscious in front of other people and feel embarrassed and awkward Ê Be very afraid that other people will judge them Ê Stay away from places where there are other people What causes social anxiety disorder? Social anxiety disorder sometimes runs in families, but no one knows for sure why some family members have it while others don’t. Researchers have found that several parts of the brain are involved in fear and anxiety. Some researchers think that misreading of others’ behavior may play a role in causing or worsening social anxiety. For example, you may think that people are staring or frowning at you when they truly are not. Underdeveloped social skills are another possible contributor to social anxiety. For example, if you have underdeveloped social skills, you may feel discouraged after talking with people and may worry about doing it in the future. By learning more about fear and anxiety in the brain, scientists may be able to create better treatments. Researchers are also looking for ways in which stress and environmental factors may play a role. How is social anxiety disorder treated? First, talk to your doctor or health care professional about your symptoms. Your doctor should do an exam and ask you about your health history to make sure that an unrelated physical problem is not causing your symptoms. Your doctor may refer you to a mental health specialist, such as a psychiatrist, psychologist, clinical social worker, or counselor. The first step to effective treatment is to have a diagnosis made, usually by a mental health specialist. Social anxiety disorder is generally treated with psychotherapy (sometimes called “talk” therapy), medication, or both. Speak with your doctor or health care provider about the best treatment for you. If your health care provider cannot provide a referral, visit the NIMH Help for Mental Illnesses web page at www.nimh.nih.gov/findhelp for resources you may find helpful. http://www.nimh.nih.gov/findhelp Psychotherapy A type of psychotherapy called cognitive behavioral therapy (CBT) is especially useful for treating social anxiety disorder. CBT teaches you different ways of thinking, behaving, and reacting to situations that help you feel less anxious and fearful. It can also help you learn and practice social skills. CBT delivered in a group format can be especially helpful. For more information on psychotherapy, please visit www.nimh.nih.gov/ psychotherapies. Support Groups Many people with social anxiety also find support groups helpful. In a group of people who all have social anxiety disorder, you can receive unbiased, honest feedback about how others in the group see you. This way, you can learn that your thoughts about judgment and rejection are not true or are distorted. You can also learn how others with social anxiety disorder approach and overcome the fear of social situations. Medication There are three types of medications used to help treat social anxiety disorder: Ê Anti-anxiety medications Ê Antidepressants Ê Beta-blockers Anti-anxiety medications are powerful and begin working right away to reduce anxious feelings; however, these medications are usually not taken for long periods of time. People can build up a tolerance if they are taken over a long period of time and may need higher and higher doses to get the same effect. Some people may even become dependent on them. To avoid these problems, doctors usually prescribe anti-anxiety medications for short periods, a practice that is especially helpful for older adults. Antidepressants are mainly used to treat depression, but are also helpful for the symptoms of social anxiety disorder. In contrast to anti-anxiety medications, they may take several weeks to start working. Antidepressants may also cause side effects, such as headaches, nausea, or difficulty https://www.nimh.nih.gov/psychotherapies https://www.nimh.nih.gov/psychotherapies sleeping. These side effects are usually not severe for most people, especially if the dose starts off low and is increased slowly over time. Talk to your doctor about any side effects that you have. Beta-blockers are medicines that can help block some of the physical symptoms of anxiety on the body, such as an increased heart rate, sweating, or tremors. Beta-blockers are commonly the medications of choice for the “performance anxiety” type of social anxiety. Your doctor will work with you to find the best medication, dose, and duration of treatment. Many people with social anxiety disorder obtain the best results with a combination of medication and CBT or other psychotherapies. Don’t give up on treatment too quickly. Both psychotherapy and medication can take some time to work. A healthy lifestyle can also help combat anxiety. Make sure to get enough sleep and exercise, eat a healthy diet, and turn to family and friends who you trust for support. For basic information about these and other mental health medications, visit www.nimh.nih.gov/medications. Visit the Food and Drug Administration’s website (www.fda.gov/) for the latest information on warnings, patient medication guides, or newly approved medications. For More Information To learn more about social anxiety disorder, visit: MedlinePlus (National Library of Medicine) http://medlineplus.gov (En Español: http://medlineplus.gov/spanish) For information on clinical trials, visit: ClinicalTrials.gov: http://www.clinicaltrials.gov (En Español: http://salud.nih.gov/investigacion-clinica/) For more information on conditions that affect mental health, resources, and research, visit the NIMH website http://www.nimh.nih.gov https://www.nimh.nih.gov/medications http://www.fda.gov/ http://medlineplus.gov/spanish http://www.clinicaltrials.gov http://www.nimh.nih.gov https://medlineplus.gov/ http://salud.nih.gov/investigacion-clinica/ Finding Help Mental Health Treatment Program Locator The Substance Abuse and Mental Health Services Administration (SAMHSA) provides this online resource for locating mental health treatment facilities and programs. 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If you have questions regarding these guidelines and use of NIMH publications, please contact the NIMH Information Resource Center at 1-866-615-6464 or e-mail [email protected] https://findtreatment.samhsa.gov/ http://www.nimh.nih.gov/health/find-help/index.shtml mailto:[email protected] National Institute of Mental Health Office of Science Policy, Planning, and Communications Science Writing, Press, and Dissemination Branch 6001 Executive Boulevard Room 6200, MSC 9663 Bethesda, MD 20892-9663 Phone: 301-443-4513 or 1-866-615-NIMH (6464) toll-free TTY: 301-443-8431 or 1-866-415-8051 toll-free Fax: 301-443-4279 Email: [email protected] Website: www.nimh.nih.gov U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES  National Institutes of Health  NIH Publication No. 19-MH-8083 Revised 2016 mailto:[email protected] http://www.nimh.nih.gov/ SOCIAL ANXIETY DISORDER: More Than Just Shyness What is it like having social anxiety disorder? What is social anxiety disorder? What are the signs and symptoms of social anxiety disorder? What causes social anxiety disorder? How is social anxiety disorder treated? Psychotherapy Support Groups Medication For More Information Finding Help Mental Health Treatment Program Locator Reprints National Institute of Mental Health 34 EW RESEARCH N 4 Are Social and Communication Difficulties a Risk Factor for the Development of Social Anxiety? Hannah Pickard, MSc, Fruhling Rijsdijk, PhD, Francesca Happ�e, PhD, William Mandy, PhD Objective: Social anxiety (SA) is a common condition associated with social and communication (SC) difficulties in typically developing young people, as well as those with autism spectrum disorder (ASD). Whether SC diffi- culties place children at risk for developing SA is unclear. Using a longitudinal design, the present study aimed to disentangle the relationship between SA symptoms and SC difficulties using a population-based sample of 9,491 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Method: Parent-reported data on SC difficulties and SA symptoms were collected at ages 7, 10, and 13 years. A cross-lagged panel model was used to investigate the longitudinal stability and directional relationship between latent SC difficulties and SA constructs over time. Results: More SC difficulties were associated with greater SA symptoms at all ages. Earlier SC difficulties predicted a This article can be used to obtain continuing medical education (CME) at www.jaacap.com. Supplemental material cited in this article is available online. www.jaacap.com small but significant amount of variance in later SA symptoms. The reverse relationship from SA to SC diffi- culties was not observed. The relationship from SC diffi- culties to SA was strongest from age 7 to 10 years. No sex differences were observed. Conclusion: The evidence suggests that SC difficulties may be an important risk factor for the development of SA. These findings suggest the potential usefulness of incorporating social skills training alongside effective in- terventions to prevent or alleviate symptoms of SA in childhood. Key words: ALSPAC, social anxiety, social and communication difficulties, autism spectrum disorders, longitudinal J Am Acad Child Adolesc Psychiatry 2017;56(4):344–351. ocial anxiety (SA) disorder is characterized by an intense fear of social situations, which is often S accompanied by the fear of being scrutinized by others.1 SA is often experienced during several social situa- tions, including interacting with others, eating in public, or giving speeches. Anxiety-related fears are commonly driven by negative self-perceptions and a fear of being ridiculed by others, which can lead to increased social withdrawal and avoidance.2 SA is the third most common psychiatric dis- order, with epidemiological research showing prevalence rates between 3% to 4% in childhood and 9% in adoles- cence.3,4 The onset of SA is usually between late childhood and adolescence5; however, SA disorder can manifest in children at 7 or 8 years of age.6 SA is a dimensional trait that is continuously distributed throughout the general population. Subthreshold symp- toms of SA are associated with adverse outcomes and an increased risk of developing SA disorder and additional comorbid disorders.7 Given the burden that subthreshold SA can have on an individual’s well-being, it is important that research investigates potential risk factors under- pinning dimensionally measured SA traits in the general population. SA and Social Communication Difficulties in Childhood Etiological models of SA in childhood have implicated the role of several development risk factors, including behav- ioral inhibition, parent–child interactions, and peer re- lationships.8 In addition, social and communication (SC) difficulties, including problems in social behaviors, social cognition, and reciprocal social communication, are common among children with SA and have also been proposed as a risk factor. SC ability is a continuously distributed trait that extends throughout the general population,9 with those who experience severe difficulties often receiving a diagnosis of autism spectrum disorder (ASD), a neurodevelopmental condition characterized by SC difficulties and restricted in- terests and repetitive behaviors. SA co-occurs highly in children with ASD (4.5�9.5 years) and high subthreshold ASD traits (10�15 years),10,11 suggesting that those with greater SC difficulties may have a heightened risk of developing SA disorder. However, the developmental rela- tionship between SC difficulties and SA is unclear. The present study aims to address whether an individual’s po- sition on the continuum of SC traits influences their risk of later developing SA. Cross-sectional research has supported the association between SC difficulties and SA. For example, typically developing children with SA disorder exhibited lower self and peer ratings of social competence during both labora- tory and school-based social interaction tasks, compared to peers without anxiety.4,12 Furthermore, using parent-report questionnaires, research has found that SC difficulties are higher among children with SA disorder compared to those JOURNAL OF THE AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 56 NUMBER 4 APRIL 2017 http://www.jaacap.com http://crossmark.crossref.org/dialog/?doi=10.1016/j.jaac.2017.01.007&domain=pdf http://www.jaacap.com SOCIAL AND COMMUNICATION DIFFICULTIES AS RISK FACTOR FOR SOCIAL ANXIETY with other anxiety disorders,13 suggesting a specific rela- tionship between SC difficulties and SA. Although SC dif- ficulties may not be universal in SA,14 the evidence suggests that for a significant subgroup in the general population, SC difficulties may underlie the development of SA.15 Intervention studies in children have informed our un- derstanding of the relationship between SC difficulties and SA. Research has shown that children (age 8�12 years) with SA disorder who completed a Social Effectiveness Therapy (SET) program to enhance social skills and peer relationships showed increases in social skills and decreases in SA at posttreatment and after 6 months, compared to the control participants in a nonspecific intervention.16 It is evident that a relationship between SA and SC difficulties exists and that social skills training effectively reduces SA; however, we do not fully understand whether SC difficulties contribute to the development of SA. This research is important for identifying early warning signs on the developmental trajectory of SA. In the ASD literature, cross-sectional studies have shown that social skill deficits and greater physiological arousal contributed toward elevated SA symptoms in adolescents with ASD.17 Contradictory research in children with ASD revealed that higher levels of SA predicted lower respon- sible and assertive social skills.18 Inconclusive findings regarding the directional relationship between SA and SC difficulties have led researchers to postulate a bidirectional relationship in ASD. It is suggested that SC difficulties may hinder social experiences, contributing to increased SA and social withdrawal, which subsequently impedes an in- dividual’s SC ability.19 However, this relationship remains to be explored. Research using population-based samples has supported the relationship between SA symptoms and SC difficulties. Population-based research allows the use of large samples to examine associations across the trait distribution. These findings can inform research in clinical populations. Using a population-based twin sample of children with ASD and their affected and unaffected cotwins, Hallett et al.11 found that increased SC difficulties and higher IQ were associated with greater parent-reported SA, supporting clinical find- ings. To date, no longitudinal work using a population- based sample has specifically assessed whether SC difficulties are a risk factor for SA, or whether SA reduces an individual’s SC ability. TABLE 1 Demographic Information for the Sample at 7, 10, and 1 Demographics Age 7 (n ¼ 7,90 Female % 49 Parental HE% (age 18þ) 42 Owned/mortgaged home % 82 Ethnicity, white % 96 Full scale IQ, mean (SD) (Range: 45�151)a 105.30 (16.32 Verbal IQ 108.14 (16.68 Performance IQ 100.57 (16.94 Note: IQ age 7 (n ¼ 5,829), 10 (n ¼ 5,761), and 13 (n ¼ 5,307) years. HE ¼ h aFull range of scores at all ages. JOURNAL OF THE AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 56 NUMBER 4 APRIL 2017 We aim to examine the directional relationship between parent-reported SA symptoms and SC difficulties in a population-based sample of children at ages 7, 10, and 13 years. Sex differences will also be explored. Furthermore, the relationship between SA and SC difficulties will be examined while controlling for generalized anxiety, to test whether SC difficulties are related to SA-specific symptoms, compared to generalised anxiety. Based on previous research, we predict a directional and specific relationship between SC difficulties and SA, with early SC difficulties contributing to later SA symptoms. METHOD Sample All participants were from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort, a population-based sample of children born in Bristol between 1991 and 1992. A total of 14,541 children were recruited into the original cohort, with 14,062 live births and 13,988 alive at 12 months.20 (The study website contains details of all of the data available through a fully searchable data dictionary at http://www.bris.ac.uk/alspac/researchers/data- access/data-dictionary/.) Ethical approval for this study was ob- tained from the ALSPAC Law and Ethics Committee and local research ethics committees. A total of 9,597 children had available data to test the study hypotheses at ages 7 (n ¼ 8,148), 10 (n ¼ 7,723), and 13 (n ¼ 7,008) years. Following ALSPACs exclusion criteria for prorated scores, only children with 50% or more complete data on all measures of interest at all ages were included in the present study. Based on these exclusion criteria, 248 children (3%), 204 children (2.6%), and 226 children (3.2%) were excluded at ages 7, 10, and 13 years, respectively. Merging the three samples at ages 7 (n ¼ 7,900), 10 (n ¼ 7,519), and 13 (n ¼ 6,782) years, the final sample included 9,491 children (4,654 female) with data at one, two, or three time points. This final sample was used in all further analyses (Table 1). Compared to the original ALSPAC cohort not included in the current analyses, young people in our final sample were more likely to have a mother who was a homeowner (odds ratio [OR] ¼ 2.94, 95% CI ¼ 2.72, 3.19) and had completed higher edu- cation (OR ¼ 2.33, 95% CI ¼ 2.13, 2.55). Measures Socioeconomic Status. Socioeconomic status (SES) was captured using parental maternal education. Previous research in ALSPAC has re- ported that maternal education is a valid indicator of SES.21 At 32 weeks of gestation, mothers reported their current highest level of educational achievement from six possible responses: “none,” “CSE” (basic UK qualification), “vocational,” “O-level” (a prerequisite to 3 Years of Age 0) Age 10 (n ¼ 7,519) Age 13 (n ¼ 6,782) 50 50 43 44 83 84 96 96 ) 105.24 (16.39) 105.70 (16.31) ) 108.08 (16.69) 108.51 (16.63) ) 100.59 (17.03) 100.98 (16.93) igher education; SD ¼ standard deviation. www.jaacap.com 345 http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary/ http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary/ http://www.jaacap.com PICKARD et al. further education), “A-levels,” and “degree or above.” Higher scores are indicative of better maternal education and thus higher SES. Wechsler Intelligence Scale for Children�Third Edition. The Wechsler Intelligence Scale for Children�Third Edition (WISC-III)22 is a measure of child IQ. In the present study, the abbreviated version of the WISC, including random items from 10 subtests, was administered during the clinical data collection wave at age 8 years. A total of 6,726 children (70.9%) from the final sample had a com- plete IQ measure at age 8 years. Social and Communication Disorders Checklist. The Social and Communication Disorders Checklist (SCDC)23,24 is a parent- reported questionnaire that measures social and communication (SC) difficulties related to ASD. The questionnaire consists of 12 items with a response scale ranging from 0 to 2 (“not true,” “quite or sometimes true,” “very often true”), which was designed to capture a child’s social behavior and functioning over the previous 6 months. A total score ranges from 0 to 24, with higher scores indicating greater SC difficulties. The SCDC shows high internal consistency (0.93), as well as good specificity (0.91) and sensitivity (0.88) when discriminating between individuals with and without ASD.23 Furthermore, research conducted in the ALSPAC cohort supports both the construct validity and reliability of the SCDC at measuring SC traits in the general population.24 In the ALSPAC sample, research has shown that the SCDC measures SC trait vari- ability in the general population that overlaps with ASD in terms of genetic effects,25 supporting the SCDC’s validity as a measure of ASD-specific SC difficulties. The SCDC had excellent internal reli- ability (a ¼ 0.81�0.89). Development and Wellbeing Assessment. The Development and Wellbeing Assessment (DAWBA)26 questionnaire was administered as a parent-report questionnaire to capture child and adolescent psychopathology that corresponds with the International Classifica- tion of Diseases–10th Revision (ICD-10) and Diagnostic and Statistical Manual of Mental Disorders—4th Edition (DSM-IV) criteria. The DAWBA has been tested and validated in large population sam- ples.26 In the present research, SA symptoms were measured using the social fears (SF) subscale, and generalized anxiety was measured using the general anxiety (GA) subscale. The DAWBA-SF has six items in which parents report whether their child had experienced any specific SA symptoms over the last month: “no,” “a little,” “a lot,” and “hasn’t done this in last month.” Any parent responses FIGURE 1 Cross-lagged panel model of social and communicatio Note: A ¼ autoregressive paths, b ¼ cross-lagged paths; c ¼ cova 346 www.jaacap.com of “hasn’t done this in last month” were excluded, as this response is not present in the original online DAWBA and is ambiguous in its answer to the six SF items. An SF total score (range 0�12) can be created by summing the responses over the six SA items, which was used in the present study. Higher scores on the DAWBA-SF indicate more severe SA symptoms. The DAWBA-SF showed good internal reliability (a ¼ 0.79�0.81). The DAWBA-GA subscale consists of seven items in which parents report the frequency of their child worrying over the past 6 months: “no,” “sometimes,” and “often.” A GA total score (range 0�14) is computed by summing responses on all items, with higher scores indicating more generalized anxiety symptoms. The DAWBA-GA showed acceptable internal reliability (a ¼ 0.53�0.72). Data Analyses Analyses were conducted in R, using the Lavaan package for structural equation modeling (SEM).27 The present study used a three-wave (time), two-level cross-lagged panel model to estimate relationships between SC difficulties and SA symptoms. The cross- lagged panel model incorporates the inherent time nature of longi- tudinal data and is frequently used to assess causal relationships in nonexperimental studies using panel data.28,29 Confirmatory Factor Analyses. Three confirmatory factor ana- lyses were conducted to assess the construct validity of the DAWBA-SF and SCDC at all ages. A two-factor structure was specified with a single factor for each scale: SC difficulties (SCDC) with 12 indicators, and SA (DAWBA-SF) with 6 in- dicators. Measures recommended for large datasets were used.30 Absolute fit measures included the standardized root mean square residual (SRMR) and root mean square error of approxi- mation (RMSEA). For the SRMR, a value less than 0.08 indicates a good model fit, and for RMSEA, a value below 0.08 indicates an acceptable model fit, with values less than 0.05 indicating good model fit.31,32 The comparative fit index (CFI) was also used, with values above 0.90 and 0.95 indicating acceptable to good model fit, respectively.32 Cross-Lagged Panel Model. The predicted relationships between SC difficulties and SA symptoms at ages 7, 10, and 13 years are depicted in Figure 1. The simultaneously solved paths are re- ported as partial regression coefficients: autoregressive paths n difficulties (SC Diff) and social anxiety (SA) latent factors. riance paths. JOURNAL OF THE AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 56 NUMBER 4 APRIL 2017 http://www.jaacap.com SOCIAL AND COMMUNICATION DIFFICULTIES AS RISK FACTOR FOR SOCIAL ANXIETY estimate the stability of one trait over time; covariance paths es- timate the correlation between two traits at each time point; cross- lagged paths estimate the predictive relationship of one variable on another at a later time point, independent of the stability and covariance paths. The relationships were tested between latent factors to capture more robust constructs free of measurement error. Each latent factor was specified within the model, with the 6 items from the DAWBA- SF loading on to the SA construct and the 12 items from the SCDC loading on to the SC difficulties construct (excluded from Figure 1 for simplicity). In the full model, latent factors were free to covary within time points. Latent factor item residuals were specified to covary between time points. Model fit was tested with the Satorra–Bentler Scaled c2 statistic,33 to compare c2 when data are nonnormal. To test the study’s first hypothesis, model fit across 8 nested models were examined to assess the following: longitudinal stability of each latent variable; the relationship between the latent variables within time; and the stability of cross-lagged paths and difference in the cross- lagged paths at each time point (7/10, 10/13). Model fit was determined by the difference in fit statistics of the full model and a nested model in which equality constraints are applied to path estimates (e.g., a1 ¼ a2 or a3 ¼ a4 to assess stability of the auto- regressive paths). To assess sex differences, likelihood ratio testing was conducted between a full model in which all paths were freely estimated across sex and one in which either all cross-lagged paths (b12, b21, b23, b32) or autoregressive paths (a1, a2, a3, a4) were equated across sex. A Bonferroni correction was applied to assess the significance of all path coefficients (p < .003). c2 for model-fit differences were considered to be statistically significant at p < .006. Specificity. To explore the specificity of the relationship between SC difficulties and SA, scores on the DAWBA-GA subscale (where available) were regressed out of the SA latent variable traits at ages 7, 10, and 13 years to create a more specific SA-related latent construct. RESULTS All questionnaire data were cleaned using ALSPAC guide- lines for data preparation. Tests of selective attrition for SC difficulties and SA symptoms were conducted, and accept- able results were observed (see Supplements 1 and 2, available online). Mean scores on the SCDC and DAWBA-SF are reported in Table 2. The full distribution of scores on the SCDC and DAWBA-SF scales are available online (see Table S1, available online). Confirmatory Factor Analysis Three two-factor models were specified to test the construct validity of the SCDC scale and DAWBA-SF subscale at ages 7, TABLE 2 Parent-Reported Child Characteristics on Questionnaire D Questionnaires Age 7 y (n ¼ 7,900) Mean (SD) [CI] SCDC 2.8 (3.66) (Range: 0�24)a [2.72, 2.88] DAWBA-SF 0.88 (1.6) (Range: 0�12)a [0.85, 0.92] Note: DAWBA-SF ¼ Development and Wellbeing AssessmenteSocial Fears; SCDC ¼ aFull range of scores at all ages. JOURNAL OF THE AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 56 NUMBER 4 APRIL 2017 10, and 13 years. Two out of three of the fit indices for the two- factor models at 7 years (RMSEA ¼ 0.067 [0.065, 0.068], SRMR ¼ 0.06, CFI ¼ 0.83), 10 years (RMSEA ¼ 0.067 [0.066, 0.069], SRMR ¼ 0.06, CFI ¼ 0.84), and 13 years (RMSEA ¼ 0.073 [0.072, 0.074], SRMR ¼ 0.06, CFI ¼ 0.82) were indicative of a good/acceptable model fit. The results imply that the SCDC and DAWBA-SF are two distinct and separate constructs measuring SC difficulties and SA symptoms. Latent Variable Correlations A saturated model with no cross-lagged or stability paths was fitted to examine the correlations among all latent fac- tors. Significant associations among all latent factors were observed (Table 3). Cross-Lagged Panel Model Path Estimates In the cross-lagged panel model, effects of IQ and SES were regressed out of the SA latent variable at ages 7 years (IQ: b ¼ �0.18, SES: b ¼ �0.02) 10 years (IQ: b ¼ �0.11, SES: b ¼ 0.01), and 13 years (IQ: b ¼ �0.04, SES: b ¼ 0.00). For the SC difficulties latent variable, the effects were at ages 7 years (IQ: b ¼ �0.17, SES: b ¼ 0.00), 10 years (IQ: b ¼ �0.11, SES: b ¼ �0.00), and 13 years (IQ: b ¼ �0.04, SES: b ¼ �0.00). Covariance Paths The covariance path estimates between SC difficulties and SA were significant at all ages (Figure 2). The covariance path weights steadily decreased over time; however, no significant decrease in model fit was observed when the covariance paths at ages 7 and 10 years (Dc2[df] ¼ 4.92[1], p ¼ .03) and ages 10 and 13 years (Dc2[df] ¼ 0.12[1], p ¼ .73) were constrained to be equal (see Table S2, available online). Stability Paths The autoregressive paths for SC difficulties (a1 and a2) and SA (a3 and a4) were significantly stable over time. However, the longitudinal stability of both SC difficulties and SA significantly decreased over time: SC difficulties (Dc2[df] ¼ 53.87[1], p ¼ 2.15e-13) and SA symptoms (Dc2[df] ¼ 12.16[1], p ¼ 4.89e-04). Cross-Lagged Paths The cross-lagged paths from SC difficulties to SA (b12 and b23) were both significant, but not significantly different in size ata Age 10 y (n ¼ 7,519) Age 13 y (n ¼ 6,782) Mean (SD) [CI] Mean (SD) [CI] 2.37 (3.58) 2.52 (3.60) [2.29, 2.45] [2.44, 2.61] 0.98 (1.7) 1.26 (1.91) [0.94, 1.02] [1.21, 1.30] Social Communication Disorders Checklist; SD ¼ standard deviation. www.jaacap.com 347 http://www.jaacap.com TABLE 3 Correlation Coefficients Among All Latent Factors in the Saturated Model R [CI] 1 2 3 4 5 6 1. SA7 1 2. SC Diff7 0.20*** [0.17, 0.24] 1 3. SA10 0.54*** [0.51, 0.58] 0.21*** [0.18, 0.25] 1 4. SC Diff10 0.16*** [0.12, 0.19] 0.74*** [0.72, 0.77] 0.23*** [0.19, 0.26] 1 5. SA13 0.40*** [0.36, 0.44] 0.17*** [0.14, 0.21] 0.52*** [0.49, 0.56] 0.20*** [0.16, 0.23] 1 6. SC Diff13 0.14*** [0.11, 0.18] 0.61*** [0.58, 0.65] 0.19*** [0.16, 0.23] 0.71*** [0.68, 0.74] 0.22*** [0.19, 0.26] 1 Note: Subscript numbers show the age at assessment. SA ¼ social anxiety symptoms; SC Diff ¼ social and communicative difficulties. ***p < .001. PICKARD et al. (Dc2[df] ¼ 4.52[1], p ¼ .03). The reverse cross-lagged paths from SA to SC difficulties (b21 and b32) were not significant. Subsequent analyses explored the difference in cross-lagged path weights at ages 7/10 years and 10/13 years. A sig- nificant difference in the cross-lagged paths from age 7/10 years was observed (Dc2[df] ¼ 13.04[1], p ¼ 3.06e-04), with the path from SC difficulties to SA having a significantly greater contribution compared to the reverse cross-lagged path. No significant difference was seen for the cross-lagged paths from age 10/13 years (Dc2[df] ¼ 1.06[1], p ¼ .30). Sex Differences No significant decrease in model fit was observed for a nested model constraining all cross-lagged paths to be equal across male and female participants (Dc2[df] ¼ 1.59[4], p ¼.81), compared to a full model, indicating no sex differ- ences in the predictive relationship between SA and SC difficulties constructs at all ages. Analyses investigating sex differences in the longitudinal stability showed a significant difference in the autoregressive pathways for SC difficulties (Dc2[df] ¼ 22.68[2], p ¼ 1.19e-05), with females showing less stability in SC difficulties compared to males. No sex dif- ferences were observed for the SA autoregressive paths (Dc2[df] ¼ 4.61[2], p ¼ .10). Specificity Analyses Specificity analyses tested the relationship between SC dif- ficulties and SA, while controlling for generalized anxiety (see Table S3, available online). The analyses revealed a pattern of results identical to that of the full cross-lagged panel model, showing both significant autoregressive paths and significant cross-lagged paths from SC difficulties to SA at ages 7/10 and 10/13 years. The reverse cross-lagged paths from SA to SC difficulties were not significant. DISCUSSION We used a longitudinal design to investigate the relationship between SC difficulties and SA symptoms in a population- based cohort of children at ages 7, 10, and 13 years. We predicted that SC difficulties would contribute specifically to the development of SA symptoms in later childhood. We found that, first, more parent-reported SC difficulties were 348 www.jaacap.com associated with heightened SA symptoms across all ages. Second, the data supported the construct validity of the SCDC and DAWBA-SF, suggesting that SA and SC diffi- culties are distinct domains across childhood. Third, extending previous research and supporting our predictions, we found a directional and asymmetrical relationship be- tween SC difficulties and SA symptoms; earlier SC diffi- culties contributed toward the development of later SA symptoms, but not vice versa. In terms of this directional relationship, sex differences were not observed. Finally, SC difficulties predicted later SA symptoms while controlling for generalized anxiety, emphasizing that SC difficulties are a specific risk factor for SA. The interpretation of these re- sults, clinical implications, limitations, and conclusions are discussed below. In typically developing children, associations between clinical SA symptoms and poorer social skills have been reported.4,12 Our results both support and extend previous findings by illustrating the stability of these relationships throughout childhood. In accordance with research report- ing more SC difficulties and greater SA symptoms in in- dividuals with ASD,11,13 we found similar associations in a population-based sample of children. The magnitude of these associations, although only modest compared to re- sults in clinical samples,11 mimic the findings from previous traitwise research examining parent-reported SC difficulties and SA symptoms.34 Our results may be indicative of the low levels of SA and SC difficulty scores in the present sample. Previous intervention studies have supported the effi- cacy of social skills therapies for improving SC ability and having downstream benefits on SA.16 