Literature Review - Psychology
Integrate and synthesize the below 6 peer-reviewed journal articles and how they relate to social anxiety. References Below/Articles attached Hajure, M., & Abdu, Z. (2020). Social Phobia and Its Impact on Quality of Life Among Regular Undergraduate Students of Mettu University, Mettu, Ethiopia. Adolescent health, medicine, and therapeutics, 11, 79–87. https://doi.org/10.2147/AHMT.S254002 Hakami, R. M., Mahfouz, M. S., Adawi, A. M., Mahha, A. J., Athathi, A. J., Daghreeri, H. H., Najmi, H. H., & Areeshi, N. A. (2018). Social anxiety disorder and its impact in undergraduate students at Jazan University, Saudi Arabia. Mental illness, 9(2), 7274. https://doi.org/10.4081/mi.2017.7274 Kampmann, I. L., Emmelkamp, P. M. G., Hartanto, D., Brinkman, W.-P., Zijlstra, B. J. H., & Morina, N. (2016). Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial. Behaviour Research & Therapy, 77, 147–156. https://doi-org.ezp.waldenulibrary.org/10.1016/j.brat.2015.12.016 Kivity, Y., Cohen, L., Weiss, M., Elizur, J., & Huppert, J. D. (2021). The role of expressive suppression and cognitive reappraisal in cognitive behavioral therapy for social anxiety disorder: A study of self-report, subjective, and electrocortical measures. Journal of Affective Disorders, 279, 334–342. https://doi-org.ezp.waldenulibrary.org/10.1016/j.jad.2020.10.021 Mesri, B., Niles, A. N., Pittig, A., LeBeau, R. T., Haik, E., & Craske, M. G. (2017). Public speaking avoidance as a treatment moderator for social anxiety disorder. Journal of behavior therapy and experimental psychiatry, 55, 66–72. https://doi.org/10.1016/j.jbtep.2016.11.010 Rosen, A. (2021). How Social Anxiety Impacts Higher Education and Career Choices - The Center for Treatment of Anxiety and Mood Disorders. Retrieved 27 August 2021, from https://centerforanxietydisorders.com/social-anxiety-impacts-higher-education-career-choices/ O R I G I N A L R E S E A R C H Social Phobia and Its Impact on Quality of Life Among Regular Undergraduate Students of Mettu University, Mettu, Ethiopia This article was published in the following Dove Press journal: Adolescent Health, Medicine and Therapeutics Mohammedamin Hajure Zakir Abdu Department of Psychiatry, Mettu University, Mettu, Oromia, Ethiopia Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/ggViE65C2Fo Background: Social anxiety disorder is a serious and disabling mental health problem that begins before or during adolescence, with the potential to significantly interfere with an individual’s daily functioning and overall quality of life. Objective: The aims of this study were to assess the prevalence, severity, and quality of life towards social anxiety disorder among students of Mettu University, Ethiopia. Subjects and Methods: A cross-sectional study was conducted among a stratified sample of 523 undergraduate students to identify the prevalence, correlates of social anxiety dis- order, and impacts on quality life. All participants completed the Social Phobia Inventory, Liebowitz Social Anxiety Scale, and World Health Organization Quality of Life-Brief Form, Turkish Version (WHOQOL-BREF-TR). Of 523 students, 26% were screened positive for social anxiety disorder. About 69.4% and 17.4% of the students had mild and moderate symptoms of social anxiety disorder, respectively. WHOQOL BREF-TR scores showed that students with social phobia had significantly lower quality of life quality than those without social phobia. Being criticized by others or fear of parties was the most commonly feared situations. Talking to strangers was the most commonly avoided situations. Being females, current tobacco use, and family history of psychiatric illness were factors significantly associated with social phobia symptoms using logistic regression analysis. Conclusion: The current study shows high prevalence of social phobia among the university students and its significant negative effects on quality of life which require prompt identi- fication and treatment. Keywords: social anxiety, university, quality of life Background Social phobia or social anxiety disorder is a serious and disabling mental health problem that begins before or during adolescence, has a chronic course, is asso- ciated with significant impairment in social functioning and work, and reduced quality of life.1 Among university, social phobia symptoms arise in a great number of students or existing symptoms increase.2 During this period, students go into the effort of having himself or herself accepted by others as a self-governing person and showing himself or herself. Performing or giving a talk in front of an audience was the most commonly feared situations and also showed an association with increased disability, and impaired quality of life.3,4 It is generally estimated that 13% of the population will meet the diagnostic criteria for lifetime social phobia with onset typically occurring in adolescence or early Correspondence: Mohammedamin Hajure Email [email protected] Adolescent Health, Medicine and Therapeutics Dovepress open access to scientific and medical research Open Access Full Text Article submit your manuscript | www.dovepress.com Adolescent Health, Medicine and Therapeutics 2020:11 79–87 79 http://doi.org/10.2147/AHMT.S254002 DovePress © 2020 Hajure and Abdu. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). http://orcid.org/0000-0002-4596-9611 http://orcid.org/0000-0001-5637-5651 http://www.dovepress.com http://www.dovepress.com https://www.facebook.com/DoveMedicalPress/ https://twitter.com/dovepress https://www.linkedin.com/company/dove-medical-press https://www.youtube.com/user/dovepress http://www.dovepress.com/permissions.php adulthood.5 However, recent studies suggest that lifetime prevalence rates may be much higher.6,7 After major depres- sion disorder and alcohol dependence, social anxiety disorder is the third most common disorder in the general population and it is also the most prevalent anxiety disorder.8 A cross-sectional study conducted in Swedish, Jordan University, Saudi Arabia (2014), and University of Parakuo students showed that about 9–16.1% of partici- pants were positive of social phobia.9–12 Research con- ducted in Nigeria shows SAD in about 9.4% which states that there will be a significant difference in the phobic health of adolescents in the selected private and public Nigerian universities.13 In Ethiopia, research conducted on prevalence of social phobia among high school students in Woldia, Gondar and Hawassa was 27.5%, 31.2%, 32.8%.14–16 Factors have shown to have an association include being the first or only child,17 medical science faculties,18,19 being female, younger age, reli- gion, marital status (unmarried), the presence psychiatric ill- ness, having a positive family history of mental disorder had a significant role for development of social phobia.16,20 Evidence showed that social phobia was associated with sub- stance use,21 low socioeconomic status, unemployment, low level of education, and social support.22 Also decreased aca- demic achievement, poor clinical exam performance,11 and impaired quality of life23 also shown to have associated with social phobia. Despite the high worldwide burden of social phobia, like shy, withdraw, unfriendly, and disinterested in social activity and limited evidence is available, particularly in developing countries. To the best of the author’s knowl- edge, no study has investigated the effects of social phobia on quality of life in Ethiopia. The present study aimed to determine the prevalence of social phobia among univer- sity students, its correlate, and impacts on quality of life. Subjects and Methods An institution based cross-sectional study conducted at Mettu University from May to April, 2019. Mettu University is one of the higher institutions in Ethiopia, which is a third Generation University. It is located at 600 km southwest of Addis Ababa. Mettu University established in 2011. Mettu University currently has two campuses. Main campus was study area containing 7 faculties. Those are faculty of health science, faculty of natural and computational science, faculty of social science and Humanity, school of law. The campus has a total of 43 departments and 8290 regular undergraduate students. This study included 8290 undergraduate students at Mettu University during the 2019–2020 academic years. Using a confidence interval of 95%, 5% margin of error, design effect of 2, the prevalence of social phobia of 19.9%16 and adding 10% non-response rate of 10%, mak- ing a final number of participants to be 523. As such, 523 students were selected as the study group. A study is part of a mega project undertaken in among regular undergraduate students of Mettu University and previously published study assessing suicidal behavior among this population were also part of the project.24 Multistage stratified sampling technique was used to select the study participants. Stratification was first done on the faculty/college level, then by department and by the year of study. Finally, taking students from registration as a sampling frame a random selection was done. All regular undergraduate students aged 18yrs old and above were included, while critically ill students were excluded. A self-administered structured questionnaire was used to collect information. Questionnaires about demographic, family and campus related and clinical factors were devel- oped after an extensive review of literatures and similar study tools. Rating instruments included the Social Phobia Inventory to detect Social Phobia, the Liebowitz Social Anxiety Scale to measure the severity of Social Phobia and the WHO Quality of Life – BREF questionnaire to assess Quality of Life. The questionnaire was translated to Amharic and Afaan Oromo language, and then retranslated back to English so as to see and keep the consistency. Pretest was done on 26 students in Bedele agricultural campus whose completed the questionnaires beforehand and the questions were evaluated and re-arranged accord- ingly before actual data collection. Ethical clearance was obtained from the ethical review board of Mettu University and permission was obtained from the concerned body. Rating Instruments Social Phobia Inventory (SPIN, a 17-item self-rating scale developed to measure social phobia). It shows the symp- tom domains of social phobia (fear, avoidance, and phy- siological arousal) and has reliable and valid psychometric properties in screening social phobia in adolescents and other populations. The Cronbach’s α in this study was 0.87. Subjects are asked to rate symptoms occurrences as 0 (not at all), 1 (a little bit), 2 (somewhat), 3 (very much), or 4 (extremely during the past week) and the sum score ranged from 0 to 68. A student with a score of 20 and Hajure and Abdu Dovepress submit your manuscript | www.dovepress.com DovePress Adolescent Health, Medicine and Therapeutics 2020:1180 http://www.dovepress.com http://www.dovepress.com above on SPIN will be considered as having social phobia.25 Liebowitz Social Anxiety Scale is a self-rating scale used to rate fear/anxiety and avoidance regarding com- monly feared performance or social situations. The scale includes 24 items and 2 subscales. The first subscale has 11 items and investigates social relationships. The second subscale has 13 items and investigates performance. The 4-point Likert-type scale measures the intensity of fear and avoidance behaviour during the previous week. It has a good internal consistency and evaluates the severity of fear and avoidance in common social situations. A score of <55 suggests mild social anxiety disorder, 55–64 suggests the moderate social anxiety disorder, 65–79 suggests marked social anxiety disorder, 80–94 suggests severe social anxiety disorder, and >95 suggests very severe social anxiety disorder. It is validated in and reliable for measuring the severity of social phobia26. The Cronbach’s α in this study was 0.98. World Health Organization Quality of Life Scale – Brief version (WHOQOL – BREF) which is a 26-item self- administered generic questionnaire. It produces a profile with four domain scores: physical health (7 items), psy- chological health (6 items), social relationships (3 items), environmental domain (8 items) as well as two separately scored items about the individuals‟ perception of their quality of life (QI) and health (Q2). Each item was scored in a Likert format from 1 (very dissatisfied) to 5 (very satisfied) in a positive direction, which means that higher scores indicate a higher quality of life. The scores of ques- tions 3, 4 and 26 are reversed, so as to transform these negatively framed questions to positively frame. The Turkish version of the form had an internal validity score of 0.83 (Cronbach’s alpha) in physical terms, 0.66 in men- tal terms, 0.53 in social terms, and 0.73 in both environ- mental and environment-national terms27. The Cronbach’s α in this study was 0.82 Statistical Analysis The data were analyzed using SPSS version 21. Descriptive (frequency and percentage) and inferential statistics (chi square test was used for categorical variables, and ANOVA (analysis of variance) were used to compare groups in terms of SPIN and LSAS scores). An independent samples t-test was used to analyze the difference between the two groups (students with/without social anxiety disorder). Logistical regression analysis was used to evaluate the significance of the relationship between two dependent and independent variables. The Pearson cor- relation coefficient was used for correlation analysis. Result Socio-Demographic Characteristics of the Study Participants A total of 523 participants were recruited for the study, which makes the response rate 100%. The results show that 270 (51.6%) of respondents were males and 253 (48.6%) were females. The mean age of students was 22.07 (SD = 2.36), with ages ranging from 18 to 32 years and the majority of them (61.0%) were at the age of 22 years or below. The sample consisted of different faculties with the highest number of engineering faculty (110, 21.0%) and the lowest number from Institute of education (42, 8.0%) which was proportionally recruited from each stratum. Also the study has revealed that 351 (67.1%) of the participants had one of two siblings and most perceived that their family income as bad (58.9%). The majority of the participants 319 (61.0%) were from rural backgrounds and first-year students comprises the majority of participants (222, 42.4%) (Table 1). Social Phobia The regarding students’ reports of their social phobia symptoms, the analysis (Table 2) showed that the mean score for students in general was 13.08 (SD = 9.24), with scores ranging from 0 to 43. About, 70% (n = 