Building on this work, our study demonstrates that these SC difficulties not only co-occur with SA, but also appear to play a role in the development of SA across childhood. In addition, our novel longitudinal findings in a population-based sample suggest that SC difficulties are a risk factor for the development of SA across the trait distribution. These findings emphasize a potential marker for the develop- ment of SA that could be targeted with early prevention approaches. Furthermore, our results are consistent with etiological theories proposing that SC difficulties may provoke negative JOURNAL OF THE AMERICAN ACADEMY OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 56 NUMBER 4 APRIL 2017 http://www.jaacap.com FIGURE 2 Cross-lagged panel model showing the relationship between social and communication difficulties (SC Diff) and social anxiety (SA) latent factors at 7, 10, and 13 years of age. Note: Standardized b coefficients with standard errors. All analyses controlled for IQ and socioeconomic status (SES). Significant paths are shown in bold. *p < .001. SOCIAL AND COMMUNICATION DIFFICULTIES AS RISK FACTOR FOR SOCIAL ANXIETY reactions from others, which, through repeated experience, may result in increased SA.15 This is one possible mechanism through which SC difficulties may predispose to greater SA symptoms in childhood; however, there may be several alternative mechanisms, for example peer victimization, bullying, or social insight,35 that may contribute to the development of SA in those who exhibit severe SC diffi- culties. For example, in adolescents with ASD, self-reported peer victimization and bullying are associated with increased internalizing problems.36 It is possible that SC difficulties predispose to these additional risk factors or that they develop independent of social ability. Further research exploring the mediating mechanisms on the developmental pathway from SC difficulties to SA in childhood is warranted. Interestingly, SC difficulties in earlier childhood made a greater contribution to SA symptoms, compared to the alternative cross-lagged path from age 7 to 10 years, sug- gesting that earlier SC problems heighten a child’s risk of developing … Available online at www.sciencedirect.com ScienceDirect Behavior Therapy 45 (2014) 530–540 www.elsevier.com/locate/bt Theory of Mind Impairments in Social Anxiety Disorder Dianne M. Hezel Richard J. McNally Harvard University Social anxiety disorder (SAD) is a common psychiatric disorder characterized by a persistent, excessive fear and avoidance of social and performance situations. Research on cognitive biases indicates individuals with SAD may lack an accurate view of how they are perceived by others, especially in social situations when they allocate important attentional resources to monitoring their own actions as well as external threat. In the present study, we explored whether socially anxious individuals also have impairments in theory of mind (ToM), or the ability to comprehend others’ mental states, including emotions, beliefs, and intentions. Forty socially anxious and 40 non-socially-anxious comparison participants completed two ToM tasks: the Reading the Mind in the Eyes and the Movie for the Assessment of Social Cognition. Participants with SAD performed worse on ToM tasks than did non-socially-anxious participants. Relative to comparison participants, those with SAD were more likely to attribute more intense emotions and greater meaning to what others were thinking and feeling. These group differences were not due to interpretation bias. The ToM impairments in people with SAD are in the opposite direction of those in people with autism spectrum conditions whose inferences about the mental states of other people are absent or very limited. This association between SAD and ToM may have important implications for our understanding of both the maintenance and treatment of social anxiety disorder. The authors thank Christine Hooker for her valuable feedback on this study and David Dodell-Feder for his help with program- ming the tasks and measures used in this study. They also thank members of the McNally Lab who assisted in the MIE valence ratings. Address correspondence to Dianne M. Hezel, Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138; e-mail: [email protected] 0005-7894/45/530-540/$1.00/0 © 2014 Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd. All rights reserved. Keywords: social anxiety disorder; theory of mind; social cognition; anxiety disorders SOCIAL ANXIETY DISORDER (SAD) affects 6.8% of American adults annually, and its lifetime prevalence is 12.1% (Kessler, Berglund, et al., 2005; Kessler, Chiu, Demler, & Walters, 2005). SAD is character- ized by a marked, persistent fear of scrutiny and humiliation and by avoidance of social and perfor- mance situations (American Psychiatric Association, 2000). Cognitive-processing biases figure in the onset and maintenance of SAD (Constans, Penn, Ihen, & Hope, 1999). Attentional (Amir, Foa, & Coles, 1998; Hope, Rapee, Heimberg, & Dombeck, 1990), mem- ory (Foa, Gilboa-Schechtman, Amir, & Freshman, 2000; Kim, 2004), imagery (Hirsch, Meynen, & Clark, 2004; Makkar & Grisham, 2011; Wells & Papageorgiou, 1999), and interpretive biases (Amir et al., 1998; Constans et al., 1999; Stopa & Clark, 2000; Voncken, Bogels, & de Vries, 2003) for threat-relevant information are evident in SAD. Studies on interpretive bias suggest that people with SAD construe neutral and ambiguous stimuli as more threatening than do non-socially-anxious individuals. For example, Niels-Christensen, Stein, and Means-Christensen (2003) found that socially anxious individuals evaluated themselves negatively, and erroneously believed that others judged them negatively in a social interaction, implying they seemingly lack an accurate view of how others view them, consistent with an interpretation bias. Other research has suggested that socially anxious people possess abnormal processing of positive stimuli, including fearful responses to favorable feedback (for a review, see Kashdan, Weeks, & Savostyanova, 2011) and the absence of a positive interpretation bias that nonanxious individuals possess (Hirsch http://dx.doi.org/ http://dx.doi.org/ http://dx.doi.org/ mailto:[email protected] 531the ory of mi nd i n sad & Mathews, 1997, 2000). It is also possible, how- ever, that socially anxious individuals have difficulty comprehending the mental states of others irrespec- tive of the valence or ambiguity of the stimulus. That is, they may be impaired in inferring and reasoning about others’ beliefs, emotions, and intentions, and hence in predicting their thoughts and actions, especially in social situations. The cognitive capacity to identify and reason about mental states in other people is called theory of mind (Premack & Woodruff, 1978). A term coined by researchers studying the cog- nitive abilities of chimpanzees, theory of mind (ToM) is both a critical adaptation for social functioning and an important developmental mile- stone in humans. Sabbagh (2004) delineates two component processes of ToM: “(1) detecting or decoding others’ mental states based on immedi- ately available observation information and (2) reasoning about those mental states in the service of explaining or predicting others’ actions” (p. 210). Decoding abilities refer to basic skills, such as identifying facial expressions or following eye gaze, whereas reasoning abilities require higher-order skills such as detecting sarcasm or inferring that someone is upset because they did poorly on a job review (Sabbagh, 2004; Washburn, 2012). People with ToM deficits have difficulty evaluat- ing others’ thoughts, and thereby experience social impairment that may contribute to functional impairment seen in autism (Baron-Cohen, 1995, 2005; Baron-Cohen, Leslie, & Frith, 1985; Frith, 1989) and schizophrenia (Brune, 2005; Corcoran, 2000; Couture, Penn, & Roberts, 2006). Likewise, it is possible that if individuals have trouble identifying and reasoning about others’ emotions and intentions that they may experience anxiety when in social situations. Social anxiety and ToM ability correlate inversely among people with schizophrenia spectrum disorders; one interpreta- tion of this finding is that “… fully intact ToM capacities have a protective effect against paranoia or that high levels of social anxiety have a negative impact on ToM” (p. 84; Lysaker et al., 2010). Similarly, others (Samson, Lackner, Weiss, & Papousek, 2012) found that people with high levels of social anxiety rated cartoons requiring an understanding of others’ mental states (“ToM cartoons”), but not other cartoons, as less humor- ous than did people without social anxiety. However, only one study has examined ToM in individuals with diagnosed SAD (Washburn, 2012). This study found that nondepressed, socially anxious participants performed worse than non- anxious participants on one decoding measure of ToM, whereas individuals with comorbid depres- sion and anxiety performed better on the task (one interpretation of enhanced decoding abilities in individuals with depression is that these individuals may be especially attentive to subtle social cues). However, the nondepressed, socially anxious group, which consisted of only nine participants, was rather small and hence perhaps underpowered to reveal group differences in the two other reasoning ToM tasks used in the study. In the present study, we compared socially anxious and non-socially-anxious participants’ performance on socially relevant ToM tasks that require participants to both decode others’ emo- tions and reason about their mental states. We attempted to extend the findings of Washburn (2012) with the addition of a cognitive load condition. According to cognitive-behavioral models, people with SAD disproportionately allo- cate attentional resources to monitoring self-image, external threat, and personal expectations of how others will react to them in social situations (Rapee & Heimberg, 1997). This increased cognitive load, in turn, impairs performance on unrelated, complex cognitive tasks. Hope, Heimberg, and Klein (1990) found that socially anxious participants reported increased self-focused attention and performed less accurately than did nonanxious participants on a recall task following a social interaction. Hence, increased allocation of attentional resources may impair the processing of social information. If self-preoccupation impairs the ability to make accurate inferences about the mental states of other people, we would expect cognitive load to impair ToM ability in both non-socially-anxious compar- ison and socially anxious participants. To test this hypothesis, we gave half of the participants a memory task prior to completing the ToM measures. If, on the other hand, socially anxious participants have impairments in ToM irrespective of cognitive load, we would expect them to perform worse than non- socially-anxious participants in the no-load condition when they are presumably not self-monitoring. Unlike interpretation bias paradigms, the tasks used in this study require that participants identify not only the emotions, but also the thoughts and intentions of others, irrespective of valence. By analyzing the errors that people make on these ToM tasks, one can discern whether participants’ errors are due to an interpretation bias (in which case we would expect that they would choose answers more negative in valence than the correct answer) as well as the extent to which they are taking the perspective of others. These ToM tasks are ecologically valid in that they require that participants make real-time assessments of what other people are thinking and feeling and why they 532 hezel & mcnally are acting a certain way. If individuals with social anxiety disorder do possess impairments in ToM, clinicians could potentially target these weaknesses in treatment. Research indicates that people with schizophrenia have benefited greatly from cognitive remediation, which aims to improve cognition and social cognition through different computerized exercises (McGurk, Twamley, Sitzer, McHugo, & Mueser, 2007; Wykes, Huddy, Cellard, McGurk, & Czobor, 2011). Lastly, we examined the relation of IQ to ToM performance to ensure that differences in cognitive ability did not account for differential performance on the ToM tasks. Similarly, we measured depressive symptoms since some studies have identified less accurate ToM performance in depressed individuals (Lee, Harkness, Sabbagh, & Jacobson, 2005) whereas other studies have found enhanced ToM performance in dysthymic individuals (Harkness, Sabbagh, Jacobson, Chowdrey, & Chen, 2005). Method participants Participants were recruited from the Harvard Uni- versity study pool, which consists of Harvard undergraduate students and adults living in metro- politan Boston, and from a Boston University job/ volunteer site. The online postings included a brief description of the study and instructions that anyone, socially anxious or not, between the ages of 18 and 65 were welcome to participate. Individuals who signed up for the Harvard study pool have the option of completing a prescreen questionnaire. Three of the questions on the prescreen were specific to the current study and included items from the Mini Social Phobia Inventory, a self-report measure that assesses the extent to which a person fears and avoids social situations (Seeley-Wait, Abbott, & Rapee, 2009). In order to recruit additional socially anxious participants, we emailed individuals who scored six or higher on the scale, which is indicative of social anxiety, to invite them to take part in the study. All participants, irrespective of the results of the prescreen questionnaire, were assessed with the Mini International Neuropsychiatric Interview (Sheehan et al., 1998). The first author classified all participants into one of two groups: (1) those meeting DSM-IV criteria for SAD and (2) those without SAD (see Table 3 for information on the groups’ additional Axis I diagnoses). The SAD group comprised 40 participants (27 women) with a mean age of 26.5 years (SD = 11.9), and the non-SAD comparison group comprised 40 participants (34 women) with a mean age of 20.1 years (SD = 2.2). We excluded the data of 10 additional participants for various reasons, including suspected malingering and inability to complete the cognitive load task. With the remaining 80 participants, we had .94 power to detect large effects (Faul, Erdfelder, Lang, & Buchner, 2007). Harvard students received study pool credit, whereas others received $10 per hour for their participation. Data on race and ethnicity were not collected. materials The Mini International Neuropsychiatric Interview (MINI) is a structured interview used to diagnose a range of current and lifetime Axis I disorders according to DSM-IV criteria (Sheehan et al., 1998). Administration takes approximately 15 minutes, and the MINI has good to very good concordance with the International Classification of Diseases and the Structured Clinical Interview for DSM-IV Diagnoses (SCID). Interrater reliability is excellent, with the majority of the scales having a kappa of .9 or higher; and test-retest reliability isvery good, with most scales having a kappa of .75. The Liebowitz Social Anxiety Scale Self-Report (LSAS) is a 24-item scale that accurately identifies the presence and severity of SAD (Fresco et al., 2001; Rytwinski et al., 2009). Participants indicate on a Likert Scale of zero to three the extent to which they fear and avoid 24 different social and performance situations (e.g., eating in public, speaking to an authority figure, etc.). Scores range from 0 to 144, with higher scores signifying greater social anxiety; a score of 60 indicates generalized SAD (Mennin et al., 2002; Rytwinski et al., 2009). The LSAS has high internal consis- tency (α = .95), strong convergent and discrimi- nant validity, and good test-retest reliability (r = .83, p b .01) (Baker, Heinrichs, Kim, & Hofmann, 2002). The Center for Epidemiologic Studies Depres- sion Scale, Revised (CESD) scale consists of 20 items that assess the frequency at which individ- uals have experienced symptoms of depression over the prior week (Eaton, Smith, Ybarra, Muntaner, & Tien, 2004). Scores ranging from 0 to 60 are calculated by adding item responses (four items are reversed scored), and 16 is the suggested clinical cutoff score for depression. The CESD has high internal consistency (α = .90), acceptable test-retest reliability (r = .57), and good discrimi- nant and concurrent validity as measured by correlations with self-report measures (r = .74) and clinical interviews of depression (r = .46; Radloff, 1977). The American National Adult Reading Test (NART) requires participants to read aloud a list of 50 short words of irregular pronunciation. The number of pronunciation errors are tallied and Table 1 Reading the Mind in the Eyes: Valence of All Answer Choices on the Task Word t(11) p Word t(11) p Negative Valenced Words Upset -16.58 b.001 Doubtful -5.00 b.001 Insisting -3.02 .01 Tentative -2.35 .04 Worried -11.00 b.001 Defiant -2.87 .02 Uneasy -5.93 b.001 Hostile -16.58 b.001 Despondent -9.57 b.001 Cautious -2.57 .03 Preoccupied -4.18 .002 Serious -2.80 .02 Cautious -2.57 .03 Distrustful -17.23 b.001 Regretful -11.00 b.001 Nervous -7.34 b.001 Skeptical -3.55 .005 Suspicious -11.00 b.001 Accusing -10.34 b.001 Neutral Valenced Words Anticipating 1.82 .10 Concerned -1.48 .17 Pensive 0 1.00 Positive Valenced Words Playful 12.54 b.001 Friendly 10.58 b.001 Desire 5.20 b.001 Interested 4.73 .001 Fantasizing 4.53 .001 Reflective 3.92 .002 Contemplative 2.35 .04 Flirtatious 6.28 b.001 Thoughtful 8.86 b.001 Confident 12.54 b.001 Decisive 2.97 .01 533the ory of mi nd i n sad used to estimate aspects of IQ. The NART validly estimates general IQ, verbal IQ, and performance IQ (Crawford, Parker, Stewart, Besson, & De Lacey, 1989), and has very high test-retest reliability (r = .98), very high interrater reliability (ranging from r = .96 to r = .98), and high split-half reliability (r = .90 to .93; Crawford et al., 1989). Administration takes approximately 2 to 3 minutes. NART scores were not used for eight participants (five SAD and three non-SAD) who were not native English speakers. The Wechsler Adult Intelligence Scale–Fourth Edition (WAIS) measures the cognitive ability, or IQ, of adults. In the present study, we used Similarities, a verbal comprehension task, and Matrix Reasoning, a perceptual organization task (Wechsler, 2008). Both Similarities and Matrix Reasoning have good to excellent internal consisten- cy (r = .87 and .90, respectively), good test-retest stability (r = .83 and r = .76, respectively), excellent interrater reliability (r = .93 and .98, respectively), and high convergent and discriminant validity. The Reading the Mind in the Eyes (MIE) is a decoding theory of mind task that consists of photographs of the eye-regions of actors and actresses (Baron-Cohen, Wheelwright, Hill, Raste, & Plumb, 2001). Individuals are asked to choose which of four words best describes what the person in the picture is thinking or feeling, as determined by the test-maker, earning one point per correct answer. This ToM test comprises two 18-question parts (Part A and Part B) and scores range from 0 to 18 (on each part), with low scores indicating impaired decoding abilities. The Mind in the Eyes is an advanced ToM task as individuals must identify complex emotions by relying on a limited amount of information (from the eyes only). The Mind in the Eyes has good test-retest reliability with an intraclass correlation coefficient of .83 and good internal consistency with a Cronbach’s alpha of .61 (Vallante et al., 2013), and can reliably detect subtle differences in social cognitive abilities (Baron- Cohen et al., 2001). Following others (Harkness et al., 2005), we classified all possible answers (both correct and incorrect) on this task in terms of accuracy and valence. Specifically, 12 members of our lab rated each emotion on a 1 (negative) to 7 (positive) scale, yielding a mean intraclass reliability correlation coefficient of .98. We then conducted one-sample t-tests to determine what words were significantly different from neutral (a score of 4). Words that had a significantly higher mean than 4 were classified as positive, words that had a mean significantly lower than 4 were classified as negative, and words that did not differ from 4 were classified as neutral. We determined that 20 of the eyes depict a negative valence, 13 a positive valence, and 3 a neutral valence (see Table 1). The Movie for the Assessment of Social Cognition (MASC) is a reasoning ToM task that consists of a 15-minute video depicting four actors and actresses interacting (Dziobek et al., 2006). Throughout the task, the film is paused and participants are asked to answer a total of 45 questions requiring them to identify the characters’ feelings, thoughts, and intentions (e.g., “What is Sandra feeling?”). Correct answers receive 1 point and incorrect answers are scored in one of three ways: (1) no ToM, meaning the answer was based on some physical aspect (e.g., “her hair does not look that nice”); (2) less ToM signifying an insufficient response that misses a crucial aspect of the social situation (i.e., a “half-right” answer [e.g., “she is pleased about his compliment”]); and (3) excessive ToM, signifying reading too much into the character’s state of mind (e.g., “she is exasperated about Michael coming on too strong”). Identifying the types of errors people make on this task enables one to evaluate the extent to which participants are taking the perspective of the characters in the film. The task also includes six additional control questions assessing understanding of non-socially-relevant as- pects of the plot and characters; these questions are totaled separately from the overall MASC score. The MASC has high internal consistency (α = .84) and strong test-retest reliability (ICC = .97) and high 534 hezel & mcnally convergent validity with other measures of social cognition (Dziobek et al., 2006). procedure Participants provided written informed consent as approved by Harvard’s Committee on the Use of Human Subjects and in compliance with the Helsinki Declaration of 1975. After being catego- rized as either socially anxious or not, participants were randomly assigned to either a cognitive load or no cognitive load condition. We achieved random assignment by using an Excel sheet that was programmed to randomly assign group mem- bership; at no time were the investigators able to predict what the next assignment would be. Participants first completed the CESD scale and the LSAS, followed by Part A of Mind in the Eyes, which was used as a baseline measure of participants’ performance. Participants completed these tasks, which took approximately 15 minutes combined, on a computer that was facing away from the examiner (as to reduce any anxiety participants may feel when completing the measures). The first author then administered the Similarities and Matrix Reasoning subscales of the WAIS-IV and the NART. Administration of these cognitive ability assessments took approximately 20 minutes. Finally, participants completed Part B of the MIE and the MASC on the same computer as the other measures. Participants in the load condition received a memory task before completing Part B of the MIE and the MASC. Specifically, before the MIE task, they had 20 seconds to memorize a sequence of eight symbols (e.g., * ? = \ N & ! #) and were instructed to rehearse them aloud while completing the task (Gilbert & Osborne, 1989; van den Bos, Peters, Bobocel, & Ybema, 2006). When they finished the test, participants repeated the symbols back to the first author and then rated how difficult they found the memory task on a scale of 1 to 10. Table 2 Group Characteristics and Cognitive Ability SAD M (SD) Non- M (S LSAS (anxiety severity) 72.48 (22.35) 26. CESD (depression severity) 20.70 (13.88) 6. NART: full-scale IQ 118.23 (5.10) 118. NART: verbal IQ 118.63 (5.35) 118. NART: performance IQ 113.31 (3.7) 113. WAIS-IV: Similarities 1 10.73 (2.21) 11. WAIS-IV: Matrix Reasoning 1 10.75 (2.73) 11. Note. * = p ≤ .05 criteria; 1 = scaled scores. LSAS = Liebowitz Social Anxiety Scale; CESD = Center for Epidemiolo WAIS-IV = Weschler Adult Intelligence Scale, Fourth Edition. Participants received a second sequence of symbols before the MASC, whereas those in the no cognitive load condition performed a filler task for about 20 seconds before completing the ToM tasks. To reduce any anxiety experienced during the cognitive load task, the experimenter told participants in this condition that some people find the memory task challenging and that they should try to do the best they could. The entire study took a maximum of 2 hours to complete, and participants were permit- ted to take a break if necessary. Results preliminary results The groups did not differ significantly in number of men and women, χ(1) = 3.38, p = .07, or in cog- nitive ability (Table 2). Relative to non-socially- anxious comparison participants, those with SAD were older, t(78) = 3.34, p = .001, r = .35, and had higher levels of social anxiety and depression (see Table 2). The SAD group had an average LSAS score of 72.48 (SD = 22.35), thereby scoring above the clinical threshold (Rytwinski et al., 2009). Fourteen of the 40 nonanxious comparison partic- ipants and 32 of the 40 participants with SAD met criteria for Axis I disorders on the MINI (Table 3). The socially anxious group had more Axis I diagnoses (other than SAD; M = 1.55, SD = 1.13) than did the non-socially-anxious group (M = .48, SD = .75), t(78) = 1.08, p b .001. theory of mind To test the hypothesis that individuals with social anxiety have ToM impairments that appear either independent of or only when under cognitive load, we conducted a 2 (group: SAD vs. non-SAD) × 2 (cognitive load: high vs. low) Analysis of Variance (ANOVA) for each ToM task. The dependent variable for each ANOVA was the number of correctly answered questions on the MIE and the SAD D) t(df) p r 03 (16.37) t(78) = 10.60 b.001* .77 35 (6.63) t(78) = 5.90 b.001* .56 38 (3.66) t(70) = .14 .89 .02 97 (4.02) t(70) = .31 .76 .04 51 (2.71) t(70) = .26 .79 .03 33 (1.79) t(78) = 1.34 .19 .15 58 (2.76) t(78) = 1.34 .90 .15 gic Studies – Depression; NART = National Adult Reading Test; Table 3 Axis I Diagnoses Present in the Study Groups Diagnosis SAD n (%) Non-SAD n (%) Major Depressive Disorder 27 (67.5%) 10 (25%) Current 0 1 (2.5%) Lifetime 26 (67.5%) ⁎ 9 (22.5%) ⁎⁎ Generalized Anxiety Disorder 13 (32.5%) 1 (2.5%) Panic Disorder (with and without Agoraphobia) 12 (30%) 1 (2.5%) Substance Abuse/Dependence 6 (15%) 1 (2.5%) Bipolar Disorder (I or II) 3 (7.5%) 2 (5%) Post Traumatic Stress Disorder 2 (5%) 0 Agoraphobia (without Panic Disorder) 1 (2.5%) 3 (7.5%) Obsessive Compulsive Disorder 1 (2.5%) 0 Bulimia 0 1 (2.5%) ⁎ Six of the 26 individuals in the SAD group met criteria for a single past major depressive episode; the remaining 20 individuals met criteria for recurrent MDD. ⁎⁎ Five of the nine individuals in the non-socially anxious group met criteria for a single past major depressive episode; the remaining four individuals met criteria for recurrent MDD. 535the ory of mi nd i n sad MASC, respectively. Because participants received the MIE twice (the first as a baseline measure, the second either under cognitive load or not), we conducted a repeated measures ANOVA for this task. The socially anxious group performed worse than the comparison group did on the MIE, F(1, 76) = 6.73, p = .01, r = .29, and participants in the load condition performed worse than those in the no-load condition, F(1, 76) = 5.10, p = .03, r = .22, whereas the Group × Cognitive Load inter- action fell short of significance, F(1, 76) = 2.67, p = .11, r = .18 (see Figure 1). Likewise, there were no significant main effects or interactions for the 0 6 12 18 24 30 36 SAD No Load Load No Load Load Non-SAD # C o rr e ct FIGURE 1 Performance on Reading the Mind in the Eyes Revised. Note. Dotted line represents mean score of subjects with Asperger Syndrome or High Functioning Autism (Baron-Cohen et al., 2001). repeated measure (MIE at time one versus MIE at time two). To evaluate the type of errors participants made on the Mind in the Eyes task, we used our classi- fication of the MIE items to determine if valence was related to group performance. A repeated mea- sure ANOVA showed an interaction effect between group and the valence of the eyes in question. Using follow-up t-tests, we found that participants with SAD made significantly more errors than did comparison participants on questions about nega- tive, t(78) = 3.40, p = .001, r = .36, valenced sets of eyes, and this difference remained significant after we applied a Bonferroni correction for multiple comparisons (p b .02). The groups did not differ, however, in the number of errors they made in response to positive, t(78) = .24, p = .81, r = .03, or neutral, t(78) = .72, p = .47, r = .08, valenced expressions. We categorized each incor- rect answer on the MIE as more negatively valenced, more positively valenced, or the same valence as the correct answer. For example, if the correct answer for a particular item was positive in valence, but the participant chose an incorrect answer that was either neutral or negative in valence, this would be coded as a “more negative error.” Alternatively, if a participant chose an incorrect answer that was more positive in valence than the correct answer, this was coded as a “more positive error.” Finally, if someone chose an incorrect answer that was the same valence as the correct answer (e.g., the correct answer is negative in valence and the person chose an incorrect answer that was also negative in valence), this was coded as a “same valence error.” After a repeated-measures ANOVA indicated a significant interaction between group and error type, we performed follow-up t-tests, which revealed no group differences in the number of more positive, t(78) = .39, p = .70, r = .04, or more negative answers, t(78) = .61, p = .54, r = .07. However, socially anxious participants chose significantly more incorrect answers that were the same valence as the correct answer, t(78) = 3.5, p = .001, r = .37. This difference remained significant after we corrected for multiple comparisons (Bonferroni corrected p b .02). Analysis of MASC scores (with a second 2 × 2 ANOVA) showed a similar pattern of findings to the MIE, though performance on the two tasks was uncorrelated when we controlled for the presence of SAD (partial r = .17, p = .13). Participants with SAD were less accurate on the task than were non-socially-anxious participants, F(1, 76) = 9.37, p = .003, r = .33. Moreover, participants in the cognitive load condition performed worse overall on the MASC than did participants under no load, 0 5 10 15 20 25 30 35 40 45 SAD No Load Load No Load Load Non-SAD # C o rr e ct FIGURE 2 Performance on the Movie for the Assessment of Social Cognition. Note. Dotted line represents mean score of subjects with Asperger Syndrome (Dziobek et al., 2006). 536 hezel & mcnally F(1, 76) = 4.02, p = .05, r = .22. There was no significant interaction between group … O R I G I N A L R E S E A R C H Social Phobia and Its Impact on Quality of Life Among Regular Undergraduate Students of Mettu University, Mettu, Ethiopia This article was published in the following Dove Press journal: Adolescent Health, Medicine and Therapeutics Mohammedamin Hajure Zakir Abdu Department of Psychiatry, Mettu University, Mettu, Oromia, Ethiopia Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/ggViE65C2Fo Background: Social anxiety disorder is a serious and disabling mental health problem that begins before or during adolescence, with the potential to significantly interfere with an individual’s daily functioning and overall quality of life. Objective: The aims of this study were to assess the prevalence, severity, and quality of life towards social anxiety disorder among students of Mettu University, Ethiopia. Subjects and Methods: A cross-sectional study was conducted among a stratified sample of 523 undergraduate students to identify the prevalence, correlates of social anxiety dis- order, and impacts on quality life. All participants completed the Social Phobia Inventory, Liebowitz Social Anxiety Scale, and World Health Organization Quality of Life-Brief Form, Turkish Version (WHOQOL-BREF-TR). Of 523 students, 26% were screened positive for social anxiety disorder. About 69.4% and 17.4% of the students had mild and moderate symptoms of social anxiety disorder, respectively. WHOQOL BREF-TR scores showed that students with social phobia had significantly lower quality of life quality than those without social phobia. Being criticized by others or fear of parties was the most commonly feared situations. Talking to strangers was the most commonly avoided situations. Being females, current tobacco use, and family history of psychiatric illness were factors significantly associated with social phobia symptoms using logistic regression analysis. Conclusion: The current study shows high prevalence of social phobia among the university students and its significant negative effects on quality of life which require prompt identi- fication and treatment. Keywords: social anxiety, university, quality of life Background Social phobia or social anxiety disorder is a serious and disabling mental health problem that begins before or during adolescence, has a chronic course, is asso- ciated with significant impairment in social functioning and work, and reduced quality of life.1 Among university, social phobia symptoms arise in a great number of students or existing symptoms increase.2 During this period, students go into the effort of having himself or herself accepted by others as a self-governing person and showing himself or herself. Performing or giving a talk in front of an audience was the most commonly feared situations and also showed an association with increased disability, and impaired quality of life.3,4 It is generally estimated that 13% of the population will meet the diagnostic criteria for lifetime social phobia with onset typically occurring in adolescence or early Correspondence: Mohammedamin Hajure Email [email protected] Adolescent Health, Medicine and Therapeutics Dovepress open access to scientific and medical research Open Access Full Text Article submit your manuscript | www.dovepress.com Adolescent Health, Medicine and Therapeutics 2020:11 79–87 79 http://doi.org/10.2147/AHMT.S254002 DovePress © 2020 Hajure and Abdu. This work is published and licensed by Dove Medical Press Limited. 