361) had a score of 16 or less. Further analysis using LSAS score, for the levels of social anxiety symptoms showed that the majority of uni- versity students had mild symptoms, 69.4% (n = 363) followed by moderate symptoms 91 (17.4%), and those with marked to severe represented about 13.2% (n = 69). The Cronbach’s alpha for LSAS scale obtained in this sample was 0.976. As shown in Table 2, 25.8% of the subjects had a SPIN score of 19 (Connor et al, 2000), and more which accounted for about one-fourth of participants, ie, There was a statistically significant difference in the prevalence of SAD regarding the age category, birth order, faculties, family history of mental illness. Being a younger age18–20 group was associated with higher prevalence of SAD (26.7%) and being in the age group of 21–23years was associated with lower prevalence of SAD (9.6%) (X2= 0.24, P<0.05). There is a higher prevalence of SAD among students in Engineering Dovepress Hajure and Abdu Adolescent Health, Medicine and Therapeutics 2020:11 submit your manuscript | www.dovepress.com DovePress 81 http://www.dovepress.com http://www.dovepress.com faculties, while lower prevalence is seen in the faculty of social science and humanities (X2=0.163, P<0.05). The results of the present study show that significantly more of the students without social phobia have a family history of psychiatric illness than those with social phobia. Table 1 The Basic Sociodemographic, Clinical and Substance Use Characteristics of the Participants (n= 523) Variables Categories Frequency Percentage Sex Male 270 51.6 Female 253 48.6 Age 18–20 148 28.3 21–23 87 16.6 24–26 149 28.5 ≥27 139 26.6 Ethnicity Oromo 321 61.4 Amhara 117 22.4 Gurage 41 7.8 Tigre 25 4.8 Others* 19 3.6 Faculty Engineering 110 21.0 Health sciences 97 18.5 Social science and humanities 85 16.3 Natural and computational 89 17.0 Business and economics 52 9.9 School of Law 48 9.2 Institute of education 42 8.0 Residence before campus Urban 204 39.0 Rural 319 61.0 Birth order Frist or only child 123 23.5 Middle 320 61.2 Last 80 15.3 Year of study First 130 24.9 Second 133 25.4 Third 107 20.5 Fourth 77 14.7 Fifth 76 14.5 Alcohol use Yes 299 57.4 No 127 42.5 Cigarette use Yes 78 14.9 No 53 67.9 Khat use Yes 98 18.3 No 67 68.4 Note: *Wolayta, Dawuro, Kefa, Sidama, Gurage, Silte. Table 2 Comparing Social Phobia with Demographic and Clinical Variables Variables Categories Frequency Percentage Sex Male 270 51.6 Female 253 48.6 Age 18–20 148 28.3 21–23 87 16.6 24–26 149 28.5 ≥27 139 26.6 Ethnicity Oromo 321 61.4 Amhara 117 22.4 Gurage 41 7.8 Tigre 25 4.8 Others* 19 3.6 Faculty Engineering 110 21.0 Health sciences 97 18.5 Social science and humanities 85 16.3 Natural and computational 89 17.0 Business and economics 52 9.9 School of Law 48 9.2 Institute of education 42 8.0 Residence before campus Urban 204 39.0 Rural 319 61.0 No. of siblings Mean ±SD (1.98±1.16) Birth order Frist or only child 123 23.5 Middle 320 61.2 Last 80 15.3 Fathers education No formal education 50 9.6 Primary school 217 41.5 Secondary school 137 26.2 Above secondary 119 22.8 Mothers’ education No formal education 62 11.9 Primary school 187 35.8 Secondary school 235 44.9 Above secondary 39 7.5 Perceived family monthly income Bad 308 58.9 Moderate 127 24.3 (Continued) Hajure and Abdu Dovepress submit your manuscript | www.dovepress.com DovePress Adolescent Health, Medicine and Therapeutics 2020:1182 http://www.dovepress.com http://www.dovepress.com However, with respect to gender, ethnicity, year of study, family educational status, perceived family income, and residency, there was no statistically significant difference in the prevalence of SAD (all P values >0.05). Using logistical regression analysis, three independent variables that were significantly shown to have association in the final model. The risk of social phobia was 1. Ninety- five-fold higher among female students than male students, 1. Eighty-four-fold higher among those with a family history of psychiatric illness than those without, and 2. Ninety-five-fold higher among students who smoked cigarettes in the past 3months compared to those who did not (Table 3). Using item analysis to examine the items that had the highest and lowest scores (Table 4), the analysis showed that the mean items ranged from 0.56 (SD = 0.81) (item 13: Heart palpitations bother me when I am around peo- ple) to 0.99 (SD = 1.07) (item 2: I am bothered by blush- ing in front of people). The highest three items in addition to item 2 were item 10 (M = 0.96, SD = 1.10: Talking to strangers scares me) and item 7 (M = 0.85, SD = 1.009: Sweating in front of people causes me distress). This also goes for the highest three items that students reported being very much to extremely experiencing social phobia symptoms over the past week as items 2, 10, and 7 had the highest percentage among all other items. Table 2 (Continued). Variables Categories Frequency Percentage Good 88 16.8 Year of study First 130 24.9 Second 133 25.4 Third 107 20.5 Fourth 77 14.7 Fifth 76 14.5 Alcohol use Yes 299 57.4 No 127 42.5 Cigarette use Yes 78 14.9 No 53 67.9 Khat use Yes 98 18.3 No 67 68.4 Note: *Wolayta, Dawuro, Kefa, Sidama, Gurage, Silte. Table 3 Logistical Regression Analysis Showing Factors Associated with Social Phobia Among Students in Mettu Health Science Students, Mettu, Ethiopia, 2019 (n=523) Variables Category COR (95% CI) AOR (95% CI) Sex Male ® Female 1.78 (1.20–2.64) 2.04 (1.26–3.28)* Previous history of chronic physical illness No ® Yes 1.83 (1.02–3.30) 1.84 (1.01–3.35)* Current tobacco use No ® Yes 1.27 (.74–2.2) 2.95 (1.36–6.40)** Lifetime khat use No ® Yes 1.99 (1.00–3.99) 1.52 (0.68–3.37) Residence Urban ® Rural 4.52 (2.69–7.7) 1.24 (.494–3.12) Notes: *P value < 0.05, **P value < 0.01, VIF 1.06–2.10. Hosmer–Lemeshow - goodness of fit test corresponding, P value = 0.77, Reference = ® . Abbreviations: COR, crude odds ratio; AOR, adjusted odds ratio. Table 4 Item Analysis of SPIN Among University Student in Mettu (n= 523) Item Mean SD 1 I am afraid of people in authority. 0.68 0.976 2 I am bothered by blushing in front of people. 0.99 1.073 3 Parties and social events scare me. 0.82 0.957 4 I avoid talking to people I do not know. 0.75 0.961 5 Being criticized scares me a lot. 0.85 0.959 6 Fear of embarrassment causes me to avoid doing things or speaking to people. 0.80 0.921 7 Sweating in front of people causes me distress. 0.85 1.009 8 I avoid going to parties. 0.79 0.892 9 I avoid activities in which I am the center of attention. 0.79 0.993 10 Talking to strangers scares me. 0.96 1.109 11 I avoid having to give speeches. 0.83 0.990 12 I would do anything to avoid being criticized. 0.65 0.925 13 Heart palpitations bother me when I am around people. 0.56 0.811 14 I am afraid of doing things when people might be Watching. 0.59 0.885 15 Being embarrassed or looking stupid is my worst fears. 0.67 0.931 16 I avoid speaking to anyone in authority. 0.72 0.888 17 Trembling or shaking in front of others is distressing to me. 0.78 0.955 Notes: Copyright ©, Jonathan Davidson. 1995, 2008, 2015. All rights reserved. Permission to use the SPIN must be obtained from the copyright holder at [email protected] The SPIN may not be reproduced or transmitted in any form, or by any means, electronic or mechanical, or by any information storage or retrieval system without permission in writing from the copyright holder. Dovepress Hajure and Abdu Adolescent Health, Medicine and Therapeutics 2020:11 submit your manuscript | www.dovepress.com DovePress 83 http://www.dovepress.com http://www.dovepress.com The highest mean item scores varied among the two subscales (more among physiological discomfort) and also, two of lowest mean item scores (item 1,14) belong to fear of the social situation subscale. The results do not strictly support the mean scores of the subscales mentioned above in Table 2 that physiological discomfort in social situation was the lowest reported subscale among the three subscales. The Cronbach’s alpha for SPIN scale obtained in this study sample was 0.869. Generally, about one-fourth of the stu- dents showed positive symptoms of social phobia (score of >19) and the majority of them present with mild category. Quality of Life of Students with and Without Social Phobia Study participants’ quality of life was assessed by the world health organization quality of life brief version scale (WHOQOL-BREF) and the mean total quality of life score was found to be (70.87+16.22). The highest QOL domain of the students with social phobia in the current study was environmental health domain mean score of (23.55 ± 3.46), followed by physical health domain mean score of (22.34±3.76), psychological health domain mean score of (17.67±2.62) and social relation- ships domain mean score of (6.87±2.27). The WHOQOL- BREF scale demonstrated a high internal consistency reliability coefficient (Cronbach’s alpha=0.821). WHOQOL-BREF-TR scores showed that students with- out social phobia had significantly higher quality of life scores in all areas than the students with social phobia (Table 5). Correlating SPIN and LSAS with QOL Scores As seen in Table 6. Regarding correlation of LSAS scores to QOL scores, they were negatively correlated with respect to physical health, psychological health, social relationship and environment, although not significant in majority of the domains, except the psychological domain. Again, SPIN scores were also negatively correlated with QOL scores in all areas. Thus, social phobia was associated with reported deterioration in physical, psycho- logical health, social relationship and environmental func- tioning. SPIN and LSAS scores were found to be more strongly correlated with psychological domain scores and SPIN score were more strongly correlated with physical health domain compared to other domain (Table 6). Discussion This study aims on the prevalence of social phobia and its impact on quality of life among university students in Mettu, South western, Ethiopia. The prevalence of social phobia varies widely among different countries. In this study, social phobia was found in 26% of subjects, much more than other studies among undergraduate university students in different settings.18,28-31 Regarding the severity of social phobia, using LSAS score, the majority of the students have mild forms of social anxiety disorder. In other words, levels of social anxiety symptoms show about 17.4% of them had moderate symptoms, which is in line with the study undertaken at the University of Jordan (6.8%). However, the finding was lower than study done in Woldia, Ethiopia (27.5%),15 Saudi Arabia, Table 5 Mean Distribution of QOL of Students with and Without Social Phobia at Mettu University, 2019 Areas Students with Social Phobia (χ ± SD) Students Without Social Phobia (χ ± SD) Analysis* T P Physical 22.34±3.76 21.55±4.49 −1.821 < 0.01 Psychological 17.67±2.62 16.03±4.03 −4.42 < 0.001 Social 6.87±2.27 5.59±2.93 −4.59 < 0.001 Environmental 23.55±3.46 22.01±5.02 −3.32 < 0.001 Notes: ANOVA, χ ± SD (arithmetic mean ± standard deviation). *For all analyses the degree of freedom was 522. Abbreviation: QOL, quality of life. Table 6 Correlating SPIN and LSAS with QOL Scores Instrument Domain of Quality of Life Physical Health Psychological Health Social Relationship Environmental LSAS score R −0.010 −0.168 −0.019 −0.053 P value 0.820 0.000 0.662 0.227 SPIN score r −0.199 −0.102 −0.082 −0.013 P value 0.000 0.020 0.062 0.768 Note: r = Pearson correlation coefficient. Abbreviations: SPIN, Social Phobia Inventory; LSAS, Liebowitz Social Anxiety Scale; QOL, quality of life. Hajure and Abdu Dovepress submit your manuscript | www.dovepress.com DovePress Adolescent Health, Medicine and Therapeutics 2020:1184 http://www.dovepress.com http://www.dovepress.com Riyadh (24.3%).32 Different studies have shown an asso- ciation of social phobia with gender. The results of the current study, which showed higher social phobia scores of female students compared to their counterparts. This was in line with the international report of different countries such as India,11 Turkey,33 German.3 However, in one study social phobia prevalence is found to be higher in men in studies of prevalence conducted with clinical samples.34 The current study shows an association of cigarette smoking and social anxiety disorder. This finding was in agreement with international report such as in the USA35 and Turkey.36 The reason behind might be related to smoking, which used for its reinforcing effect, by socially anxious people to elevated negative affect especially for social interaction.37 In contrast to studies done in Australia18 and Swedish,9 SAD was more prevalent among students of engineering faculties than students of social science and humanities faculties. It may be related to the consequences of social anxiety on academic performance during pre-engineering years and career choices made thereafter, in addition to a larger quota of students in the school, as this stage greatly matters their life on the campus, particularly. Considering birth order, SAD was more prevalent among first or only child than being middle or last child. Which was in agreement with study done in Egypt (birth order).17 It was hypothesized that the first-born child will have a higher level of social anxiety than a non-first born child.38 In terms of age, the current study shows significant association, with higher prevalence of SAD among stu- dents in the age group of 18–20 years as compared to older age groups. The finding was in accordance with many of the prior studies, shown an early onset of social anxiety symptoms.20 Family history of psychiatric illness was found to have significant association with SAD. This could be explained by studies showed association of social phobia and genetic inheritability, although the underlying mechanisms remain unclear.39 The most commonly reported feared social situations in the target sample were being criticized by others or fear of parties and social events, followed by doing things or speak- ing to people and the most commonly avoided situations were talking to strangers followed by being a center of attention. These findings were consistent with result of earlier studies.4 This is because college years are a critical period to socialize themselves, particularly via social interaction. Again their expectation matter the way they interact, they may avoid such interaction because of negative evaluation. The Effects of Social Phobia on Quality of Life To the best of the author’s knowledge, the present study is the first to investigate the direct relationship between social phobia and its impact on quality of life among university students in Ethiopia. In the present study students with social phobia had lower scores on all areas of life quality, including physical and psychological health, social relationships, and the environment than those without social phobia. Results of an epidemiological study from report that students with social phobia have reduced quality of life in all domains as … [page 42] [Mental Illness 2017; 9:7274] Social anxiety disorder and its impact in undergraduate stu- dents at Jazan University, Saudi Arabia Ramzi M. Hakami,1 Mohamed S. Mahfouz,2 Abdulrahman M. Adawi,1 Adeebah J. Mahha,1 Alaa J. Athathi,1 Hadi H. Daghreeri,1 Hatim H. Najmi,1 Nuha A. Areeshi1 1Faculty of Medicine, Jazan University, Jazan; 2Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia Abstract Although social anxiety disorder (SAD) is a common mental disorder, it is often under diagnosed and under treated. The aim of this study is to assess the preva- lence, severity, disability, and quality of life towards SAD among students of Jazan University, Saudi Arabia. A cross-sectional study was conducted among a stratified sample of 500 undergraduate students to identify the prevalence of SAD, its corre- lates, related disability, and its impact on the quality life. All participants completed the Social Phobia Inventory, Leibowitz Social Anxiety Scale, Sheehan Disability Scale, and the WHO Quality of Life – BREF ques- tionnaire. Of 476 students, 25.8% were screened positive for SAD. About 47.2% of the students had mild symptoms, 42.3% had moderate to marked symptoms, and 10.5% had severe to very severe symptoms of SAD. Students who resulted positive for SAD reported significant disabilities in work, social, and family areas, and this has adversely affected their quality of life as compared to those who screened negative for SAD. Students reported several clinical manifestations that affected their function- ing and social life. Acting, performing or giving a talk in front of an audience was the most commonly feared situation. Blushing in front of people was the most commonly avoided situation. Since the present study showed a marked prevalence of SAD among students, increased disability, and impaired quality of life, rigorous efforts are needed for early recognition and treatment of SAD. Introduction While most of us experience some level of social unease when we feel scrutinized by others, such as while speaking in public or presenting at meetings, social anxiety disorder (SAD) is defined as an excessive and persistent fear of acting in a way that will be embarrassing and humiliating. This fear is almost invariably provoked by the feared situations, which are avoided or endured with severe distress, and interferes significantly with personal, occupational, and social functioning.1 Social anxiety disorder commonly appears in the teenage years,2 and usually affects 3 to 5% of youths.3 It is an extraor- dinarily persistent condition if left untreated and it may lead to a variety of comorbidi- ties, such as other anxiety disorders, affec- tive disorders, nicotine dependence, and substance-use disorder,4-6 predicting poorer treatment outcomes.7 Most of patients with SAD have been reported to have at least moderate impairment at some point in their lives. Education, employment, family, romantic relationships, friendships, social networks, quality of life, and other areas of life have been reported to be liable to impairment in patients with SAD.8-12 Unfortunately, although it is the third most common mental disorder in adults world- wide,13 SAD is often under diagnosed and undertreated.14 Furthermore, it has received little attention by both clinicians and researchers.8 In general, there is a lack of data on the prevalence of SAD and the reported rates vary widely between studies, with much of the variability possibly being due to differ- ent instruments used to determine diagno- sis.10 However, SAD is obviously one of the most common of all anxiety disorders.10 For instance, Kesseler and colleagues (2005) interviewed 9282 English-speaking partici- pants aged 18 years and older and found that SAD was the most common anxiety disorder, with a lifetime prevalence of up to 12%15 and a 12-month prevalence of 6.8%.16 Studies looking at country-specific pop- ulations of university students have pro- duced quite variable results when it comes to the prevalence of SAD. Many studies have indicated that social anxiety is a preva- lent disorder among university stu- dents.11,12,17-20 For example, studies from Sweden and India have reported the preva- lence of SAD among university students to be 16.1% and 19.5%, respectively.11,12 In the Kingdome of Saudi Arabia, less is known about SAD in general and among undergraduate students. However, high prevalence rates have been reported among Saudis, especially adolescents and young adults.21-25 Elhadad and colleagues (2017) have carried out a study on 380 medical stu- dents and found that as high as 59.5% of them were screened positive for SAD. In the same study, SAD was associated with decreased academic achievement, weak clinical exam performance, and avoidance of oral presentation.22 The present study aims to investigate SAD prevalence, severity, related disabili- ties, and its impact in students from five faculties at Jazan University, Saudi Arabia. We expect that this study would be helpful in bridging the gap in the local research of SAD, and will be useful to the future studies attempting to reduce the high prevalence of this disorder and to prevent its long-term consequences. Materials and Methods Study place, design and participants Jazan University is situated in Jazan region, southwest of the kingdom of Saudi Arabia. It is the leading higher educational institution in Jazan province. This is an Mental Illness 2017; volume 9:7274 Correspondence: Ramzi Mohammed Hakami, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia. E-mail: [email protected] Key words: Mental disorder; social phobia; social anxiety disorder; Saudi Arabia; Social Phobia Inventory. Acknowledgements: the authors thank Dr. Rashad Alsanosy (Substance Abuse Research Center (SARC), Jazan University and the Department of Family and Community Medicine) for his assistance with the research project. Contributions: the authors contributed equally. Conflict of interest: the authors declare no potential conflict of interest. Received for publication: 20 June 2017. Revision received: 7 August 2017. Accepted for publication: 8 August 2017. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). ©Copyright R.M.Hakami et al., 2017 Licensee PAGEPress, Italy Mental Illness 2017; 9:7274 doi:10.4081/mi.2017.7274 [Mental Illness 2017; 9:7274] [page 43] observational cross-sectional survey target- ing Jazan University students who are over 18 years and registered for the academic year 2016/2017. The target colleges were Applied Medical Sciences, Pharmacy, Sciences, Computer sciences and Business administration. Sample size and sample design A sample of 400 participants was esti- mated for the purpose of this study. The sample size was calculated using the formu- la for a cross-sectional study, n=[(z2 * p * q)]/d2. Sample size was calculated using the following parameters: p=prevalence of Knowledge 50%, Z=95% confidence inter- val, d=error ≤5%, and a 25% non-response rate. Probability proportional to size sam- pling (PPS) was used to adjust the number of students in each faculty. Data collection The structured questionnaire was writ- ten in Arabic and distributed by six medical students to the study population. After explaining the purpose of the study and obtaining verbal consents, data collectors waited somewhere near for the completion of the questionnaire to give the respondents the opportunity to ask clarifying questions regarding the interpretation of terms or items in the questionnaire. All respondents were asked to fill out the survey separately to make sure that they do not duplicate each other’s answers. The data collection process took place in the period from November 2016 to January 2017. Instruments The questionnaire consisted of demo- graphic information such as age, sex, facul- ty type, family size, birth order, perceived family income, marital status, and housing type. Rating instruments included the Social Phobia Inventory (SPIN) to detect social anxiety disorder, the Leibowitz Social Anxiety Scale (LSAS) to evaluate social anxiety disorder severity, the Sheehan Disability Scale (SDS) to assess disability due to social anxiety disorder, and the WHO Quality of Life – BREF questionnaire to assess the quality of life. All study tools were translated to simple Arabic by the study authors. The questionnaire took about 15 to 20 minutes to complete. Social Phobia Inventory The SPIN is a short, self-rating scale developed by Dr. K.M. Connor to capture the social phobia symptoms.26 It consists of 17 items and each item is rated from 0 (not at all) to 4 (extremely). The scale ranges from 0-68. A score ≥19 suggests social anx- iety disorder. It has good test-retest reliabil- ity, internal consistency, convergent and divergent validity and can be used for screening of and detecting treatment response to social anxiety disorder. Regarding diagnosis of social anxiety disor- der, it has a sensitivity of 73-85% and a specificity of 69-84%. Although Shah and Kataria12 used a cut-off point of 19 on this scale in a similar study, Dogaheh27 reported that the cut-off point of 29 resulted in bal- anced sensitivity (0.96) and 1-specificity (0.87), and it was more appropriate for this study (a cut-off point of 19 resulted in an oddly very high prevalence). Liebowitz Social Anxiety Scale The LSAS is self-rating scale developed by Dr. Michael Liebowitz to rate fear/anxi- ety and avoidance regarding 24 commonly feared performance or social situations.28 It consists of 13 performance-related items and 11 social-related items which are rated from 0 (none/never) to 3 (severe/usually). It has a good internal consistency and evalu- ates the severity of fear and avoidance in common social situations. A score of <55 suggests mild social anxiety disorder, 55-64 suggests moderate social anxiety disorder, 65-79 suggests marked social anxiety disor- der, 80-94 suggests severe social anxiety disorder, and >95 suggests very severe social anxiety disorder. Sheehan Disability Scale The SDS is a simple and commonly used scale developed by David V. Sheehan29 to evaluate functional impair- ments/disabilities in the domains of work, social life/leisure and family life/home responsibility due to an anxiety disorder. Each domain is rated on an 11-point, where 0=no impairment, 10=most severe, 1- 3=mild, 4-6=moderate, and 7-9=marked. WHO Quality of Life – Bref The WHOQOL-BREF is an abbreviated version of the WHOQOL-100 developed by the WHOQOL Group30 to assess the quality of life in multiple dimensions, and it is applicable cross-culturally. It consists of 26 items based on a four-domain structure: Physical health (7 items), Psychological health (6 items), Social relationships (3 items) and Environment (8 items), along with a self-rating of general quality of life Article Table 1. Socio-demographic characteristics of participants. Characteristics Male, n (%) Female, n (%) Total, n (%) N=243 N=233 N=476 Age in years* 19 – 21 78 (32.1) 161 (70.9) 239 (50.8) 22 – 24 152 (62.6) 64 (28.2) 216 (45.9) 25 – 27 13 (5.3) 2 (0.9) 15 (3.2) College Applied Medical Sciences 44 (18.1) 41 (17.6) 85 (17.9) Pharmacy 14 (5.8) 5 (2.1) 19 (4.0) Business Administration 70 (28.8) 86 (36.9) 156 (32.7) Computer Sciences 59 (24.3) 39 (16.7) 98 (20.6) Sciences 56 (23) 62 (26.6) 118 (24.8) Marital status* Single 232 (95.9) 192 (83.8) 424 (90.0) Married 8 (3.3) 31 (13.5) 39 (8.3) Divorced 2 (0.8) 6 (2.6) 8 (1.7) Family size* <6 42 (17.3) 33 (14.4) 75 (15.9) 06-10 135 (55.6) 162 (70.7) 297 (62.9) >10 66 (27.2) 34 (14.8) 100 (21.2) Birth order* First or only child 46 (18.9) 47 (20.5) 93 (19.2) In the middle 159 (65.4) 144 (62.9) 303 (64.1) Last baby 38 (15.6) 38 (16.6) 76 (16.1) Perceived family income (SR/month)* Very good 49 (20.3) 38 (17.4) 87 (19.0) Good 117 (48.5) 98 (45.0) 215 (46.8) Bad 75 (31.1) 82 (37.6) 157 (34.2) Housing type* Owning housing 191 (78.9) 207 (90.0) 398 (84.3) Rent housing 51 (21.1) 23 (10.0) 74 (15.7) *Because of missing responses, the total percentages do not add up to 100%. (1 item) and general satisfaction with health (1 item). It is self-administered and each item is scaled from 1-5 in a positive direc- tion, which means that higher scores indi- cate a higher quality of life. Each domain score (mean score of items within that domain) is converted to a scale of 0-100 and indicates an individual’s perception of qual- ity of life in that domain. In the absence of clear cut-off point for such study, a cut-off point of 88.22 (70% of the total scores) was used as suggested by Al-Fayez and Ohaeri31 and Xia et al.32 Statistical analysis The data was analysed using SPSS ver- sion 20. Descriptive (frequency and per- centage) and inferential statistics (chi- square test) were used to interpret the data. An independent samples t-test was used to analyse the difference between the two groups (students with/without social anxi- ety disorder). Pearson correlation coeffi- cient was used for correlation analysis. Ethical consideration All participants were informed of their rights to participate and that their informa- tion would be kept anonymous and only used for the purpose of this study. Ethical approval was obtained from the University Ethical Committee. Results Of 500 questionnaires, students com- pleted 476 questionnaires giving a response rate of 95.2%. Table 1 details the sociode- mographic distribution of the study popula- tion. The results show that 243 (51.1%) of respondents were males and 233 (48.9%) were females. The respondents’ age ranged from 19 to 27 years. The mean, median, and mode of students’ age were 21.49, 21, and 22 years, respectively (SD=1.57), which indicates a fairly even distribution of partic- ipants’ ages. The sample consisted of differ- ent faculties with the highest number from Business administration (156, 32.7%) and the lowest number from Pharmacy (19, 4.0%). Most of the respondents (90%) were single (N=424), 8.3% were married (N=39), and 1.7% were divorced (N=8). Those who lived in families consisted of 6-10 members comprised the majority of the study popula- tion (62.9%). Regarding birth order, a high frequency of respondents (303, 64.1%) reported that they were in the middle of their families. Most of the study population perceived their family income as very good (19.0%) and good (46.8%), and lived in their own household (84.3%). Using a cut-off score of 29, participants were screened positive for social