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For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). http://orcid.org/0000-0002-4596-9611 http://orcid.org/0000-0001-5637-5651 http://www.dovepress.com http://www.dovepress.com https://www.facebook.com/DoveMedicalPress/ https://twitter.com/dovepress https://www.linkedin.com/company/dove-medical-press https://www.youtube.com/user/dovepress http://www.dovepress.com/permissions.php adulthood.5 However, recent studies suggest that lifetime prevalence rates may be much higher.6,7 After major depres- sion disorder and alcohol dependence, social anxiety disorder is the third most common disorder in the general population and it is also the most prevalent anxiety disorder.8 A cross-sectional study conducted in Swedish, Jordan University, Saudi Arabia (2014), and University of Parakuo students showed that about 9–16.1% of partici- pants were positive of social phobia.9–12 Research con- ducted in Nigeria shows SAD in about 9.4% which states that there will be a significant difference in the phobic health of adolescents in the selected private and public Nigerian universities.13 In Ethiopia, research conducted on prevalence of social phobia among high school students in Woldia, Gondar and Hawassa was 27.5%, 31.2%, 32.8%.14–16 Factors have shown to have an association include being the first or only child,17 medical science faculties,18,19 being female, younger age, reli- gion, marital status (unmarried), the presence psychiatric ill- ness, having a positive family history of mental disorder had a significant role for development of social phobia.16,20 Evidence showed that social phobia was associated with sub- stance use,21 low socioeconomic status, unemployment, low level of education, and social support.22 Also decreased aca- demic achievement, poor clinical exam performance,11 and impaired quality of life23 also shown to have associated with social phobia. Despite the high worldwide burden of social phobia, like shy, withdraw, unfriendly, and disinterested in social activity and limited evidence is available, particularly in developing countries. To the best of the author’s knowl- edge, no study has investigated the effects of social phobia on quality of life in Ethiopia. The present study aimed to determine the prevalence of social phobia among univer- sity students, its correlate, and impacts on quality of life. Subjects and Methods An institution based cross-sectional study conducted at Mettu University from May to April, 2019. Mettu University is one of the higher institutions in Ethiopia, which is a third Generation University. It is located at 600 km southwest of Addis Ababa. Mettu University established in 2011. Mettu University currently has two campuses. Main campus was study area containing 7 faculties. Those are faculty of health science, faculty of natural and computational science, faculty of social science and Humanity, school of law. The campus has a total of 43 departments and 8290 regular undergraduate students. This study included 8290 undergraduate students at Mettu University during the 2019–2020 academic years. Using a confidence interval of 95%, 5% margin of error, design effect of 2, the prevalence of social phobia of 19.9%16 and adding 10% non-response rate of 10%, mak- ing a final number of participants to be 523. As such, 523 students were selected as the study group. A study is part of a mega project undertaken in among regular undergraduate students of Mettu University and previously published study assessing suicidal behavior among this population were also part of the project.24 Multistage stratified sampling technique was used to select the study participants. Stratification was first done on the faculty/college level, then by department and by the year of study. Finally, taking students from registration as a sampling frame a random selection was done. All regular undergraduate students aged 18yrs old and above were included, while critically ill students were excluded. A self-administered structured questionnaire was used to collect information. Questionnaires about demographic, family and campus related and clinical factors were devel- oped after an extensive review of literatures and similar study tools. Rating instruments included the Social Phobia Inventory to detect Social Phobia, the Liebowitz Social Anxiety Scale to measure the severity of Social Phobia and the WHO Quality of Life – BREF questionnaire to assess Quality of Life. The questionnaire was translated to Amharic and Afaan Oromo language, and then retranslated back to English so as to see and keep the consistency. Pretest was done on 26 students in Bedele agricultural campus whose completed the questionnaires beforehand and the questions were evaluated and re-arranged accord- ingly before actual data collection. Ethical clearance was obtained from the ethical review board of Mettu University and permission was obtained from the concerned body. Rating Instruments Social Phobia Inventory (SPIN, a 17-item self-rating scale developed to measure social phobia). It shows the symp- tom domains of social phobia (fear, avoidance, and phy- siological arousal) and has reliable and valid psychometric properties in screening social phobia in adolescents and other populations. The Cronbach’s α in this study was 0.87. Subjects are asked to rate symptoms occurrences as 0 (not at all), 1 (a little bit), 2 (somewhat), 3 (very much), or 4 (extremely during the past week) and the sum score ranged from 0 to 68. A student with a score of 20 and Hajure and Abdu Dovepress submit your manuscript | www.dovepress.com DovePress Adolescent Health, Medicine and Therapeutics 2020:1180 http://www.dovepress.com http://www.dovepress.com above on SPIN will be considered as having social phobia.25 Liebowitz Social Anxiety Scale is a self-rating scale used to rate fear/anxiety and avoidance regarding com- monly feared performance or social situations. The scale includes 24 items and 2 subscales. The first subscale has 11 items and investigates social relationships. The second subscale has 13 items and investigates performance. The 4-point Likert-type scale measures the intensity of fear and avoidance behaviour during the previous week. It has a good internal consistency and evaluates the severity of fear and avoidance in common social situations. A score of <55 suggests mild social anxiety disorder, 55–64 suggests the moderate social anxiety disorder, 65–79 suggests marked social anxiety disorder, 80–94 suggests severe social anxiety disorder, and >95 suggests very severe social anxiety disorder. It is validated in and reliable for measuring the severity of social phobia26. The Cronbach’s α in this study was 0.98. World Health Organization Quality of Life Scale – Brief version (WHOQOL – BREF) which is a 26-item self- administered generic questionnaire. It produces a profile with four domain scores: physical health (7 items), psy- chological health (6 items), social relationships (3 items), environmental domain (8 items) as well as two separately scored items about the individuals‟ perception of their quality of life (QI) and health (Q2). Each item was scored in a Likert format from 1 (very dissatisfied) to 5 (very satisfied) in a positive direction, which means that higher scores indicate a higher quality of life. The scores of ques- tions 3, 4 and 26 are reversed, so as to transform these negatively framed questions to positively frame. The Turkish version of the form had an internal validity score of 0.83 (Cronbach’s alpha) in physical terms, 0.66 in men- tal terms, 0.53 in social terms, and 0.73 in both environ- mental and environment-national terms27. The Cronbach’s α in this study was 0.82 Statistical Analysis The data were analyzed using SPSS version 21. Descriptive (frequency and percentage) and inferential statistics (chi square test was used for categorical variables, and ANOVA (analysis of variance) were used to compare groups in terms of SPIN and LSAS scores). An independent samples t-test was used to analyze the difference between the two groups (students with/without social anxiety disorder). Logistical regression analysis was used to evaluate the significance of the relationship between two dependent and independent variables. The Pearson cor- relation coefficient was used for correlation analysis. Result Socio-Demographic Characteristics of the Study Participants A total of 523 participants were recruited for the study, which makes the response rate 100%. The results show that 270 (51.6%) of respondents were males and 253 (48.6%) were females. The mean age of students was 22.07 (SD = 2.36), with ages ranging from 18 to 32 years and the majority of them (61.0%) were at the age of 22 years or below. The sample consisted of different faculties with the highest number of engineering faculty (110, 21.0%) and the lowest number from Institute of education (42, 8.0%) which was proportionally recruited from each stratum. Also the study has revealed that 351 (67.1%) of the participants had one of two siblings and most perceived that their family income as bad (58.9%). The majority of the participants 319 (61.0%) were from rural backgrounds and first-year students comprises the majority of participants (222, 42.4%) (Table 1). Social Phobia The regarding students’ reports of their social phobia symptoms, the analysis (Table 2) showed that the mean score for students in general was 13.08 (SD = 9.24), with scores ranging from 0 to 43. About, 70% (n = 361) had a score of 16 or less. Further analysis using LSAS score, for the levels of social anxiety symptoms showed that the majority of uni- versity students had mild symptoms, 69.4% (n = 363) followed by moderate symptoms 91 (17.4%), and those with marked to severe represented about 13.2% (n = 69). The Cronbach’s alpha for LSAS scale obtained in this sample was 0.976. As shown in Table 2, 25.8% of the subjects had a SPIN score of 19 (Connor et al, 2000), and more which accounted for about one-fourth of participants, ie, There was a statistically significant difference in the prevalence of SAD regarding the age category, birth order, faculties, family history of mental illness. Being a younger age18–20 group was associated with higher prevalence of SAD (26.7%) and being in the age group of 21–23years was associated with lower prevalence of SAD (9.6%) (X2= 0.24, P<0.05). There is a higher prevalence of SAD among students in Engineering Dovepress Hajure and Abdu Adolescent Health, Medicine and Therapeutics 2020:11 submit your manuscript | www.dovepress.com DovePress 81 http://www.dovepress.com http://www.dovepress.com faculties, while lower prevalence is seen in the faculty of social science and humanities (X2=0.163, P<0.05). The results of the present study show that significantly more of the students without social phobia have a family history of psychiatric illness than those with social phobia. Table 1 The Basic Sociodemographic, Clinical and Substance Use Characteristics of the Participants (n= 523) Variables Categories Frequency Percentage Sex Male 270 51.6 Female 253 48.6 Age 18–20 148 28.3 21–23 87 16.6 24–26 149 28.5 ≥27 139 26.6 Ethnicity Oromo 321 61.4 Amhara 117 22.4 Gurage 41 7.8 Tigre 25 4.8 Others* 19 3.6 Faculty Engineering 110 21.0 Health sciences 97 18.5 Social science and humanities 85 16.3 Natural and computational 89 17.0 Business and economics 52 9.9 School of Law 48 9.2 Institute of education 42 8.0 Residence before campus Urban 204 39.0 Rural 319 61.0 Birth order Frist or only child 123 23.5 Middle 320 61.2 Last 80 15.3 Year of study First 130 24.9 Second 133 25.4 Third 107 20.5 Fourth 77 14.7 Fifth 76 14.5 Alcohol use Yes 299 57.4 No 127 42.5 Cigarette use Yes 78 14.9 No 53 67.9 Khat use Yes 98 18.3 No 67 68.4 Note: *Wolayta, Dawuro, Kefa, Sidama, Gurage, Silte. Table 2 Comparing Social Phobia with Demographic and Clinical Variables Variables Categories Frequency Percentage Sex Male 270 51.6 Female 253 48.6 Age 18–20 148 28.3 21–23 87 16.6 24–26 149 28.5 ≥27 139 26.6 Ethnicity Oromo 321 61.4 Amhara 117 22.4 Gurage 41 7.8 Tigre 25 4.8 Others* 19 3.6 Faculty Engineering 110 21.0 Health sciences 97 18.5 Social science and humanities 85 16.3 Natural and computational 89 17.0 Business and economics 52 9.9 School of Law 48 9.2 Institute of education 42 8.0 Residence before campus Urban 204 39.0 Rural 319 61.0 No. of siblings Mean ±SD (1.98±1.16) Birth order Frist or only child 123 23.5 Middle 320 61.2 Last 80 15.3 Fathers education No formal education 50 9.6 Primary school 217 41.5 Secondary school 137 26.2 Above secondary 119 22.8 Mothers’ education No formal education 62 11.9 Primary school 187 35.8 Secondary school 235 44.9 Above secondary 39 7.5 Perceived family monthly income Bad 308 58.9 Moderate 127 24.3 (Continued) Hajure and Abdu Dovepress submit your manuscript | www.dovepress.com DovePress Adolescent Health, Medicine and Therapeutics 2020:1182 http://www.dovepress.com http://www.dovepress.com However, with respect to gender, ethnicity, year of study, family educational status, perceived family income, and residency, there was no statistically significant difference in the prevalence of SAD (all P values >0.05). Using logistical regression analysis, three independent variables that were significantly shown to have association in the final model. The risk of social phobia was 1. Ninety- five-fold higher among female students than male students, 1. Eighty-four-fold higher among those with a family history of psychiatric illness than those without, and 2. Ninety-five-fold higher among students who smoked cigarettes in the past 3months compared to those who did not (Table 3). Using item analysis to examine the items that had the highest and lowest scores (Table 4), the analysis showed that the mean items ranged from 0.56 (SD = 0.81) (item 13: Heart palpitations bother me when I am around peo- ple) to 0.99 (SD = 1.07) (item 2: I am bothered by blush- ing in front of people). The highest three items in addition to item 2 were item 10 (M = 0.96, SD = 1.10: Talking to strangers scares me) and item 7 (M = 0.85, SD = 1.009: Sweating in front of people causes me distress). This also goes for the highest three items that students reported being very much to extremely experiencing social phobia symptoms over the past week as items 2, 10, and 7 had the highest percentage among all other items. Table 2 (Continued). Variables Categories Frequency Percentage Good 88 16.8 Year of study First 130 24.9 Second 133 25.4 Third 107 20.5 Fourth 77 14.7 Fifth 76 14.5 Alcohol use Yes 299 57.4 No 127 42.5 Cigarette use Yes 78 14.9 No 53 67.9 Khat use Yes 98 18.3 No 67 68.4 Note: *Wolayta, Dawuro, Kefa, Sidama, Gurage, Silte. Table 3 Logistical Regression Analysis Showing Factors Associated with Social Phobia Among Students in Mettu Health Science Students, Mettu, Ethiopia, 2019 (n=523) Variables Category COR (95% CI) AOR (95% CI) Sex Male ® Female 1.78 (1.20–2.64) 2.04 (1.26–3.28)* Previous history of chronic physical illness No ® Yes 1.83 (1.02–3.30) 1.84 (1.01–3.35)* Current tobacco use No ® Yes 1.27 (.74–2.2) 2.95 (1.36–6.40)** Lifetime khat use No ® Yes 1.99 (1.00–3.99) 1.52 (0.68–3.37) Residence Urban ® Rural 4.52 (2.69–7.7) 1.24 (.494–3.12) Notes: *P value < 0.05, **P value < 0.01, VIF 1.06–2.10. Hosmer–Lemeshow - goodness of fit test corresponding, P value = 0.77, Reference = ® . Abbreviations: COR, crude odds ratio; AOR, adjusted odds ratio. Table 4 Item Analysis of SPIN Among University Student in Mettu (n= 523) Item Mean SD 1 I am afraid of people in authority. 0.68 0.976 2 I am bothered by blushing in front of people. 0.99 1.073 3 Parties and social events scare me. 0.82 0.957 4 I avoid talking to people I do not know. 0.75 0.961 5 Being criticized scares me a lot. 0.85 0.959 6 Fear of embarrassment causes me to avoid doing things or speaking to people. 0.80 0.921 7 Sweating in front of people causes me distress. 0.85 1.009 8 I avoid going to parties. 0.79 0.892 9 I avoid activities in which I am the center of attention. 0.79 0.993 10 Talking to strangers scares me. 0.96 1.109 11 I avoid having to give speeches. 0.83 0.990 12 I would do anything to avoid being criticized. 0.65 0.925 13 Heart palpitations bother me when I am around people. 0.56 0.811 14 I am afraid of doing things when people might be Watching. 0.59 0.885 15 Being embarrassed or looking stupid is my worst fears. 0.67 0.931 16 I avoid speaking to anyone in authority. 0.72 0.888 17 Trembling or shaking in front of others is distressing to me. 0.78 0.955 Notes: Copyright ©, Jonathan Davidson. 1995, 2008, 2015. All rights reserved. Permission to use the SPIN must be obtained from the copyright holder at [email protected] The SPIN may not be reproduced or transmitted in any form, or by any means, electronic or mechanical, or by any information storage or retrieval system without permission in writing from the copyright holder. Dovepress Hajure and Abdu Adolescent Health, Medicine and Therapeutics 2020:11 submit your manuscript | www.dovepress.com DovePress 83 http://www.dovepress.com http://www.dovepress.com The highest mean item scores varied among the two subscales (more among physiological discomfort) and also, two of lowest mean item scores (item 1,14) belong to fear of the social situation subscale. The results do not strictly support the mean scores of the subscales mentioned above in Table 2 that physiological discomfort in social situation was the lowest reported subscale among the three subscales. The Cronbach’s alpha for SPIN scale obtained in this study sample was 0.869. Generally, about one-fourth of the stu- dents showed positive symptoms of social phobia (score of >19) and the majority of them present with mild category. Quality of Life of Students with and Without Social Phobia Study participants’ quality of life was assessed by the world health organization quality of life brief version scale (WHOQOL-BREF) and the mean total quality of life score was found to be (70.87+16.22). The highest QOL domain of the students with social phobia in the current study was environmental health domain mean score of (23.55 ± 3.46), followed by physical health domain mean score of (22.34±3.76), psychological health domain mean score of (17.67±2.62) and social relation- ships domain mean score of (6.87±2.27). The WHOQOL- BREF scale demonstrated a high internal consistency reliability coefficient (Cronbach’s alpha=0.821). WHOQOL-BREF-TR scores showed that students with- out social phobia had significantly higher quality of life scores in all areas than the students with social phobia (Table 5). Correlating SPIN and LSAS with QOL Scores As seen in Table 6. Regarding correlation of LSAS scores to QOL scores, they were negatively correlated with respect to physical health, psychological health, social relationship and environment, although not significant in majority of the domains, except the psychological domain. Again, SPIN scores were also negatively correlated with QOL scores in all areas. Thus, social phobia was associated with reported deterioration in physical, psycho- logical health, social relationship and environmental func- tioning. SPIN and LSAS scores were found to be more strongly correlated with psychological domain scores and SPIN score were more strongly correlated with physical health domain compared to other domain (Table 6). Discussion This study aims on the prevalence of social phobia and its impact on quality of life among university students in Mettu, South western, Ethiopia. The prevalence of social phobia varies widely among different countries. In this study, social phobia was found in 26% of subjects, much more than other studies among undergraduate university students in different settings.18,28-31 Regarding the severity of social phobia, using LSAS score, the majority of the students have mild forms of social anxiety disorder. In other words, levels of social anxiety symptoms show about 17.4% of them had moderate symptoms, which is in line with the study undertaken at the University of Jordan (6.8%). However, the finding was lower than study done in Woldia, Ethiopia (27.5%),15 Saudi Arabia, Table 5 Mean Distribution of QOL of Students with and Without Social Phobia at Mettu University, 2019 Areas Students with Social Phobia (χ ± SD) Students Without Social Phobia (χ ± SD) Analysis* T P Physical 22.34±3.76 21.55±4.49 −1.821 < 0.01 Psychological 17.67±2.62 16.03±4.03 −4.42 < 0.001 Social 6.87±2.27 5.59±2.93 −4.59 < 0.001 Environmental 23.55±3.46 22.01±5.02 −3.32 < 0.001 Notes: ANOVA, χ ± SD (arithmetic mean ± standard deviation). *For all analyses the degree of freedom was 522. Abbreviation: QOL, quality of life. Table 6 Correlating SPIN and LSAS with QOL Scores Instrument Domain of Quality of Life Physical Health Psychological Health Social Relationship Environmental LSAS score R −0.010 −0.168 −0.019 −0.053 P value 0.820 0.000 0.662 0.227 SPIN score r −0.199 −0.102 −0.082 −0.013 P value 0.000 0.020 0.062 0.768 Note: r = Pearson correlation coefficient. Abbreviations: SPIN, Social Phobia Inventory; LSAS, Liebowitz Social Anxiety Scale; QOL, quality of life. Hajure and Abdu Dovepress submit your manuscript | www.dovepress.com DovePress Adolescent Health, Medicine and Therapeutics 2020:1184 http://www.dovepress.com http://www.dovepress.com Riyadh (24.3%).32 Different studies have shown an asso- ciation of social phobia with gender. The results of the current study, which showed higher social phobia scores of female students compared to their counterparts. This was in line with the international report of different countries such as India,11 Turkey,33 German.3 However, in one study social phobia prevalence is found to be higher in men in studies of prevalence conducted with clinical samples.34 The current study shows an association of cigarette smoking and social anxiety disorder. This finding was in agreement with international report such as in the USA35 and Turkey.36 The reason behind might be related to smoking, which used for its reinforcing effect, by socially anxious people to elevated negative affect especially for social interaction.37 In contrast to studies done in Australia18 and Swedish,9 SAD was more prevalent among students of engineering faculties than students of social science and humanities faculties. It may be related to the consequences of social anxiety on academic performance during pre-engineering years and career choices made thereafter, in addition to a larger quota of students in the school, as this stage greatly matters their life on the campus, particularly. Considering birth order, SAD was more prevalent among first or only child than being middle or last child. Which was in agreement with study done in Egypt (birth order).17 It was hypothesized that the first-born child will have a higher level of social anxiety than a non-first born child.38 In terms of age, the current study shows significant association, with higher prevalence of SAD among stu- dents in the age group of 18–20 years as compared to older age groups. The finding was in accordance with many of the prior studies, shown an early onset of social anxiety symptoms.20 Family history of psychiatric illness was found to have significant association with SAD. This could be explained by studies showed association of social phobia and genetic inheritability, although the underlying mechanisms remain unclear.39 The most commonly reported feared social situations in the target sample were being criticized by others or fear of parties and social events, followed by doing things or speak- ing to people and the most commonly avoided situations were talking to strangers followed by being a center of attention. These findings were consistent with result of earlier studies.4 This is because college years are a critical period to socialize themselves, particularly via social interaction. Again their expectation matter the way they interact, they may avoid such interaction because of negative evaluation. The Effects of Social Phobia on Quality of Life To the best of the author’s knowledge, the present study is the first to investigate the direct relationship between social phobia and its impact on quality of life among university students in Ethiopia. In the present study students with social phobia had lower scores on all areas of life quality, including physical and psychological health, social relationships, and the environment than those without social phobia. Results of an epidemiological study from report that students with social phobia have reduced quality of life in all domains as … lable at ScienceDirect Behaviour Research and Therapy 77 (2016) 147e156 Contents lists avai Behaviour Research and Therapy journal homepage: www.elsevier.com/locate/brat Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial Isabel L. Kampmann a, *, Paul M.G. Emmelkamp c, d, Dwi Hartanto b, Willem-Paul Brinkman b, Bonne J.H. Zijlstra e, Nexhmedin Morina a a Department of Clinical Psychology, University of Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands b Interactive Intelligence Group, Delft University of Technology, Mekelweg 4, 2628 CD, Delft, The Netherlands c Netherlands Institute for Advanced Study, Meijboomlaan 1, 2242 PR, Wassenaar, The Netherlands d King Abdulaziz University, Abdullah Sulayman, 22254, Jeddah, Saudi Arabia e Department of Educational Sciences, University of Amsterdam, Nieuwe Achtergracht 127, 1018 WS, Amsterdam, The Netherlands a r t i c l e i n f o Article history: Received 4 September 2015 Received in revised form 19 December 2015 Accepted 23 December 2015 Available online 29 December 2015 Keywords: Virtual reality Exposure therapy Social anxiety disorder Social phobia Social interaction * Corresponding author. E-mail address: [email protected] (I.L. Kampm http://dx.doi.org/10.1016/j.brat.2015.12.016 0005-7967/© 2015 Elsevier Ltd. All rights reserved. a b s t r a c t This randomized controlled trial investigated the efficacy of a stand-alone virtual reality exposure intervention comprising verbal interaction with virtual humans to target heterogeneous social fears in participants with social anxiety disorder. Sixty participants (Mage ¼ 36.9 years; 63.3% women) diagnosed with social anxiety disorder were randomly assigned to individual virtual reality exposure therapy (VRET), individual in vivo exposure therapy (iVET), or waiting-list. Multilevel regression analyses revealed that both treatment groups improved from pre-to postassessment on social anxiety symptoms, speech duration, perceived stress, and avoidant personality disorder related beliefs when compared to the waiting-list. Participants receiving iVET, but not VRET, improved on fear of negative evaluation, speech performance, general anxiety, depression, and quality of life relative to those on waiting-list. The iVET condition was further superior to the VRET condition regarding decreases in social anxiety symp- toms at post- and follow-up assessments, and avoidant personality disorder related beliefs at follow-up. At follow-up, all improvements were significant for iVET. For VRET, only the effect for perceived stress was significant. VRET containing extensive verbal interaction without any cognitive components can effectively reduce complaints of generalized social anxiety disorder. Future technological and psycho- logical improvements of virtual social interactions might further enhance the efficacy of VRET for social anxiety disorder. © 2015 Elsevier Ltd. All rights reserved. Social anxiety disorder (SAD) is defined as the fear of one or more social situations in which one might behave embarrassingly and be negatively evaluated by others (DSM-V; American Psychiatric Association, 2013). SAD is one of the most common mental disorders in the US population, with an estimated lifetime prevalence of 12.1% (Ruscio et al., 2008). Individuals who suffer from SAD can experience a reduced quality of life and significant impairments in various areas of functioning, such as work and interpersonal relationships (Wittchen, Fuetsch, Sonntag, Müller, & Liebowitz, 2000). However, only about one third of individuals with SAD seek treatment (Ruscio et al., 2008). The most researched treatment for SAD is cognitive behavior ann). therapy (CBT). CBT aims at modifying maladaptive cognitions and behavior using both cognitive (e.g., cognitive restructuring) and behavioural (e.g., exposure) strategies (Hofmann & Smits, 2008; Mayo-Wilson et al., 2014). During exposure therapy, participants encounter feared stimuli in situations containing social interaction until anxiety decreases and/or anxiety-related expectancies are violated. Traditional exposure exercises are usually practiced dur- ing therapy and as homework assignments. Interestingly, a meta- analysis of treatment efficacy found exposure therapy alone to be comparable to cognitive therapy and that the combination of both was no more effective than either one delivered exclusively (Powers, Sigmarsson, & Emmelkamp, 2008). A relatively new form of exposure therapy is Virtual Reality Exposure Therapy (VRET). During VRET, participants are confronted with computer-generated stimuli (e.g. virtual social interaction) that can elicit elevated subjective levels of social anxiety (Morina, Delta:1_given name Delta:1_surname Delta:1_given name Delta:1_surname Delta:1_given name Delta:1_surname mailto:[email protected] http://crossmark.crossref.org/dialog/?doi=10.1016/j.brat.2015.12.016&domain=pdf www.sciencedirect.com/science/journal/00057967 http://www.elsevier.com/locate/brat http://dx.doi.org/10.1016/j.brat.2015.12.016 http://dx.doi.org/10.1016/j.brat.2015.12.016 http://dx.doi.org/10.1016/j.brat.2015.12.016 I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156148 Brinkman, Hartanto, & Emmelkamp, 2014; Powers et al., 2013). Cumulative research suggests that VRET is effective in the treat- ment of several anxiety disorders (Meyerbr€oker & Emmelkamp, 2010; Morina, Ijntema, Meyerbr€oker, & Emmelkamp, 2015; Opriş et al., 2012; Parsons & Rizzo, 2008). While VRET has been extensively studied in specific phobias, research on the efficacy of VRET in the treatment of SAD is still limited. Several studies suggest that VRET can reduce SAD symp- toms (Anderson, Rothbaum, & Hodges, 2003; Anderson, Zimand, Hodges, & Rothbaum, 2005; Klinger et al., 2005). However, only three randomized controlled trials on the efficacy of VRET in SAD have been conducted (Anderson et al., 2013; Bouchard et al., 2015; Wallach, Safir, & Bar-Zvi, 2009). In the study by Wallach et al. (2009), VRET for public speaking anxiety, a specific social anxiety complaint, was combined with CBT and compared to CBT plus imagery exposure, and waiting-list. Results revealed that VRET plus CBT was effective in treating public speaking anxiety compared to waiting-list and as effective as CBT plus imagery exposure. How- ever, participants in this study were not screened for a clinical diagnosis of SAD. Anderson et al. (2013) included participants with a SAD diagnosis and compared the efficacy of CBT plus VRET with CBT plus group exposure therapy. The authors reported that CBT plus VRET was as effective as CBT plus group exposure therapy. Nonetheless, the implications of the results of this study are rather limited by the inclusion of participants who had reported public speaking anxiety as their primary complaint and by the two different formats of treatment (i.e., individual vs. group). In both the above trials, exposure exercises solely targeted public speaking-related anxiety and included only limited verbal interaction (i.e., answering questions). However, although fear of public speaking is the most common subtype of SAD, the majority of individuals with SAD report more than one fear (Ruscio et al., 2008), emphasizing the need for research on VRET targeting het- erogeneous social fears. Moreover, a large number of feared social situations reported by individuals with SAD (e.g., talking to strangers or speaking up in a meeting) contain verbal interaction (Ruscio et al., 2008). As a consequence, incorporating extensive dialogues into VRET and thus going beyond answering a limited number of questions might improve the efficacy of VRET for SAD. In contrast to Anderson et al. (2013) and Wallach et al. (2009), Bouchard et al. (2015) included virtual scenarios in VRET target- ing several social fears. They found individual CBT plus VRET to be effective compared to waiting-list and more effective than CBT plus in vivo exposure. However, all three studies investigated VRET in combination with CBT. Therefore, no conclusions can be drawn regarding the efficacy of VRET as stand-alone treatment and the possibility cannot be ruled out that the effects found were caused by CBT rather than VRET. In summary, previous research on VRET is limited by investi- gating VRET only in combination with CBT, focussing mainly on fear of public speaking and including only limited verbal interaction. The incorporation of diverse virtual scenarios with social interac- tion that resembles real life interaction into VRET might more adequately target the idiosyncratic fears of participants with SAD. The aim of the present study was to single out the effects of pure VRET without any cognitive components and to adapt VRET to in- dividuals with heterogeneous social fears by simulating social verbal interaction in a variety of virtual social situations believed to be relevant for treating individuals with SAD. In a randomized controlled trial, we examined the efficacy of VRET and in vivo exposure therapy (iVET) for adults with SAD and heterogeneous social fears. These active treatments were compared to a waiting- list control group. Both active treatments were administered in an individual format and were exposure-based only. It was hy- pothesized that relative to individuals in the waiting-list control group, participants in active conditions would report fewer social anxiety symptoms and would perform better on a behavioural assessment task at postassessment. Treatment gains were expected to be comparable for VRET and iVET at postassessment and 3- month follow-up. 1. Method 1.1. Participants Participants were recruited via online and newspaper adver- tisements, the website of the ambulatory of the University of Amsterdam, and the project's website. Sixty participants (Mage ¼ 36.9 years, age range: 18e65 years) meeting the criteria for a primary diagnosis of SAD according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 2000) were included and randomly assigned to one of three conditions (20 participants each; see Fig. 1 for an overview of the randomization procedure and Table 1 for sample characteristics per condition). Exclusion criteria were a) psychotherapy for SAD in the past year; b) current use of tran- quilizers or change in dosage of antidepressants in the past 6 weeks; c) a history of psychosis, current suicidal intentions, or current substance dependence; e) severe cognitive impairment; or f) insufficient command of the Dutch language. The average num- ber of completed sessions was 8.50 (SD ¼ 2.63) for VRET and 8.55 (SD ¼ 2.68) for iVET. All participants received free treatment and a small monetary reward (22 Euro) for the completion of the follow- up assessment. 