anxiety disorder if they scored 29 or higher on the SPIN scale. Table 2 shows that 123 (25.8%) students were screened positive for SAD, 71 of them (51.1%) were males and 52 were females (42.3%). There was a statistically significant difference in the prevalence of SAD regarding the birth order. Being a first- born child (or the only child) was associated with least prevalence of SAD (15.6%) and being a middle born child was associated with higher prevalence of SAD (61.5%) (X2=6.407, P<0.05). However, with respect to gender, faculty type, family size, per- ceived family income, and housing type, there was no statistically significant differ- ence in the prevalence of SAD (all P values >0.05). In addition, as the range of age groups was narrow, (i.e. most of students were young adults, who are the target popu- lation of this study) and as most of the stu- dents were single, these two parameters (age and marital status) were not signifi- cantly associated (P=0.777 and P=0.511, respectively) with the prevalence of SAD. The Cronbach’s alpha for SPIN scale obtained in this study sample was 0.85. Using the LSAS scale to detect the severity of SAD, 47.2% (N=58) had mild symptoms, 42.3%, (N=52) had moderate to marked symptoms, and 10.5% (N=13) had severe to very severe symptoms. As shown in Table 3, the descending ranking of com- monly feared/avoided situations (LSAS scale) was obtained. The most commonly feared situations reported by students were acting, performing or giving a talk in front of an audience (75.0%, N=357), followed by taking a test (74.0%, N=352). The most commonly avoided situations reported by students were blushing in front of people (79.4%, N=377), followed by having to give speeches (76.7%, N=365). The majority of students (76.5%, N=364) reported that being embarrassed or looking stupid is among their worst fears. The Cronbach’s alpha for LSAS scale obtained in this sam- ple was (0.87) and (0.85) for the fear/anxi- ety and avoidance domains, respectively. An independent samples t-test was employed to compare between students with SAD and students without SAD in their scores on the SDS and QOL scales. As Table 4 shows, the difference between the two groups was statistically significant. Students who screened positive for SAD reported significantly more disabilities in the work (t(474)=6.596, P<0.01), social life (t(473)=6.941, P<0.01), and home areas Article Table 2. Comparing social phobia with demographic variables of the participants. Demographic variables SPIN score <29 SPIN score ≥29 X2 P value n (%) n (%) Study population 353 (74.2) 123 (25.8) Gender 2.956 0.090 Male 172 (48.7) 71 (57.7) Female 181 (51.3) 52 (42.3) Age* 0.504 0.777 19 – 21 179 (51.1) 60 (50.0) 22 – 24 161 (46.0) 55 (45.8) 25 – 27 10 (2.9) 5 (4.2) Faculty type 0.225 0.705 Health faculties 79 (22.4) 25 (20.3) Others 274 (77.6) 98 (79.7) Family size* 0.611 0.737 <6 53 (15.1) 22 (18.0) 06-10 223 (63.7) 74 (60.7) >10 74 (21.1) 26 (21.3) Birth order 6.407 0.041 First or only child 74 (21.1) 19 (15.6) In the middle 228 (65.1) 75 (61.5) Last baby 48 (13.9) 28 (23.0) Perceived family income (SR/month)* 0.480 0.787 Very good 31 (9.2) 10 (8.3) Good 104 (30.8) 34 (28.1) Bad 203 (60.1) 77 (63.6) Housing type* 1.985 0.192 Owning housing 300 (85.7) 98 (80.3) Rent housing 50 (14.3) 24 (19.7) SPIN, Social Phobia Inventory. *Because of missing responses, total percentages do not add up to 100%. [page 44] [Mental Illness 2017; 9:7274] [Mental Illness 2017; 9:7274] [page 45] (t(474)=4.375, P<0.01). As well, students who screened positive for SAD reported significantly worse quality of life, that is, they scored lower than students who screened negative for SAD on the physical health domain (t(473)=4.220, P<0.01), psy- chological health domain (t(459)=3.970, P<0.01), social relationship domain (t(472)=1.999, P<0.05), and environment domain (t(474)=2.297, P<0.05). The Cronbach’s alpha for SDS scale obtained in this sample was (0.74), and for QOL scale, the Cronbach’s alpha for the respective domains were 0.64 (physical health), 0.64 (psychological health), 0.55 (social rela- tionships), and 0.72 (environment). As shown in Table 5, both SPIN and LSAS scores were positively correlated with SDS scores. Thus, SAD and its severi- ty were significantly associated with report- ed disabilities in the areas of work, social life, and home life. In contrast, both SPIN and LSAS scores were negatively correlat- ed with QOL score. This means that SAD and its severity were significantly associat- ed with deterioration in all domains of qual- ity of life. In general, these results suggest that students who screened positive for SAD suffered more than students who screened negative from deteriorated func- tioning and quality of life. Discussion The main purpose of the present study was to investigate SAD prevalence, severi- ty, related disabilities, and its impact in undergraduate students at Jazan University. SAD symptoms may overlap with other dis- eases making it challenging to recognize and separate SAD from shyness or poor social skills. Many studies of SAD from dif- ferent countries and cultures reported wide- ly varied estimates of the prevalence rang- ing from 1.9% and 20.4% among the gener- al population and depending on the diag- nostic threshold.33 In the present study, SAD was as high as 25.8% among the study population, much higher than many other studies among undergraduate stu- dents.11,12,17,18,34 However, as SPIN, the screening scale used in this study, has a specificity of 0.84-0.94 and the analysis using LSAS shows that 47.2% of those with SAD have a mild degree of SAD, it can be inferred that the prevalence might be lower than identified. However, the prevalence looks quite high even after this considera- tion. Within the Saudi context, a few studies have investigated SAD among university students and most of them have been con- ducted on medical students, making it diffi- cult to compare our findings with a similar study. However, consistently with the pres- ent study, social anxiety have been revealed to be a highly prevalent disorder in Saudi Article Table 3. Rank ordering of most commonly feared/avoided situations. Rank Situation N (%) Feared situations 1 Acting, performing or giving a talk in front of an audience 357 (75.0) 2 Taking a test 352 (74.0) 3 Speaking up at a meeting 326 (68.5) 4 Talking to people in authority 299 (62.8) 5 Meeting strangers 289 (60.7) 6 Working while being observed 289 … lable at ScienceDirect Behaviour Research and Therapy 77 (2016) 147e156 Contents lists avai Behaviour Research and Therapy journal homepage: www.elsevier.com/locate/brat Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial Isabel L. Kampmann a, *, Paul M.G. Emmelkamp c, d, Dwi Hartanto b, Willem-Paul Brinkman b, Bonne J.H. Zijlstra e, Nexhmedin Morina a a Department of Clinical Psychology, University of Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands b Interactive Intelligence Group, Delft University of Technology, Mekelweg 4, 2628 CD, Delft, The Netherlands c Netherlands Institute for Advanced Study, Meijboomlaan 1, 2242 PR, Wassenaar, The Netherlands d King Abdulaziz University, Abdullah Sulayman, 22254, Jeddah, Saudi Arabia e Department of Educational Sciences, University of Amsterdam, Nieuwe Achtergracht 127, 1018 WS, Amsterdam, The Netherlands a r t i c l e i n f o Article history: Received 4 September 2015 Received in revised form 19 December 2015 Accepted 23 December 2015 Available online 29 December 2015 Keywords: Virtual reality Exposure therapy Social anxiety disorder Social phobia Social interaction * Corresponding author. E-mail address: [email protected] (I.L. Kampm http://dx.doi.org/10.1016/j.brat.2015.12.016 0005-7967/© 2015 Elsevier Ltd. All rights reserved. a b s t r a c t This randomized controlled trial investigated the efficacy of a stand-alone virtual reality exposure intervention comprising verbal interaction with virtual humans to target heterogeneous social fears in participants with social anxiety disorder. Sixty participants (Mage ¼ 36.9 years; 63.3% women) diagnosed with social anxiety disorder were randomly assigned to individual virtual reality exposure therapy (VRET), individual in vivo exposure therapy (iVET), or waiting-list. Multilevel regression analyses revealed that both treatment groups improved from pre-to postassessment on social anxiety symptoms, speech duration, perceived stress, and avoidant personality disorder related beliefs when compared to the waiting-list. Participants receiving iVET, but not VRET, improved on fear of negative evaluation, speech performance, general anxiety, depression, and quality of life relative to those on waiting-list. The iVET condition was further superior to the VRET condition regarding decreases in social anxiety symp- toms at post- and follow-up assessments, and avoidant personality disorder related beliefs at follow-up. At follow-up, all improvements were significant for iVET. For VRET, only the effect for perceived stress was significant. VRET containing extensive verbal interaction without any cognitive components can effectively reduce complaints of generalized social anxiety disorder. Future technological and psycho- logical improvements of virtual social interactions might further enhance the efficacy of VRET for social anxiety disorder. © 2015 Elsevier Ltd. All rights reserved. Social anxiety disorder (SAD) is defined as the fear of one or more social situations in which one might behave embarrassingly and be negatively evaluated by others (DSM-V; American Psychiatric Association, 2013). SAD is one of the most common mental disorders in the US population, with an estimated lifetime prevalence of 12.1% (Ruscio et al., 2008). Individuals who suffer from SAD can experience a reduced quality of life and significant impairments in various areas of functioning, such as work and interpersonal relationships (Wittchen, Fuetsch, Sonntag, Müller, & Liebowitz, 2000). However, only about one third of individuals with SAD seek treatment (Ruscio et al., 2008). The most researched treatment for SAD is cognitive behavior ann). therapy (CBT). CBT aims at modifying maladaptive cognitions and behavior using both cognitive (e.g., cognitive restructuring) and behavioural (e.g., exposure) strategies (Hofmann & Smits, 2008; Mayo-Wilson et al., 2014). During exposure therapy, participants encounter feared stimuli in situations containing social interaction until anxiety decreases and/or anxiety-related expectancies are violated. Traditional exposure exercises are usually practiced dur- ing therapy and as homework assignments. Interestingly, a meta- analysis of treatment efficacy found exposure therapy alone to be comparable to cognitive therapy and that the combination of both was no more effective than either one delivered exclusively (Powers, Sigmarsson, & Emmelkamp, 2008). A relatively new form of exposure therapy is Virtual Reality Exposure Therapy (VRET). During VRET, participants are confronted with computer-generated stimuli (e.g. virtual social interaction) that can elicit elevated subjective levels of social anxiety (Morina, Delta:1_given name Delta:1_surname Delta:1_given name Delta:1_surname Delta:1_given name Delta:1_surname mailto:[email protected] http://crossmark.crossref.org/dialog/?doi=10.1016/j.brat.2015.12.016&domain=pdf www.sciencedirect.com/science/journal/00057967 http://www.elsevier.com/locate/brat http://dx.doi.org/10.1016/j.brat.2015.12.016 http://dx.doi.org/10.1016/j.brat.2015.12.016 http://dx.doi.org/10.1016/j.brat.2015.12.016 I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156148 Brinkman, Hartanto, & Emmelkamp, 2014; Powers et al., 2013). Cumulative research suggests that VRET is effective in the treat- ment of several anxiety disorders (Meyerbr€oker & Emmelkamp, 2010; Morina, Ijntema, Meyerbr€oker, & Emmelkamp, 2015; Opriş et al., 2012; Parsons & Rizzo, 2008). While VRET has been extensively studied in specific phobias, research on the efficacy of VRET in the treatment of SAD is still limited. Several studies suggest that VRET can reduce SAD symp- toms (Anderson, Rothbaum, & Hodges, 2003; Anderson, Zimand, Hodges, & Rothbaum, 2005; Klinger et al., 2005). However, only three randomized controlled trials on the efficacy of VRET in SAD have been conducted (Anderson et al., 2013; Bouchard et al., 2015; Wallach, Safir, & Bar-Zvi, 2009). In the study by Wallach et al. (2009), VRET for public speaking anxiety, a specific social anxiety complaint, was combined with CBT and compared to CBT plus imagery exposure, and waiting-list. Results revealed that VRET plus CBT was effective in treating public speaking anxiety compared to waiting-list and as effective as CBT plus imagery exposure. How- ever, participants in this study were not screened for a clinical diagnosis of SAD. Anderson et al. (2013) included participants with a SAD diagnosis and compared the efficacy of CBT plus VRET with CBT plus group exposure therapy. The authors reported that CBT plus VRET was as effective as CBT plus group exposure therapy. Nonetheless, the implications of the results of this study are rather limited by the inclusion of participants who had reported public speaking anxiety as their primary complaint and by the two different formats of treatment (i.e., individual vs. group). In both the above trials, exposure exercises solely targeted public speaking-related anxiety and included only limited verbal interaction (i.e., answering questions). However, although fear of public speaking is the most common subtype of SAD, the majority of individuals with SAD report more than one fear (Ruscio et al., 2008), emphasizing the need for research on VRET targeting het- erogeneous social fears. Moreover, a large number of feared social situations reported by individuals with SAD (e.g., talking to strangers or speaking up in a meeting) contain verbal interaction (Ruscio et al., 2008). As a consequence, incorporating extensive dialogues into VRET and thus going beyond answering a limited number of questions might improve the efficacy of VRET for SAD. In contrast to Anderson et al. (2013) and Wallach et al. (2009), Bouchard et al. (2015) included virtual scenarios in VRET target- ing several social fears. They found individual CBT plus VRET to be effective compared to waiting-list and more effective than CBT plus in vivo exposure. However, all three studies investigated VRET in combination with CBT. Therefore, no conclusions can be drawn regarding the efficacy of VRET as stand-alone treatment and the possibility cannot be ruled out that the effects found were caused by CBT rather than VRET. In summary, previous research on VRET is limited by investi- gating VRET only in combination with CBT, focussing mainly on fear of public speaking and including only limited verbal interaction. The incorporation of diverse virtual scenarios with social interac- tion that resembles real life interaction into VRET might more adequately target the idiosyncratic fears of participants with SAD. The aim of the present study was to single out the effects of pure VRET without any cognitive components and to adapt VRET to in- dividuals with heterogeneous social fears by simulating social verbal interaction in a variety of virtual social situations believed to be relevant for treating individuals with SAD. In a randomized controlled trial, we examined the efficacy of VRET and in vivo exposure therapy (iVET) for adults with SAD and heterogeneous social fears. These active treatments were compared to a waiting- list control group. Both active treatments were administered in an individual format and were exposure-based only. It was hy- pothesized that relative to individuals in the waiting-list control group, participants in active conditions would report fewer social anxiety symptoms and would perform better on a behavioural assessment task at postassessment. Treatment gains were expected to be comparable for VRET and iVET at postassessment and 3- month follow-up. 1. Method 1.1. Participants Participants were recruited via online and newspaper adver- tisements, the website of the ambulatory of the University of Amsterdam, and the project's website. Sixty participants (Mage ¼ 36.9 years, age range: 18e65 years) meeting the criteria for a primary diagnosis of SAD according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 2000) were included and randomly assigned to one of three conditions (20 participants each; see Fig. 1 for an overview of the randomization procedure and Table 1 for sample characteristics per condition). Exclusion criteria were a) psychotherapy for SAD in the past year; b) current use of tran- quilizers or change in dosage of antidepressants in the past 6 weeks; c) a history of psychosis, current suicidal intentions, or current substance dependence; e) severe cognitive impairment; or f) insufficient command of the Dutch language. The average num- ber of completed sessions was 8.50 (SD ¼ 2.63) for VRET and 8.55 (SD ¼ 2.68) for iVET. All participants received free treatment and a small monetary reward (22 Euro) for the completion of the follow- up assessment. 1.2. Measures 1.2.1. Screening and diagnostic measures The Social Interaction Anxiety Scale (SIAS; Mattick & Clarke, 1998) was used for screening purposes before the in-person interview. The SIAS consists of 20 items assessing cognitive, affec- tive, and behavioural responses to social interactions on a 5-point Likert scale. The SIAS possesses a high internal consistency and test-retest reliability (Cronbach's a ¼ .93 and r ¼ 0.92 respectively; Mattick & Clarke,1998). Individuals scoring �29 were invited for an in-person diagnostic interview with a psychologist. We choose a slightly lower cut-off than reported in previous research to prevent false-negatives in this early stage of screening where the in-person intake was still to come (Heimberg, Mueller, Holt, Hope, & Liebowitz, 1992). To assess the diagnosis of SAD and potential comorbidity, the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID- I; First, Spitzer, Gibbon, & Williams, 1994) was administered prior to inclusion. All assessors were psychologists with a master degree in clinical psychology. These assessors were blind to treatment condition and had received a SCID training in accordance with their individual level of expertise. The assessor at preassessment was in most cases a different person than the therapist (52/60). In a mi- nority of cases (8/60), the assessor became also the patient's ther- apist after the assessment. Note, however, that these assessors were also blind to condition because condition allocation took place after the preassessment. The number of administered SCID-I modules depended on participants' responses to the SCID-I screening questions (covering substance use disorders, anxiety disorders, and eating disorders). The modules on social phobia, mood disorders, psychotic disorders, post-traumatic stress disorder, and somato- form disorders were assessed for all patients. The avoidant per- sonality disorder section of the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II; First, Gibbon, Spitzer, Williams, & Benjamin, 1997) was also administered Fig. 1. Participant flow chart. VRET ¼ Virtual Reality Exposure Therapy; iVET ¼ in Vivo Exposure Therapy. I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156 149 because research suggests that avoidant personality disorder and SAD might be one disorder instead of two distinct disorders, with avoidant personality disorder being the more severe form (Reich, 2009). 1.2.2. Primary outcome measures Social anxiety symptoms were measured with the Liebowitz Social Anxiety Scale-Self Report (LSAS-SR; Liebowitz, 1987). The LSAS-SR is a 24-item questionnaire that assesses fear and avoidance in social situations on a 4-point Likert scale. The 12-week test- retest reliability of the LSAS-SR has been reported to be high (r ¼ 0.83; Baker, Heinrichs, Kim, & Hofmann, 2002) and the internal consistency in the present study was excellent (Cronbach's a ¼ .90e0.97). The subjective fear of being negatively evaluated by others in social situations was assessed with the Fear of Negative Evaluation Scale-Brief Form (FNE-B; Leary, 1983). The FNE-B is a 12-item in- strument using a 5-point Likert scale for responses. Good psycho- metric properties have been reported for the FNE-B in earlier research (Weeks et al., 2005) and the internal consistency in the present study was excellent (Cronbach's a ¼ .91e0.97). 1.2.3. Secondary outcome measures We measured speech duration and speech performance during a behavioural assessment task, in the form of a 5 min impromptu speech, to evaluate levels of behavioural avoidance. The behav- ioural assessment task was a modified version of a standardized protocol (Beidel, Turner, & Jacob, 1989). This modified version has been used in previous studies on social anxiety (Amir, Weber, Beard, Bomyea, & Taylor, 2008). Although participants with diverse social fears were included in the present study, this task was chosen because public speaking anxiety is the most prevalent Table 1 Demographic characteristics of participants per condition. Characteristics VRET (n ¼ 20) iVET (n ¼ 20) WL (n ¼ 20) Age, M (SD) 39.65 (11.77) 37.50 (11.27) 33.50 (11.44) Gender (% female) 65 75 50 Native language, n (%) Dutch 17 (85) 17 (85) 20 (100) Spanish 1 (5) 0 (0) 0 (0) Russian 1 (5) 0 (0) 0 (0) Portuguese 0 (0) 1 (5) 0 (0) Polish 0 (0) 1 (5) 0 (0) Indonesian 0 (0) 1 (5) 0 (0) Berber 1 (5) 0 (0) 0 (0) Education, n (%) High 8 (40) 10 (50) 11 (55) Middle 11 (55) 8 (40) 9 (45) Low 1 (5) 2 (10) 0 (0) Employment status, n (%) Paid employment 10 (50) 13 (65) 13 (65) Trainee/student 1 (5) 1 (5) 5 (25) Social welfare 1 (5) 1 (5) 0 (0) Unemployed with voluntary work 1 (5) 0 (0) 0 (0) Unemployed 7 (35) 5 (25) 2 (10) Marital status, n (%) Married or cohabitating 9 (45) 10 (50) 11 (55) Long distance relationship 2 (10) 3 (15) 2 (10) Single living with children 1 (5) 0 (0) 0 (0) Single living without children 7 (35) 7 (35) 6 (30) Widowed 1 (5) 0 (0) 1 (5) Comorbidity, n (%) Any anxiety disorder 3 (15) 4 (20) 0 (0) Depressive disorder 4 (20) 0 (0) 2 (10) Avoidant personality disorder 7 (35) 6 (30) 3 (15) Session completed, n 1 20 20 2 20 20 3 19 19 4 19 19 5 18 17 6 15 17 7 15 17 8 15 16 9 15 16 10 14 14 Dropout, n (%) 5 (25) 3 (15) 4 (20) Note. VRET ¼ Virtual Reality Exposure Therapy; iVET ¼ in Vivo Exposure Therapy; WL ¼ waiting-list; Low ¼ completed elementary school or lower vocational edu- cation; Middle ¼ completed high school or middle-level vocational education; High ¼ completed pre-university, college, or university degree. I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156150 social fear. Speech duration was measured using a stop watch. To assess speech performance, two independent judges, blind for condition and assessment point, rated the videotaped speeches using 17 items of a public speaking performance measure on a 5- point Likert scale (Rapee & Lim, 1992). Higher scores on this mea- sure indicated better speech performance. The internal consistency of this scale was good in earlier research (r ¼ 0.84; Rapee & Lim, 1992) and the present study (r ¼ 0.81e0.87). Symptoms of depression, general anxiety, and stress were measured with the Depression Anxiety Stress Scale (DASS-21; Lovibond & Lovibond, 1995). The DASS-21 is a 21-item self-report questionnaire measuring depression, anxiety, and stress on a 4- point Likert scale with higher scores representing higher levels of depression, anxiety, or stress, respectively. The stress scale includes items that measure subjective coping with stressful events, such as tension, irritability, and a tendency to overreact to stressful events. The DASS possesses good psychometric properties (Antony, Bieling, Cox, Enns, & Swinson, 1998; Henry & Crawford, 2005) and in the present study its internal consistency was excellent (Cronbach's a ¼ .91e0.95). Avoidant personality disorder related beliefs were assessed with the Personality Disorder Belief Questionnaire (PDBQ; Dreessen & Arntz, 1995). Research has shown that exposure therapy without cognitive components can affect cognitions (Powers et al., 2008). The avoidant subscale of the PDBQ contains 10 items to assess the strength of beliefs assumed to be specific to avoidant personality disorder. The internal consistency of this subscale was excellent in the present study (Cronbach's a ¼ .90e0.97). Subjective quality of life was measured using the Eurohis Quality of Life Scale (EUROHIS-QOL 8-item index; Schmidt, Mühlan, & Power, 2006). The EUROHIS-QOL 8-item index measures quality of life on a 5-point Likert scale with higher scores indicating a better quality of life. The psychometric properties of the EUROHIS- QOL are reported to be satisfactory (Da Rocha, Power, Bushnell, & Fleck, 2012; Schmidt et al., 2006) and the internal consistency in the present study was good (Cronbach's a ¼ .83e0.93). 1.3. Procedure The present study was approved by the Institutional Review Board of the University of Amsterdam and registered (NCT01746667; www.clinicaltrials.gov). Potential participants were asked on the telephone about former SAD treatment and whether attending treatment was logistically feasible. Afterwards, they filled in the SIAS online. Participants who scored above the cut-off were invited to an in-person intake (SCID), where they were screened for http://www.clinicaltrials.gov I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156 151 exclusion criteria. After obtaining informed consent, eligible par- ticipants underwent a preassessment comprising a battery of self- report measures (LSAS-SR, FNE-B, DASS-21, PDBQ, EUROHIS-QOL) and the behavioural assessment task. For the behavioural assess- ment task, participants were told that they would give a 5 min speech in front of a camera and a two-person jury rating the speech. They were then asked to choose one out of seven topics (nuclear power, gay marriage, euthanasia, republic or monarchy, genetic selection, burqa ban, or mandatory organ donation) and had 2 min to prepare the speech. Participants were allowed to make notes during the preparation time but they could not use them during the speech. Then, the jury entered the room and the par- ticipants gave a speech for 5 min or until they indicated that they wanted to stop. After the assessment, participants were random- ized to one of the three conditions (VRET, iVET, or waiting-list) using a computerized random number generator (http://www. randomization.com). A person who was not involved in the pre- sent study kept a list with the randomization sequence in a locked office cupboard and prepared sealed envelopes containing the condition allocation. The first author opened the envelopes after participants were enrolled. Participants in the waiting-list condi- tion received a second assessment after a waiting period of five weeks (i.e. the same aimed length of time as the treatment) before being randomized to one of the treatment conditions. After the last treatment session, all participants completed a postassessment identical to the preassessment. Three months after the post- assessment, participants were invited to an in-person follow-up assessment consisting of the battery of self-report measures (LSAS- SR, FNE-B, DASS-21, PDBQ, EUROHIS-QOL). 1.4. Treatment The treatment protocols for VRET and iVET were based on the protocols of Scholing and Emmelkamp (1993) and Hofmann and Otto (2008). Consistent with our aim of examining the potential efficacy of exposure to virtual social interactions, only behavioural exposure elements were used in both conditions and cognitive el- ements were discarded. Both treatments comprised ten 90 min sessions scheduled twice a week. In standard treatment, homework is commonly added to therapy sessions. However, due to the technical equipment necessary for VRET, virtual exposure could only be implemented in the lab. Therefore, homework assignments were not feasible in this condition. To keep the amount of exposure equal in both conditions, no homework assignment was given in either condition and therapists were instructed not to encourage participants to practice exposure outside of therapy sessions. Therapists involved in the present study were clinical psychologists and students in their last semester of a clinical master's degree program. They received training on VRET and iVET by the second and last author prior to administering both treatments. To monitor treatment adherence and competence, all therapy sessions and exposure exercises were extensively discussed during supervision. Furthermore, therapists were asked to complete a checklist immediately after each session in which they indicated any possible deviations from the protocol which were discussed during super- vision. Moreover, therapy sessions were audio recorded (except for in vivo exposure exercises) and parts of recordings were replayed and discussed during supervision. Due to logistical reasons treat- ment adherence and competence were not formally assessed. Weekly supervision was provided to the therapists by the first, second, and last author. 