1.2. Measures 1.2.1. Screening and diagnostic measures The Social Interaction Anxiety Scale (SIAS; Mattick & Clarke, 1998) was used for screening purposes before the in-person interview. The SIAS consists of 20 items assessing cognitive, affec- tive, and behavioural responses to social interactions on a 5-point Likert scale. The SIAS possesses a high internal consistency and test-retest reliability (Cronbach's a ¼ .93 and r ¼ 0.92 respectively; Mattick & Clarke,1998). Individuals scoring �29 were invited for an in-person diagnostic interview with a psychologist. We choose a slightly lower cut-off than reported in previous research to prevent false-negatives in this early stage of screening where the in-person intake was still to come (Heimberg, Mueller, Holt, Hope, & Liebowitz, 1992). To assess the diagnosis of SAD and potential comorbidity, the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID- I; First, Spitzer, Gibbon, & Williams, 1994) was administered prior to inclusion. All assessors were psychologists with a master degree in clinical psychology. These assessors were blind to treatment condition and had received a SCID training in accordance with their individual level of expertise. The assessor at preassessment was in most cases a different person than the therapist (52/60). In a mi- nority of cases (8/60), the assessor became also the patient's ther- apist after the assessment. Note, however, that these assessors were also blind to condition because condition allocation took place after the preassessment. The number of administered SCID-I modules depended on participants' responses to the SCID-I screening questions (covering substance use disorders, anxiety disorders, and eating disorders). The modules on social phobia, mood disorders, psychotic disorders, post-traumatic stress disorder, and somato- form disorders were assessed for all patients. The avoidant per- sonality disorder section of the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II; First, Gibbon, Spitzer, Williams, & Benjamin, 1997) was also administered Fig. 1. Participant flow chart. VRET ¼ Virtual Reality Exposure Therapy; iVET ¼ in Vivo Exposure Therapy. I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156 149 because research suggests that avoidant personality disorder and SAD might be one disorder instead of two distinct disorders, with avoidant personality disorder being the more severe form (Reich, 2009). 1.2.2. Primary outcome measures Social anxiety symptoms were measured with the Liebowitz Social Anxiety Scale-Self Report (LSAS-SR; Liebowitz, 1987). The LSAS-SR is a 24-item questionnaire that assesses fear and avoidance in social situations on a 4-point Likert scale. The 12-week test- retest reliability of the LSAS-SR has been reported to be high (r ¼ 0.83; Baker, Heinrichs, Kim, & Hofmann, 2002) and the internal consistency in the present study was excellent (Cronbach's a ¼ .90e0.97). The subjective fear of being negatively evaluated by others in social situations was assessed with the Fear of Negative Evaluation Scale-Brief Form (FNE-B; Leary, 1983). The FNE-B is a 12-item in- strument using a 5-point Likert scale for responses. Good psycho- metric properties have been reported for the FNE-B in earlier research (Weeks et al., 2005) and the internal consistency in the present study was excellent (Cronbach's a ¼ .91e0.97). 1.2.3. Secondary outcome measures We measured speech duration and speech performance during a behavioural assessment task, in the form of a 5 min impromptu speech, to evaluate levels of behavioural avoidance. The behav- ioural assessment task was a modified version of a standardized protocol (Beidel, Turner, & Jacob, 1989). This modified version has been used in previous studies on social anxiety (Amir, Weber, Beard, Bomyea, & Taylor, 2008). Although participants with diverse social fears were included in the present study, this task was chosen because public speaking anxiety is the most prevalent Table 1 Demographic characteristics of participants per condition. Characteristics VRET (n ¼ 20) iVET (n ¼ 20) WL (n ¼ 20) Age, M (SD) 39.65 (11.77) 37.50 (11.27) 33.50 (11.44) Gender (% female) 65 75 50 Native language, n (%) Dutch 17 (85) 17 (85) 20 (100) Spanish 1 (5) 0 (0) 0 (0) Russian 1 (5) 0 (0) 0 (0) Portuguese 0 (0) 1 (5) 0 (0) Polish 0 (0) 1 (5) 0 (0) Indonesian 0 (0) 1 (5) 0 (0) Berber 1 (5) 0 (0) 0 (0) Education, n (%) High 8 (40) 10 (50) 11 (55) Middle 11 (55) 8 (40) 9 (45) Low 1 (5) 2 (10) 0 (0) Employment status, n (%) Paid employment 10 (50) 13 (65) 13 (65) Trainee/student 1 (5) 1 (5) 5 (25) Social welfare 1 (5) 1 (5) 0 (0) Unemployed with voluntary work 1 (5) 0 (0) 0 (0) Unemployed 7 (35) 5 (25) 2 (10) Marital status, n (%) Married or cohabitating 9 (45) 10 (50) 11 (55) Long distance relationship 2 (10) 3 (15) 2 (10) Single living with children 1 (5) 0 (0) 0 (0) Single living without children 7 (35) 7 (35) 6 (30) Widowed 1 (5) 0 (0) 1 (5) Comorbidity, n (%) Any anxiety disorder 3 (15) 4 (20) 0 (0) Depressive disorder 4 (20) 0 (0) 2 (10) Avoidant personality disorder 7 (35) 6 (30) 3 (15) Session completed, n 1 20 20 2 20 20 3 19 19 4 19 19 5 18 17 6 15 17 7 15 17 8 15 16 9 15 16 10 14 14 Dropout, n (%) 5 (25) 3 (15) 4 (20) Note. VRET ¼ Virtual Reality Exposure Therapy; iVET ¼ in Vivo Exposure Therapy; WL ¼ waiting-list; Low ¼ completed elementary school or lower vocational edu- cation; Middle ¼ completed high school or middle-level vocational education; High ¼ completed pre-university, college, or university degree. I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156150 social fear. Speech duration was measured using a stop watch. To assess speech performance, two independent judges, blind for condition and assessment point, rated the videotaped speeches using 17 items of a public speaking performance measure on a 5- point Likert scale (Rapee & Lim, 1992). Higher scores on this mea- sure indicated better speech performance. The internal consistency of this scale was good in earlier research (r ¼ 0.84; Rapee & Lim, 1992) and the present study (r ¼ 0.81e0.87). Symptoms of depression, general anxiety, and stress were measured with the Depression Anxiety Stress Scale (DASS-21; Lovibond & Lovibond, 1995). The DASS-21 is a 21-item self-report questionnaire measuring depression, anxiety, and stress on a 4- point Likert scale with higher scores representing higher levels of depression, anxiety, or stress, respectively. The stress scale includes items that measure subjective coping with stressful events, such as tension, irritability, and a tendency to overreact to stressful events. The DASS possesses good psychometric properties (Antony, Bieling, Cox, Enns, & Swinson, 1998; Henry & Crawford, 2005) and in the present study its internal consistency was excellent (Cronbach's a ¼ .91e0.95). Avoidant personality disorder related beliefs were assessed with the Personality Disorder Belief Questionnaire (PDBQ; Dreessen & Arntz, 1995). Research has shown that exposure therapy without cognitive components can affect cognitions (Powers et al., 2008). The avoidant subscale of the PDBQ contains 10 items to assess the strength of beliefs assumed to be specific to avoidant personality disorder. The internal consistency of this subscale was excellent in the present study (Cronbach's a ¼ .90e0.97). Subjective quality of life was measured using the Eurohis Quality of Life Scale (EUROHIS-QOL 8-item index; Schmidt, Mühlan, & Power, 2006). The EUROHIS-QOL 8-item index measures quality of life on a 5-point Likert scale with higher scores indicating a better quality of life. The psychometric properties of the EUROHIS- QOL are reported to be satisfactory (Da Rocha, Power, Bushnell, & Fleck, 2012; Schmidt et al., 2006) and the internal consistency in the present study was good (Cronbach's a ¼ .83e0.93). 1.3. Procedure The present study was approved by the Institutional Review Board of the University of Amsterdam and registered (NCT01746667; www.clinicaltrials.gov). Potential participants were asked on the telephone about former SAD treatment and whether attending treatment was logistically feasible. Afterwards, they filled in the SIAS online. Participants who scored above the cut-off were invited to an in-person intake (SCID), where they were screened for http://www.clinicaltrials.gov I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156 151 exclusion criteria. After obtaining informed consent, eligible par- ticipants underwent a preassessment comprising a battery of self- report measures (LSAS-SR, FNE-B, DASS-21, PDBQ, EUROHIS-QOL) and the behavioural assessment task. For the behavioural assess- ment task, participants were told that they would give a 5 min speech in front of a camera and a two-person jury rating the speech. They were then asked to choose one out of seven topics (nuclear power, gay marriage, euthanasia, republic or monarchy, genetic selection, burqa ban, or mandatory organ donation) and had 2 min to prepare the speech. Participants were allowed to make notes during the preparation time but they could not use them during the speech. Then, the jury entered the room and the par- ticipants gave a speech for 5 min or until they indicated that they wanted to stop. After the assessment, participants were random- ized to one of the three conditions (VRET, iVET, or waiting-list) using a computerized random number generator (http://www. randomization.com). A person who was not involved in the pre- sent study kept a list with the randomization sequence in a locked office cupboard and prepared sealed envelopes containing the condition allocation. The first author opened the envelopes after participants were enrolled. Participants in the waiting-list condi- tion received a second assessment after a waiting period of five weeks (i.e. the same aimed length of time as the treatment) before being randomized to one of the treatment conditions. After the last treatment session, all participants completed a postassessment identical to the preassessment. Three months after the post- assessment, participants were invited to an in-person follow-up assessment consisting of the battery of self-report measures (LSAS- SR, FNE-B, DASS-21, PDBQ, EUROHIS-QOL). 1.4. Treatment The treatment protocols for VRET and iVET were based on the protocols of Scholing and Emmelkamp (1993) and Hofmann and Otto (2008). Consistent with our aim of examining the potential efficacy of exposure to virtual social interactions, only behavioural exposure elements were used in both conditions and cognitive el- ements were discarded. Both treatments comprised ten 90 min sessions scheduled twice a week. In standard treatment, homework is commonly added to therapy sessions. However, due to the technical equipment necessary for VRET, virtual exposure could only be implemented in the lab. Therefore, homework assignments were not feasible in this condition. To keep the amount of exposure equal in both conditions, no homework assignment was given in either condition and therapists were instructed not to encourage participants to practice exposure outside of therapy sessions. Therapists involved in the present study were clinical psychologists and students in their last semester of a clinical master's degree program. They received training on VRET and iVET by the second and last author prior to administering both treatments. To monitor treatment adherence and competence, all therapy sessions and exposure exercises were extensively discussed during supervision. Furthermore, therapists were asked to complete a checklist immediately after each session in which they indicated any possible deviations from the protocol which were discussed during super- vision. Moreover, therapy sessions were audio recorded (except for in vivo exposure exercises) and parts of recordings were replayed and discussed during supervision. Due to logistical reasons treat- ment adherence and competence were not formally assessed. Weekly supervision was provided to the therapists by the first, second, and last author. 1.4.1. Virtual reality exposure therapy (VRET) VRET took place in the virtual reality laboratory of the University of Amsterdam. The laboratory consisted of two rooms separated by a one-way mirror, through which the therapist could see the participant during exposure exercises while controlling the com- puter system, whereas the participant could not see the therapist. The therapist and the participant had face-to-face contact before and after exposure exercises and during exposure they communi- cated via an intercom. The virtual situations covered one-to-one and group situations designed to provoke anxiety in individuals with SAD: giving a talk in front of an audience followed by ques- tions from the audience, talking to a stranger, buying and returning clothes, attending a job interview, being interviewed by journalists, dining in a restaurant with a friend, and having a blind date (see Appendix A for a detailed description of all virtual scenarios and Figure 2 in Hartanto et al. (2014) for pictures of the virtual blind date, virtual job interview, and neutral world). For virtual exposure, we used the Delft Remote Virtual Reality Exposure Therapy (DRVRET; Brinkman et al., 2012) system with virtual worlds which were visualized using a Vizard v3.0 software package. The setup consisted of three computers. The first com- puter, a custom Dell T3400 workstation, was used to run the VR server and the data logging system. The second computer, a custom Dell T3600 workstation using Intel Quadcore E5 with NVIDIA Quadro 5000, was used to run the VR engine and environment and the therapist could see simultaneously what the participant could see in the head mounted display. The video output of this computer was split for both the head mounted display (participant) and real time monitoring purpose (therapist). On the third computer, a custom Dell T3400 workstation, the therapist controlled the virtual situations. Participants wore a nVisor SX head mounted display with 1280 � 1024 pixels, a stereographic projection, and a 60� di- agonal field of view. Semi-structured dialogues controlled by the therapist ensured a certain length and difficulty level of interaction between the virtual humans and the participant, as well as allowing for individual re- sponses for each participant (Brinkman et al., 2012). To tailor exposure exercises to the specific needs, anxiety level, and treat- ment progress of the individual participant, the system allowed the therapist to vary the following components depending on the vir- tual situation: dialogue style (friendly or unfriendly), gender of avatar, number of avatars present in the virtual world, dialogue topic's degree of personal relevance, and avatar's gestures (i.e., gaze direction and posture). Treatment Sessions 1 and 2 focused on the conveyance of the therapy rationale, the registration of participant's relevant social situations, and creating a hierarchy of the available virtual social situations according to the participants' anticipated anxiety level. Moreover, participants were introduced to virtual reality and the technological equipment by entering a virtual neutral situation (Busscher, de Vliegher, Ling, & Brinkman, 2011), without any social interaction, for a maximum of 5 min. Sessions 3 through 9 contained two 30 min blocks of exposure exercises separated by a 5 min break. The content of exposure ex- ercises followed the previously made hierarchy in ascending order with regards to individual anxiety level (i.e. gradual exposure). Participants rated their anxiety level regarding three time points in every exposure exercise: beginning, highest level during the exer- cise, and end. Participants practiced every virtual world at least once and until anxiety decreased. Yet, only a maximum of two sessions were spent on exposure exercises focussing on presenta- tion situations to limit the amount of practice in presentation performance, given that the behavioural assessment task also consisted of giving a speech. Session 10 was devoted to relapse prevention and evaluation of the therapy. 1.4.2. In vivo exposure therapy (iVET) The iVET consisted of gradual exposure therapy to real-life http://www.randomization.com http://www.randomization.com I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156152 situations. Similar to VRET, iVET comprised 10 sessions with 60 min exposure in Sessions 3 through 9. As in the VRET condition, the therapy rationale and anxiety hierarchy were discussed in Sessions 1 and 2. The hierarchy used in iVET comprised participants’ indi- vidual social situations which were translated to exposure exercises that could be implemented at the ambulatory of the University of Amsterdam or in its neighbourhood (e.g., supermarkets, subway stations, caf�es, etc.). If relevant social situations could not be translated into exercises at the ambulatory or its nearby sur- roundings (e.g., work-related social situations), participants could substitute a regular session with a session in their personal envi- ronment. In these cases, the therapist and the participant had contact via the telephone before and after the exposure assign- ment. Session 10 was identical to the last session in the VRET condition. 1.5. Statistical analyses Multilevel regression analyses were carried out to explore within-group (Time), between-group (Condition), and interaction (Time � Condition) effects. Only the fixed effects of the multilevel models were reported because they model change at the group level (in contrast to random effects, which model at the individual level). To investigate treatment effects from pre-to postassessment, each active treatment group was compared to waiting-list. The estimated model (see Table 3a) consisted of two parameters for each group: one parameter estimating the mean level of the outcome variable at preassessment and a second parameter esti- mating the rate of change from pre-to postassessment. For the active treatment groups, the second parameter described the change from pre-to postassessment relative to the change of the waiting-list group. To investigate long term effects of the two active treatments, the change from pre-to postassessment and the change from preassessment to follow-up were compared between VRET and iVET. The estimated model (see Table 3b) consisted of three parameters for each group: the first parameter describes the mean level of the outcome variable at preassessment, the … Public Speaking Avoidance as a Treatment Moderator for Social Anxiety Disorder Bita Mesria,1, Andrea N. Nilesa,2, Andre Pittigb,3, Richard T. LeBeaua,4, Ethan Haika,5, and Michelle G. Craskea,6 aUniversity of California, Los Angeles, Department of Psychology, 405 Hilgard Avenue, Los Angeles, California, United States of America, 90095-1563 bInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, Dresden, Germany, D-01187 Abstract Background and Objectives—Cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT) have both garnered empirical support for the effective treatment of social anxiety disorder. However, not every patient benefits equally from either treatment. Identifying moderators of treatment outcome can help to better understand which treatment is best suited for a particular patient. Methods—Forty-nine individuals who met criteria for social anxiety disorder were assessed as part of a randomized controlled trial comparing 12 weeks of CBT and ACT. Pre-treatment avoidance of social situations (measured via a public speaking task and clinician rating) was investigated as a moderator of post-treatment, 6-month follow-up, and 12-month follow-up social anxiety symptoms, stress reactivity, and quality of life. Results—Public speaking avoidance was found to be a robust moderator of outcome measures, with more avoidant individuals generally benefitting more from CBT than ACT by 12-month follow-up. In contrast, clinician-rated social avoidance was not found to be a significant moderator of any outcome measure. Limitations—Results were found only at 12-month follow-up. More comprehensive measures of avoidance would be useful for the field moving forward. Please address correspondence to Michelle Craske, Ph.D., Department of Psychology, UCLA, 1193 Franz Hall, Box 951563, Los Angeles, CA 90095-1563. Telephone: 1-310-825-8403; fax: 1-310-825-9048; [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author manuscript J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. Published in final edited form as: J Behav Ther Exp Psychiatry. 2017 June ; 55: 66–72. doi:10.1016/j.jbtep.2016.11.010. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t Conclusions—Findings inform personalized medicine, suggesting that social avoidance measured behaviorally via a public speaking task may be a more robust factor in treatment prescription compared to clinician-rated social avoidance. Keywords Social anxiety; Moderator; Treatment outcome; Cognitive behavioral therapy; Acceptance and commitment therapy 1. Introduction Cognitive behavioral therapy (CBT) is a well-established treatment for social anxiety disorder (Butler, Chapman, Forman, & Beck, 2006; Hofmann & Smits, 2008). Recently, acceptance and commitment therapy (ACT), a third-wave behavioral therapy, has garnered support as another effective treatment for social anxiety (Swain, Hancock, Hainsworth, & Bowman, 2013; Bluett, Homan, Morrison, Levin, & Twohig, 2014) with comparable treatment outcomes to CBT (Craske et al., 2014). Clinically significant response rates of individual patients following these interventions are around 50–55%, ranging from 43% to 70% (for a review see Loerinc et al., 2015; Craske et al., 2014; Leichsenring et al., 2014; Lincoln et al., 2005). Identifying treatment moderators may be a key to improving response rates, as they clarify for whom and under which circumstances treatments have different effects. Knowledge of such moderators can help clinicians better match patients with existing treatments from which they are likely to glean the greatest benefit (Kraemer, Wilson, Fairburn, & Agras, 2002). Unfortunately, though several predictors of treatment outcome have been identified, little research exists on treatment moderators. This is likely due to the fact that the majority of prior studies on social anxiety disorder do not compare two active treatments, which is required for assessing treatment moderators. To our knowledge, only a few papers have reported moderators of psychological treatments for individuals with social anxiety disorder. The findings are detailed below. In a previously published article on the current sample, individuals with social anxiety disorder who were rated as high in experiential avoidance (i.e., self-reported unwillingness to accept negative emotions) measured by the Acceptance and Action Questionnaire reported greater symptom reduction at 12-month follow-up in CBT than ACT (Craske et al., 2014). The same pattern of moderation was found in a separate study with a mixed anxiety sample (Wolitzky-Taylor, Arch, Rosenfield, & Craske, 2012). We speculated that individuals with high experiential avoidance benefit more from CBT in the long-term because they are motivated to practice skills (e.g., exposures) designed to decrease avoidance of anxious thoughts, feelings, and sensations. Compared to CBT, ACT emphasizes acceptance rather than reducing uncomfortable internal experiences. Conversely, in the same mixed anxiety sample, individuals with high behavioral avoidance of negative physical sensations (i.e., unwillingness to continue a hyperventilation task) were more likely to benefit from ACT than CBT (Davies, Niles, Pittig, Arch, & Craske, 2015). However, this study did not examine moderators separately by diagnosis and thus it is possible that this finding was Mesri et al. Page 2 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t driven by patients with anxiety primarily related to bodily sensations (e.g., those with panic disorder and health anxiety), which is a common but not essential or primary component of social anxiety disorder. A measure of avoidance that is more specific to social anxiety disorder would be avoidance of social situations. Behavioral measures of social avoidance including public speaking tasks are ecologically valid and easily implemented in research, but rarely used in clinical assessments (Beidel, Turner, Jacob, & Cooley, 1989; Hofmann, Newman, Ehlers, & Roth, 1995; Levin et al., 1993; Moscovitch, Suvak, & Hofmann, 2010). Instead, clinicians typically make judgments of behavioral avoidance based on patient self-report. However, anxious patients’ estimates of their avoidance can be at odds with their actual behavior (Rachman & Lopatka, 1986; Taylor & Rachman, 1994). To our knowledge there is no previous study evaluating behavioral measures of social avoidance as moderators of treatment outcome for social anxiety disorder. Theoretically, experiential and behavioral avoidance are two separate parts of anxiety. Whereas experiential avoidance is centered on avoidance of internal experiences such as thoughts, feelings, and physical sensation, behavioral avoidance is centered on avoidance of external experiences such as social events, public speaking, and meetings. It would seem likely that individuals who are avoidant of feared internal experiences would also be avoidant of feared external experiences. Moreover, both experiential avoidance and behavioral avoidance are indicators of poor emotion regulation (Craske, Street, & Barlow, 1989; Hayes, Wilson, Gifford, Follette, & Strosahl, 1996). From a deficit correction model, it is likely that those who show deficits in emotion regulation would benefit from a treatment that is targeting said deficit (e.g., CBT) compared to a treatment that is not targeting emotion regulation (e.g., ACT). Given prior evidence that individuals who report high levels of experiential avoidance (indicator of poor emotion regulation) respond more positively to CBT than ACT, we hypothesized that those with the most overt social avoidance (another indicator of poor emotion regulation), would similarly respond more positively to CBT than ACT. To evaluate the effects of in vivo versus clinician-rated social avoidance, we analyzed avoidance via a public speaking task and clinician rating prior to treatment. To isolate the effect of social avoidance above social fear, we analyzed public speaking avoidance, clinician-rated social avoidance, public speaking fear, and clinician-rated social fear as moderators of all outcomes. 2. Materials and methods 2.1. Participants Forty-nine individuals who met diagnostic criteria for principal or co-principal generalized social anxiety disorder as diagnosed using the Anxiety Disorders Interview Schedule IV (Brown, Di Nardo, & Barlow, 1994, see Craske et al., 2014, for more details) were included in the current analyses. Fifty-two participants completed treatment but follow-up behavioral and self-report data were missing for 3 individuals. A clinician severity rating of 4 or higher on the ADIS-IV indicated clinical severity and served as the cutoff for study eligibility. Mesri et al. Page 3 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t Individuals were a subset of a larger sample that included randomization to a waitlist condition (Craske et al., 2014). Because moderator analyses examine differential response to two active treatments and not differential response to active treatment versus control, we did not include participants assigned to the waitlist in these analyses. Demographics for the current subsample are in Table 1. There were no significant group differences on any demographic or diagnostic variable at baseline. Exclusion criteria included active suicidal ideation, pregnancy, substance abuse or dependence within the last 6 months, bipolar disorder, psychosis, or certain medical diseases. Additional exclusion criteria (i.e., left handedness, metal implants, claustrophobia) were included due to a neuroimaging component. Individuals were permitted to receive concurrent psychotherapy or psychotropic medication if they were stabilized on benozodiazepines and beta blockers for a minimum of 1 month; on SSRIs, SNRIs, heterocylics, and MAO inhibitors for a minimum of 3 months; and on non-anxiety related psychotherapy for a minimum of 6 months prior to study entrance. Individuals were recruited through online and newspaper advertisements as well as community flyers and referrals from the greater Los Angeles area. The study took place at the Anxiety Disorders Research Center in the University of California, Los Angeles (UCLA). 2.2. Design Individuals were assessed prior to treatment (i.e., pre-treatment), within 6 weeks after the end of treatment (i.e., post-treatment), 6 months after pre-treatment (i.e., 6-month follow- up), and 12 months after pre-treatment (i.e., 12-month follow-up)1. 2.3. Treatments Individuals in CBT and ACT groups received 12 weekly, 1-hr individual therapy sessions based on standard manuals2. ACT and CBT were matched on number of exposure sessions but differed in framing of the intent of exposure. CBT and ACT were administered by advanced clinical psychology students at UCLA (see Craske et al., 2014). Therapists received a two-day training session in CBT and ACT by Drs. Craske and Hayes, respectively. They received weekly group supervision by Dr. Craske and members of Dr. Craske’s and Hayes’s teams. CBT—The 12-session CBT protocol has been effective for social anxiety disorder (Craske et al., 2014; Arch et al., 2012). Session 1 included assessment, psychoeducation, and self- monitoring. Sessions 2–4 covered cognitive restructuring, hypothesis testing, and breathing retraining. Session 5–11 included exposures to social stimuli. Session 12 focused on relapse prevention. ACT—Session 1 included psychoeducation and experiential exercises. Sessions 2–3 covered creative hopelessness. Sessions 4–5 covered mindfulness, acceptance, and cognitive 16-month follow-up was approximately 3 months after treatment completion and 12-month follow-up was approximately 9 months after treatment completion. 2See authors for a copy of the CBT treatment manual (CBT manual modified from Hope, Heimberg, Juster, & Turk, 2000); the ACT manual is published (Eifert & Forsyth, 2005). Mesri et al. Page 4 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t defusion. Sessions 6–11 honed previous skills and introduced value exploration. Exposures were used throughout to observe and accept anxiety as well as to engage in valued activities despite anxiety. Session 12 created a plan for future use of skills. 2.4. Moderator Variables 2.4.1. Public Speaking Avoidance and Fear—At pre-treatment, individuals were asked to give a 3-minute speech in front of a video camera and two confederates. Speech topics included global warming and corporeal punishment. These topics were selected to be moderate in terms of difficulty and controversy. Individuals were given 5 minutes to prepare the speech on one or both topics. They were instructed to rate their fear level using a 0–100 Subjective Units of Distress Scale (SUDS; Wolpe, 1990) with 0 being no fear and 100 being maximum fear at the start of the speech, at each 1-minute interval, and at the end of the speech. After 3 minutes, individuals were given the opportunity to continue speaking for up to 3 more minutes. Mean SUDS ratings were calculated for each individual and analyzed as a measure of fear on the public speaking task. Number of minutes spoken was used as a measure of avoidance. Individuals who refused the public speaking task altogether were given a score of 0 minutes and SUDS rating of 100. See appendix A for the brief protocol used to assess public speaking avoidance. 