1.4.1. Virtual reality exposure therapy (VRET) VRET took place in the virtual reality laboratory of the University of Amsterdam. The laboratory consisted of two rooms separated by a one-way mirror, through which the therapist could see the participant during exposure exercises while controlling the com- puter system, whereas the participant could not see the therapist. The therapist and the participant had face-to-face contact before and after exposure exercises and during exposure they communi- cated via an intercom. The virtual situations covered one-to-one and group situations designed to provoke anxiety in individuals with SAD: giving a talk in front of an audience followed by ques- tions from the audience, talking to a stranger, buying and returning clothes, attending a job interview, being interviewed by journalists, dining in a restaurant with a friend, and having a blind date (see Appendix A for a detailed description of all virtual scenarios and Figure 2 in Hartanto et al. (2014) for pictures of the virtual blind date, virtual job interview, and neutral world). For virtual exposure, we used the Delft Remote Virtual Reality Exposure Therapy (DRVRET; Brinkman et al., 2012) system with virtual worlds which were visualized using a Vizard v3.0 software package. The setup consisted of three computers. The first com- puter, a custom Dell T3400 workstation, was used to run the VR server and the data logging system. The second computer, a custom Dell T3600 workstation using Intel Quadcore E5 with NVIDIA Quadro 5000, was used to run the VR engine and environment and the therapist could see simultaneously what the participant could see in the head mounted display. The video output of this computer was split for both the head mounted display (participant) and real time monitoring purpose (therapist). On the third computer, a custom Dell T3400 workstation, the therapist controlled the virtual situations. Participants wore a nVisor SX head mounted display with 1280 � 1024 pixels, a stereographic projection, and a 60� di- agonal field of view. Semi-structured dialogues controlled by the therapist ensured a certain length and difficulty level of interaction between the virtual humans and the participant, as well as allowing for individual re- sponses for each participant (Brinkman et al., 2012). To tailor exposure exercises to the specific needs, anxiety level, and treat- ment progress of the individual participant, the system allowed the therapist to vary the following components depending on the vir- tual situation: dialogue style (friendly or unfriendly), gender of avatar, number of avatars present in the virtual world, dialogue topic's degree of personal relevance, and avatar's gestures (i.e., gaze direction and posture). Treatment Sessions 1 and 2 focused on the conveyance of the therapy rationale, the registration of participant's relevant social situations, and creating a hierarchy of the available virtual social situations according to the participants' anticipated anxiety level. Moreover, participants were introduced to virtual reality and the technological equipment by entering a virtual neutral situation (Busscher, de Vliegher, Ling, & Brinkman, 2011), without any social interaction, for a maximum of 5 min. Sessions 3 through 9 contained two 30 min blocks of exposure exercises separated by a 5 min break. The content of exposure ex- ercises followed the previously made hierarchy in ascending order with regards to individual anxiety level (i.e. gradual exposure). Participants rated their anxiety level regarding three time points in every exposure exercise: beginning, highest level during the exer- cise, and end. Participants practiced every virtual world at least once and until anxiety decreased. Yet, only a maximum of two sessions were spent on exposure exercises focussing on presenta- tion situations to limit the amount of practice in presentation performance, given that the behavioural assessment task also consisted of giving a speech. Session 10 was devoted to relapse prevention and evaluation of the therapy. 1.4.2. In vivo exposure therapy (iVET) The iVET consisted of gradual exposure therapy to real-life http://www.randomization.com http://www.randomization.com I.L. Kampmann et al. / Behaviour Research and Therapy 77 (2016) 147e156152 situations. Similar to VRET, iVET comprised 10 sessions with 60 min exposure in Sessions 3 through 9. As in the VRET condition, the therapy rationale and anxiety hierarchy were discussed in Sessions 1 and 2. The hierarchy used in iVET comprised participants’ indi- vidual social situations which were translated to exposure exercises that could be implemented at the ambulatory of the University of Amsterdam or in its neighbourhood (e.g., supermarkets, subway stations, caf�es, etc.). If relevant social situations could not be translated into exercises at the ambulatory or its nearby sur- roundings (e.g., work-related social situations), participants could substitute a regular session with a session in their personal envi- ronment. In these cases, the therapist and the participant had contact via the telephone before and after the exposure assign- ment. Session 10 was identical to the last session in the VRET condition. 1.5. Statistical analyses Multilevel regression analyses were carried out to explore within-group (Time), between-group (Condition), and interaction (Time � Condition) effects. Only the fixed effects of the multilevel models were reported because they model change at the group level (in contrast to random effects, which model at the individual level). To investigate treatment effects from pre-to postassessment, each active treatment group was compared to waiting-list. The estimated model (see Table 3a) consisted of two parameters for each group: one parameter estimating the mean level of the outcome variable at preassessment and a second parameter esti- mating the rate of change from pre-to postassessment. For the active treatment groups, the second parameter described the change from pre-to postassessment relative to the change of the waiting-list group. To investigate long term effects of the two active treatments, the change from pre-to postassessment and the change from preassessment to follow-up were compared between VRET and iVET. The estimated model (see Table 3b) consisted of three parameters for each group: the first parameter describes the mean level of the outcome variable at preassessment, the … Contents lists available at ScienceDirect Journal of Affective Disorders journal homepage: www.elsevier.com/locate/jad Research paper The role of expressive suppression and cognitive reappraisal in cognitive behavioral therapy for social anxiety disorder: A study of self-report, subjective, and electrocortical measures Yogev Kivity⁎,1, Lior Cohen, Michal Weiss, Jonathan Elizur, Jonathan D. Huppert Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel A R T I C L E I N F O Keywords: Social Anxiety Emotion Regulation Cognitive Reappraisal Expressive Suppression Cognitive Behavioral Therapy A B S T R A C T Background: Contemporary models of cognitive behavioral therapy (CBT) for social anxiety disorder (SAD) emphasize emotion dysregulation as a core impairment whose reduction may play a causal role in psy- chotherapy. The current study examined changes in use of emotion regulation strategies as possible mechanisms of change in CBT for SAD. Specifically, we examined changes in expressive suppression and cognitive reappraisal during CBT and whether these changes predict treatment outcome. Methods: Patients (n = 34; 13 females; Mean age = 28.36 (6.97)) were allocated to 16-20 sessions of CBT. An electrocortical measure of emotion regulation and a clinician-rated measure of SAD were administered monthly. Self-report measures of emotion regulation and social anxiety were administered weekly. Multilevel models were used to examine changes in emotion regulation during treatment and cross-lagged associations between emotion regulation and anxiety. Results: CBT led to decreased suppression frequency, increased reappraisal self-efficacy, and decreased un- pleasantness for SAD-related pictures (ps < .05). At post-treatment, patients were equivalent to healthy controls in terms of suppression frequency and subjective reactivity to SAD-related stimuli. Gains were maintained at 3- months follow-up. Decreases in suppression frequency and electrocortical reactivity to SAD-related pictures predicted lower subsequent anxiety but not the other way around (ps < .05). Lower anxiety predicted greater subsequent increases in reappraisal self-efficacy. Limitations: The lack of a control group precludes conclusions regarding mechanisms specificity. Conclusions: Decreased frequency of suppression is a potential mechanism of change in CBT for SAD. 1. Introduction Recent models of anxiety, including social anxiety disorder (SAD), emphasize impairments in emotion regulation (Hofmann, Sawyer, Fang, & Asnaani, 2012; Morrison & Heimberg, 2013). Two regulation strategies, cognitive reappraisal and expressive suppression, may be particularly relevant for SAD (Morrison & Heimberg, 2013). In the process model of emotion regulation (Gross, 2015), cognitive re- appraisal is generally considered an adaptive strategy that involves cognitive change to regulate one's emotion – for example, attempts to reinterpret emotional stimuli in less threatening ways (Gross, 2015). On the other hand, expressive suppression is an attempt to inhibit one's expression of emotions and is generally considered maladaptive (Gross, 2015). In Heimberg's updated model (Morrison & Heimberg, 2013), emotion dysregulation in SAD includes avoidance of anxiety (e.g. avoidance or escape from stressful situations) and expressive suppres- sion due to believing that expressing emotions will lead to rejection or to excessive focus on oneself. The model further proposes that in- dividuals with SAD are less effective in implementing reappraisal. Ac- cordingly, decreased suppression and increased effective use of re- appraisal are hypothesized to lead to symptom reduction, for example, by outward shifting of attention and by reducing exaggerated prob- ability and cost of rejection. Recently, studies have examined suppression and reappraisal in SAD (reviewed in Dryman & Heimberg, 2018). Cross-sectional and daily diary studies typically focus on the frequency of use of a strategy and self-efficacy (perceived success in implementation). Individuals with SAD report an over-reliance on suppression and lower frequency and self-efficacy of reappraisal (e.g., Farmer & Kashdan, 2012; https://doi.org/10.1016/j.jad.2020.10.021 Received 10 May 2020; Received in revised form 16 August 2020; Accepted 11 October 2020 ⁎ Corresponding author: Yogev Kivity, Department of Psychology, Bar Ilan University, Ramat Gan 5290002, Israel, Telephone: +972-3-5318715 E-mail address: [email protected] (Y. Kivity). 1 Yogev Kivity is now in the Department of Psychology, Bar Ilan University, Israel. Journal of Affective Disorders 279 (2021) 334–342 Available online 14 October 2020 0165-0327/ © 2020 Elsevier B.V. All rights reserved. T http://www.sciencedirect.com/science/journal/01650327 https://www.elsevier.com/locate/jad https://doi.org/10.1016/j.jad.2020.10.021 https://doi.org/10.1016/j.jad.2020.10.021 mailto:[email protected] https://doi.org/10.1016/j.jad.2020.10.021 http://crossmark.crossref.org/dialog/?doi=10.1016/j.jad.2020.10.021&domain=pdf Gaebler, Daniels, Lamke, Fydrich, & Walter, 2014). Impairments in frequency seem to be larger than impairments in self-efficacy in sup- pression while the opposite is true for reappraisal (Kivity & Huppert, 2018, 2019), thus supporting the Heimberg model. In addition, studies have also utilized subjective ratings during lab tasks of emotion regulation to study reappraisal and suppression abil- ities in SAD. These studies typically present SAD-related stimuli to participants, such as pictures of rejecting faces (Goldin et al., 2009a), pictures portraying scenes of rejection and embarrassment (Kivity & Huppert, 2016, 2018, 2019) and idiographic statements of negative self-beliefs (Goldin et al., 2009b) while asking participants to change the way they interpret these stimuli in order to reduce the distress they evoke in them. However, compared to questionnaires and daily diary measures, these lab studies have shown intact emotion regulation abilities in SAD compared to controls, even under social stress (e.g., Gaebler et al., 2014; Kivity & Huppert, 2016, 2018, 2019). Thus, self- reported impairments are not reflected in lab performance. Among other possibilities, this discrepancy may suggest a difficulty im- plementing strategies in daily life despite an intact ability to implement them upon instruction in controlled circumstances, low ecological va- lidity of lab-based measures, or a bias in self-reports that does not exist in lab-based measures. Examining the role that each of these aspects (lab-based performance, self-reported frequency and self-reported self- efficacy) plays in treatments for SAD may shed light on their relative importance. Several techniques of cognitive behavioral therapy (CBT) for SAD seem relevant for improving emotion regulation. Psychoeducation and exposures likely decrease suppression, as patients learn that hiding their anxiety is futile and likely to backfire. Outward shifting of at- tention (focusing on the task at hand instead of on how one is per- ceived) presumably decreases suppression by decreasing patients’ pre- occupation with their overt signs of anxiety. Furthermore, cognitive restructuring can potentially increase the use of reappraisal by chan- ging biased catastrophic cognitions. Finally, psychoeducation and in- vivo exposure challenge biased cognitions and are expected to promote reappraisal too. Studies have shown that self-reported reappraisal (frequency and self-efficacy) increases in CBT (Goldin et al., 2014a; Goldin, Morrison, Jazaieri, Heimberg, & Gross, 2017; Kocovski, Fleming, Hawley, Huta, & Antony, 2013; Moscovitch et al., 2012). However, findings regarding self-reported suppression are inconclusive, with one study reporting a decrease in frequency (Goldin et al., 2014a) and another reporting no change (Moscovitch et al., 2012). Less is known regarding lab-based measures: one study found improvements in reappraisal of negative social evaluations and negative self-beliefs during CBT (Goldin et al., 2013, 2014b). Importantly, the best test of the importance of emotion regulation as a treatment target for SAD is to examine its contribution to symptom improvement (Nock, 2007). Changes in reappraisal and suppression that predict treatment outcome would provide further support to Heimberg's model. Several studies found that increases in self-reported frequency and self-efficacy of reappraisal predicted subsequent symptom reduction (Goldin et al., 2017; Kocovski, Fleming, Hawley, Ho, & Antony, 2015; Moscovitch et al., 2012), although another study found that only self-efficacy (but not frequency) of reappraisal pre- dicted subsequent outcome (Goldin et al., 2014a). Decreases in self- reported suppression frequency predicted contemporaneous, but not subsequent, symptoms reduction in one study (Goldin et al., 2014a) and did not predict outcome at all in another (Moscovitch et al., 2012). The only examination of lab-based reappraisal (Goldin et al., 2014b) found that greater changes in fMRI measures of reappraisal predicted greater symptom change during CBT for SAD, although subjective task per- formance did not. Thus, the self-report findings suggest that reappraisal increases during CBT for SAD and may be driving symptom change, with more consistent findings regarding self-efficacy than frequency. Additional studies are needed regarding lab-based emotion regulation. The present study examines changes in suppression and reappraisal during CBT for SAD and their role in treatment outcome using data from a previously completed study (Huppert, Kivity, Cohen, Strauss, Elizur & Weiss, 2018). We collected weekly self-reports of the frequency and self-efficacy of reappraisal and suppression, and monthly lab-based measures of reappraisal and suppression in response to SAD-related pictures. Given past findings, our primary focus was self-reported self- efficacy of reappraisal and frequency of suppression. Frequency of re- appraisal and self-efficacy of suppression were of secondary interest. For the lab-based task, we focused on unpleasantness and event- related potentials (ERP) during reappraisal and suppression of SAD- related pictures. We focused on the late positive potential (LPP), an ERP with a posterior midline distribution and an onset of 300 ms post-sti- mulus (Proudfit, Dunning, Foti, & Weinberg, 2013). Larger LPP reflect sustained attention to stimuli and elaborative engagement in order to regulate the emotion (Proudfit et al., 2013). The LPP is sensitive to emotional intensity and to emotion regulation, with higher amplitudes for highly arousing stimuli that are reduced following instructions to regulate, including reappraisal and suppression, even within several seconds from the presentation of the stimuli (Proudfit et al., 2013). The LPP shows less habituation over repeated exposure to stimuli compared to other psychophysiological measures (Proudfit et al., 2013), which allows for repetition of stimuli and attribution of changes in LPPs to the same stimuli as due to regulation. The LPP has been utilized in SAD (Kinney, Burkhouse, & Klump, 2019; Kivity & Huppert, 2018, 2019; Yuan et al., 2014) but we are unaware of studies examining it during CBT for SAD. We examined these hypotheses: 1) CBT will result in significant improvements in suppression and reappraisal, including reduced fre- quency of suppression and increased self-efficacy, frequency, and suc- cessful lab implementation of reappraisal. 2) Improvements in sup- pression and reappraisal will play a potentially causal role in CBT: improvements will predict subsequent improvements in anxiety and not vice versa. 3) We examined whether patients reached an equivalent level of emotion regulation to healthy controls (HCs) at post-treatment, and whether gains were maintained at 3-months follow-up without an a-priori hypothesis. 2. Method 2.1. Participants Data were drawn from the CBT arm of a study of treatments for SAD (Huppert et al., 2018)2. Patients were recruited via advertisements and referrals. Participants were 34 patients who met DSM-IV-TR (American Psychiatric Association, 2000) criteria for SAD and 40 HCs with no history of psychiatric disorders, matched to patients on sex, age and education. One patient decided not to enter treatment and 5 HCs were removed because they did not have a continued low social anxiety score between screening and participation. The final sample included 33 patients (13 females, Age: 18-53, M = 28.36, SD = 6.97) and 35 HCs (15 females, Age: 19-45, M = 28.49, SD = 6.28). Participants were Hebrew speaking and family status was: single: CBT = 59%, HC = 61%; in a relationship: CBT = 41%, HC = 35%; divorced: CBT = 0%, HC = 4%. Education levels were: high school: CBT = 15%, HC = 29%; post-high school: CBT = 21%, HC = 9%; undergraduate degree/student: CBT = 42%, HC = 27%; graduate degree/student: 2 The original study also included participants receiving a computerized treatment for SAD called Attention Bias Modification. This treatment was of shorter duration compared to CBT, of a smaller sample size and only included three measurements of lab-based emotion regulation. In addition, group as- signment was random only for a subset of the CBT patients. Due to these rea- sons, we decided not to include data from this treatment in the current study, which a priori was designed to examine the role of ER in CBT. Y. Kivity, et al. Journal of Affective Disorders 279 (2021) 334–342 335 CBT = 21%, HC = 26%. Groups did not differ on demographics (ps > .05). Ten SAD participants (29.41%) had one comorbid disorder and two (5.88%) had more than one. The most common comorbid disorders were depression (n = 9; 26.47%) or other anxiety disorders (n = 4; 11.76%). 2.2. Measures Liebowitz Social Anxiety Scale (LSAS; Liebowitz, 1987). A 24- item interviewer-rated measure of fear and avoidance of social inter- actions and social performance. The Hebrew version (Levin, Marom, Gur, Wechter, & Hermesh, 2002) was administered by trained clinical psychology doctoral students, blind to hypotheses. Internal consistency in all assessments was α = .90 – .96; interrater reliability for 15 ran- domly chosen interviews was r = .94. Social Phobia Inventory (SPIN; Connor et al., 2000). A valid and reliable 17-item self-report measure of social anxiety symptoms, translated and back translated to Hebrew for previous studies. Internal consistency in all assessments was: α = .78 – .95. Emotion Regulation Questionnaire – Self-Efficacy and Frequency (ERQ; Gross & John, 2003). We used the reliable and valid Hebrew version (Carthy, Horesh, Apter, Edge, & Gross, 2010). Fol- lowing Goldin et al. (2009b), we measured both the frequency (ERQ-F) and self-efficacy (ERQ-SE) in social situations instead of frequency only (internal consistency of all subscales: α = .73 – .97). Items tap into reappraisal (e.g., “When I want to feel less negative emotion, I change the way I'm thinking about the situation”) and suppression (e.g., “I control my emotions by not expressing them”) which participants en- dorse using a 1 ("Seldom"/"Ineffectively") to 7 ("Often"/"Effectively") scale. Emotion Regulation Task. Full details are provided in supple- mental material, section 1. We used a task that was developed by Hajcak and Nieuwenhuis (2006) who presented emotionally-salient pictures to participants and instructed them to either passively view the picture or to reappraise the emotion it evokes in them while ERP ac- tivity was recorded and unpleasantness ratings were collected. Hajcak and Nieuwenhuis found that the amplitude of the LPP and the level of subjective unpleasantness were decreased during reappraisal compared to passive viewing. Thus, the task is validated and suitable for studying the effects of emotion regulation on electrocortical activity and sub- jective unpleasantness. In the current study, we adapted the task to measure suppression in addition to reappraisal and used SAD-related pictures rather than general pictures (Kivity & Huppert, 2018, 2019). In selecting the stimuli for the task, we chose to focus on shame, embar- rassment and rejection because these experiences are central in SAD (Goldin et al., 2009b; Morrison & Heimberg, 2013; Moscovitch, 2009)3. Twenty trials of each condition were included: viewing of SAD-related pictures, viewing of neutral pictures, reappraisal of SAD-related pic- tures and suppression of SAD-related pictures. When viewing SAD-related pictures, participants imagined them- selves as the character that is the focus of shame, rejection, and em- barrassment. When viewing neutral pictures, participants responded naturally. When reappraising, participants first imagined themselves as the character and then changed the way they think of the picture to decrease their unpleasantness (e.g., "This guy is not laughing at me, but at someone else"). When suppressing, participants first imagined themselves as the character and then concealed any expression of emotions. To enhance the effect of the suppression manipulation, a web camera was placed above the computer screen and participants were told that a member of the research team would review the recordings. Participants were instructed to avoid any expression of their emotions such that it would be impossible to tell whether they were viewing neutral pictures or concealing their emotions4. After each trial, participants rated their unpleasantness on a Self- Assessment Manikin (SAM; Lang, Bradley, & Cuthbert, 2008) scale (1 through 9; 5 being neutral; transformed such that higher ratings express greater unpleasantness). We focused on unpleasantness ratings in order to complement the LPP data (which is mostly correlated with arousal) and arrive at a more complete picture of the participants’ emotional experience that takes into account the two basic dimensions of emo- tions – valence and arousal. After providing unpleasantness ratings, participants were asked to indicate the instructions they followed during that trial. In the reappraisal condition, participants were also asked to record the new interpretation they came up with for the pic- ture (results not reported here). Ratings were averaged for each condition and a regulation score (view – regulate; calculated on the transformed scores) was calculated to capture the amount of reduction in unpleasantness. Higher scores indicate larger regulation effects. SAD-related pictures were collected from the internet5, normed and shown to evoke moderate shame, embarrassment, rejection and un- pleasantness (Kivity & Huppert, 2018, 2019). These depicted situations of shame, rejection, and/or embarrassment such as scenes of people pointed and laughed at, anxious people during a public speech, and facial expressions of contempt. Neutral pictures were taken from the International Affective Picture System (IAPS) database (Lang et al., 2008). Psychophysiological Recording, Data Reduction, and Analysis. Full details are provided in section 2 of the supplement. ERPs were constructed by averaging trials in each condition (view, suppression, reappraisal and view neutral). Following Moser, Hartwig, Moran, Jendrusina, & Kross (2014), the LPP was quantified as the average voltage in 5 parietal electrodes (CPz, P1, Pz, P2, POz) in the entire segment (400-2000 ms). A regulation change score (view – regulate) was calculated to capture the amount of reduction in the LPP. Higher scores indicate larger regulation effects. Trials in which participants failed to use the instructed strategy were excluded (4.57% on average, no group differences). Studies have shown that the LPP can be reliably measured with as little as 8 trials and that it varies little beyond 12 trials (Moran, Jendrusina, & Moser, 2013). Assessments with fewer than 12 valid trials in each condition were removed from analyses (5% across groups, no group differences). 2.3. Treatment and therapists Individual CBT was delivered for up to 20 sessions using a manual by Roth-Ledley, Foa, & Huppert (2006), based on Clark's (2005) CBT for SAD. Components such as building an idiographic model, outward shifting of attention, safety behaviors experiment, video feedback, be- havioral experiments and exposures, and optional use of imaginal ex- posure, assertiveness training, or social skills training are included. Therapists were four clinical psychology doctoral students with 2-4 years of CBT experience. Videorecordings of sessions were used in group supervision by the last author. 3 Shame, embarrassment and rejection are likely separate, but related, ex- periences. Similar to previous studies (e.g., Goldin et al., 2009), when designing and validating the task (Kivity & Huppert, 2018, 2019) we were not able to examine these experiences separately due to a small number of stimuli that purely fall into one of these categories. It remains for future studies to examine these experiences separately. 4 It should be noted that although the view condition is not entirely a passive one (as it includes perspective taking), it is still possible that it requires less cognitive effort than the reappraisal and suppression conditions. However, studies have shown that cognitive effort alone does not explain the down-reg- ulatory effects of reappraisal (Foti & Hajack, 2008). 5 See a sample picture at https://tinyurl.com/ShameArousingPicture. Y. Kivity, et al. Journal of Affective Disorders 279 (2021) 334–342 336 https://tinyurl.com/ShameArousingPicture 2.4. Procedure The institutional review board approved the study. After providing informed consent, participants were evaluated by trained independent evaluators (blind to hypotheses) using the Mini-International Neuropsychiatric Interview (Sheehan et al., 1998) and the LSAS. Par- ticipants completed a baseline assessment and entered treatment. Pa- tients completed the ERQ before and after each session (post-session ratings were of secondary interest and are only reported in Supple- mental Material, Section 4). Patients also completed in-lab assessments at pre-treatment, every four sessions during treatment, at post-treat- ment and at 3-months follow-up which included the LSAS, SPIN, ERQ, and the lab task. Thus, each patient had up to seven assessments (pre- treatment, sessions 4, 8, 12 and 16, post-treatment, and follow-up). HCs only completed a single assessment and were not followed long- itudinally. Thus, HCs were included only in analyses of equivalency. 