2.4.2. Clinician-Rated Social Avoidance and Fear—As part of the pre-treatment ADIS-IV, clinicians rated individuals’ avoidance and fear (0 = none, 8 = extreme anxiety or avoidance) of 13 social situations (e.g., dating, public speaking, speaking with unfamiliar people). Avoidance scores for all 13 situations were averaged to create a clinician-rated social avoidance score (α = .74). Fear scores for all 13 social situations were also averaged to create a clinician-rated social fear score (α = .77). 2.5. Outcome Variables 2.5.1. Symptom Composite Score—The self-report version of the Liebowitz Social Anxiety Scale (LSAS-SR; Fresco et al., 2001) is a 24-item measure of fear and avoidance of social and performance situations. Total ratings demonstrate good test-retest reliability (r = . 83), internal consistency (α = .95), convergent validity and the scale is sensitive to change following treatment (Baker, Heinrichs, Kim, & Hofmann, 2002). The Social Interaction Anxiety Scale (SIAS; Mattick & Clarke, 1998) is a 20-item measure of thoughts, feelings, and behaviors in social situations. The SIAS correlates highly with other measures of social phobia and has good internal consistency (α = .90) (Osman, Gutierrez, Barrios, Kopper, & Chiros, 1998). The Social Phobia Scale (SPS; Mattick & Clarke, 1998) is a 20-item measure of being observed by others during routine activities (e.g., eating, writing). The SPS correlates highly with other measures of social phobia and has good internal consistency (α = .91) (Osman et al., 1998). Alphas for the LSAS-SR, SIAS, and SPS were all at or above . 90 in this sample across all time points (Niles, Mesri, Burklund, Lieberman, & Craske, 2013). To improve construct validity for the measurement of social anxiety severity, a composite was created from the three scales. Z-scores for each measure were combined to create a standardized measure with mean 0 and standard deviation 1. The composite score includes averages of all three measures at pre, post, and 12-month follow-up. The LSAS-SR was not administered at 6-month follow-up, which includes only the SPS and SIAS. Mesri et al. Page 5 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t 2.5.2. State-Trait Anxiety Inventory—The State-Trait Anxiety Inventory – A State (STAI AState; Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983) is a 20-item measure of temporary anxiety in response to a stressor. Example items include “I feel nervous” and “I feel tense.” Each item is rated on a scale from 1 to 4, with 1 being not at all and 4 being to a great extent. The STAI A-State demonstrates good internal consistency (α = .83 – .92) (Spielberger et al., 1983). The STAI was administered at the start of the laboratory assessment (which included a hyperventilation task, a public speaking task, and computer tasks) in order to assess stress reactivity. Because the laboratory assessment was not conducted at 6-month follow-up, STAI data were analyzed only at pre, post, and 12-month follow-up. 2.5.3. Quality of Life Inventory—The Quality of Life Inventory (QOLI; Frisch, 1994a, 1994b) is a measure of satisfaction with regard to 16 broad life domains. Each domain is first rated for importance on a scale from 0 to 2, with 0 being not important and 2 being extremely important. Then, individuals rate their life satisfaction with that domain on a −3 to +3 scale, with −3 being very dissatisfied and +3 being very satisfied. The QOLI demonstrates good test-retest reliability (r = .80 – .91), internal consistency (α = .77 – .89) and is sensitive to treatment change (Frisch et al., 2005). 2.6. Statistical analyses A multi-level model with repeated measures design was used. Pre-treatment scores were modeled as a covariate rather than a repeated measure to minimize the variance in the outcome measures (Tabachnick & Fidell, 2006). This model has been previously used in examining moderators of treatment outcome (Craske et al., 2014; Niles et al., 2013; Wolitzky-Taylor et al., 2012). Analyses were run in Stata 13 using the xtmixed command. A two level growth curve model was used. Time (post-treatment, 6-month follow-up, 12-month follow-up) was modeled on level 1 as a continuous linear predictor. On level 2, we included baseline levels of the outcome measures (as a covariate), Group (CBT or ACT), status (0 = completed 12-month measures, 1 = not completed 12-month measures) and the moderators. To test specificity of public speaking avoidance as a moderator above fear, we included fear during the public speaking task as a covariate. When testing public speaking fear, we included public speaking avoidance as a covariate. Pairwise correlations between public speaking avoidance and public speaking fear revealed only a moderate correlation, r = −.39, p < .001. However, pairwise correlations between clinician-rated social avoidance and clinician-rated social fear revealed a strong correlation, r = .81, p < .001. Hence, we did not include clinician-rated social fear in the model when analyzing clinician-rated social avoidance and vice versa. Models were fitted using maximum likelihood. Random effects of intercept and time were included in all models. Because moderators may interact with Group (CBT or ACT) or Time, both of these interactions, and the three-way interaction between moderator, Group, and Time were included in each analysis. Quadratic relationships between moderator, Group, and Time were assessed. If there was no quadratic relationship, Time was dropped and a moderation of Mesri et al. Page 6 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t Group without Time was assessed. Tests of simple effects were used to explain moderation effects. More specifically, 1 SD above and below the mean was used to categorize high avoidant/ fear or low avoidant/ fear individuals. 1 SD was used in order to capture representative avoidance or fear behavior in a social anxiety group and is typical in previous moderation studies (Niles et al., 2013). 3. Results As reported in Craske et al. (2014), CBT and ACT were each more effective than a waitlist comparison control for symptoms of social anxiety, with no differences between them. 3.1. Moderator of Symptom Composite Public speaking avoidance significantly interacted with Group and Time to moderate symptom composite, z = −2.25, p = .045 (see Fig. 1). Tests of simple effects revealed that at 12-month follow-up, more avoidant individuals (operationally defined as 1 SD above the mean) reported .87 SD fewer symptoms following CBT than ACT, 95% confidence interval (CI) = .05 to 1.70, z = 2.07, p = .038. No group differences were found for low avoidant individuals (1 SD below the mean), p > .05. Public speaking avoidance did not moderate post-treatment or 6-month follow-up, ps > .05. Neither fear on the public speaking task nor clinician-rated social avoidance or social fear were significant moderators of symptom composite at any time point, ps > .05. 3.2. Moderator of Stress Reactivity Public speaking avoidance significantly interacted with Group and Time to moderate stress reactivity (measured by STAI A-State prior to a stressful laboratory assessment), z = −3.87, p < .001 (see Fig. 2). Tests of simple effects revealed that at 12-month follow-up, more avoidant individuals reported 15.77 fewer points in stress reactivity following CBT than ACT, CI = 8.38 to 23.17, z = 4.18, p < .001. No group differences were found for low avoidant individuals, p > .05. Public speaking avoidance did not moderate at post-treatment or 6-month follow-up, ps > .05. Neither fear on the public speaking task nor clinician-rated social avoidance or social fear were significant moderators of stress reactivity at any time point, ps > .05. 3.3. Moderator of Quality of Life Clinician-rated social fear significantly moderated quality of life, z = −2.12, p = .006 (see Fig. 3). Tests of simple effects revealed that at 6-month follow-up, less fearful individuals reported 1.32 fewer points in quality of life following CBT than ACT, CI = −2.33 to −.31, z = −2.56, p = .010 and more fearful individuals reported 1.26 more points in quality of life following CBT than ACT, CI = .003 to 2.52, z = 1.96, p = .049. There were no significant differences between high and low clinician-rated fearful individuals in CBT and ACT at post-treatment and 12-month follow-up, ps > .05. Therefore, this finding is no longer discussed in this paper. Public speaking fear, public speaking avoidance, and clinician-rated social avoidance were not significant moderators of quality of life at any time point, ps > . 05. Mesri et al. Page 7 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t 4. Discussion The current study tested social avoidance as a moderator of treatment outcome for social anxiety disorder. Understanding moderators of treatment outcome allow us to better match patients to a particular treatment, which has important implications for improving treatment outcome. Our findings suggest that individuals who are more avoidant during a public speaking task benefit more, in terms of long-term symptoms and stress reactivity, from CBT than ACT. Conversely, fear during the public speaking task did not moderate the treatment effects, suggesting that the results were specific to public speaking avoidance versus fear. Moreover, clinician-rated social avoidance did not moderate treatment effects, which could imply that the results were specific to avoidance of public speaking in particular rather than social avoidance in general. Alternatively, these results may suggest that clinicians may not be particularly accurate judges of a patient’s degree of social avoidance in their daily life. Such judgments are likely to be heavily reliant on a patient’s self-report, particularly at an initial assessment when the clinician has limited information about the patient, and self-report of avoidance behavior may not be an exact indicator of actual avoidance behavior in laboratory paradigms (Gamez, Kotov, & Watson, 2010; McNeil, Ries, & Turk, 1995). We found that more avoidance on the public speaking task predicts better long-term outcome in CBT than ACT. One possible explanation is that CBT targets avoidance in a structured way through creation of an exposure hierarchy followed by in-session and homework exposure assignments. Avoidant individuals may benefit from this structure. A similar finding has been reported in a panic disorder sample that was randomly assigned to exposure therapy with an active therapist who guided patients through exposures or a less active therapist who was not present during assigned exposures (Hamm, et al., 2016). Overall, panic disorder patients benefitted from exposure therapy; however, patients with greater public speaking avoidance benefitted even more from therapist-directed exposures than self- directed exposures. This finding may highlight the added benefit of structure during exposures (which may be more present in CBT than ACT) for patients with high public speaking avoidance. Although ACT includes exposure, these exposures are less structured and their focus is not on fear reduction. Rather, in ACT, individuals conduct exposures in order to be present, open, mindful, and accepting of their anxious feelings with the eventual goal of taking committed action toward their values. Thus, in contrast to CBT in which exposures are a critical strategy for alleviating symptoms, the connection between exposures and treatment goals is more removed in ACT and possibly simply one of many approaches toward valued living. Indeed, there was greater adherence to behavioral exposures in CBT than ACT in the present sample (Craske et al., 2014). Moderation was found only at the 12-month follow-up, which replicated our prior studies in the same and different samples (Craske et al., 2014; Niles et al., 2013; Wolitzky-Taylor et al., 2012). In prior studies, we proposed that experiential avoidance motivated continued exposure practice over the months following treatment, in turn leading to improved long- term outcomes (Wolitzky-Taylor et al., 2012). Perhaps those who were most avoidant of public speaking similarly perceived the benefits of continued exposure practice following the Mesri et al. Page 8 J Behav Ther Exp Psychiatry. Author manuscript; available in PMC 2018 June 01. A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t A u th o r M a n u scrip t end of treatment resulting in better long-term outcome in CBT than ACT. It is also important to note that CBT was supervised directly by Dr. Craske and her team, whereas ACT was only supervised by Dr. Hayes’s team and not himself. It is possible that if Dr. Hayes had supervised the therapists, outcomes from ACT may have differed. Moreover, more comprehensive measures of avoidance would be useful for the field moving forward. Despite limitations, this is one of few studies that investigated moderators of ACT and CBT for social anxiety disorder. Asking patients to give a speech and identifying how long they are willing to speak may be a simple way of assessing behavioral avoidance. It may provide useful long-term prognostic information not gleaned by traditional methods such as rating levels of social avoidance based largely on patient self-report. Furthermore, should these results be replicated, they suggest that those who are more behaviorally avoidant may benefit more from CBT than ACT. Acknowledgments Funding: This project was funded by the National Institutes of Mental Health 1 R21 MH081299 References Arch JJ, Eifert GH, Davies C, Vilardaga JCP, Rose RD, Craske MG. Randomized clinical trial of cognitive behavioral therapy (CBT) versus acceptance and commitment therapy (ACT) for mixed anxiety disorders. Journal of Consulting and Clinical Psychology. 2012; 80(5):750–765. doi:http:// dx.doi.org/10.1037/a0028310. [PubMed: 22563639] Baker … RESEARCH ARTICLE Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder Mădălina Elena Costache1, Andreas Frick2, Kristoffer Månsson1,3,4,5, Jonas Engman1, Vanda Faria 1,6,7 , Olof Hjorth 1 , Johanna M. Hoppe 1 , Malin Gingnell 1,8 , Örjan Frans 1 , Johannes Björkstrand 1,9 , Jörgen Rosén 1 , Iman Alaie 1,10 , Fredrik Åhs11, Clas Linnman12, Kurt Wahlstedt 1 , Maria Tillfors 13 , Ina Marteinsdottir 14 , Mats Fredrikson 15 , Tomas FurmarkID 1* 1 Department of Psychology, Uppsala University, Uppsala, Sweden, 2 The Beijer Laboratory, Department of Neuroscience, Uppsala University, Uppsala, Sweden, 3 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden, 4 Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany and London, United Kingdom, 5 Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, 6 Center for Pain and The Brain, Department of Anesthesiology, Harvard Medical School, Boston Children’s Hospital, Perioperative and Pain Medicine, Boston, MA, United States of America, 7 Department of Otorhinolaryngology, Smell & Taste Clinic, TU Dresden, Dresden, Germany, 8 Department of Neuroscience, Uppsala University, Uppsala, Sweden, 9 Department of Psychology, Lund University, Lund, Sweden, 10 Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden, 11 Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden, 12 Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, United States of America, 13 Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden, 14 Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, 15 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden * [email protected] Abstract Social anxiety disorder (SAD) can come in different forms, presenting problems for diagnos- tic classification. Here, we examined personality traits in a large sample of patients (N = 265) diagnosed with SAD in comparison to healthy controls (N = 164) by use of the Revised NEO Personality Inventory (NEO-PI-R) and Karolinska Scales of Personality (KSP). In addi- tion, we identified subtypes of SAD based on cluster analysis of the NEO-PI-R Big Five per- sonality dimensions. Significant group differences in personality traits between patients and controls were noted on all Big Five dimensions except agreeableness. Group differences were further noted on most lower-order facets of NEO-PI-R, and nearly all KSP variables. A logistic regression analysis showed, however, that only neuroticism and extraversion remained significant independent predictors of patient/control group when controlling for the effects of the other Big Five dimensions. Also, only neuroticism and extraversion yielded large effect sizes when SAD patients were compared to Swedish normative data for the NEO-PI-R. A two-step cluster analysis resulted in three separate clusters labelled Prototypi- cal (33%), Introvert-Conscientious (29%), and Instable-Open (38%) SAD. Individuals in the Prototypical cluster deviated most on the Big Five dimensions and they were at the most severe end in profile analyses of social anxiety, self-rated fear during public speaking, trait anxiety, and anxiety-related KSP variables. While additional studies are needed to deter- mine if personality subtypes in SAD differ in etiological and treatment-related factors, the PLOS ONE PLOS ONE | https://doi.org/10.1371/journal.pone.0232187 April 29, 2020 1 / 20 a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: Costache ME, Frick A, Månsson K, Engman J, Faria V, Hjorth O, et al. (2020) Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder. PLoS ONE 15 (4): e0232187. https://doi.org/10.1371/journal. pone.0232187 Editor: Frantisek Sudzina, Aalborg University, DENMARK Received: October 25, 2019 Accepted: April 8, 2020 Published: April 29, 2020 Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here: https://doi.org/10.1371/journal.pone.0232187 Copyright: © 2020 Costache et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The data underlying the results presented in the study are available from https://www.psyk.uu.se/forskning/ http://orcid.org/0000-0001-6821-9058 https://doi.org/10.1371/journal.pone.0232187 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0232187&domain=pdf&date_stamp=2020-04-29 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0232187&domain=pdf&date_stamp=2020-04-29 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0232187&domain=pdf&date_stamp=2020-04-29 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0232187&domain=pdf&date_stamp=2020-04-29 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0232187&domain=pdf&date_stamp=2020-04-29 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0232187&domain=pdf&date_stamp=2020-04-29 https://doi.org/10.1371/journal.pone.0232187 https://doi.org/10.1371/journal.pone.0232187 https://doi.org/10.1371/journal.pone.0232187 http://creativecommons.org/licenses/by/4.0/ https://www.psyk.uu.se/forskning/forskargrupper/uppsala-affective-neuroscience-group/ present results demonstrate considerable personality heterogeneity in socially anxious indi- viduals, further underscoring that SAD is a multidimensional disorder. Introduction Social anxiety disorder (SAD) is one of the most common psychiatric disorders [1] character- ized by a persistent and over-whelming fear of being negatively evaluated in one or more social or interactional situation [2]. It is associated with considerable individual suffering [3], large societal costs [4,5] and typically follows a chronic course if left untreated [6]. Cognitive behav- ioral therapy (CBT), serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reup- take inhibitors (SNRIs) are first-line treatment options for SAD [7,8]. Although these treatments are helpful, as many as 40–50% of patients have been reported to be either treat- ment resistant or not responding sufficiently [9]. Several factors, like variations in symptom profile and comorbidity of personality disorders, may underlie this and more research is needed to better understand the etiology and relevant treatment approaches of SAD. Social anxiety can be studied, not only as a disorder, but also as one or more dispositional traits involving emotional discomfort and social withdrawal [10]. Spence and Rapee suggested that social anxiety may be a personality-like construct while SAD diagnosis reflects an interaction between social anxiety and the degree of impairment such anxiety imposes in life [11]. Mal- adaptive personality traits may have a large impact on psychosocial functioning and, hence, the course and expression of psychiatric disorders. Moreover, disorders and traits may share a common etiology [12] and personality traits could be predictive of treatment outcome [13,14]. Deciphering the complex relationships between basic personality traits and SAD is therefore theoretically and clinically important. The revised NEO Personality Inventory (NEO-PI-R) provides comprehensive assessment of personality dimensions, and their underlying facets, based on the five-factor model of per- sonality i.e., the “Big Five” neuroticism, extraversion, openness, agreeableness, and conscien- tiousness [15]. Previous studies have reported that SAD is associated high scores of neuroticism and low scores of extraversion [16–19]. Marteinsdottir and colleagues [20] assessed personality traits in a sample of Swedish untreated SAD individuals by use of another common personality inventory, the Karolinska Scales of Personality; KSP [21]. In comparison to normative data, the SAD sample scored higher on the KSP scales related to vulnerability for anxiety, detachment, irritability, and indirect aggression, and lower on socialization and social desirability. SAD patients with comorbid avoidant personality disorder scored higher on inhi- bition of aggression and psychic anxiety [20]. Personality dimensions in SAD have also been evaluated by means of the Temperament and Character Inventory (TCI) [22]. Clinical SAD samples have then exhibited significantly higher harm-avoidance, and significantly lower self- directedness, persistence, cooperativeness, self-transcendence, and novelty seeking when com- pared to healthy participants [23,24]. Notably, sample sizes in these studies have been limited, generally not exceeding N = 60. More studies with larger samples are needed to clarify the cru- cial personality components associated with SAD, including higher-order dimensions as well as lower-order facets. Also, little is known regarding the impact of such personality compo- nents on subtypes of SAD. The heterogeneity of SAD has been widely acknowledged [25] and several subtypes have been proposed over the years. However, empirical research into SAD subtypes has yielded mixed findings and a resultant general lack of consensus, partly reflecting use of different PLOS ONE Personality and subtypes in social anxiety disorder PLOS ONE | https://doi.org/10.1371/journal.pone.0232187 April 29, 2020 2 / 20 forskargrupper/uppsala-affective-neuroscience- group/ Funding: Supported by the Swedish Research Council (grant 2016-0228) and Riksbankens Jubileumsfond - the Swedish Foundation for Research in Social Sciences and the Humanities (grant P17-0639:1) https://www.vr.se/ https:// www.rj.se/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist. https://doi.org/10.1371/journal.pone.0232187 https://www.psyk.uu.se/forskning/forskargrupper/uppsala-affective-neuroscience-group/ https://www.psyk.uu.se/forskning/forskargrupper/uppsala-affective-neuroscience-group/ https://www.vr.se/ https://www.rj.se/ https://www.rj.se/ statistical methods and samples [26]. Social anxiety may extend to a broad range of situations and the generalized subtype of SAD was introduced in DSM-III-R as a descriptor of individu- als who fear most social situations. The residual category has often been referred to as “nonge- neralized”. However, anxiety reactions may also be limited to one or two social situations, typically performance situations like public speaking. Heimberg and colleagues [27] proposed that “circumscribed” SAD should be added to the generalized and nongeneralized subtypes, and other labels have also been suggested such as “specific”, “discrete”, and “limited interac- tional” SAD [27,28]. Blöte and colleagues argued that public speaking anxiety is a distinct subtype, different from other subtypes [29]. In the current version of DSM, i.e. DSM-5, gener- alized SAD has been replaced by “performance type” as the only subtype specifier, although this may not do justice to the complexity of the issue. As in psychiatry in general, it has been debated whether SAD subtypes are best described as categories or dimensions. Support for a dimensional mild-moderate-severe subtype distribu- tion was found in a cluster analytic study of SAD in a community sample [28] and other empirical studies have also concluded that the heterogeneity of SAD should be seen as a con- tinuum of severity, greater number of social fears being associated with greater disability [30– 33]. On the other hand, subgrouping can also be based on the type of social anxiety. The pres- ence of observational vs. interactional anxiety could be a putative qualitative demarcation of SAD subtypes [34]. Using factor analysis in a clinical SAD sample, Perugi and colleagues found support for the existence of five types of social anxiety: interpersonal anxiety, formal speaking anxiety, stranger-authority anxiety, eating and drinking while being observed, and anxiety of doing something while observed [35]. Moreover, studies have found evidence of qualitatively different SAD subgroups based on Cloninger’s temperamental characteristics [22]. By use of cluster or latent class analysis, researchers have identified not only a prototypi- cal SAD subgroup characterized by high harm-avoidance and low novelty seeking, but also an anxious-impulsive subtype scoring high on novelty seeking [36–39]. While individuals in the former group show behavioral inhibition and risk aversion, individuals in the latter exhibit an atypical pattern of risk-prone approach behaviors while still being highly anxious. From a the- oretical perspective, Hofmann and colleagues have suggested that subtypes of SAD vary across six dimensions: fearfulness, anxiousness, shyness, self-consciousness, submissiveness, and anger [25]. Notably, these dimensions overlap considerably with neuroticism and extraversion facets that can be assessed with instruments like the NEO-PI-R. The controversies around SAD subtyping bear strong resemblance with debates in person- ality research concerning the usefulness of qualitative types vs. quantitative traits and person- centered vs. variable-centered approaches [40,41]. There have been attempts to quantify per- sonality types from trait instruments like the NEO-PI-R [42], and according to a widely-cited typology, people may fall into three distinct categories: ‘resilient’, ‘overcontrolled’ or ‘under- controlled’, e.g. [40]. Resilients have below average scores on neuroticism and above average or intermediate scores on the remaining four dimensions; overcontrollers score high in neu- roticism and low in extraversion whereas undercontrollers have low scores in conscientious- ness and agreeableness [43]. Recently Gerlach et al. [44] found evidence of four robust personality types in a Big Five data set comprising 1.5 million individuals. These were labelled “average”, “self-centred”, “reserved” and “role model” respectively, the latter showing resem- blance with “resilient” [44]. It is not well understood how SAD subgroups compare with these personality types. Presumably, prototypical SAD individuals are overcontrollers but this may not be true for the anxious-impulsive SAD subtype [36–39]. Anyhow, studies exploring sub- types of SAD by personality inventories are scant and, to our knowledge, no previous study has evaluated potential subtypes of SAD derived from the widely researched Big Five personal- ity dimensions. PLOS ONE Personality and subtypes in social anxiety disorder PLOS ONE | https://doi.org/10.1371/journal.pone.0232187 April 29, 2020 3 / 20 https://doi.org/10.1371/journal.pone.0232187 As social anxiety may be conceptually intertwined with several personality components, the principal aim of the present study was to examine personality traits in a large sample of indi- viduals diagnosed with SAD (N = 265), in comparison to healthy controls (N = 164) and Swed- ish normative data, by use of the NEO-PI-R and KSP instruments. We expected elevated neuroticism and lower extraversion on the NEO-PI-R, as well as higher scores on KSP items related to anxiety and behavioral inhibition, in SAD individuals. Further aims were to explore subtypes of SAD by use of cluster analysis of the Big Five personality dimensions, and to com- pare the personality types with respect to other clinical variables including social anxiety symp- tom severity, interaction anxiety, trait anxiety, KSP scales and affective ratings during a public speaking challenge. Methods Participants characteristics and general study set-up In total, 265 patients [117 men, 148 women; mean age (SD): 33.5 (10.3) years] diagnosed with DSM-IV SAD [45] and 164 healthy controls [82 men, 82 women; mean age: 30.9 (9.9) years], answered paper-and-pen version of the personality scales NEO-PI-R and KSP. All participants were volunteers in neuroimaging treatment trials, data being collected from 1998 to 2018, as described elsewhere [46–54]. NEO-PI-R data were collected from trials conducted from 2003 and onwards. All studies were approved by the Regional Ethical Review Board in Uppsala and all participants provided written informed consent. The personality forms were filled out in the home-environment before neuroimaging assessment and any subsequent treatment. Patients with SAD were recruited mainly through media advertisements while healthy con- trols answered both to public billboards at Uppsala University and newspaper advertisements. The psychiatric status was assessed either by a clinical psychologist or a psychiatrist, who administered the anxiety disorders section of Structured Clinical Interview for DSM-IV (SCID-I) [55] and the Mini International Neuropsychiatric Interview [56]. The complete SCID-I and SCID-II interviews were administered in one study [54]. Participants underwent a medical check-up and were considered physically healthy. All patients met the criteria for a primary SAD diagnosis according to DSM-IV [45] with marked fear of social situations including public speaking. Forty-four (17%) presented one comorbid secondary Axis I disor- der, 21 (8%) presented two comorbidities and 2 patients (0.8%) had three comorbidities. Comorbid conditions included generalized anxiety disorder, specific phobia, obsessive-com- pulsive disorder, panic disorder with or without agoraphobia, post-traumatic stress disorder and mild major depressive disorder. None of the controls fulfilled the screening criteria for SAD or any other psychiatric condition. Exclusion criteria were: previous or current neurological and somatic illnesses, current pre- dominant axis I mental disorder other than SAD (e.g. bipolar or severe major depressive disor- der, psychosis), pregnancy, menopause, psychological or psychotropic treatment that was ongoing or had ended within the previous three months, alcohol and narcotics addiction or abuse, age outside the range of 18–65, or other characteristics that could be expected to inter- fere with the original neuroimaging study such as claustrophobia or metal implants [46–54]. Personality instruments Personality traits were measured by Swedish versions of the NEO-PI-R [15] and KSP [21]. The NEO-PI-R consists of 240 Likert-scale items, rated from 0 (“absolutely disagree) to 4 (“abso- lutely agree). It is a widely recognized instrument developed to improve the general compre- hension of personality in adults by assessing five factors (neuroticism, extraversion, agreeableness, openness to experience, and conscientiousness), and six categories (facets) of PLOS ONE Personality and subtypes in social anxiety disorder PLOS ONE | https://doi.org/10.1371/journal.pone.0232187 April 29, 2020 4 / 20 https://doi.org/10.1371/journal.pone.0232187 each one of the five higher-order traits. Cronbach’s alpha values for NEO-PI-R factors in the present study were: neuroticism 0.92, extraversion 0.86, openness 0.75, conscientiousness 0.80, and agreeableness 0.62. The KSP inventory was created with the aim of quantifying imperative dimensions of per- sonality or temperament, based on psychobiological theories and research [57–59]. The instru- ment is composed of 135 items grouped into 15 scales: five scales assess propensity to experience anxiety states (somatic anxiety, psychic anxiety, muscular tension, psychasthenia, and inhibition of aggression), three dimensions are related to susceptibility for behavioral dis- inhibition (impulsivity, monotony avoidance, and detachment), and the remaining scales are mainly associated to hostility and aggression (indirect and verbal aggression, irritability, suspi- cion, guilt, socialization, and social desirability). In the present study, internal consistency ran- ged from 0.61 for hostility to 0.92 for anxiety dimensions. Other instruments Additional clinical measures were used to compare clusters of SAD individuals. Social anxiety symptom severity was measured primarily by the Liebowitz Social Anxiety Scale, LSAS [60,61]. Social interaction anxiety was measured by the Social Interaction Anxiety Scale, SIAS [62]. Trait anxiety was assessed by Spielberger’s State-trait Anxiety Inventory, STAI-T [63]. Moreover, self-rated fear and distress were assessed with 0–100 (min-max) scales during a public speaking behavioral test administered in conjunction with the neuroimaging trial, see e.g., [49,50,52,54]. Because the public speaking challenge was administered within the scanner for PET trials, but outside the scanner for fMRI trials, we used type of test as a covariate in group comparisons. Finally, clinician-rated data on severity category (mild/moderate/severe) were retrieved from the diagnostic interview (SCID) forms or, in