2.5. Data Analyses We used intent-to-treat linear multi-level models (assessments at level 1 repeated within patients at level 2) implemented in R package 'nlme' (Pinheiro, Bates, DebRoy, Sarkar, & R Core Team, 2016). In- cluding therapists as a third level showed negligible and non-significant effects (ICCs: Med = .00, range: 0 – 0.049) and therefore this level was removed. We used restricted maximum likelihood estimation, a first- order autoregressive level 1 covariance structure and random intercepts and slopes at level 2. For H1, linear rates of change were examined by including session/assessment number as a level 1 predictor (centered at pre-treatment). Intercepts represent estimated levels of the dependent variable at pre-treatment and slopes represent estimated changes in the dependent variable between two assessment points (one/four sessions, depending on the measure). To examine changes from post-treatment to follow-up we fitted a piece-wise model that examines changes during treatment and from post-treatment to follow-up separately. This was done by adding the follow-up data to the abovementioned model and adding a dummy coded variable that captures post-treatment to follow- up changes (coded “1” for follow-up assessment and “0” for all other assessment). The fixed effect of the dummy variable expresses the amount and significance of the change from post-treatment to follow- up. H2 was examined by modeling within-patient variation in the pre- dictor following recommended procedures (Wang & Maxwell, 2015). Monthly scores of the predictor (patient mean-centered) served as within-patient scores in a cross-lagged (1-month) model. Within-subject effects represent cross-lagged associations between the predictor and the outcome. Per Wang and Maxwell (2015) we did not control for linear time effects as we wished to model and explain these very effects. Following Falkenström, Finkel, Sandell, Rubel, and Holmqvist (2017), we did not include the lagged dependent variable as a predictor because it introduces a dependency between the dependent variable and the error, thus violating assumptions. However, the first auto-regressive residual structure partly accounts for the effects of prior on current levels of the outcome. For consistency, we only analyzed monthly scores of the SPIN and ERQ. A cross-lagged association was interpreted as significant only if effects were significant for clinician-rated and self- reported anxiety. For H3, comparisons were conducted using clinical equivalency procedures (Kendall, Marrs-Garcia, Nath, & Sheldrick, 1999) through t tests examining non-inferiority (i.e., < 1 SD difference) of post-treat- ment scores compared to HCs. A significant effect in noninferiority tests suggests that patients are non-inferior to HCs. Effect sizes were calculated as semi-partial r (rs; Jaeger, Edwards, Das, & Sen, 2016; Nakagawa & Schielzeth, 2013) using package 'r2glmm' in R (Jaeger & R Core Team, 2016). These represent the un- ique contribution above and beyond the contribution of other pre- dictors in the model and are presented in absolute values. 3. Results 3.1. Changes in regulation (H1) and equivalency to HCs (H3) 3.1.1. Change in self-reports Descriptive statistics for all study variables are presented in sup- plemental material, section 3. Changes are shown in Fig. 1. Suppression. Consistent with hypotheses, the frequency of sup- pression decreased during treatment (t467 = -3.98, p < .01, rs = .22 [.14, .30]) and did not change from post-treatment to follow-up (b = -.10, t490 = -.62, p = .53, rs = .01 [.00, .10]). In contrast to hypotheses, self-efficacy of suppression decreased during treatment (t467 = -2.85, p < .01, rs = .14 [.05, .22]) and did not change from post-treatment to follow-up (b = -.09, t490 = -.64, p = .52, rs = .01 [.00, .10]). Reappraisal. Consistent with hypotheses, self-efficacy of reappraisal increased during treatment (t467 = 3.67, p < .01, rs = .17 [.08, .25]) and did not change from post-treatment to follow-up (b = -.02, t490 = -.10, p = .92, rs = .00 [.00, .10]). In contrast to hypotheses, no changes in frequency of reappraisal were observed (t467 = .04, p = .97, rs = .00 [.00, .10]) nor did they change from post-treatment to follow- up (b = .08, t490 = .33, p = .74, rs = .01 [.00, .10]). 3.1.2. Change in lab-based measures Changes are shown in Fig. 2 and Fig. 3. View SAD-related pictures. As hypothesized, unpleasantness ratings decreased during treatment (t115 = 4.49, p < .01, rs = .28 [.13, .42]) and did not change from post-treatment to follow-up (b = .08, t138 = .70, p = .49, rs = .03 [.00, .18]). The LPP while viewing SAD- related pictures did not change significantly during treatment (b = -.46, t103 = -1.80, p = .07, rs = .14 [.01, .30]) or from post-treatment to Fig. 1. Change in frequency and self-efficacy of reappraisal (top panel) and suppression (bottom panel) during Cognitive Behavioral Therapy (CBT). Error bars represent estimated standard errors. Only data from sessions 1-16 are presented because only 5 patients received more than 16 sessions. b = esti- mated weekly change in emotion regulation. ** p < .01 Y. Kivity, et al. Journal of Affective Disorders 279 (2021) 334–342 337 follow-up (b = 1.73, t126 = 1.11, p = .27, rs = .05 [.00, .20]). View neutral pictures. Supporting our hypotheses, we found no change in unpleasantness ratings during CBT or from post-treatment to follow-up (during: t115 = -.43, p = .67, rs = .04 [.00, .20]; post- treatment to follow-up: b = -.05, t138 = -.26, p = .79, rs = .02 [.00, .17]) and in the LPP (during: b = -.29, t103 = -1.04, p = .30, rs = .09 [.00, .25]; post-treatment to follow-up: b = 1.86, t126 = 1.09, p = .28, rs = .05 [.00, .20]) while viewing neutral pictures. Suppression. Examining suppression-related reductions in un- pleasantness (compared to viewing pictures) we found that reductions were significantly different from zero at pre-treatment (b = .25, t115 = 3.84, p < .01), indicating that suppression was effective in down-regulating negativity. Consistent with hypotheses, regulation scores did not change during treatment (t115 = -1.77, p = .08, rs = .16 [.02, .31]) or from post-treatment to follow-up (b = .03, t138 = .29, p = .78, rs = .02 [.00, .18]). Reductions in LPP via suppression were not different from zero at pre-treatment (b = .69, t103 = 1.00, p = .32), suggesting that suppression was not effective in down regulating the LPP. Also consistent with hypotheses, regulation scores … Paper demonstrates an excellent understanding of all of the concepts and key points presented in the text(s) and Learning Resources. Paper provides significant detail including multiple relevant examples, evidence from the readings and other sources, and discerning ideas. Paper is well organized, uses scholarly tone, follows APA Style, uses original writing and proper paraphrasing, contains very few or no writing and/or spelling errors, and is fully consistent with graduate-level writing style. Paper contains multiple, appropriate and exemplary sources expected/required for the Assignment.
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Develop a community-wide intervention to reduce elevated blood pressure and hypertension in the State of Alabama that in in body of the report Conclusions References (8 References Minimum) *** Words count = 2000 words. *** In-Text Citations and References using Harvard style. *** In Task section I’ve chose (Economic issues in overseas contracting)" Electromagnetism w or quality improvement; it was just all part of good nursing care.  The goal for quality improvement is to monitor patient outcomes using statistics for comparison to standards of care for different diseases e a 1 to 2 slide Microsoft PowerPoint presentation on the different models of case management.  Include speaker notes... .....Describe three different models of case management. visual representations of information. They can include numbers SSAY ame workbook for all 3 milestones. You do not need to download a new copy for Milestones 2 or 3. When you submit Milestone 3 pages): Provide a description of an existing intervention in Canada making the appropriate buying decisions in an ethical and professional manner. Topic: Purchasing and Technology You read about blockchain ledger technology. Now do some additional research out on the Internet and share your URL with the rest of the class be aware of which features their competitors are opting to include so the product development teams can design similar or enhanced features to attract more of the market. The more unique low (The Top Health Industry Trends to Watch in 2015) to assist you with this discussion.         https://youtu.be/fRym_jyuBc0 Next year the $2.8 trillion U.S. healthcare industry will   finally begin to look and feel more like the rest of the business wo evidence-based primary care curriculum. Throughout your nurse practitioner program Vignette Understanding Gender Fluidity Providing Inclusive Quality Care Affirming Clinical Encounters Conclusion References Nurse Practitioner Knowledge Mechanics and word limit is unit as a guide only. The assessment may be re-attempted on two further occasions (maximum three attempts in total). All assessments must be resubmitted 3 days within receiving your unsatisfactory grade. You must clearly indicate “Re-su Trigonometry Article writing Other 5. June 29 After the components sending to the manufacturing house 1. In 1972 the Furman v. Georgia case resulted in a decision that would put action into motion. Furman was originally sentenced to death because of a murder he committed in Georgia but the court debated whether or not this was a violation of his 8th amend One of the first conflicts that would need to be investigated would be whether the human service professional followed the responsibility to client ethical standard.  While developing a relationship with client it is important to clarify that if danger or Ethical behavior is a critical topic in the workplace because the impact of it can make or break a business No matter which type of health care organization With a direct sale During the pandemic Computers are being used to monitor the spread of outbreaks in different areas of the world and with this record 3. Furman v. Georgia is a U.S Supreme Court case that resolves around the Eighth Amendments ban on cruel and unsual punishment in death penalty cases. The Furman v. Georgia case was based on Furman being convicted of murder in Georgia. Furman was caught i One major ethical conflict that may arise in my investigation is the Responsibility to Client in both Standard 3 and Standard 4 of the Ethical Standards for Human Service Professionals (2015).  Making sure we do not disclose information without consent ev 4. Identify two examples of real world problems that you have observed in your personal Summary & Evaluation: Reference & 188. Academic Search Ultimate Ethics We can mention at least one example of how the violation of ethical standards can be prevented. Many organizations promote ethical self-regulation by creating moral codes to help direct their business activities *DDB is used for the first three years For example The inbound logistics for William Instrument refer to purchase components from various electronic firms. During the purchase process William need to consider the quality and price of the components. In this case 4. A U.S. Supreme Court case known as Furman v. Georgia (1972) is a landmark case that involved Eighth Amendment’s ban of unusual and cruel punishment in death penalty cases (Furman v. Georgia (1972) With covid coming into place In my opinion with Not necessarily all home buyers are the same! When you choose to work with we buy ugly houses Baltimore & nationwide USA The ability to view ourselves from an unbiased perspective allows us to critically assess our personal strengths and weaknesses. This is an important step in the process of finding the right resources for our personal learning style. Ego and pride can be · By Day 1 of this week While you must form your answers to the questions below from our assigned reading material CliftonLarsonAllen LLP (2013) 5 The family dynamic is awkward at first since the most outgoing and straight forward person in the family in Linda Urien The most important benefit of my statistical analysis would be the accuracy with which I interpret the data. The greatest obstacle From a similar but larger point of view 4 In order to get the entire family to come back for another session I would suggest coming in on a day the restaurant is not open When seeking to identify a patient’s health condition After viewing the you tube videos on prayer Your paper must be at least two pages in length (not counting the title and reference pages) The word assimilate is negative to me. I believe everyone should learn about a country that they are going to live in. It doesnt mean that they have to believe that everything in America is better than where they came from. It means that they care enough Data collection Single Subject Chris is a social worker in a geriatric case management program located in a midsize Northeastern town. She has an MSW and is part of a team of case managers that likes to continuously improve on its practice. The team is currently using an I would start off with Linda on repeating her options for the child and going over what she is feeling with each option.  I would want to find out what she is afraid of.  I would avoid asking her any “why” questions because I want her to be in the here an Summarize the advantages and disadvantages of using an Internet site as means of collecting data for psychological research (Comp 2.1) 25.0\% Summarization of the advantages and disadvantages of using an Internet site as means of collecting data for psych Identify the type of research used in a chosen study Compose a 1 Optics effect relationship becomes more difficult—as the researcher cannot enact total control of another person even in an experimental environment. Social workers serve clients in highly complex real-world environments. Clients often implement recommended inte I think knowing more about you will allow you to be able to choose the right resources Be 4 pages in length soft MB-920 dumps review and documentation and high-quality listing pdf MB-920 braindumps also recommended and approved by Microsoft experts. The practical test g One thing you will need to do in college is learn how to find and use references. References support your ideas. College-level work must be supported by research. You are expected to do that for this paper. You will research Elaborate on any potential confounds or ethical concerns while participating in the psychological study 20.0\% Elaboration on any potential confounds or ethical concerns while participating in the psychological study is missing. Elaboration on any potenti 3 The first thing I would do in the family’s first session is develop a genogram of the family to get an idea of all the individuals who play a major role in Linda’s life. After establishing where each member is in relation to the family A Health in All Policies approach Note: The requirements outlined below correspond to the grading criteria in the scoring guide. At a minimum Chen Read Connecting Communities and Complexity: A Case Study in Creating the Conditions for Transformational Change Read Reflections on Cultural Humility Read A Basic Guide to ABCD Community Organizing Use the bolded black section and sub-section titles below to organize your paper. For each section Losinski forwarded the article on a priority basis to Mary Scott Losinksi wanted details on use of the ED at CGH. He asked the administrative resident