case of missing information, a severity rating was derived from the Clinical Global Impression–Severity (CGI-S) scale [64], with scores of �5 indicating severe, 4 = moderate, and 3 = mild. Diagnostic interview data on DSM-IV subgroup (generalized/nongeneralized SAD), and avoidant personality disorder (yes/ no) as assessed with the SCID-II [65] was obtained in a subset (n = 72) of the SAD sample. Statistical analyses Statistical analyses were performed using SPSS Version 25 (IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp). Independent sample t-tests were run to compare the mean scores between the two groups on both personality scales. Bonferroni adjustment for multiple comparisons was used for Big Five dimensions whereas Holm adjusted alpha levels were applied for NEO-PI-R facets and KSP variables due to the larger number of comparisons. To determine the magnitude of observed significant effects, a between-group effect size was calculated using Cohen’s d formula [66]. For informatory purposes effect sizes (d) were also calculated for SAD vs. normative group comparisons, using Swedish norm data for NEO-PI-R [67] and KSP [68]. Logistic regression analysis including the Big Five personality variables was performed (with a p<.01 Bonferroni criterion) to identify independent predictors of group (patient or control). Two-step cluster analysis with log-likelihood distance measures was used in SPSS for exploratory detection of potentially similar groups of persons with relatively homogenous per- sonality traits [69]. The 15 KSP variables were previously found to represent “lower-order traits” for neuroticism, extraversion, agreeableness, while no representation was found for openness or conscientiousness [68]. Because of this, the NEO-PI-R Big Five dimensions were selected as cluster variables, and the KSP scales as profile variables, in the analysis. One-way analyses of variance (ANOVAs) were performed to ascertain significant differentiation PLOS ONE Personality and subtypes in social anxiety disorder PLOS ONE | https://doi.org/10.1371/journal.pone.0232187 April 29, 2020 5 / 20 https://doi.org/10.1371/journal.pone.0232187 between the resultant clusters, using a standard level of significance (p<0.05) followed by Bon- ferroni post hoc comparisons, controlling for multiple comparisons. Results Group differences in demographic characteristics There were no differences between the SAD patients and healthy controls with respect to gen- der distribution (χ2 = 1.394;p = .273). There was a group difference in age (t = 2.601;df = 427; p = .010), but age did not correlate with the NEO-PI-R or KSP personality variables, except for weak correlations with Neuroticism (r = −.113,p<.05), Openness (r = −.138,p<.01), Social Desirability (r = .190,p<.01), Monotony Avoidance (r = −.137,p<.05), and Detachment (r = .193,p<.01). Controlling for age in the subsequent statistical analyses did not alter any signifi- cant result. Group differences in the revised NEO personality inventory In total, 211 SAD patients (91 men, 120 women; mean age ± SD: 32.7 ±10.6 years) and 138 healthy control participants (73 men, 65 women; 30.8 ± 9.9 years) completed the NEO-PI-R self-report. Independent samples t-tests revealed that subjects with SAD had significantly higher scores on neuroticism and significantly lower scores on extraversion, openness, and conscientiousness, with large effect sizes, as compared to healthy controls (p<.001)—see Table 1. On facets, there were statistically robust group differences on all lower-order traits of extraversion and neuroticism (S1 Table). For openness and conscientiousness facets, between- group effect sizes varied from moderate to large and significant differences, exceeding the Bon- ferroni criterion, were found on openness to actions-O4, ideas-O5, and values-O6; compe- tence-C1, dutifulness-C3, and self-discipline-C5. Despite no group difference on the full agreeableness dimension, significant differences were found at the facet level but in mixed directions, with lower trust-A1 and altruism-A3, but higher straightforwardness-A2 and mod- esty-A5, in patients–see S1 Table. When comparing SAD patients to Swedish normative data [68] large effect sizes were only noted for neuroticism and extraversion and a moderate effect size for conscientiousness (Table 1). Effect sizes were also large for 8 of the 12 neuroticism and extraversion facets, as well as for self-discipline-C5 (S1 Table). On openness to ideas-O5 and values-O6, patients scored lower than the control sample but higher than the Swedish normative group, whereas patients were steadily lower on openness for actions-O4. To further evaluate personality dimensions that were independent predictors of group (SAD or control), a logistic regression analysis was conducted. Results showed that only neu- roticism and extraversion were robust significant predictors (p�.001) when all dimensions were included in the statistical model (Table 2). The model explained 83% of the variance, according to Nagelkerke R Square and correctly classified 93% of cases. Hosmer and Leme- show test indicated adequate goodness of fit (χ2 = 5.536; p = .699). Variance inflation factors (VIF) were <2.22 indicating no serious multicollinearity. Controlling for age in the model did not alter results, neuroticism and extraversion remaining highly significant (p < .001) predictors. Group differences in the Karolinska Scales of Personality The KSP was completed by 217 patients (99 men, 118 women; mean age ± SD 34.1 ±10.6 years) and 123 healthy control subjects (64 men, 59 women; 30.4 ±10.0 years). Significantly higher scores for the SAD sample, in comparison to controls, were noted on psychic anxiety, PLOS ONE Personality and subtypes in social anxiety disorder PLOS ONE | https://doi.org/10.1371/journal.pone.0232187 April 29, 2020 6 / 20 https://doi.org/10.1371/journal.pone.0232187 somatic anxiety, psychasthenia, inhibition of aggression, detachment, muscular tension, irrita- bility, suspicion, and guilt. Significantly lower scores were noted for socialization, monotony avoidance, impulsivity, social desirability and verbal aggression (p�.005)–see Table 3. Effect sizes were generally large or very large. Only on indirect aggression, the group difference was non-significant (p = 0.062). Comparing SAD with normative data also confirmed a largely deviant KSP profile in the patient sample although with more conservative estimates of effect size (Table 3). Because of the large number of scales and multicollinearity issues, logistic regression was not used for the KSP. Correlations between KSP scales and NEO-PI-R dimen- sions are given in S2 Table (SAD sample). Two-step cluster analysis of personality types in social anxiety disorder The 211 SAD patients with complete NEO-PI-R data were included in a two-step cluster analy- sis using log-likelihood distance measures, Schwarz’s Bayesian Criterion (BIC) as validation measure [70], and the Big Five dimensions as cluster variables. This resulted in a three-cluster solution–see Fig 1. The five input variables yielded a silhouette coefficient of 0.3, indicative of fair cluster homogeneity. The variable exhibiting the highest predictor importance, in the crea- tion of the three clusters, was extraversion, followed by neuroticism, conscientiousness and openness (Fig 1A). Based on the subsequent descriptive and profile analyses (see further below), cluster 1 was labelled Prototypical (n = 69, 32.7%); cluster 2 Introvert-Conscientious (n = 62; 29.4%); and cluster 3 Instable-Open (n = 80, 37.9%)–see Fig 1B. As indicated by separate ANOVA’s, … Original Paper Predicting Social Anxiety From Global Positioning System Traces of College Students: Feasibility Study Mehdi Boukhechba1, PhD; Philip Chow2, PhD; Karl Fua2, PhD; Bethany A Teachman2, PhD; Laura E Barnes1, PhD 1Systems and Information Engineering Department, School of Engineering and Applied Science, University of Virginia, Charlottesville, VA, United States 2Department of Psychology, University of Virginia, Charlottesville, VA, United States Corresponding Author: Laura E Barnes, PhD School of Engineering and Applied Science Systems and Information Engineering Department University of Virginia 151 Engineer's Way, Olsson Hall 101B Charlottesville, VA, 22904 United States Phone: 1 (434) 924 1723 Email: [email protected] Abstract Background: Social anxiety is highly prevalent among college students. Current methodologies for detecting symptoms are based on client self-report in traditional clinical settings. Self-report is subject to recall bias, while visiting a clinic requires a high level of motivation. Assessment methods that use passively collected data hold promise for detecting social anxiety symptoms and supplementing self-report measures. Continuously collected location data may provide a fine-grained and ecologically valid way to assess social anxiety in situ. Objective: The objective of our study was to examine the feasibility of leveraging noninvasive mobile sensing technology to passively assess college students’ social anxiety levels. Specifically, we explored the different relationships between mobility and social anxiety to build a predictive model that assessed social anxiety from passively generated Global Positioning System (GPS) data. Methods: We recruited 228 undergraduate participants from a Southeast American university. Social anxiety symptoms were assessed using self-report instruments at a baseline laboratory session. An app installed on participants’ personal mobile phones passively sensed data from the GPS sensor for 2 weeks. The proposed framework supports longitudinal, dynamic tracking of college students to evaluate the relationship between their social anxiety and movement patterns in the college campus environment. We first extracted the following mobility features: (1) cumulative staying time at each different location, (2) the distribution of visits over time, (3) the entropy of locations, and (4) the frequency of transitions between locations. Next, we studied the correlation between these features and participants’ social anxiety scores to enhance the understanding of how students’ social anxiety levels are associated with their mobility. Finally, we used a neural network-based prediction method to predict social anxiety symptoms from the extracted daily mobility features. Results: Several mobility features correlated with social anxiety levels. Location entropy was negatively associated with social anxiety (during weekdays, r=−0.67; and during weekends, r=−0.51). More (vs less) socially anxious students were found to avoid public areas and engage in less leisure activities during evenings and weekends, choosing instead to spend more time at home after school (4 pm-12 am). Our prediction method based on extracted mobility features from GPS trajectories successfully classified participants as high or low socially anxious with an accuracy of 85% and predicted their social anxiety score (on a scale of 0-80) with a root-mean-square error of 7.06. Conclusions: Results indicate that extracting and analyzing mobility features may help to reveal how social anxiety symptoms manifest in the daily lives of college students. Given the ubiquity of mobile phones in our society, understanding how to leverage passively sensed data has strong potential to address the growing needs for mental health monitoring and treatment. (JMIR Ment Health 2018;5(3):e10101) doi: 10.2196/10101 JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 1http://mental.jmir.org/2018/3/e10101/ (page number not for citation purposes) Boukhechba et alJMIR MENTAL HEALTH XSL•FO RenderX mailto:[email protected] http://dx.doi.org/10.2196/10101 http://www.w3.org/Style/XSL http://www.renderx.com/ KEYWORDS mental health; mHealth; mobility; GPS; social anxiety disorder Introduction Social anxiety is marked by an extreme fear of being scrutinized and judged by others in social or performance situations [1]. In addition to being a widespread problem among college students, a high social anxiety level is associated with a low quality of life. For example, socially anxious individuals suffer from impaired academic functioning and relationships [2]. The American College Health Association reported that 40% of students reported feeling “overwhelming anxiety” at least once in the preceding year [3]. Current techniques to identify social anxiety are typically based on self-report via questionnaires or interviews in traditional clinical settings, where only small numbers of people can be monitored and client motivation is required to seek an assessment. This approach is inadequate and fails to meet the growing needs of mental health monitoring and treatment on college campuses. As a result, many individuals who should seek help never receive any. For example, according to the Anxiety and Depression Association of America, 36% people with social anxiety disorder report having symptoms for 10 or more years before seeking help [1]. Mental health symptoms can be indirectly assessed through both subjective (eg, self-report surveys and interviews) and objective (physiological variables such as heart rate) methods. Such methods have largely been employed in clinical or laboratory settings, which limits the ecological validity of findings. To increase the generalizability of findings, researchers have tried to understand mental health through noninvasive and real-time data collected from people’s everyday lives. For example, studies using surveys to repeatedly sample people’s momentary affective experiences over time have found that individuals with high (vs low) social anxiety symptoms report more anger and fewer and less intense positive emotions [4,5]. While studies that administer repeated surveys offer a glimpse of the socioemotional aspects of daily life, regularly prompting individuals to answer questions also raises the issue of participation burden. Importantly, embedded mobile phone sensors (eg, accelerometers, light sensors, Global Positioning System [GPS]) are now advanced enough to allow for passive and continuous data collection [6,7] and are increasingly being used to enhance the understanding of the relationship between objective behavior and mental health status, such as bipolar disorder [8], anxiety and depression [7,9-13], and Alzheimer disease and dementia [14]. Digital phenotyping, which is a term used for describing this new approach of measuring behavior from mobile phones and wearable sensors, is already revealing new aspects of behaviors that appear clinically relevant [15]. For example, Saeb et al [16,17] provided preliminary evidence that extracting location-based mobility features could be used to detect depression and anxiety levels. Barnet et al [18] were able to use passively generated mobile phone data to identify statistically significant anomalies in patients with schizophrenic behavior in the days prior to relapse. The above studies show the importance of analyzing behaviors to better understand mental states. Because social anxiety is marked by intense fear of social scrutiny, passively sensed location information may reveal key markers that can be used to detect a high distress level. Semantic locations (ie, the type of social location someone visits) might be particularly important in the context of social anxiety. For example, individuals with social anxiety might systematically avoid specific places, such as those of leisure, or choose to spend peak social hours by isolating themselves at home. Thus, analyzing GPS data from college students and the types of places they frequent might provide crucial information about key mobility features associated with social anxiety levels. Some examples of mobility features include how long students spend at different types of locations (eg, home, leisure) and how often they frequent those locations. Important contributions [7,9,12,17,19] have been made to determine how passively sensed mobile phone data relates to users’ mental health statuses and stress levels. We followed the key steps from these valuable early studies and extended the scope of features and questions addressed, as outlined below: (1) recruiting participants and deploying a mobile app for data collection; (2) collecting data such as GPS locations, recognized activities, or self-reported data from participants during the study; (3) assessing participants’ mental health status using validated clinical measures; (4) extracting meaningful features or metrics from participants’ data (eg, time spent at each different location); and (5) correlating these features or metrics with participants’ mental health status (eg, Pearson correlation between number of distinct locations and clinically validated measures). This study builds on prior work in several ways and improves our understanding of the relationships between social anxiety symptoms and daily routines. In this paper, we introduce and analyze a set of passively extracted spatiotemporal features that enhance our understanding of the temporal and spatial dynamics of behavioral patterns (eg, regularly visiting a location during specific hours) of socially anxious students, which may allow for more precise, personalized interventions. We also propose a hierarchical social anxiety prediction method based on neural networks. This work may ultimately help researchers and clinicians to passively and remotely monitor patients’ social anxiety levels. The primary aim of this paper was not to test specific hypotheses, but rather to explore a framework for using passively collected GPS data to detect social anxiety levels. Methods Study Organization and Data Collection Participants were undergraduate students with varying social anxiety levels, recruited from undergraduate psychology classes that provide course credit as a participation incentive. Because some participants met or exceeded their course credit limit, a JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 2http://mental.jmir.org/2018/3/e10101/ (page number not for citation purposes) Boukhechba et alJMIR MENTAL HEALTH XSL•FO RenderX http://www.w3.org/Style/XSL http://www.renderx.com/ subset of participants was eligible to receive a small amount of monetary compensation (up to a maximum of US $40). Students were recruited through email advertisements as well as through an undergraduate study participant pool. The decision to recruit university students was based on two reasons: (1) there are high social anxiety levels among young adults, and (2) recruiting young adults in a university setting provides a relatively homogeneous sample in terms of life phase, psychological stressors, and life experiences, thereby eliminating a wide variety of potential confounding factors. After receiving approval from the university Institutional Review Board, 228 participants were recruited. Social anxiety level was first assessed via the Social Interaction Anxiety Scale (SIAS) [20] in a prestudy screening battery offered to select undergraduate psychology classes in exchange for course credit. The SIAS contains 20 items, each rated from 0 to 4. Generally, a higher SIAS score (specifically, higher than 34) [21] indicates a higher risk of having social anxiety concerns; a low score indicates a lower risk for social anxiety concerns. Following informed consent, a custom mobile app (Sensus) [22] was installed on participants’ personal mobile phone (either IOS or Android device). As shown in Figure 1, participants were informed that the app passively collected the GPS location information every 150 seconds and uploaded it to an Amazon Web Services S3 server. After the 2-week experiment was completed, researchers could access all participants’ raw GPS data for analysis. Global Positioning System Data Preprocessing Participants’ raw GPS data were parsed by semantic locations (eg, restaurant, campus area, and shops) by combining a spatiotemporal clustering algorithm and OpenStreetMap (OSM) geodatabase [23]. Specifically, we first clustered participants’ GPS locations using time and space dimensions, and then, each cluster was associated with a semantic location using OSM data [24] (Figure 2). Our clustering algorithm is inspired by the work of Kang et al [25], and it aims to eliminate the intermediate locations between important places and determine the number of clusters (important places) autonomously. The core idea guiding our approach is to cluster the locations along the time axis. As a new location measurement is read, the new location is compared with previous locations. If the new location is moving away from previous locations (within a certain distance of each other—a parameter of our algorithm), the new location is considered to belong to a different cluster than the one for the previous locations. Otherwise, it is considered to belong to the previous cluster. If a cluster’s time duration is longer than the threshold (the second parameter of our algorithm), the cluster is considered to be a significant place (see A and B in Figure 2); otherwise, it is ignored (see i1 and i2 in Figure 2). The algorithm is depicted in Textbox 1 (d and t are our distance and time threshold parameters). When a new location measurement event is generated, the cluster function is invoked. The current cluster cl is the set of location measurements that belong to the current cluster. The pending location pl is used to eliminate outliers. Even if the new location is far away from the current cluster (distance is larger than the distance threshold d), the algorithm does not start a new cluster right away with the new location. Instead, the algorithm waits for the next location to determine if the user is really moving away from the cluster or if the location reading was just a spurious outlier. The Places contain the significant places where the user stays longer than the time threshold t. Figure 1. Social anxiety monitoring framework. JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 3http://mental.jmir.org/2018/3/e10101/ (page number not for citation purposes) Boukhechba et alJMIR MENTAL HEALTH XSL•FO RenderX http://www.w3.org/Style/XSL http://www.renderx.com/ Figure 2. Illustration of our time-based clustering algorithm using real GPS data retrieved from one participant in the study. In (1), GPS locations are clustered using the algorithm described in Textbox 1. In (2), the trajectory is summarized to two places (A and B) and the transition state, which aggregates all GPS points between the clusters A and B. Finally, in (3), the clusters A and B are labeled using OSM data. GPS: Global Positioning System, OSM: open street map. Textbox 1. Spatiotemporal clustering algorithm. Input: measured location loc Output: current cluster cl, pending location pl, significant places Places if distance (cl, loc) < d then add loc to cl pl = null else ifpl ≠ null then if duration(cl) > t then if contain long gaps(cl) then remove gaps from cl end if add cl to Places end if clear cl add pl to cl if distance (cl, pl) < dthen add loc to cl pl = null else pl = loc end if else pl = loc end if end if Our algorithm was tuned using d=60 m and t=600 seconds. These values appeared to give the best clustering results for our data; they have also been reported in the literature to give the best performance for spatiotemporal clustering algorithms [25]. After detecting the significant clusters, we transformed each GPS cluster to a meaningful semantic label using OSM data. Each GPS cluster’s centroid is associated to a geographic entity (eg, in Figure 2, cluster A is associated to Gilmer Hall and cluster B to Olsson Hall, both of which are buildings on the JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 4http://mental.jmir.org/2018/3/e10101/ (page number not for citation purposes) Boukhechba et alJMIR MENTAL HEALTH XSL•FO RenderX http://www.w3.org/Style/XSL http://www.renderx.com/ university campus) using a spatial query in our geodatabase powered by OSM. The semantic data obtained from OSM is then classified to one of the following classes: • Home: our algorithm has been trained to recognize “Home” as the place having a house OSM tag (eg, apartment, dormitory, house, etc) where a subject stays the most between 10 pm and 9 am; see [23] for more details about OSM tags. • Other houses: all houses other than “Home”; in this study, given all participants are college students, other houses were assumed to mostly be friends’ houses. • Education: eg, university and libraries • Leisure: eg, sports locations, pubs, cinemas, and coffee shops • Food: eg, dining halls and restaurants including fast food joints • Supermarket: all full-service grocery stores • Religious: all places of worship, including churches, mosques, cathedrals, synagogues, temples, etc • Service: eg, bank, post office, courthouse • Out of town: locations outside of the city where the study was conducted • In transition: going from one place to another Note that ideally, food places would be merged with leisure and supermarkets with service classes. However, we decided to separate them because we discovered a particular pattern that high socially anxious participants (SAP) share in terms of time spent at food places and supermarkets, which will be discussed in the next section. When constructing GPS clusters labeled with semantics, we verified if the users’ data contained GPS gaps. We defined a GPS gap gi as a minimum 10-minute time span where GPS data were missing. Gaps could be caused by different events, such as turning the phone off or “killing” the app. For gaps ∈ [5 min, 30 min], we compared the cluster cli and the cluster cli+1, created before and after the gap, respectively. If the 2 clusters had the same semantic labels, we considered that the user did not change his or her location during gi; thus, we merged the clusters cli, cli+1, and the gap gi. However, if the 2 clusters had different semantic labels, we assigned the “Transition” label to gi; ie, the user changed locations during this gap. For gaps exceeding 30 minutes in duration, we removed the corresponding time periods from the experiment (see Textbox 1, line 7), because it was hard to predict what the participants did during such long gaps. Mobility Feature Extraction After detecting participants’ visited places and labeling them using OSM, we used the semantic labels to identify the following mobility features for each participant: Cumulative Staying Time in each type of location: Given a type of location and a specific participant, this metric characterized the percentage of total time that the participant spent at one type of location during a specific time window (eg, during a day, during mornings vs afternoons). Distribution of visits for each type of location: Given a type of location and a specific participant, this metric calculated the density distribution of time of visits over the time of day. For instance, if a participant was more likely to go to leisure places during evenings, we would find more density during the evening periods for this type of locations. We introduced this metric because cumulative staying time captures only time spent at each different location without recording when these visits happened; for instance, spending 2 hours at the university during mornings was different than that during evenings. Location entropy: This metric was calculated using the entropy of Shannon [26] to measure how each participant’s time was distributed over different location classes, where pi is the percentage of time spent at location i and n is the total number of visited locations: Transition Frequency from one type of location to another: Given a specific participant and two types of locations (eg, “Home” and “Work”), this metric characterized the frequency at which the participant transited from one type of location to another. This metric was applied unidirectionally; for example, the transition frequency of “Home”   “Work” and the transition frequency of “Work”   “Home” were different. Results Participants Participants comprised 228 university students (mean age 19.43 [SD 2.92] years; 141/228, 62%, females). Participants reported their race or ethnicity as white (118/228, 52%), Asian (61/228, 27%), black (12/228, 5%), Latino (5/228, 2%), and multiracial (32/228, 14%). Figure 3 shows the distribution of SIAS scores among the 228 participants. The SIAS scores ranged between 11 and 54 with a mean score 29.91 (SD 9.1). The goal of our study was: (1) to understand the relationship between the extracted mobility features and the preassessed SIAS score and (2) to investigate whether the extracted features could predict SIAS scores. Consequently, in the next two sections, we will first analyze the relationship between the mobility features and social anxiety and then investigate whether these features can accurately predict social anxiety. Mobility Data Analysis In this section, we present the results of our analysis investigating the relationship between social anxiety levels (using the preassessed SIAS measures) and the four extracted mobility metrics: cumulative staying time, distribution of visits, location entropy, and transition frequency. JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 5http://mental.jmir.org/2018/3/e10101/ (page number not for citation purposes) Boukhechba et alJMIR MENTAL HEALTH XSL•FO RenderX http://www.w3.org/Style/XSL http://www.renderx.com/ Figure 3. The distribution of Social Interaction Anxiety Scale (SIAS) scores for recruited participants. The Epanechnikov kernel function was used to compute the density estimates presented in this figure. Cumulative Staying Time We calculated the Pearson correlation between each participant’s average daily cumulative staying time at each different location and his or her SIAS score to identify the direction (positive or negative) and strength of each correlation. To assess the reliability of the correlations, we also calculated significance levels (P value). Results presented in graph 1 of Figure 4 show that daily time spent at some locations was associated with the SIAS score. Indeed, time spent at food locations, such as restaurants and dining halls, was negatively correlated with the SIAS score. However, time spent at supermarkets was positively correlated with the SIAS score. This suggests that high SAP are more likely to buy food from supermarkets so they can eat at home, perhaps to avoid social interactions at restaurants. College students may have common mobility patterns that bias the daily correlation analysis, such as class times at the university following a typical schedule. In order to find the hidden patterns between the cumulative staying time and SIAS score, we analyzed correlations in different daily time epochs: 8 am-4 pm, 4 pm-12 am, and 12 am-8 am. Results presented in graphs 2, 3, and 4 of Figure 4 suggest the following: • Similar to the 24-hour analysis (Figure 4, graph 1), the time spent at food locations was negatively correlated with the SIAS score, while time spent at supermarkets was positively correlated with the SIAS score in both the 12 am-8 am and 8 am-4 pm time windows. • Time spent doing leisure activities was positively correlated with the SIAS score between 8 am and 4 pm, while the rest of time it was negatively correlated with the SIAS score. This suggests that high SAP prefer to do their leisure activities between 8 am and 4 pm, rather than during the evenings. This may reflect the social demands typical of different types of leisure activities done during the day versus evening (eg, it is more normative to be alone at a coffee shop than at a pub or bar). • We did not find a correlation between time spent at home and the SIAS score between 12 am and 4 pm (Figure 4, graphs 2 and 4), which may simply indicate that no matter how socially anxious students were, they tended to stay at home (sleeping) between 12 am-8 am and leave home to go to school between 8 am and 4pm. However, during the time after typical school hours (between 4 pm and 12 am, when students have the choice to stay at home or not), we found a positive correlation between the SIAS score and time spent at home (Figure 4, graph 3). This finding is consistent with a prior work that associates time spent at home with depressive and social isolation symptoms [27]. • Finally, we found a small correlation (0.22) between time spent out of town and the SIAS score during the 4 pm-12 am time window, perhaps indicating that more socially anxious students leave the university to visit familiar individuals or family, rather than engaging in campus night life, which may have more demands to be social with unfamiliar individuals. After analyzing the correlation between cumulative staying time and the SIAS score, we studied the difference between cumulative staying time during weekdays versus weekends for high (SIAS score ≥ 34) versus low (SIAS < 34) SAP. A score of 34 is an established clinical cutoff for the SIAS score to classify a subject as high or low socially anxious [21]. The reason for this analysis is that students’ patterns may differ between weekdays and weekends. For instance, maybe the time spent at the university is not a good predictor of social anxiety during weekdays, but it is during weekends when students presumably have more autonomy in determining their schedule (because classes are not set). JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 6http://mental.jmir.org/2018/3/e10101/ (page number not for citation purposes) Boukhechba et alJMIR MENTAL HEALTH XSL•FO RenderX http://www.w3.org/Style/XSL http://www.renderx.com/ Figure 4. The correlations between time spent at each different type of location and Social Interaction Anxiety Scale (SIAS) scores using different time windows. In (1), we have presented the correlations on a daily basis, while in the other figures, we have focused on specific portions of the day, ie, between 8 am and 4 pm, between 4 pm and 12 am, and between 12 am and 8 am. The x-axis represents the correlation significance; the left y-axis describes the type of locations, and the right y-axis represents the P value of the Pearson correlation in that specific type of location. Correlations having a coefficient r>0.2 and a strength P<0.05 are presented in purple. Table 1. The difference between high and low socially anxious students in terms of average daily time spent (in minutes) at each different location during weekdays versus weekends. WeekendsWeekdaysLocation LowaHighaLowaHigha 10.41b16.64b1.41b6.64bSupermarket 5.739.971.836.97Service 2.7510.351.637.35Religious 27.8b88.25b22.33b38.25bOut of town 75.09b43.16b45.19b26.04bLeisure 469.02b594.74b386.94434.74Home 64.81b16.21b24.81b17.63bOther houses 32.97b9.78b12.97b3.78bFood 102.98b148.79b316.88338.44Education aSocial anxiety levels were classified to high and low using SIAS score=34 as cutoff. bSignificant differences (P<.05) between high and low SAP detected using unpaired two-samples t test. Results presented in Table 1 show that high SAP spent less time at leisure and food places and more time at home and out of town during both weekdays and weekends. However, during weekends, high SAP tended to spend more time at education places (around 148 minute) compared with low SAP (around 102 minute). They also appeared to spend less time at other houses (a difference of 48 minute), perhaps because they were less comfortable engaging in social interactions that may happen at friends’ houses or simply had fewer opportunities (invitations) for these interactions. Distribution of Visits To better understand the relationship between students’ daily routines and their social anxiety, we analyzed the distribution of location visits over the day for both high and low SAP. Figure 5 illustrates the difference in the distribution of location visits between the two populations. Note that this figure analyzes the time of visits (the time that a participant visited a specific location) without considering the duration of visits because cumulative staying time has already been studied above. The results show a difference in the pattern of visits to food places, supermarkets, others’ houses, and leisure places. Low SAP appeared to prefer going to friends’ houses and food and leisure places during evenings (after 4 pm) more than high SAP. On the other hand, high SAP preferred to stay at home or go to the supermarket during that time period. This suggests that there may be a difference in how students plan their daily activities based on how socially anxious they are. Understanding these patterns may help clinicians identify when a person is starting JMIR Ment Health 2018 | vol. 5 | iss. 3 | e10101 | p. 7http://mental.jmir.org/2018/3/e10101/ (page number not for … Contents lists available at ScienceDirect Journal of Affective Disorders journal homepage: www.elsevier.com/locate/jad Research paper The role of expressive suppression and cognitive reappraisal in cognitive behavioral therapy for social anxiety disorder: A study of self-report, subjective, and electrocortical measures Yogev Kivity⁎,1, Lior Cohen, Michal Weiss, Jonathan Elizur, Jonathan D. Huppert Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel A R T I C L E I N F O Keywords: Social Anxiety Emotion Regulation Cognitive Reappraisal Expressive Suppression Cognitive Behavioral Therapy A B S T R A C T Background: Contemporary models of cognitive behavioral therapy (CBT) for social anxiety disorder (SAD) emphasize emotion dysregulation as a core impairment whose reduction may play a causal role in psy- chotherapy. The current study examined changes in use of emotion regulation strategies as possible mechanisms of change in CBT for SAD. Specifically, we examined changes in expressive suppression and cognitive reappraisal during CBT and whether these changes predict treatment outcome. Methods: Patients (n = 34; 13 females; Mean age = 28.36 (6.97)) were allocated to 16-20 sessions of CBT. An electrocortical measure of emotion regulation and a clinician-rated measure of SAD were administered monthly. Self-report measures of emotion regulation and social anxiety were administered weekly. Multilevel models were used to examine changes in emotion regulation during treatment and cross-lagged associations between emotion regulation and anxiety. Results: CBT led to decreased suppression frequency, increased reappraisal self-efficacy, and decreased un- pleasantness for SAD-related pictures (ps < .05). At post-treatment, patients were equivalent to healthy controls in terms of suppression frequency and subjective reactivity to SAD-related stimuli. Gains were maintained at 3- months follow-up. Decreases in suppression frequency and electrocortical reactivity to SAD-related pictures predicted lower subsequent anxiety but not the other way around (ps < .05). Lower anxiety predicted greater subsequent increases in reappraisal self-efficacy. Limitations: The lack of a control group precludes conclusions regarding mechanisms specificity. Conclusions: Decreased frequency of suppression is a potential mechanism of change in CBT for SAD. 1. Introduction Recent models of anxiety, including social anxiety disorder (SAD), emphasize impairments in emotion regulation (Hofmann, Sawyer, Fang, & Asnaani, 2012; Morrison & Heimberg, 2013). Two regulation strategies, cognitive reappraisal and expressive suppression, may be particularly relevant for SAD (Morrison & Heimberg, 2013). In the process model of emotion regulation (Gross, 2015), cognitive re- appraisal is generally considered an adaptive strategy that involves cognitive change to regulate one's emotion – for example, attempts to reinterpret emotional stimuli in less threatening ways (Gross, 2015). On the other hand, expressive suppression is an attempt to inhibit one's expression of emotions and is generally considered maladaptive (Gross, 2015). In Heimberg's updated model (Morrison & Heimberg, 2013), emotion dysregulation in SAD includes avoidance of anxiety (e.g. avoidance or escape from stressful situations) and expressive suppres- sion due to believing that expressing emotions will lead to rejection or to excessive focus on oneself. The model further proposes that in- dividuals with SAD are less effective in implementing reappraisal. Ac- cordingly, decreased suppression and increased effective use of re- appraisal are hypothesized to lead to symptom reduction, for example, by outward shifting of attention and by reducing exaggerated prob- ability and cost of rejection. Recently, studies have examined suppression and reappraisal in SAD (reviewed in Dryman & Heimberg, 2018). Cross-sectional and daily diary studies typically focus on the frequency of use of a strategy and self-efficacy (perceived success in implementation). Individuals with SAD report an over-reliance on suppression and lower frequency and self-efficacy of reappraisal (e.g., Farmer & Kashdan, 2012; https://doi.org/10.1016/j.jad.2020.10.021 Received 10 May 2020; Received in revised form 16 August 2020; Accepted 11 October 2020 ⁎ Corresponding author: Yogev Kivity, Department of Psychology, Bar Ilan University, Ramat Gan 5290002, Israel, Telephone: +972-3-5318715 E-mail address: [email protected] (Y. Kivity). 1 Yogev Kivity is now in the Department of Psychology, Bar Ilan University, Israel. Journal of Affective Disorders 279 (2021) 334–342 Available online 14 October 2020 0165-0327/ © 2020 Elsevier B.V. All rights reserved. T http://www.sciencedirect.com/science/journal/01650327 https://www.elsevier.com/locate/jad https://doi.org/10.1016/j.jad.2020.10.021 https://doi.org/10.1016/j.jad.2020.10.021 mailto:[email protected] https://doi.org/10.1016/j.jad.2020.10.021 http://crossmark.crossref.org/dialog/?doi=10.1016/j.jad.2020.10.021&domain=pdf Gaebler, Daniels, Lamke, Fydrich, & Walter, 2014). Impairments in frequency seem to be larger than impairments in self-efficacy in sup- pression while the opposite is true for reappraisal (Kivity & Huppert, 2018, 2019), thus supporting the Heimberg model. In addition, studies have also utilized subjective ratings during lab tasks of emotion regulation to study reappraisal and suppression abil- ities in SAD. These studies typically present SAD-related stimuli to participants, such as pictures of rejecting faces (Goldin et al., 2009a), pictures portraying scenes of rejection and embarrassment (Kivity & Huppert, 2016, 2018, 2019) and idiographic statements of negative self-beliefs (Goldin et al., 2009b) while asking participants to change the way they interpret these stimuli in order to reduce the distress they evoke in them. However, compared to questionnaires and daily diary measures, these lab studies have shown intact emotion regulation abilities in SAD compared to controls, even under social stress (e.g., Gaebler et al., 2014; Kivity & Huppert, 2016, 2018, 2019). Thus, self- reported impairments are not reflected in lab performance. Among other possibilities, this discrepancy may suggest a difficulty im- plementing strategies in daily life despite an intact ability to implement them upon instruction in controlled circumstances, low ecological va- lidity of lab-based measures, or a bias in self-reports that does not exist in lab-based measures. Examining the role that each of these aspects (lab-based performance, self-reported frequency and self-reported self- efficacy) plays in treatments for SAD may shed light on their relative importance. Several techniques of cognitive behavioral therapy (CBT) for SAD seem relevant for improving emotion regulation. Psychoeducation and exposures likely decrease suppression, as patients learn that hiding their anxiety is futile and likely to backfire. Outward shifting of at- tention (focusing on the task at hand instead of on how one is per- ceived) presumably decreases suppression by decreasing patients’ pre- occupation with their overt signs of anxiety. Furthermore, cognitive restructuring can potentially increase the use of reappraisal by chan- ging biased catastrophic cognitions. Finally, psychoeducation and in- vivo exposure challenge biased cognitions and are expected to promote reappraisal too. Studies have shown that self-reported reappraisal (frequency and self-efficacy) increases in CBT (Goldin et al., 2014a; Goldin, Morrison, Jazaieri, Heimberg, & Gross, 2017; Kocovski, Fleming, Hawley, Huta, & Antony, 2013; Moscovitch et al., 2012). However, findings regarding self-reported suppression are inconclusive, with one study reporting a decrease in frequency (Goldin et al., 2014a) and another reporting no change (Moscovitch et al., 2012). Less is known regarding lab-based measures: one study found improvements in reappraisal of negative social evaluations and negative self-beliefs during CBT (Goldin et al., 2013, 2014b). Importantly, the best test of the importance of emotion regulation as a treatment target for SAD is to examine its contribution to symptom improvement (Nock, 2007). Changes in reappraisal and suppression that predict treatment outcome would provide further support to Heimberg's model. Several studies found that increases in self-reported frequency and self-efficacy of reappraisal predicted subsequent symptom reduction (Goldin et al., 2017; Kocovski, Fleming, Hawley, Ho, & Antony, 2015; Moscovitch et al., 2012), although another study found that only self-efficacy (but not frequency) of reappraisal pre- dicted subsequent outcome (Goldin et al., 2014a). Decreases in self- reported suppression frequency predicted contemporaneous, but not subsequent, symptoms reduction in one study (Goldin et al., 2014a) and did not predict outcome at all in another (Moscovitch et al., 2012). The only examination of lab-based reappraisal (Goldin et al., 2014b) found that greater changes in fMRI measures of reappraisal predicted greater symptom change during CBT for SAD, although subjective task per- formance did not. Thus, the self-report findings suggest that reappraisal increases during CBT for SAD and may be driving symptom change, with more consistent findings regarding self-efficacy than frequency. Additional studies are needed regarding lab-based emotion regulation. The present study examines changes in suppression and reappraisal during CBT for SAD and their role in treatment outcome using data from a previously completed study (Huppert, Kivity, Cohen, Strauss, Elizur & Weiss, 2018). We collected weekly self-reports of the frequency and self-efficacy of reappraisal and suppression, and monthly lab-based measures of reappraisal and suppression in response to SAD-related pictures. Given past findings, our primary focus was self-reported self- efficacy of reappraisal and frequency of suppression. Frequency of re- appraisal and self-efficacy of suppression were of secondary interest. For the lab-based task, we focused on unpleasantness and event- related potentials (ERP) during reappraisal and suppression of SAD- related pictures. We focused on the late positive potential (LPP), an ERP with a posterior midline distribution and an onset of 300 ms post-sti- mulus (Proudfit, Dunning, Foti, & Weinberg, 2013). Larger LPP reflect sustained attention to stimuli and elaborative engagement in order to regulate the emotion (Proudfit et al., 2013). The LPP is sensitive to emotional intensity and to emotion regulation, with higher amplitudes for highly arousing stimuli that are reduced following instructions to regulate, including reappraisal and suppression, even within several seconds from the presentation of the stimuli (Proudfit et al., 2013). The LPP shows less habituation over repeated exposure to stimuli compared to other psychophysiological measures (Proudfit et al., 2013), which allows for repetition of stimuli and attribution of changes in LPPs to the same stimuli as due to regulation. The LPP has been utilized in SAD (Kinney, Burkhouse, & Klump, 2019; Kivity & Huppert, 2018, 2019; Yuan et al., 2014) but we are unaware of studies examining it during CBT for SAD. We examined these hypotheses: 1) CBT will result in significant improvements in suppression and reappraisal, including reduced fre- quency of suppression and increased self-efficacy, frequency, and suc- cessful lab implementation of reappraisal. 2) Improvements in sup- pression and reappraisal will play a potentially causal role in CBT: improvements will predict subsequent improvements in anxiety and not vice versa. 3) We examined whether patients reached an equivalent level of emotion regulation to healthy controls (HCs) at post-treatment, and whether gains were maintained at 3-months follow-up without an a-priori hypothesis. 2. Method 2.1. Participants Data were drawn from the CBT arm of a study of treatments for SAD (Huppert et al., 2018)2. Patients were recruited via advertisements and referrals. Participants were 34 patients who met DSM-IV-TR (American Psychiatric Association, 2000) criteria for SAD and 40 HCs with no history of psychiatric disorders, matched to patients on sex, age and education. One patient decided not to enter treatment and 5 HCs were removed because they did not have a continued low social anxiety score between screening and participation. The final sample included 33 patients (13 females, Age: 18-53, M = 28.36, SD = 6.97) and 35 HCs (15 females, Age: 19-45, M = 28.49, SD = 6.28). Participants were Hebrew speaking and family status was: single: CBT = 59%, HC = 61%; in a relationship: CBT = 41%, HC = 35%; divorced: CBT = 0%, HC = 4%. Education levels were: high school: CBT = 15%, HC = 29%; post-high school: CBT = 21%, HC = 9%; undergraduate degree/student: CBT = 42%, HC = 27%; graduate degree/student: 2 The original study also included participants receiving a computerized treatment for SAD called Attention Bias Modification. This treatment was of shorter duration compared to CBT, of a smaller sample size and only included three measurements of lab-based emotion regulation. In addition, group as- signment was random only for a subset of the CBT patients. Due to these rea- sons, we decided not to include data from this treatment in the current study, which a priori was designed to examine the role of ER in CBT. Y. Kivity, et al. Journal of Affective Disorders 279 (2021) 334–342 335 CBT = 21%, HC = 26%. Groups did not differ on demographics (ps > .05). Ten SAD participants (29.41%) had one comorbid disorder and two (5.88%) had more than one. The most common comorbid disorders were depression (n = 9; 26.47%) or other anxiety disorders (n = 4; 11.76%). 2.2. Measures Liebowitz Social Anxiety Scale (LSAS; Liebowitz, 1987). A 24- item interviewer-rated measure of fear and avoidance of social inter- actions and social performance. The Hebrew version (Levin, Marom, Gur, Wechter, & Hermesh, 2002) was administered by trained clinical psychology doctoral students, blind to hypotheses. Internal consistency in all assessments was α = .90 – .96; interrater reliability for 15 ran- domly chosen interviews was r = .94. Social Phobia Inventory (SPIN; Connor et al., 2000). A valid and reliable 17-item self-report measure of social anxiety symptoms, translated and back translated to Hebrew for previous studies. Internal consistency in all assessments was: α = .78 – .95. Emotion Regulation Questionnaire – Self-Efficacy and Frequency (ERQ; Gross & John, 2003). We used the reliable and valid Hebrew version (Carthy, Horesh, Apter, Edge, & Gross, 2010). Fol- lowing Goldin et al. (2009b), we measured both the frequency (ERQ-F) and self-efficacy (ERQ-SE) in social situations instead of frequency only (internal consistency of all subscales: α = .73 – .97). Items tap into reappraisal (e.g., “When I want to feel less negative emotion, I change the way I'm thinking about the situation”) and suppression (e.g., “I control my emotions by not expressing them”) which participants en- dorse using a 1 ("Seldom"/"Ineffectively") to 7 ("Often"/"Effectively") scale. Emotion Regulation Task. Full details are provided in supple- mental material, section 1. We used a task that was developed by Hajcak and Nieuwenhuis (2006) who presented emotionally-salient pictures to participants and instructed them to either passively view the picture or to reappraise the emotion it evokes in them while ERP ac- tivity was recorded and unpleasantness ratings were collected. Hajcak and Nieuwenhuis found that the amplitude of the LPP and the level of subjective unpleasantness were decreased during reappraisal compared to passive viewing. Thus, the task is validated and suitable for studying the effects of emotion regulation on electrocortical activity and sub- jective unpleasantness. In the current study, we adapted the task to measure suppression in addition to reappraisal and used SAD-related pictures rather than general pictures (Kivity & Huppert, 2018, 2019). In selecting the stimuli for the task, we chose to focus on shame, embar- rassment and rejection because these experiences are central in SAD (Goldin et al., 2009b; Morrison & Heimberg, 2013; Moscovitch, 2009)3. Twenty trials of each condition were included: viewing of SAD-related pictures, viewing of neutral pictures, reappraisal of SAD-related pic- tures and suppression of SAD-related pictures. When viewing SAD-related pictures, participants imagined them- selves as the character that is the focus of shame, rejection, and em- barrassment. When viewing neutral pictures, participants responded naturally. When reappraising, participants first imagined themselves as the character and then changed the way they think of the picture to decrease their unpleasantness (e.g., "This guy is not laughing at me, but at someone else"). When suppressing, participants first imagined themselves as the character and then concealed any expression of emotions. To enhance the effect of the suppression manipulation, a web camera was placed above the computer screen and participants were told that a member of the research team would review the recordings. Participants were instructed to avoid any expression of their emotions such that it would be impossible to tell whether they were viewing neutral pictures or concealing their emotions4. After each trial, participants rated their unpleasantness on a Self- Assessment Manikin (SAM; Lang, Bradley, & Cuthbert, 2008) scale (1 through 9; 5 being neutral; transformed such that higher ratings express greater unpleasantness). We focused on unpleasantness ratings in order to complement the LPP data (which is mostly correlated with arousal) and arrive at a more complete picture of the participants’ emotional experience that takes into account the two basic dimensions of emo- tions – valence and arousal. After providing unpleasantness ratings, participants were asked to indicate the instructions they followed during that trial. In the reappraisal condition, participants were also asked to record the new interpretation they came up with for the pic- ture (results not reported here). Ratings were averaged for each condition and a regulation score (view – regulate; calculated on the transformed scores) was calculated to capture the amount of reduction in unpleasantness. Higher scores indicate larger regulation effects. SAD-related pictures were collected from the internet5, normed and shown to evoke moderate shame, embarrassment, rejection and un- pleasantness (Kivity & Huppert, 2018, 2019). These depicted situations of shame, rejection, and/or embarrassment such as scenes of people pointed and laughed at, anxious people during a public speech, and facial expressions of contempt. Neutral pictures were taken from the International Affective Picture System (IAPS) database (Lang et al., 2008). Psychophysiological Recording, Data Reduction, and Analysis. Full details are provided in section 2 of the supplement. ERPs were constructed by averaging trials in each condition (view, suppression, reappraisal and view neutral). Following Moser, Hartwig, Moran, Jendrusina, & Kross (2014), the LPP was quantified as the average voltage in 5 parietal electrodes (CPz, P1, Pz, P2, POz) in the entire segment (400-2000 ms). A regulation change score (view – regulate) was calculated to capture the amount of reduction in the LPP. Higher scores indicate larger regulation effects. Trials in which participants failed to use the instructed strategy were excluded (4.57% on average, no group differences). Studies have shown that the LPP can be reliably measured with as little as 8 trials and that it varies little beyond 12 trials (Moran, Jendrusina, & Moser, 2013). Assessments with fewer than 12 valid trials in each condition were removed from analyses (5% across groups, no group differences). 2.3. Treatment and therapists Individual CBT was delivered for up to 20 sessions using a manual by Roth-Ledley, Foa, & Huppert (2006), based on Clark's (2005) CBT for SAD. Components such as building an idiographic model, outward shifting of attention, safety behaviors experiment, video feedback, be- havioral experiments and exposures, and optional use of imaginal ex- posure, assertiveness training, or social skills training are included. Therapists were four clinical psychology doctoral students with 2-4 years of CBT experience. Videorecordings of sessions were used in group supervision by the last author. 3 Shame, embarrassment and rejection are likely separate, but related, ex- periences. Similar to previous studies (e.g., Goldin et al., 2009), when designing and validating the task (Kivity & Huppert, 2018, 2019) we were not able to examine these experiences separately due to a small number of stimuli that purely fall into one of these categories. It remains for future studies to examine these experiences separately. 4 It should be noted that although the view condition is not entirely a passive one (as it includes perspective taking), it is still possible that it requires less cognitive effort than the reappraisal and suppression conditions. However, studies have shown that cognitive effort alone does not explain the down-reg- ulatory effects of reappraisal (Foti & Hajack, 2008). 5 See a sample picture at https://tinyurl.com/ShameArousingPicture. Y. Kivity, et al. Journal of Affective Disorders 279 (2021) 334–342 336 https://tinyurl.com/ShameArousingPicture 2.4. Procedure The institutional review board approved the study. After providing informed consent, participants were evaluated by trained independent evaluators (blind to hypotheses) using the Mini-International Neuropsychiatric Interview (Sheehan et al., 1998) and the LSAS. Par- ticipants completed a baseline assessment and entered treatment. Pa- tients completed the ERQ before and after each session (post-session ratings were of secondary interest and are only reported in Supple- mental Material, Section 4). Patients also completed in-lab assessments at pre-treatment, every four sessions during treatment, at post-treat- ment and at 3-months follow-up which included the LSAS, SPIN, ERQ, and the lab task. Thus, each patient had up to seven assessments (pre- treatment, sessions 4, 8, 12 and 16, post-treatment, and follow-up). HCs only completed a single assessment and were not followed long- itudinally. Thus, HCs were included only in analyses of equivalency. 2.5. Data Analyses We used intent-to-treat linear multi-level models (assessments at level 1 repeated within patients at level 2) implemented in R package 'nlme' (Pinheiro, Bates, DebRoy, Sarkar, & R Core Team, 2016). In- cluding therapists as a third level showed negligible and non-significant effects (ICCs: Med = .00, range: 0 – 0.049) and therefore this level was removed. We used restricted maximum likelihood estimation, a first- order autoregressive level 1 covariance structure and random intercepts and slopes at level 2. For H1, linear rates of change were examined by including session/assessment number as a level 1 predictor (centered at pre-treatment). Intercepts represent estimated levels of the dependent variable at pre-treatment and slopes represent estimated changes in the dependent variable between two assessment points (one/four sessions, depending on the measure). To examine changes from post-treatment to follow-up we fitted a piece-wise model that examines changes during treatment and from post-treatment to follow-up separately. This was done by adding the follow-up data to the abovementioned model and adding a dummy coded variable that captures post-treatment to follow- up changes (coded “1” for follow-up assessment and “0” for all other assessment). The fixed effect of the dummy variable expresses the amount and significance of the change from post-treatment to follow- up. H2 was examined by modeling within-patient variation in the pre- dictor following recommended procedures (Wang & Maxwell, 2015). Monthly scores of the predictor (patient mean-centered) served as within-patient scores in a cross-lagged (1-month) model. Within-subject effects represent cross-lagged associations between the predictor and the outcome. Per Wang and Maxwell (2015) we did not control for linear time effects as we wished to model and explain these very effects. Following Falkenström, Finkel, Sandell, Rubel, and Holmqvist (2017), we did not include the lagged dependent variable as a predictor because it introduces a dependency between the dependent variable and the error, thus violating assumptions. However, the first auto-regressive residual structure partly accounts for the effects of prior on current levels of the outcome. For consistency, we only analyzed monthly scores of the SPIN and ERQ. A cross-lagged association was interpreted as significant only if effects were significant for clinician-rated and self- reported anxiety. For H3, comparisons were conducted using clinical equivalency procedures (Kendall, Marrs-Garcia, Nath, & Sheldrick, 1999) through t tests examining non-inferiority (i.e., < 1 SD difference) of post-treat- ment scores compared to HCs. A significant effect in noninferiority tests suggests that patients are non-inferior to HCs. Effect sizes were calculated as semi-partial r (rs; Jaeger, Edwards, Das, & Sen, 2016; Nakagawa & Schielzeth, 2013) using package 'r2glmm' in R (Jaeger & R Core Team, 2016). These represent the un- ique contribution above and beyond the contribution of other pre- dictors in the model and are presented in absolute values. 3. Results 3.1. Changes in regulation (H1) and equivalency to HCs (H3) 3.1.1. Change in self-reports Descriptive statistics for all study variables are presented in sup- plemental material, section 3. Changes are shown in Fig. 1. Suppression. Consistent with hypotheses, the frequency of sup- pression decreased during treatment (t467 = -3.98, p < .01, rs = .22 [.14, .30]) and did not change from post-treatment to follow-up (b = -.10, t490 = -.62, p = .53, rs = .01 [.00, .10]). In contrast to hypotheses, self-efficacy of suppression decreased during treatment (t467 = -2.85, p < .01, rs = .14 [.05, .22]) and did not change from post-treatment to follow-up (b = -.09, t490 = -.64, p = .52, rs = .01 [.00, .10]). Reappraisal. Consistent with hypotheses, self-efficacy of reappraisal increased during treatment (t467 = 3.67, p < .01, rs = .17 [.08, .25]) and did not change from post-treatment to follow-up (b = -.02, t490 = -.10, p = .92, rs = .00 [.00, .10]). In contrast to hypotheses, no changes in frequency of reappraisal were observed (t467 = .04, p = .97, rs = .00 [.00, .10]) nor did they change from post-treatment to follow- up (b = .08, t490 = .33, p = .74, rs = .01 [.00, .10]). 3.1.2. Change in lab-based measures Changes are shown in Fig. 2 and Fig. 3. View SAD-related pictures. As hypothesized, unpleasantness ratings decreased during treatment (t115 = 4.49, p < .01, rs = .28 [.13, .42]) and did not change from post-treatment to follow-up (b = .08, t138 = .70, p = .49, rs = .03 [.00, .18]). The LPP while viewing SAD- related pictures did not change significantly during treatment (b = -.46, t103 = -1.80, p = .07, rs = .14 [.01, .30]) or from post-treatment to Fig. 1. Change in frequency and self-efficacy of reappraisal (top panel) and suppression (bottom panel) during Cognitive Behavioral Therapy (CBT). Error bars represent estimated standard errors. Only data from sessions 1-16 are presented because only 5 patients received more than 16 sessions. b = esti- mated weekly change in emotion regulation. ** p < .01 Y. Kivity, et al. Journal of Affective Disorders 279 (2021) 334–342 337 follow-up (b = 1.73, t126 = 1.11, p = .27, rs = .05 [.00, .20]). View neutral pictures. Supporting our hypotheses, we found no change in unpleasantness ratings during CBT or from post-treatment to follow-up (during: t115 = -.43, p = .67, rs = .04 [.00, .20]; post- treatment to follow-up: b = -.05, t138 = -.26, p = .79, rs = .02 [.00, .17]) and in the LPP (during: b = -.29, t103 = -1.04, p = .30, rs = .09 [.00, .25]; post-treatment to follow-up: b = 1.86, t126 = 1.09, p = .28, rs = .05 [.00, .20]) while viewing neutral pictures. Suppression. Examining suppression-related reductions in un- pleasantness (compared to viewing pictures) we found that reductions were significantly different from zero at pre-treatment (b = .25, t115 = 3.84, p < .01), indicating that suppression was effective in down-regulating negativity. Consistent with hypotheses, regulation scores did not change during treatment (t115 = -1.77, p = .08, rs = .16 [.02, .31]) or from post-treatment to follow-up (b = .03, t138 = .29, p = .78, rs = .02 [.00, .18]). Reductions in LPP via suppression were not different from zero at pre-treatment (b = .69, t103 = 1.00, p = .32), suggesting that suppression was not effective in down regulating the LPP. Also consistent with hypotheses, regulation scores … RESEARCH ARTICLE Social anxiety in young people: A prevalence study in seven countries Philip JefferiesID*, Michael Ungar Resilience Research Centre, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada * [email protected] Abstract Social anxiety is a fast-growing phenomenon which is thought to disproportionately affect young people. In this study, we explore the prevalence of social anxiety around the world using a self-report survey of 6,825 individuals (male = 3,342, female = 3,428, other = 55), aged 16–29 years (M = 22.84, SD = 3.97), from seven countries selected for their cultural and economic diversity: Brazil, China, Indonesia, Russia, Thailand, US, and Vietnam. The respondents completed the Social Interaction Anxiety Scale (SIAS). The global prevalence of social anxiety was found to be significantly higher than previously reported, with more than 1 in 3 (36%) respondents meeting the threshold criteria for having Social Anxiety Disor- der (SAD). Prevalence and severity of social anxiety symptoms did not differ between sexes but varied as a function of age, country, work status, level of education, and whether an indi- vidual lived in an urban or rural location. Additionally, 1 in 6 (18%) perceived themselves as not having social anxiety, yet still met or exceeded the threshold for SAD. The data indicate that social anxiety is a concern for young adults around the world, many of whom do not recognise the difficulties they may experience. A large number of young people may be experiencing substantial disruptions in functioning and well-being which may be ameliorable with appropriate education and intervention. Introduction Social anxiety occurs when individuals fear social situations in which they anticipate negative evaluations by others or perceive that their presence will make others feel uncomfortable [1]. From an evolutionary perspective, at appropriate levels social anxiety is adaptive, prompting greater attention to our presentation and reflection on our behaviours. This sensitivity ensures we adjust to those around us to maintain or improve social desirability and avoid ostracism [2]. However, when out of proportion to threats posed by a normative social situation (e.g., interactions with a peer group at school or in the workplace) and when impairing functioning to a significant degree, it may be classified as a disorder (SAD; formerly ‘social phobia’; [3]). The hallmark of social anxiety in western contexts is an extreme and persistent fear of embar- rassment and humiliation [1, 4, 5]. Elsewhere, notably in Asian cultures, social anxiety may also manifest as embarrassment of others, such as Taijin kyofusho in Japan and Korea [6]. Common concerns involved in social anxiety include fears of shaking, blushing, sweating, PLOS ONE PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 1 / 18 a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: Jefferies P, Ungar M (2020) Social anxiety in young people: A prevalence study in seven countries. PLoS ONE 15(9): e0239133. https://doi.org/10.1371/journal.pone.0239133 Editor: Sarah Hope Lincoln, Harvard University, UNITED STATES Received: March 11, 2020 Accepted: August 31, 2020 Published: September 17, 2020 Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here: https://doi.org/10.1371/journal.pone.0239133 Copyright: © 2020 Jefferies, Ungar. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All data files are available from the Open Science Framework repository (DOI: 10.17605/OSF.IO/VCNF7). Funding: The author(s) received no specific funding for this work. http://orcid.org/0000-0003-4477-9012 https://doi.org/10.1371/journal.pone.0239133 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0239133&domain=pdf&date_stamp=2020-09-17 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0239133&domain=pdf&date_stamp=2020-09-17 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0239133&domain=pdf&date_stamp=2020-09-17 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0239133&domain=pdf&date_stamp=2020-09-17 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0239133&domain=pdf&date_stamp=2020-09-17 http://crossmark.crossref.org/dialog/?doi=10.1371/journal.pone.0239133&domain=pdf&date_stamp=2020-09-17 https://doi.org/10.1371/journal.pone.0239133 https://doi.org/10.1371/journal.pone.0239133 http://creativecommons.org/licenses/by/4.0/ https://doi.org/10.17605/OSF.IO/VCNF7 appearing anxious, boring, or incompetent [7]. Individuals experiencing social anxiety visibly struggle with social situations. They show fewer facial expressions, avert their gaze more often, and express greater difficulty initiating and maintaining conversations, compared to individu- als without social anxiety [8]. Recognising difficulties can lead to dread of everyday activities such as meeting new people or speaking on the phone. In turn, this can lead to individuals reducing their interactions or shying away from engaging with others altogether. The impact of social anxiety is widespread, affecting functioning in various domains of life and lowering general mood and wellbeing [9]. For instance, individuals experiencing social anxiety are more likely to be victims of bullying [10, 11] and are at greater risk of leaving school early and with poorer qualifications [11, 12]. They also tend to have fewer friends [13], are less likely to marry, more likely to divorce, and less likely to have children [14]. In the workplace, they report more days absent from work and poorer performance [15]. A lifetime prevalence of SAD of up to 12% has been reported in the US [16], and 12-month prevalence rates of .8% have been reported across Europe [17] and .2% in China [18]. How- ever, there is an increasing trend to consider a spectrum of social anxiety which takes account of those experiencing subthreshold or subclinical social anxiety, as those experiencing more moderate levels of social anxiety also experience significant impairment across different domains of functioning [19–21]. Therefore, the proportion of individuals significantly affected by social anxiety, which include a substantial proportion of individuals with undiagnosed SAD [8], may be higher than current estimates suggest. Studies also indicate younger individuals are disproportionately affected by social anxiety, with prevalence rates at around 10% by the end of adolescence [22–24], with 90% of cases occurring by age 23 [16]. Higher rates of social anxiety have also been observed in females and are associated with being unemployed [25, 26], having lower educational status [27], and living in rural areas [28, 29]. Leigh and Clark [30] have explored the higher incidence of social anxi- ety in younger individuals, suggesting that moving from a reliance on the family unit to peer interactions and the development of neurocognitive abilities including public self-conscious- ness may present a period of greater vulnerability to social anxiety. While most going through this developmentally sensitive period are expected to experience a brief increase in social fears [31], Leigh and Clark suggest that some who may be more behaviourally inhibited by tempera- ment are at greater risk of developing and maintaining social anxiety. Recent accounts suggest that levels of social anxiety may be rising. Studies have indicated that greater social media usage, increased digital connectivity and visibility, and more options for non-face-to-face communication are associated with higher levels of social anxiety [32– 35]. The mechanism underpinning these associations remains unclear, though studies have suggested individuals with social anxiety favour the relative ‘safety’ of online interactions [32, 36]. However, some have suggested that such distanced interactions such as via social media may displace some face to face relationships, as individuals experience greater control and enjoyment online, in turn disrupting social cohesion and leading to social isolation [37, 38]. For young people, at a time when the development of social relations is critical, the perceived safety of social interactions that take place at a distance may lead some to a spiral of with- drawal, where the prospect of normal social interactions becomes ever more challenging. Therefore, in this study, we sought to determine the current prevalence of social anxiety in young people from different countries around the world, in order to clarify whether rates of social anxiety are increasing. Specifically, we used self-report measures (rather than medical records) to discover both the frequency of the disorder, severity of symptoms, and to examine whether differences exist between sexes and other demographic factors associated with differ- ences in social anxiety. PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 2 / 18 Competing interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: Unilever funds the lead author’s research fellowship at Dalhousie University’s Resilience Research Centre, though in no way have they directed this research, its analysis or the reporting or results. https://doi.org/10.1371/journal.pone.0239133 Materials and methods Design This study is a secondary analysis of a dataset that was created by Edelman Intelligence for a market research campaign exploring lifestyles and the use of hair care products that was commissioned by Clear and Unilever. The original project to collect the data took place in November 2019, where participants were invited to complete a 20-minute online question- naire containing measures of social anxiety, resilience, social media usage, and questions related to functioning across various life domains. Participants were randomly recruited through the market research companies Dynata, Online Market Intelligence (OMI), and GMO Research, who hold nationally representative research panels. All three companies are affiliated with market research bodies that set standards for ethical practice. Dynata adheres to the Market Research Society code of conduct; OMI and GMO adhere to the ESOMAR market research code of conduct. The secondary analyses of the dataset were approved by Dalhousie University’s Research Ethics Board. Participants There were 6,825 participants involved in the study (male = 3,342, female = 3,428, other = 55), aged 16–29 years (M = 22.84, SD = 3.97), from seven countries selected for their social and economic diversity (Brazil, China, Indonesia, Russia, Thailand, US, and Vietnam) (see Table 1 for full sample characteristics). Participant ages were collected in years, but some individuals aged 16–17 were recruited through their parents and their exact age was not given. They were assigned an age of 16.5 years in order to derive the mean age and standard deviation for the full sample. Procedure Email invitations to participate were sent to 23,346 young people aged 16–29, of whom 76% (n = 17,817) were recruited to take the survey. These were panel members who had previously registered and given their consent to participate in surveys. Sixty-five percent of respondents were ineligible, with 10,816 excluded because they or their close friends worked in advertising, market research, public relations, journalism or the media, or for a manufacturer or retailer of haircare products. A further 176 respondents were excluded for straight-lining (selecting the same response to every item of the social anxiety measure, indicating they were not properly engaged with the survey; [39]). The final sample comprised 6,825 participants and matched Table 1. Sample characteristics. Male Female Other a Total Brazil 479 491 7 977 China 486 500 6 992 Indonesia 494 457 8 959 Russia 475 500 8 983 Thailand 469 487 12 968 US 452 500 10 962 Vietnam 487 493 4 984 Total 3,342 3,428 55 6,825 a “Other” includes individuals who selected non-binary (n = 17), prefer to self-describe (n = 7), and prefer not to say (n = 31). https://doi.org/10.1371/journal.pone.0239133.t001 PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 3 / 18 https://doi.org/10.1371/journal.pone.0239133.t001 https://doi.org/10.1371/journal.pone.0239133 quotas for sex, region, and age, to achieve a sample with demographics representative of each country. Participants were compensated for their time using a points-based incentive system, where points earned at the end of the survey could be redeemed for gift cards, vouchers, donations to charities, and other products or services. Measures The survey included the 20-item self-report Social Interaction Anxiety Scale (SIAS; [40]). Based on the DSM, the SIAS was originally developed in conjunction with the Social Phobia Scale to determine individuals’ levels of social anxiety and how those with SAD respond to treatment. Both the SIAS and Social Phobia Scale correlate strongly with each other [40–43], but while the latter was developed to assess fears of being observed or scrutinised by others, the SIAS was developed more specifically to assess fears and anxiety related to social interac- tions with others (e.g., meeting with others, initiating and maintaining conversations). The SIAS discriminates between clinical and non-clinical populations [40, 44, 45] and has also been found to differentiate between those with social anxiety and those with general anxiety [46], making it a useful clinical screening tool. Although originally developed in Australia, it has been tested and found to work well in diverse cultures worldwide [47–50], and has strong psychometric properties in clinical and non-clinical samples [40, 42, 43, 45–47]. For the current study, all 20 items of the SIAS were included in the survey, though we omit- ted the three positively-worded items from analyses, as studies have demonstrated that includ- ing them results in weaker than expected relationships between the SIAS and other measures, that they hamper the psychometric properties of the measure, and that the SIAS performs bet- ter without them [e.g., 51–53] (the omitted items were ‘I find it easy to make friends my own age’, ‘I am at ease meeting people at parties, etc’, and ‘I find it easy to think of things to talk about’.). One item of the SIAS was also modified prior to use: ‘I have difficulty talking to attrac- tive persons of the opposite sex’ was altered to ‘I have difficulty talking to people I am attracted to’, to make it more applicable to individuals who do not identify as heterosexual, given that the original item was meant to measure difficulty talking to an attractive potential partner [54]. The questionnaire also included measures of resilience, in addition to other questions con- cerning functioning in daily life. These were included as part of a corporate social responsibil- ity strategy to investigate the rates of social anxiety and resilience in each target market. A translation agency (Language Connect) translated the full survey into the national languages of the participants. Analyses We analysed social anxiety scores for the overall sample, as well as by country, sex, and age (for sex, given the limited number and heterogeneity of individuals grouped into the ‘other’ cate- gory, we only compared males and females). As social anxiety is linked to work status [25], we also examined differences in SIAS scores between those working and those who were unem- ployed. Urban/rural differences were also investigated as previous research has suggested anxi- ety disorders may differ depending on where an individual lives [28]. Education level [27], too, was included using completion of secondary education (ISCED level 3) in a subgroup of par- ticipants aged 20 years and above to ensure all were above mandatory ages for completing high school. Descriptive statistics are reported for each group with significant differences explored using ANOVA (with Tukey post-hoc tests) or t-tests. PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 4 / 18 https://doi.org/10.1371/journal.pone.0239133 The SIAS is said to be unidimensional when using just the 17 straightforwardly-worded items [52], with item scores summed to give general social anxiety scores. Higher scores indi- cate greater levels of social anxiety. Heimberg and colleagues [42] have suggested a cut-off of 34 on the 20-item SIAS to denote a clinical level of social anxiety (SAD). This level has been adopted in other studies [e.g., 45] and found to accurately discriminate between clinical and non-clinical participants [53]. This threshold for SAD scales to 28.9 when just the 17 items are used, and this is slightly more conservative than others who have used 28 as an adjusted 17-item threshold [53, 55]. Therefore, in addition to analyses of raw scores to gauge the sever- ity of social anxiety (and reflect consideration of social anxiety as a spectrum), we also report the proportion of individuals meeting or exceeding this threshold for SAD (�29) and analyse differences between groups using chi-square tests. Additionally, despite the unidimensionality of the SIAS, the individual items can be inter- preted as examples of contexts where social anxiety may be more or less acutely experienced (e.g., social situations with authority: ‘I get nervous if I have to speak with someone in authority’, social situations with strangers: ‘I am nervous mixing with people I don’t know well’). Therefore, as social anxiety may be experienced differently depending on culture [6], we also sorted the items in the measure to understand the top and least concerning contexts for each country. Finally, we also sought to understand whether individuals perceived themselves as having social anxiety. After completing the SIAS, participants were presented with a definition of social anxiety and asked to reflect on whether they thought this was what they experienced. We contrasted responses with a SIAS threshold analysis to determine discrepancies, including assessment of the proportion of false positives (those who thought they had social anxiety but did not exceed the threshold) and false negatives (those who thought they did not have social anxiety but exceeded the threshold). All analyses were conducted using SPSS v25 [56]. Results As the survey required a response for each item, there were no missing data. The internal reli- ability of the SIAS was found to be strong (α = .94), with the removal of any item resulting in a reduction in consistency. Social anxiety by sex, age, and country In the overall sample, the distribution of social anxiety scores formed an approximately normal distribution with a slightly positive skew, indicating that most respondents scored lower than the midpoint on the measure (Fig 1). However, more than one in three (36%) were found to score above the threshold for SAD. There were no significant differences in social anxiety scores between male and female participants (t(6768) = -1.37, n.s.) and the proportion of males and females scoring above the SAD threshold did not significantly differ either (χ2(1,6770) = .54, n.s.). Social anxiety scores significantly differed between countries (F(6,6818) = 74.85, p < .001, ηp 2 = .062). Indonesia had the lowest average scores (M = 18.94, SD = 13.21) and the US had the highest (M = 30.35, SD = 15.44). Post-hoc tests revealed significant differences (ps�.001) between each of the countries, except between Brazil and Thailand, between China and Viet- nam, between Russia and China, and between Russia and Indonesia (see Table 2). The propor- tion of individuals exceeding the threshold for SAD was also found to significantly differ between the seven countries (χ2(6,6825) = 347.57, p < .001). Like symptom severity, the US had the highest prevalence with more than half of participants surveyed exceeding the thresh- old (57.6%), while Indonesia had the lowest, with fewer than one in four (22.9%). PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 5 / 18 https://doi.org/10.1371/journal.pone.0239133 A significant age difference was also observed (F(2,6822) = 39.74, p < .001, ηp 2 = .012), where 18-24-year-olds scored significantly higher (M = 25.33, SD = 13.98) than both 16- 17-year-olds (M = 21.92, SD = 14.24) and 25-29-year-olds (M = 22.44, SD = 14.22). Also, 25- 29-year-olds scored significantly higher than 18-24-year-olds (ps < .001). The proportion of individuals scoring above the threshold for SAD also significantly differed between age groups (χ2(2,6825) = 48.62, p < .001) (Fig 2). A three-way ANOVA confirmed significant main effect differences in social anxiety scores between age groups (F(2,6728) = 38.93, p < .001, ηp 2 = .011) and countries (F(6,6728) = 45.37, p < .001, ηp 2 = .039), as well as the non-significant difference between males and females (F(1,6728) = .493, n.s.). However, of the interactions between sex, age, and country, the two- way country�age interaction was significant (F(12,6728) = 1.89, p = .031, ηp 2 = .003), where 16- 17-year-olds in Indonesia were found to have the lowest scores (M = 15.70, SD = 13.46) and 25-29-year-olds in the US had the highest (M = 30.47, SD = 16.17) (Fig 3). There was also a sig- nificant country�sex interaction (F(6,6728) = 2.25, p = .036, ηp 2 = .002), where female partici- pants in Indonesia had the lowest scores (M = 18.07, SD = 13.18) and female participants in the US had the highest (M = 30.37, SD = 15.11) (Fig 4). Fig 1. Frequency of social anxiety scores (full sample). https://doi.org/10.1371/journal.pone.0239133.g001 PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 6 / 18 https://doi.org/10.1371/journal.pone.0239133.g001 https://doi.org/10.1371/journal.pone.0239133 Work status Social anxiety scores were also found to significantly differ in terms of work status (employed/ studying/unemployed; F(2,6030) = 9.48, p < .001, ηp 2 = .003), with those in employment hav- ing the lowest scores (M = 23.28, SD = 14.32), followed by individuals who were studying (M = 23.96, SD = 13.50). Those who were unemployed had the highest scores (M = 26.27, SD = 14.54). Post-hoc tests indicated there were significant differences between those who were employed and unemployed (p < .001), between those studying and unemployed (p = .006), but not between those employed and those who were studying. The difference between those exceeding the SAD threshold between groups was also significant (χ2(2,6033) = 7.55, p = .023). Table 2. Social anxiety scores. SCORES SCORE DIFFERENCE BETWEEN GROUPS (T / F, P) PROPORTION WITH SAD (SIAS�29) (%) PROPORTION DIFFERENCE BETWEEN GROUPS (Χ2, P)M SD Overall sample 23.82 14.18 36.2 Sex -1.37, n.s. .54, n.s. Male 23.53 14.12 35.6 Female 24.00 14.18 36.5 Country 74.85, < .001 347.57, < .001 Brazil 26.18 15.23 42.4 China 22.30 13.52 32.1 Indonesia 18.94 13.21 22.9 Russia 20.78 12.79 27.0 Thailand 25.57 13.92 41.4 US 30.35 15.44 57.6 Vietnam 22.68 11.77 30.7 Age 39.74, < .001 48.62, < .001 16–17 21.92 14.24 30.8 18–24 25.33 13.98 40.3 25–29 22.44 14.22 32.8 Work 9.48, < .001 7.55, .023 Employed 23.28 14.32 35.3 Studying 23.96 13.50 36.5 Unemployed 26.27 14.54 41.7 Urban/rural 9.95, < .001 35.84, < .001 Central urban 22.70 14.67 33.0 Urban area 23.62 13.77 35.3 Suburban 25.64 14.08 42.4 Semi-rural 24.53 13.74 37.9 Rural 25.37 13.91 41.9 Education 5.51, < .001 38.75, < .001 L3 unfinished 27.94 15.07 52.0 L3 finished 23.40 14.15 34.8 M = mean, SD = standard deviation, t = t-test, F = ANOVA, χ2 = chi-square, p = significance, L3 = ISCED level 3 (secondary education), SAD = Social Anxiety Disorder. https://doi.org/10.1371/journal.pone.0239133.t002 PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 7 / 18 https://doi.org/10.1371/journal.pone.0239133.t002 https://doi.org/10.1371/journal.pone.0239133 Urban/Rural Social anxiety scores also significantly varied depending on an individual’s place of residence (F(4,6820) = 9.95, p < .001, ηp 2 = .006). However, this was not a linear relationship from urban Fig 2. Proportion of individuals meeting the threshold for Social Anxiety Disorder by age group and country. https://doi.org/10.1371/journal.pone.0239133.g002 PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 8 / 18 https://doi.org/10.1371/journal.pone.0239133.g002 https://doi.org/10.1371/journal.pone.0239133 to rural extremes (Fig 5); instead, those living in suburban areas had the highest scores (M = 25.64, SD = 14.08) and those in central urban areas had the lowest (M = 22.70, SD = 14.67). This pattern was reflected in the proportions of individuals exceeding the SAD threshold (χ2(4,6825) = 35.84, p < .001). Education level In the subsample of individuals aged 20 or above, level of education also resulted in a signifi- cant differences in social anxiety scores (t(5071) = 5.51, p < .001), with individuals who com- pleted secondary education presenting lower scores (M = 23.40, SD = 14.15) than those who had not completed secondary education (M = 27.94, SD = 15.07). Those exceeding the thresh- old for SAD also significantly differed (χ2(1,5073) = 38.75, p < .001), with half of those who had not finished secondary education exceeding the cut-off (52%), compared to just over a third of those who had (35%). Concerns by context Table 3 illustrates the items of the SIAS sorted by severity for each country. For East-Asian countries, speaking with someone in authority was a top concern, but less so for Brazil, Russia, and the US. Patterns became less discernible between countries beyond this top concern, indi- cating heterogeneity in the specific situations related to social anxiety, although individuals in most countries appeared to be least challenged by mixing with co-workers and chance encoun- ters with acquaintances. Self-perceptions of social anxiety Just over a third of the sample perceived themselves to experience social anxiety (34%). Although this was similar to the proportion of individuals who exceeded the threshold for Fig 3. Levels of social anxiety by country and age. https://doi.org/10.1371/journal.pone.0239133.g003 PLOS ONE Social anxiety in young people: A prevalence study in seven countries PLOS ONE | https://doi.org/10.1371/journal.pone.0239133 September 17, 2020 9 / 18 https://doi.org/10.1371/journal.pone.0239133.g003 https://doi.org/10.1371/journal.pone.0239133 SAD (36%), perceptions significantly differed from threshold results (χ2(1,6825) = 468.80, p < .001). Just fewer than half of the sample (48%) perceived themselves as not being socially anx- ious and were also below the threshold, and a fifth (18%) perceived themselves as being socially anxious and exceeded the threshold (Fig 6). However, 16% perceived themselves to be socially anxious yet did not exceed the threshold (false positives) and 18% perceived themselves not to be socially anxious yet exceeded the threshold (false negatives). This suggests a large propor- tion of individuals do not properly recognise their level of social anxiety (over a third of the sample), and perhaps most importantly, that more than 1 in 6 may experience SAD yet not recognise it (Table 4). Discussion This study provides an estimate of the prevalence of social anxiety among young people from seven countries around the world. We found that levels of social anxiety were significantly higher than those previously reported, including studies using the 17-item version of the SIAS [e.g., 55, 57, 58]. Furthermore, our findings show that over a third of participants met the threshold for SAD (23–58% across the different countries). This far exceeds the highest of fig- ures previously reported, such as Kessler and colleague’s [16] lifetime prevalence rate of 12% in the US. As this study specifically focuses on social anxiety in young people, it may be that the inclu- sion of older participants in other …
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Develop a community-wide intervention to reduce elevated blood pressure and hypertension in the State of Alabama that in in body of the report Conclusions References (8 References Minimum) *** Words count = 2000 words. *** In-Text Citations and References using Harvard style. *** In Task section I’ve chose (Economic issues in overseas contracting)" Electromagnetism w or quality improvement; it was just all part of good nursing care.  The goal for quality improvement is to monitor patient outcomes using statistics for comparison to standards of care for different diseases e a 1 to 2 slide Microsoft PowerPoint presentation on the different models of case management.  Include speaker notes... .....Describe three different models of case management. visual representations of information. They can include numbers SSAY ame workbook for all 3 milestones. You do not need to download a new copy for Milestones 2 or 3. When you submit Milestone 3 pages): Provide a description of an existing intervention in Canada making the appropriate buying decisions in an ethical and professional manner. Topic: Purchasing and Technology You read about blockchain ledger technology. Now do some additional research out on the Internet and share your URL with the rest of the class be aware of which features their competitors are opting to include so the product development teams can design similar or enhanced features to attract more of the market. The more unique low (The Top Health Industry Trends to Watch in 2015) to assist you with this discussion.         https://youtu.be/fRym_jyuBc0 Next year the $2.8 trillion U.S. healthcare industry will   finally begin to look and feel more like the rest of the business wo evidence-based primary care curriculum. Throughout your nurse practitioner program Vignette Understanding Gender Fluidity Providing Inclusive Quality Care Affirming Clinical Encounters Conclusion References Nurse Practitioner Knowledge Mechanics and word limit is unit as a guide only. The assessment may be re-attempted on two further occasions (maximum three attempts in total). All assessments must be resubmitted 3 days within receiving your unsatisfactory grade. You must clearly indicate “Re-su Trigonometry Article writing Other 5. June 29 After the components sending to the manufacturing house 1. In 1972 the Furman v. Georgia case resulted in a decision that would put action into motion. Furman was originally sentenced to death because of a murder he committed in Georgia but the court debated whether or not this was a violation of his 8th amend One of the first conflicts that would need to be investigated would be whether the human service professional followed the responsibility to client ethical standard.  While developing a relationship with client it is important to clarify that if danger or Ethical behavior is a critical topic in the workplace because the impact of it can make or break a business No matter which type of health care organization With a direct sale During the pandemic Computers are being used to monitor the spread of outbreaks in different areas of the world and with this record 3. Furman v. Georgia is a U.S Supreme Court case that resolves around the Eighth Amendments ban on cruel and unsual punishment in death penalty cases. The Furman v. Georgia case was based on Furman being convicted of murder in Georgia. Furman was caught i One major ethical conflict that may arise in my investigation is the Responsibility to Client in both Standard 3 and Standard 4 of the Ethical Standards for Human Service Professionals (2015).  Making sure we do not disclose information without consent ev 4. Identify two examples of real world problems that you have observed in your personal Summary & Evaluation: Reference & 188. Academic Search Ultimate Ethics We can mention at least one example of how the violation of ethical standards can be prevented. Many organizations promote ethical self-regulation by creating moral codes to help direct their business activities *DDB is used for the first three years For example The inbound logistics for William Instrument refer to purchase components from various electronic firms. During the purchase process William need to consider the quality and price of the components. In this case 4. A U.S. Supreme Court case known as Furman v. Georgia (1972) is a landmark case that involved Eighth Amendment’s ban of unusual and cruel punishment in death penalty cases (Furman v. Georgia (1972) With covid coming into place In my opinion with Not necessarily all home buyers are the same! When you choose to work with we buy ugly houses Baltimore & nationwide USA The ability to view ourselves from an unbiased perspective allows us to critically assess our personal strengths and weaknesses. This is an important step in the process of finding the right resources for our personal learning style. Ego and pride can be · By Day 1 of this week While you must form your answers to the questions below from our assigned reading material CliftonLarsonAllen LLP (2013) 5 The family dynamic is awkward at first since the most outgoing and straight forward person in the family in Linda Urien The most important benefit of my statistical analysis would be the accuracy with which I interpret the data. The greatest obstacle From a similar but larger point of view 4 In order to get the entire family to come back for another session I would suggest coming in on a day the restaurant is not open When seeking to identify a patient’s health condition After viewing the you tube videos on prayer Your paper must be at least two pages in length (not counting the title and reference pages) The word assimilate is negative to me. I believe everyone should learn about a country that they are going to live in. It doesnt mean that they have to believe that everything in America is better than where they came from. It means that they care enough Data collection Single Subject Chris is a social worker in a geriatric case management program located in a midsize Northeastern town. She has an MSW and is part of a team of case managers that likes to continuously improve on its practice. The team is currently using an I would start off with Linda on repeating her options for the child and going over what she is feeling with each option.  I would want to find out what she is afraid of.  I would avoid asking her any “why” questions because I want her to be in the here an Summarize the advantages and disadvantages of using an Internet site as means of collecting data for psychological research (Comp 2.1) 25.0\% Summarization of the advantages and disadvantages of using an Internet site as means of collecting data for psych Identify the type of research used in a chosen study Compose a 1 Optics effect relationship becomes more difficult—as the researcher cannot enact total control of another person even in an experimental environment. Social workers serve clients in highly complex real-world environments. Clients often implement recommended inte I think knowing more about you will allow you to be able to choose the right resources Be 4 pages in length soft MB-920 dumps review and documentation and high-quality listing pdf MB-920 braindumps also recommended and approved by Microsoft experts. The practical test g One thing you will need to do in college is learn how to find and use references. References support your ideas. College-level work must be supported by research. You are expected to do that for this paper. You will research Elaborate on any potential confounds or ethical concerns while participating in the psychological study 20.0\% Elaboration on any potential confounds or ethical concerns while participating in the psychological study is missing. Elaboration on any potenti 3 The first thing I would do in the family’s first session is develop a genogram of the family to get an idea of all the individuals who play a major role in Linda’s life. After establishing where each member is in relation to the family A Health in All Policies approach Note: The requirements outlined below correspond to the grading criteria in the scoring guide. At a minimum Chen Read Connecting Communities and Complexity: A Case Study in Creating the Conditions for Transformational Change Read Reflections on Cultural Humility Read A Basic Guide to ABCD Community Organizing Use the bolded black section and sub-section titles below to organize your paper. For each section Losinski forwarded the article on a priority basis to Mary Scott Losinksi wanted details on use of the ED at CGH. He asked the administrative resident